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Analysis of Adverse Drug Reactions Combination of Zidovudine, Lamivudine, and Nevirapine Drugs in the Treatment of HIV/AIDS Patients in a Denpasar District Hospital Udayani, Ni Nyoman Wahyu; Dewi, Putu Intan Candra
Budapest International Research and Critics Institute-Journal (BIRCI-Journal) Vol 4, No 4 (2021): Budapest International Research and Critics Institute November
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v4i4.2858

Abstract

HIV/AIDS is a disease caused by infection with the Human Immunodeficiency Virus (HIV). Antiretroviral therapy is used for treatment. The three most commonly used combination antiretroviral regimens are zidovudine, lamivudine, and nevirapine. The problem that arises from the use of antiretroviral drugs is the emergence of adverse drug reactions (ADR). The purpose of this study was to identify and analyze the incidence of adverse drug reactions from the use of combination antiretroviral drugs in the treatment of HIV/AIDS patients in a Denpasar district hospital. This study is a descriptive study with prospective data collection on the patient's medical record. The sampling technique in this study uses a non-probability technique (Purposive Sampling). This study involved 102 patients. The results obtained were descriptive analysis for patient demographic data, duration of therapy and adverse drug reactions that occurred. The results showed that there was an adverse drug reaction in 50% of patients who used a combination of antiretroviral drugs zidovudine, lamivudine and nevirapine. The longest duration of ARV therapy in one of the hospitals in Denpasar Regency was the age > more than 2 years to 4 years, which was 33.3%. The types of ADR that occurred were nausea/vomiting (25 events), skin rash (23 events), headache (11 events), lethargy/fatigue (6 events), fever (6 events), muscle pain (5 events), diarrhea (4 events), neuropathy (2 events), anemia (2 events), and the least is nail hyperpigmentation (1 event).
Phytochemical and Pharmacological Activities of Three Colors Fruit (Eugenia Uniflora L) As Antidiabetes and Antibacteries Santoso, Puguh; Udayani, Ni Nyoman Wahyu; Putra, I Made Agus Sunadi; Yuwono, Moch.
Budapest International Research and Critics Institute-Journal (BIRCI-Journal) Vol 4, No 4 (2021): Budapest International Research and Critics Institute November
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v4i4.2861

Abstract

Eugenia uniflora with local name Indonesia   Dewandaru is a plant of the family Myrtaceae. It has green, orange, red, to blackish purple fruits which is widespread in South America, Asia, Africa and Australia. E. uniflora can be used as traditional medicine. The fruits is parts of plants that are widely used in various field nutrition, cosmetic and health, . The active secondary contained in this fuits were applied in anti inflammatory, anti diabetic, adstringent and antioxidant.   Several active compounds found in fruits such a carotene esensial oil and polyphenols have been reported to have some biological activities such as antioxidant antidiabetic and antibacterial. The level maturity of fruits level is related to the contend of secondary metabolites such a fenoloic, carotene esential oils.  The color of E. uniflora fruit is related to the active phytochemical content and antioxidant activity. Three colors of E. uniflora fruit contain beta carotene and phenolic compounds, essential oil, the highest content of phenolic compounds and antioxidants is found in purple fruit This review provides insight into the effort of discovery and development of pharmaceutical agents derived from fruits of Dewandaru (Eugenia uniflora) plants to  make product.
Co-Authors Adnyani, Putu Mesi Dian Adrianta, I Ketut Agus Agung Ari Chandra Wibawa Agung Ari Chandra Wibawa Agustin, Ni Kadek Jessica Agustini, Ni Putu Dewi Anggreni, Ayu Putu Puspa Anita Dewi, Ni Luh Kade Arman Apriani, Rista Ciptawati, Ni Wayan Cokorda Javandira Debby Juliadi Dewi, Ni Kadek Dhea Cipta Dewi, Putu Intan Candra Dwipayanti, Ni Kadek Sari Erna Cahyaningsih Febryna Dharma Yanti, Ni Luh Putu Fitria Megawati Fitria Megawati Fredinan Yulianda Fridayana, Ni Luh Gede Erica Herleeyana Meriyani Herleeyana Meriyani I Dewa Ayu Anom Yustari Nida I Gede Made Suradnyana I Gede Yodhi Trismawan I Gusti Agung Ayu Kusuma Wardhani I Gusti Ayu Arya Ditha Suari I Ketut Sumantra I Made Agus Sunadi Putra I Made Agus Sunadi Putra I Made Agus Sunadi Putra I Made Agus Sunadi Putra I Nyoman Gede Tri Sutrisna I Putu Pasek Jaya Separsa I Putu Tangkas Suwantara I Putu Werda Bisama Ida Ayu Gede Syntya Mahayani IGAA Kusuma Wardani Kadek Ayu Puspa Pratiwi Ketut Agus Adrianta Ketut Agus Adrianta Ketut Agus Adrianta Ketut Agus Adrianta Ketut Agus Adrianta Ketut Agus Adrianta Ketut Agus Adrianta Laksmi, Luh Putri Dianti Lestari, Ketut Sita Citra Lilis Adnyani Ni Putu Luh Putu Febryana L Lusi Puspitasari, Ni Wayan Made Dwik Lestari Maharani, Ade Dwi Karisma Mahardika, I Made Agus Mahendra, I Putu Aldy Manik Suka Dewi Yani Ni Komang Maria Daniela Tupa Hokor Maria Malida Vernandes Sasadara Mayun Anak Agung Istri Mega Ratnasari, Ni Luh Ayu Megawati, Fitri Megawati, Fitria Meika, Ni Putu Trisna Mendra, Ni Nyoman Yudianti Meriyani, Herleeyana Nggaba, Ellenoire Rambu Kabeba Hammu Ni Komang Enny Wahyuni Ni Luh Ayu Mega Ratnasari Ni Luh Kade Arman Anita Dewi Ni Luh Kade Arman Anita Dewi Ni Luh Putu Dewi Purnama Sari Ni Luh Putu Sulasmini Ni Luh Putu Tris Yoga Cahyani Ni Made Dharma Shantini Suena Ni Made Dwi Mara Widyani Nayaka Ni Made Sukma Sanjiwani Ni Nyoman Ayu Puspita Sari Ni Putu Dewi Agustini Ni Putu Leona Yorita Dewi Ni Putu Lilis Adnyani Ni Putu Lilis Adnyani Ni Putu Putri Cahya Anggreni Ni Putu Refina Dharma Yanti Ni Putu Sintia Rahayu Ni Wayan Ciptawati Ni Wayan Riastini Nindya Kartika, Dewa Ayu Kintan Nugraha, Nyoman Dhamapada Nyoman Budiartha Siada Pendet, Ni Made Diah Pusparini Puguh Santoso Puguh Santoso puguh santoso, puguh Putra Hilmi Prayitno Putra, I Made Agus Sunadi Putri, Ni Komang Ary Agustina Berliana Putu Era Sandhi K.Yuda Putu Era Sandhi Kusuma Yuda Putu Mesi Dian Adnyani Riastini, Ni Wayan Sasadara, Maria Malida Vernandes Siluh Putu Astini Sugijanto, Milyadi Sunadi Putra I Made Agus Wardani, I Gusti Agung Ayu Kusuma Widiasriani, Ida Ayu Putu Wiguna, I Putu Bagus Artha Wiguna, Putu Dony Saputra Woro Enjang Santi Prihatin Wulandari, Ni Kadek Ganis Yowani, Anak Agung Sagung Iswarani Yustari Nida, I Dewa Ayu Anom Yuwono, Moch.