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All Journal Jurnal Teknologi Dan Industri Pangan Teknotan: Jurnal Industri Teknologi Pertanian Prosiding Seminar Biologi Jurnal Kedokteran Brawijaya The Journal of Experimental Life Sciences (JELS) El-Hayah : Jurnal Biologi Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Ilmu-Ilmu Peternakan (Indonesian Journal of Animal Science) Journal of Innovation and Applied Technology Research Journal of Life Science Jurnal Pangan dan Agroindustri Jurnal Teknologi Pertanian Industria: Jurnal Teknologi dan Manajemen Agroindustri Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Aplikasi Teknologi Pangan TEKNOLOGI PANGAN : Media Informasi dan Komunikasi Ilmiah Teknologi Pertanian PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Teknologi Hasil Pertanian Canrea Journal: Food Technology, Nutritions, and Culinary Journal Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Jurnal Mnemonic Proceeding Biology Education Conference Agroindustrial Journal
Elok Zubaidah
Universitas Brawijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Anti-hyperglycemic and Immunomodulatory Activity of a Polyherbal Composed of Sesbania grandiflora, Salacca zalacca and Acalypha indica Zamroni, Ahmad; Zubaidah, Elok; Rifa'i, Muhaimin; Widjanarko, Simon Bambang
The Journal of Experimental Life Science Vol. 8 No. 3 (2018)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2018.008.03.09

Abstract

Diabetes has become a serious global public health problem due to its high prevalence and mortality. Unfortunately, current anti-diabetic drugs are having some limitations and adverse effects. Therefore, searching for a new anti-diabetic agent is an urgent challenge. In this research, we examined the effectiveness of a traditional anti-diabetic polyherbal composed of Sesbania grandiflora seeds, Salacca zalacca leaves and Acalypha indica roots (2:1:1). The study was aimed to explore the anti-hyperglycemic effect of the polyherbal in STZ-induced diabetic mice and to investigate the immunomodulatory activity involved in the process of controlling hyperglycemia. Our results showed that the polyherbal water extract (150 mg.kgBW-1) could suppress blood glucose elevation and preserve pancreatic islet of diabetic mice. Moreover, the polyherbal treatment could normalize the relative amount of activated CD4+CD62L- and CD8+CD62L- T cells. The polyherbal extract also stimulated the production of CD4+CD25+FoxP3+ regulatory T cells (Tregs) which is known to play an important role in diabetes control. In addition, polyherbal treatment also increased the relative amount of anti-inflammatory cytokines IL-10 and TGF-β. These results revealed that the polyherbal extract has an anti-hyperglycemic and immunomodulatory activity that may provide beneficial function in diabetes healing. Keywords: Antidiabetes, Immunomodulator, Polyherbal, Regulatory T cell.
Co-Authors - Austin, - Aan Muzaky Kusuma Abdul Jabar Jordana Kalfat Abdul Jabar Jordana Kalfat Abdullah Nasich Ulwan Abdullah Nasich Ulwan, Abdullah Nasich Aji Sutrisno Alfredo Johan Wahyu Sagita Sitompul Ali Mashuri Alinna Listyani Alinna Listyani Ampu Marojahan Resmanto Ampu Marojahan Resmanto, Ampu Marojahan Anang Lastriyanto Andayani, Dian Wuri Anindita Mufti Rizky Anindita Mufti Rizky Anton Nudyanto Anton Nudyanto Arie Srihardyastutie Ario Betha Juanssilfero Arni Ardila Sari Bambang Poerwadi Bimo, Igoy Chatarina Umbul Wahyuni Christina Veronica Christine Natalia Halim Christine Natalia Halim Citra Pradani P Daniar Putri Dinson Daniar Putri Dinson Denty Wiryawan, Alivianisa Carissa Detya Pitaloka Sari Devrina Nova Maria Devrina Nova Maria Dewi Maya Maharani Dewi Permatasari, Dewi Dewi, Camelia Norosita Dian Widya Ningtyas Dimawarnita, Firda Diyah Dewanti, Beauty Suestining Duwi Wistiana Duwi Wistiana Ella Saparianti Elvina Wulandari Elvina Wulandari Erryana Martati Estri Laras Arumingtyas Evan Tedjautama Evan Tedjautama Fadhila Erwin Fadhila Erwin Falasifah, Ratu Faramitha, Yora Felix Deni Arentino Feronika Heppy Sriherfyna Fithri Choirun Nisa Gilang Satrio Wicaksono Hairil Fikri hardiansyah, bagus Hartono, Elvianto Dwi Hasfiani, Yuliatin Hasna, Tanalyna Heliana, Almaria Heni Adhianata, Heni Hidayat Sujuti Ilham Dwi Nurcahyono Ilham Dwi Nurcahyono Indria Purwantiningrum Indria Purwantiningrum Irfi Wahyuningrum Irfi Wahyuningrum Jamhari Jamhari Jaya Mahar Maligan Joni Kusnadi Josep Hindrawan KIKI FIBRIANTO Kristian Purwohadisantoso Kusuma, Azzakiyya Salsabila Syifa Lalong, Paulus Risan F. Lila Prastyaharasti Lila Prastyaharasti M Fatkhul Mubin M Fatkhul Mubin M. Maria Marrisa Mawardhani Masahid, Ardiyan Dwi Maulidiyah, Nuris Shobah Mentari Sekar Arum Miftachurrochmah, Anis Mochamad Nurcholis Monika Maria P.S. Mora, Giral Baines Muhammad Muizuddin Muhammad Muizuddin Munawaroh - Munawaroh Munawaroh Musdholifah Musdholifah Musdholifah Musdholifah N. Sholahudin Nadzira Nadzira Nadzira Nadzira, Nadzira Nawa Aldina Nela Endy Restiengtias Nestya Hariyoko Nina Marlina A Nur Ida Panca Nugrahini Nur Kusmiyati Nur, Mokhamad Pendik Setiawan Pino Tri Anggara Pino Tri Anggara Prasis Nursyam Suhardini Prasis Nursyam Suhardini Putri, Aldila Putri, Belvania Nabila Putri, Nazhifah Vitya Putu Ayu Chintia Devi Pendit Putu Ayu Chintia Devi Pendit, Putu Ayu Chintia Devi Putu Bayu Tantrayana Putu Bayu Tantrayana Raehana Saria Gahari Rahmawati, Siti Irma Ratih Anggraini Ratih Anggraini, Ratih Rebecca Oktanesia Rifa'i, Muhaimin Riyanto, Eko Isro Rochmad Chusaini Maulidianto Rochmad Chusaini Maulidianto Rosyid Ulul Albab Rosyid Ulul Albab Safindra, Naswadhia Salafy, Rahma Aulia Sanita Friska Sitepu Septina Dwi Widiyana SIMON BAMBANG WIDJANARKO Soviandini Dwiki Kartikaputri Sudarma Dita Wijayanti Tri Ardyati Tri Ardyati Urip Perwitasari, Urip Vicka Jacinda Masye Kusuma Vicka Jacinda Masye Kusuma Vindhya Tri Widayanti, Vindhya Tri Wahyudi, Aleyda Nur Halizah Wellang, Ambo Weni Liandani Weni Liandani Widya Dwi Rukmi Putri Yogi Trio Sandi Yogi Trio Sandi Yua, Ezza Selisa Yusfardyanto Yunus Yusfardyanto Yunus Yusnita Liasari Yusry Muqit Suryawira Yusuf Hendrawan Zamroni, Ahmad Zia Rossanieldha Zia Rossanieldha