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All Journal Farmaka Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Kesehatan Masyarakat JURNAL PHARMASCIENCE Majalah Obat Tradisional Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Journal of Tropical Biodiversity and Biotechnology INDONESIAN JOURNAL OF PHARMACY Pharmascience Edukasi: Jurnal Pendidikan Jurnal Fitofarmaka Indonesia JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Epidemiologi Kesehatan Komunitas Al-Khidmah PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) GERVASI: Jurnal Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia Jurnal Jamu Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Sasambo Journal of Pharmacy Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Komunitas Pharmaceutical Sciences and Research (PSR) Jurnal Natural Jurnal Vokasi Kesehatan Jurnal Pendidikan Kesehatan (e-Journal) Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu
Eka Kartika Untari
Departemen Farmasi, Fakultas Kedokteran, Universitas Tanjung Pura
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Jurnal Natural

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Hylocereus polyrhizus effect on catalase and malondialdehyde in rats with oxidative stress SRI WAHDANINGSIH; EKA KARTIKA UNTARI
Jurnal Natural Volume 21 Number 3, October 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1156.051 KB) | DOI: 10.24815/jn.v21i3.19474

Abstract

The excessive production of free radicals causes oxidative damage and degenerative diseases. Whereas, catalase is a macromolecule with a specific activity, but Malondialdehyde (MDA) is a small molecule with no activity. The peels of red dragon fruit (H. polyrhizus) are potential to be natural exogenous antioxidants. This research aimed to determine the effects of methanol fraction from H. polyrhizus peels on catalase activity and MDA level. The peel was macerated using chloroform and fractionated using methanol. The stress condition was done through five-day fasting and ten-minute swimming per day. The activity of catalase and MDA was measured using UV-Vis spectrophotometer. Thirty five rats were divided into 7 groups: normal, negative, dose I (5 mg/200gBW), dose II (10 mg/200gBW), dose III (20 mg/200gBW), positive control (quercetin) (4 mg/200gBW) and vitamin E (17.64 mg/kg). The activity of catalase in the normal, negative, vitamin E, and quercetin, dose I, II, and II respectively were: 28.37; 7.8; 24.85; 34.33; 59.92; 28.18; and 70.85 Unit/mL. The average MDA level in the groups respectively were: 0.042; 0.051; 0.034; 0.042; 0.037; 0.033; 0.030 μg/mL. The result of One Way ANOVA test showed that the catalase activity in dose III was significantly different than normal group; the MDA levels in all groups were significantly different than normal group. This research revealed that methanol fraction from H. polyrhizus peels is a potent antioxidant for its capacity to increase the activity of catalase and reduce the MDA level in rats with oxidative stress.
Hylocereus polyrhizus effect on catalase and malondialdehyde in rats with oxidative stress SRI WAHDANINGSIH; EKA KARTIKA UNTARI
Jurnal Natural Volume 21 Number 3, October 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v21i3.19474

Abstract

The excessive production of free radicals causes oxidative damage and degenerative diseases. Whereas, catalase is a macromolecule with a specific activity, but Malondialdehyde (MDA) is a small molecule with no activity. The peels of red dragon fruit (H. polyrhizus) are potential to be natural exogenous antioxidants. This research aimed to determine the effects of methanol fraction from H. polyrhizus peels on catalase activity and MDA level. The peel was macerated using chloroform and fractionated using methanol. The stress condition was done through five-day fasting and ten-minute swimming per day. The activity of catalase and MDA was measured using UV-Vis spectrophotometer. Thirty five rats were divided into 7 groups: normal, negative, dose I (5 mg/200gBW), dose II (10 mg/200gBW), dose III (20 mg/200gBW), positive control (quercetin) (4 mg/200gBW) and vitamin E (17.64 mg/kg). The activity of catalase in the normal, negative, vitamin E, and quercetin, dose I, II, and II respectively were: 28.37; 7.8; 24.85; 34.33; 59.92; 28.18; and 70.85 Unit/mL. The average MDA level in the groups respectively were: 0.042; 0.051; 0.034; 0.042; 0.037; 0.033; 0.030 μg/mL. The result of One Way ANOVA test showed that the catalase activity in dose III was significantly different than normal group; the MDA levels in all groups were significantly different than normal group. This research revealed that methanol fraction from H. polyrhizus peels is a potent antioxidant for its capacity to increase the activity of catalase and reduce the MDA level in rats with oxidative stress.
Co-Authors A.A. Ketut Agung Cahyawan W Agilina, Alvani Renata Agustia Damayanti Agustia Damayanti Agustia Damayanti Agustia Damayanti, Agustia Alvani Renata Agilina Anas Putri Maria Natasya Panamuan Apridamayanti, Pratiwi Asri Adyttia Asri Adyttia Asri Adyttia Asri Adyttia, Asri Ayu Pratiwi Butarbutar, Ruth Haryati Ediati Sasmito Egida Rachmadani Gamayanti, Tasiana Gisela Hadi Kurniawan, Hadi Hati, Anita Kumala Herlina, Tutun Intan Khairunnisa Irene Mahwal Khairunnisa, Intan Kusuma, Ria Liberti, Oktaviona Winda Meilita, Dewi Melda Mery Andiriyani Monika Rosmimi Muhammad Akib Yuswar Muhammad Akib Yuswar Muhammad Akib Yuswar Muhammad Akib Yuswar Nabilla Putri Pratiwi Nanang Munif Yasin Nera Umilia Purwanti, Nera Umilia Niken Larasati Novi Permata Sari Nurmainah Nurmainah Nurul Mar'atus Sholihah Octaviani, Peppy Oskar Skarayadi, Oskar Pinasti Utami, Pinasti pramestutie, hananditia rachma Pratiwi Apridamayanti Pratiwi Apridamayanti, Pratiwi Pratiwi, Nabilla Putri Rachmadani, Egida Rafika Sari Rafika Sari Rafika Sari Ratna Widyaningrum Ria Kusuma Rise Desnita, Rise Rizka Humardewayanti Asdie Robiyanto Robiyanto, Robiyanto Robiyanto, Robiyanto Rosmimi, Monika Ruth Haryanti Butarbutar Safitri Caesaria Samudra, Nizam Elang Sholihah, Nurul Mar'atus Shoma Rizkifani Siti Nani Nurbaeti Sri Amalia Sri Amalia Sri Amalia, Sri Sri Mulyaningsih Sri Wahdaningsih Sri Wardaningsih Susanti, Ressi Susanti, Ressi Tri Murti Andayani Vanie, Vanie Veronika, Vina Wirna Maya Sari Wirna Maya Sari Wirna Maya Sari Wirna Maya Sari, Wirna Maya Yunita Fauziah Yunita Fauziah Yunita Fauziah Yunita Fauziah, Yunita Yuswar, M. Akib Yuswar, Muhammad Akib