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All Journal Farmaka Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Kesehatan Masyarakat JURNAL PHARMASCIENCE Majalah Obat Tradisional Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Journal of Tropical Biodiversity and Biotechnology INDONESIAN JOURNAL OF PHARMACY Edukasi: Jurnal Pendidikan Jurnal Fitofarmaka Indonesia JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Epidemiologi Kesehatan Komunitas Al-Khidmah PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) GERVASI: Jurnal Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia Jurnal Jamu Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Sasambo Journal of Pharmacy Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Komunitas Pharmaceutical Sciences and Research (PSR) Jurnal Natural Jurnal Vokasi Kesehatan Jurnal Pendidikan Kesehatan (e-Journal) Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu Journal of Pharmascience
Eka Kartika Untari
Departemen Farmasi, Fakultas Kedokteran, Universitas Tanjung Pura
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Journal of Pharmascience

 1 
Pengaruh Pemberian Fraksi Metanol Kulit Buah Naga Merah (Hylocerecus polyhizus) Terhadap Kadar Malondialdehid Pada Tikus (Rattus novergicus) Wistar Yang Mengalami Stres Oksidatif Sri Wahdaningsih; Eka Kartika Untari
Journal of Pharmascience Vol. 3 No. 1 (2016): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v3i1.5834

Abstract

ABSTRAK  Produksi radikal bebas berlebihan dalam tubuh dapat menyebabkan stres oksidatif. Salah satu indikator stres oksidatif pada manusia adalah kadar Malondialdehid (MDA). Kulit Hylocereus polyrhizus berpotensi sebagai antioksidan eksogen alami. Tujuan penelitian ini untuk mengetahui efek fraksi metanol kulit H. polyhizus terhadap kadar MDA dan mengetahui dosis fraksi metanol kulit H. polyhizus yang dapat menurunkan kadar MDA. Kulit H. polyhizus dimaserasi menggunakan kloroform p.a, kemudian difraksinasi dengan pelarut metanol. Kadar MDA diukur menggunakan Spektrofotometer UV-Vis pada panjang gelombang 532 nm. Tikus dibagi menjadi 7 kelompok yaitu kontrol normal, kontrol negatif, kontrol positif vitamin E(18 mg/ kgBB), kontrol positif kuersetin (4 mg/ 200gBB), dosis I (5 mg/ 200gBB), Dosis II (10 mg/ 200gBB) dan dosis III (20 mg/ 200gBB). Setiap kelompok terdiri dari 4 ekor tikus dan diberikan stres oksidatif berupa perenangan 10 menit perhari dan puasa pakan selama 5 hari. Analisis data dilakukan dengan menggunakan One way ANOVA dan uji LSD (Least Significant Difference). Hasil analisis data kadar rata-rata MDA pada kelompok normal, negatif, vitamin E, kuersetin, dosis I,II dan III berturut-turut adalah 0,042; 0,051; 0,034; 0,042; 0,037; 0,033; 0,030 µg/ml. Dosis fraksi metanol kulit H. polyhizus berpotensi sebagai antioksidan karena dapat menurunkan kadar malondialdehid pada tikus yang mengalami stres oksidatif.   Kata Kunci : Stres oksidatif, Malondialdehid, Antioksidan, Hylocereus polyrhizus, Metanol ABSTRACT Excessive free radical production will lead to oxidative stress. One of the indicators used to determine stress oxidative is malondialdehyde (MDA). Hylocereus polyhizus peel is potential as natural exogenous antioxidant. The aim of this research was  to study the effect of methanol fraction of H. polyhizus peel on MDA level and  to determine that dose that could  reduce the MDA level. H. polyhizus peel was macerated with chloroform, fractionated with methanol. Measurement of MDA level was used Spectrophotometer UV-Vis in 532 nm.  Rats were divided into 7 groups : normal, negative, positive control vitamin E (18 mg/ kgbw), positive control quercetin (4 mg/200gbw), H. polyhizus peel extract group treated with dose I (5 mg/200gbw), dose II (10 mg/200gbw) and dose III (20 mg/200gbw). Each group consist of 4 rats and induced with oxidative stress by 10 minute swimming each day and food restriction for 5 days. MDA levels were analyzed using One way Anova and LSD test. The data shown that MDA level at normal, negative, vitamin E, kuarsetin, dose I, II, III group is 0.042; 0.051; 0.034; 0.042; 0.037; 0.033; 0,030 µg/ml. The methanol fraction of red dragon fruit peel was a potent antioxidant  because posessing the ability to lowering the MDA level on stress oxidative rats. Key Word : Stress Oxidative, Malondialdehyde, Antioxidant, Hylocereus polyrhizus, Methanol.
The Antibacterial Activity of Red Dragon Fruit Peel (Hylocereus polyrhizus Britton & Rose) Methanolic Fraction Against Staphylococcus epidermidis and Propionibacterium acnes Sri Wahdaningsih; Eka Kartika Untari
Journal of Pharmascience Vol. 8 No. 2 (2021): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.10378

Abstract

Acnes can be caused by Propionibacterium acnes and Staphylococcus epidermidis. Red dragon (Hylocereus polyrhizus B & R) fruit peels is one of natural materials which is assumed to possess an antibacterial activity. The purpose of this study was to determine the antibacterial activity of red dragon fruit peels methanol fraction (RDFPMF) against S. epidermidis and P. acne by disc diffusion Kirby-Bauer method. Red dragon fruit peels were maceration in chloroform and fractionation in methanol. Clindamycin 4µg/disk was used as positive control and DMSO 10% was used as negative control. This research showed that the RDFPMF has antibacterial activity against P. acnes which the average of inhibition zones obtained from the concentrations from 100, 50, and 25 mg/mL respectively were 10.5 ± 0.50 mm, 10.0 ± 0.00 mm, and 8.5 ± 0.50 mm. The RDFPMF has no inhibition zone toward S. epidermidis. The red dragon fruit peels methanol fraction has antibacterial activity on P. acnes by disc diffusion method (Kirby-Bauer test).
Co-Authors A.A. Ketut Agung Cahyawan W Agilina, Alvani Renata Agustia Damayanti Agustia Damayanti Agustia Damayanti Agustia Damayanti, Agustia Alvani Renata Agilina Anas Putri Maria Natasya Panamuan Apridamayanti, Pratiwi Asri Adyttia Asri Adyttia Asri Adyttia Asri Adyttia, Asri Ayu Pratiwi Butarbutar, Ruth Haryati Ediati Sasmito Egida Rachmadani Gamayanti, Tasiana Gisela Hadi Kurniawan, Hadi Hati, Anita Kumala Herlina, Tutun Intan Khairunnisa Irene Mahwal Khairunnisa, Intan Kusuma, Ria Liberti, Oktaviona Winda Meilita, Dewi Melda Mery Andiriyani Monika Rosmimi Muhammad Akib Yuswar Muhammad Akib Yuswar Muhammad Akib Yuswar Muhammad Akib Yuswar Nabilla Putri Pratiwi Nanang Munif Yasin Nera Umilia Purwanti, Nera Umilia Niken Larasati Novi Permata Sari Nurmainah Nurmainah Nurul Mar'atus Sholihah Octaviani, Peppy Oskar Skarayadi, Oskar Pinasti Utami, Pinasti pramestutie, hananditia rachma Pratiwi Apridamayanti Pratiwi Apridamayanti, Pratiwi Pratiwi, Nabilla Putri Rachmadani, Egida Rafika Sari Rafika Sari Rafika Sari Ratna Widyaningrum Ria Kusuma Rise Desnita, Rise Rizka Humardewayanti Asdie Robiyanto Robiyanto, Robiyanto Robiyanto, Robiyanto Rosmimi, Monika Ruth Haryanti Butarbutar Safitri Caesaria Samudra, Nizam Elang Sholihah, Nurul Mar'atus Shoma Rizkifani Siti Nani Nurbaeti Sri Amalia Sri Amalia Sri Amalia, Sri Sri Mulyaningsih Sri Wahdaningsih Sri Wardaningsih Susanti, Ressi Susanti, Ressi Tri Murti Andayani Vanie, Vanie Veronika, Vina Wirna Maya Sari Wirna Maya Sari Wirna Maya Sari Wirna Maya Sari, Wirna Maya Yunita Fauziah Yunita Fauziah Yunita Fauziah Yunita Fauziah, Yunita Yuswar, M. Akib Yuswar, Muhammad Akib