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All Journal Jurnal Kedokteran Syiah Kuala Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease Nusantara Medical Science Journal Jurnal Keperawatan Padjadjaran Jurnal Kesehatan Prima Oceana Biomedicina Journal Jurnal Ilmu Kefarmasian Indonesia J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Medical and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Indian Journal of Forensic Medicine & Toxicology International Islamic Medical Journal journal of Basic Medical Veterinary Oceana Biomedicina Journal Cerdika: Jurnal Ilmiah Indonesia Jurnal Kedokteran Meditek Borneo Journal of Pharmacy Folia Medica Indonesiana
Yuani Setiawati
Departemen Farmakologi, Fakultas Kedokteran, Universitas Airlangga, Surabaya, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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The Protective Effect of Amorphophallus oncophyllus against Indomethacin-Induced Duodenal Mucosal Injury in Rats via Inhibition of Inflammatory Cell Infiltration Setiawati, Yuani; Kurnijasanti, Rochmah; D'Arqom, Annette; Nugraha, Jusak; Illiandri, Oski; Sudjarwo, Sri Agus
Borneo Journal of Pharmacy Vol. 8 No. 4 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i4.10233

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) can cause significant gastrointestinal mucosal injury, particularly in the duodenum. This damage is often initiated by localized erosion of the duodenal mucosa, which triggers a subsequent inflammatory cascade. The porang tuber (Amorphophallus oncophyllus) is a promising candidate for mitigating this injury due to its rich composition of bioactive compounds, including flavonoids, alkaloids, tannins, and glucomannan, all of which possess known anti-inflammatory properties. This study investigated the protective effect of an ethanolic A. oncophyllus extract on the duodenal mucosa in an indomethacin-induced rat model. Thirty Wistar white rats (Rattus norvegicus) were randomly assigned to five groups: a vehicle control, a model group receiving indomethacin, and three treatment groups that were pretreated with A. oncophyllus extract at doses of 50, 100, and 200 mg/kg, respectively, for seven days before a single dose of indomethacin. Our findings demonstrated that the A. oncophyllus extract, particularly at a dose of 200 mg/kg, effectively reduced duodenal mucosal injury caused by indomethacin. This protective effect is likely attributable to the extract's phytochemical profile, which contains flavonoids, tannins, saponins, terpenoids, and alkaloids. In conclusion, this research confirms that A. oncophyllus extract has the potential to protect the duodenal mucosa from NSAID-induced damage.
Profile of Drug Hypersensitivity Patients Hospitalized in Dr. Soetomo Hospital, Surabaya, Indonesia: Preliminary Data of 6 Months Observation Isyroqiyyah, Nur Moya; Soegiarto, Gatot; Setiawati, Yuani
Folia Medica Indonesiana Vol. 55, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Drug hypersensitivity is defined as an untoward response to medication which is noxious and unintended, and which occurs at doses normally used in human either for the prophylaxis, diagnosis, or therapy of disease or for the modification of physiological function. Drug hypersensitivity is common and may cause emergency condition until death. The incidence of drug hypersensitivity-related hospitalizations has usually been assessed within hospitals. The aim of this study is to determine the profile of drug hypersensitivity patients hospitalized at Dr. Soetomo Hospital in 6 months period from January to June 2016. This study was a descriptive retrospective study on medical records of drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital in 6 months period. The patient's demographic data, the type of hypersensitivity reaction, and the final outcome of the hospitalization were collected. Within the 6 months period, there were 16 drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital. Most of them are female (56.25%), and aged between 46-55 years (25%). There were 4 patients (25%) with type I hypersensitivity: urticaria, angioedema and anaphylaxis; while type IV hypersensitivity occured in 12 patients (75%): Stevens-Johnson syndrome, Stevens-Johnson syndrome-Toxic Epidermal Necrolysis overlap, erythroderma, maculopapular drug eruptions, and DRESS. Most of the patients (87.5%) had favorable outcome after hospitalization. There were 16 patients with drug hypersensitivity reaction hospitalized in Dr. Soetomo Hospital, Surabaya in 6 months period. Most of them were female and had type IV hypersensitivity reactions.
Co-Authors Abdul Khairul Rizki Purba Mustofa Indwiani Astuti Achmad Basori, Achmad ACHMAD RIFAI Agung Dwi Wahyu Widodo Akbar Kurniawan, Mohammad Al Alim, Muhammad Khafidin Anna Surgean Veterini Annete d’Arqom Annette d’Arqom, Annette Ardana, Arin Aurilia Arifa Mustika Asrianti, Nur Ilma Baitul Fatimah Benny Iswanto Pantoro Cindy ApriliaEkaPrasanty Citagami, Salsabila Dennia Oktavia Zahidah Hulwah Dennia Oktavia Zahidah Hulwah Dewangga Sakti Satria Kinasih Dewinta Enggar Pramesthi Djoko Marsudi Eko Budi Koendhori, Eko Budi Fadilah Fadilah Farhadi, Azmi Farhan Nurdiansyah Fatimah, Nurmawati Felicia Jiwantono Feriawan Tan Fiqih Faizara Ustadi Firda Fitra Qolbina Fitriati, Mariza Gatot Soegiarto Indiastuti, Danti Nur Indri Safitri Mukono, Indri Safitri Isyroqiyyah, Nur Moya Izzatul Fithriyah Jihan Bobsaid Jihan Bobsaid Junaidah Yusof Jusak Nugraha Khaerunnisa, Siti Kusuma Eko Purwantari Maftuchah Maftuchah Manaf, Syifa Az Zahrah Maya Hapsari Kusumaningtyas Mhd Zamal Nasution Mia Rahardjo Muflikhah Ramadhani Muflikhah Ramadhani Muhammad Khafidin Al Alim NOOR CHOLIES Nurina Hasanatuludhhiyah Nurul Wiqoyah, Nurul Oski Illiandri Pepy Dwi Endraswari, Pepy Dwi Purwanta, Marijam Puteri, Fira Adilah Qorib, Mohammad Fathul Raden Mohamad Herdian Bhakti Rehatta, Nancy Margarita Rizki Awaluddin Rochmah Kurnijasanti Shazia Hafazhah Aulia Siti Khaerunnisa Siti Khaerunnisa Sri Purwaningsih Trisniartami Setyaningrum Vivi Permata Sari Wiwin Retnowati Wiyogo, Illona Okvita Yuri Widia, Yuri