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All Journal Journal of Islamic Pharmacy MNJ (Malang Neurology Journal) Majalah Obstetri dan Ginekologi JIEET (Journal of Information Engineering and Educational Technology) Pharmaceutical Journal of Indonesia Majalah Kedokteran Neurosains JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Indian Journal of Forensic Medicine & Toxicology Cermin Dunia Kedokteran AKSONA Indonesian Journal of Cancer Neurona Cermin Dunia Kedokteran Folia Medica Indonesiana
Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo******
Department Of Neurology, Faculty Of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Neurona

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PENGUKURAN TINGKAH LAKU PADA MODEL NYERI NEUROPATIK PERIFER: TIKUS DENGAN CCI (CHRONIC CONSTRICTION INJURY) Hanik Badriyah Hidayati; Paulus Sugianto; Junaidi Khotib; Chrismawan Ardianto; Kuntoro Kuntoro; Mohammad Hasan Machfoed
NEURONA Vol 35 No 3 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i3.15

Abstract

BEHAVIORAL ASSESMENT OF THE PERIPHERAL NEUROPATHIC PAIN MODEL: RAT WITH CCI (CHRONIC CONSTRICTION INJURY)ABSTRACTNeuropathic pain occurs in 20% of patients with chronic pain. This mainly due to the lack of effective treatment and the presence of drug’s side effects. Animal models have been broadly utilized in validating the therapeutic target and the development of analgesic drugs. Chronic constriction injury (CCI) is a model of peripheral neuropathic pain characterized by allodynia and hyperalgesia. Chronic constriction injury model is produced by loose ligation of the sciatic nerve resulting in nerve damage, thus sensitizes and lowers pain threshold. The pain threshold test is performed by providing a pressure and thermal sensory stimulus that results in observable withdrawal behavior. This article discusses several methods in assessing pain-related behavior on the CCI neuropathic pain model.Keywords: Behavioral, chronic constriction injury, mechanical, neuropathic painABSTRAKNyeri neuropatik terjadi pada seperlima pasien dengan nyeri kronik. Hal ini disebabkan karena terapi nyeri neuropatik masih kurang efektif dan adanya efek samping obat. Model hewan terbukti bermanfaat untuk validasi target dan perkembangan obat analgesik. Chronic constriction injury (CCI) merupakan model nyeri neuropatik perifer dengan karakteristik alodinia dan hiperalgesia. Model CCI dibuat dengan memberikan ligasi longgar pada saraf skiatik yang menyebabkan kerusakan saraf, sehingga terjadi sensitisasi dan ambang nyeri menurun. Tes ambang nyeri dilakukan dengan memberikan stimulus sensorik berupa tekanan dan panas yang akan menghasilkan tingkah laku withdrawal yang bisa diobservasi. Artikel ini membahas penilaian tingkah laku nyeri pada model nyeri neuropatik CCI.Kata kunci: Chronic constriction injury, mekanik, nyeri neuropatik, tingkah laku
BEKAM SEBAGAI TERAPI ALTERNATIF UNTUK NYERI Hanik Badriyah Hidayati; Mohammad Hasan Machfoed; Kuntoro Kuntoro; Soetojo Soetojo; Budi Santoso; Suroto Suroto; Budi Utomo
NEURONA Vol 36 No 2 (2019)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v36i2.69

Abstract

      CUPPING AS PAIN ALTERNATIVE THERAPYABSTRACTPain is still a world’s problem. Current pain treatment is still unsatisfactory due to its chronicity and existing drugs’ side effects. Due to dissatisfaction with the existing treatment, many patients are choosing a traditional therapy for their pain treatment. Cupping therapy is one of the traditional therapies that is widely used to relieve pain. Cupping therapy has been used in many countries in the world. Some of these countries have used cupping therapy as a pain treatment in hospitals. Neurologists are handling pain cases in their daily practice. Nearly 80% of patients come to the doctor with one of their complaint related to pain directly. The knowledge of cupping therapy for pain is important for the development of new therapies in order to solve the pain problems that so far have not reached a satisfactory level.Keyword: Alternative therapy, cupping therapy, pain, pain problemsABSTRAKNyeri masih merupakan masalah dunia. Pengobatan nyeri saat ini masih belum sampai tahap yang memuaskan terkait kronisitas dan efek samping obat yang ada. Akibat ketidakpuasan dengan pengobatan yang ada, banyak pasien yang memilih terapi tradisional untuk pengobatan nyerinya. Terapi bekam merupakan salah satu terapi tradisional yang banyak dipakai untuk meredakan keluhan nyeri. Terapi bekam telah dipakai di banyak negara di dunia. Sebagian negara tersebut telah menggunakan bekam sebagai terapi nyeri di rumah sakit. Bekam menurunkan nyeri melalui efek antinosiseptifnya, dengan cara stimulasi sistem saraf perifer dan menurunkan stres oksidatif. Studi terbaru menunjukkan bahwa terapi bekam basah dapat meningkatkan ekspresi ß-endorphin dan HSP70 keratinosit pada lokasi bekam. Dalam praktek sehari-hari dokter spesialis saraf menangani kasus nyeri. Hampir 80% pasien datang ke dokter dengan disertai salah satu keluhan yang berkaitan dengan nyeri secara langsung. Pengetahuan tentang terapi bekam untuk nyeri penting diketahui untuk pengembangan terapi baru guna menyelesaikan permasalahan nyeri yang sampai saat ini belum sampai pada tahap yang memuaskan.Kata kunci: Masalah nyeri, nyeri, terapi alternatif, terapi bekam  
MANIFESTASI NEUROPSIKIATRIK PADA LUPUS ERITEMATOSUS SISTEMIK DI RSUD DR. SOETOMO SURABAYA Nadya Rinda Eka Rana; Awalia Awaliah; Yetti Hernaningsih; Hanik Badriyah Hidayati
NEURONA Vol 36 No 4 (2019)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v36i4.88

Abstract

    NEUROPSYCHIATRIC MANIFESTATION AMONG SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS IN GENERAL HOSPITAL SURABAYAABSTRACTIntroduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with unknown causes and extensive clinical manifestations and diverse disease pathways. The clinical manifestations of SLE are very diverse, including the involvement of the nervous system and psychiatric syndrome (neuropsychiatric).Aims: To describe clinical neuropsychiatric manifestations of   patients with SLE in Soetomo General Hospital Surabaya.Methods: This was a cross-sectional study based on medical record data on all SLE patients treated at Dr. Soetomo Hospital Surabaya, from January-December 2017. Neuropsychiatric manifestations assessment were based on the nomenclature of the American College of Rheumatology (ACR) in 1999.Results: There were 49 patients, mostly women (98%) with mean age 30,8±10,2 years old. Neurological manifestation was the 3rd  most common diagnosis (43%) after hematologic disorder (73.5%) arthritis (53.1%). The manifestations of neuropsychiatric manifestation were mainly seizures (40.8%), headache (34.7%), cerebrovascular disease (26.5%), acute confusional state (20.4%), cognitive dysfunction (6.1%), and polyneuropathy (8.2%).Discussion: The most common neuropsychiatric clinical features in SLE patients are seizures, headache, cerebrovascular disease, and acute confusional state.Keywords: Lupus neuropsychiatry, prevalence, systemic lupus erythematosusABSTRAKPendahuluan: Lupus eritematosus sistemik (LES) merupakan penyakit inflamasi autoimun kronik yang belum diketahui penyebabnya dengan perjalanan penyakit yang luas. Manifestasi klinis LES sangat beragam, antara lain keterlibatan sistem saraf dan sindrom psikiatri (neuropsikiatri).Tujuan: Untuk mengetahui manifestasi neuropsikiatrik pasien dengan LES di RSUD Dr. Soetomo, Surabaya.Metodologi: Penelitian potong lintang berdasarkan data rekam medik terhadap semua pasien LES yang dirawat di RSUD Dr. Soetomo, Surabaya, pada bulan Januari hingga Desember 2017. Manifestasi neuropsikiatrik dinilain berdasarkan nomenklatur American College of Rheumatology (ACR) tahun 1999.Hasil: Didapatkan 49 subjek yang hampir semuanya (98%) adalah perempuan dengan rerata usia 30,8±10,2 tahun. Gangguan neurologis merupakan ketiga tersering (43%) setelah gangguan hematologi (73,5%) dan artritis (53,1%). Manifestasi neuropsikiatri terutama kejang (40,8%), nyeri kepala (34,7%), penyakit serebrovaskular (26,5%), keadaan konfusi akut (20,4%), dan polineuropati (8,2%).Diskusi: Manifestasi klinis neuropsikiatri yang paling banyak dialami oleh pasien LES adalah kejang, nyeri kepala, penyakit serebrovaskular, dan keadaan konfusi akut.Kata kunci: Lupus eritematosus sistemik, manifestasi klinis, neuropsikiatri  
HUBUNGAN FAKTOR SOSIODEMOGRAFI TERHADAP SKOR QUALITY OF LIFE IN EPILEPSY INVENTORY-10 PASIEN EPILEPSI DEWASA DI RSUD DR. SOETOMO Dwiastri Iris Sarwastuti; Paulus Sugianto; Hanik Badriyah Hidayati; Azimatul Karimah
NEURONA Vol 38 No 3 (2021)
Publisher : PERDOSNI

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Abstract

Introduction: Several socio-demographic factors, such as age, sex, marital status, level of education, and employment status can determine adult epilepsy patients’ quality of life, which Quality of Life quantitively presents in Epilepsy Inventory-10 (QOLIE-10) score. Aim: This study was to understand the correlation between age, sex, marital status, level of education, and employment status on adult epilepsy patients’ QOLIE-10 score at Soetomo General Hospital. Methods: Analytical observational study using accidental sampling of adult epilepsy patients at Soetomo General Hospital in June 2019-December 2019 was implemented. Several socio-demographic factors were obtained, including age, sex, marital status, level of education, employment status, and their QOLIE-10 score calculation. Correlation analysis against the QOLIE-10 score was carried out, including the Spearman test for socio-demographic factors of age and level of education; and the Mann-Whitney test for socio-demographic factors of gender and marital status, and employment status. Results: Obtained a total of 47 samples with the most common characteristics such as aged 18-25 years (29.8%), male (53.2%), married (57.4%), had the last educational level in senior high school (68.1%), and unemployed (68.1%). Correlation analysis showed an insignificant relationship between age, sex, marital status, recent education, and employment status on the QOLIE-10 score of adult epilepsy patients (p≥0.05). Discussion: Age, sex, marital status, recent education, and employment status did not show a significant relationship to the QOLIE-10 score of adult epilepsy patients. Keywords: epilepsy, QOLIE-10
Co-Authors Abdurachman Abdurachman Agindra, Bani Agus Prihanto Aisyah Shabrina Alia, Safia Amelia, Elena Ghentilis Fitri Arinda Putri Auna Vanadia Askandar Tjokroprawiro atika Atika Aulia Rachma Nur Azizah Awalia Awaliah Azizah, Aulia Rachma Nur Azzahra, Zahwa Arsy Bodová, Klára Budi Santoso Budi Utomo Chrismawan Ardianto Dwiastri Iris Sarwastuti Elena Ghentilis Fitri Amelia Endah Purwanti Ernawati Ernawati Ernawati, Iin Fahmi Achmad Faisal Fahmi, Achmad Fitri Amelia, Elena Ghentilis Hapsari Peni Agustin Tjahyaningtijas HERAWATI, LILIK Hermina Novida, Hermina I'tishom, Reny Ilmanita, Dzikrina Imami, Nabilah Hasna Indri Wahyuni Intan Indah Permatasari IRWANTO Junaidi Khotib Jusak Nugraha Karimah, Azimatul Kuntoro Kuntoro Kuntoro Kuntoro Lely Retno W Lukas Widhiyanto Machin, Abdulloh Martono Tri Utomo Mohammad Hasan Machfoed Mohammad Hasan Machfoed Muhammad Hamdan Muhammad Hamdan Nabilah Hasna Imami Nadya Rinda Eka Rana Naim Rochmawati Nila Kurniasari Novianto, Rifky Alif Nugraha, Priya Paulus Sugianto Prastiya Indra Gunawan Priya Nugraha Puspasari, Riska Rahayu Nofita Sari Rehatta, Nancy Margarita Rejeki, Purwo Sri Riska Puspasari Riska Puspasari Rivarti, Arina Windri Rozalina Loebis, Rozalina Safia Alia Sensusiati, Anggraini Dwi Setianti, Ariani Rahayu Shofwana, Haura Almash Aulia Siti Khaerunnisa Soetojo Soetojo Suhartati Suhartati SUMARNO Sumbawati, Mulia Dian Suroto Suroto Susi Wahyuning Asih Tamara Audrey Kadarusman Turchan, Agus WITA SARASWATI, WITA Wiyli Yustanti Yetti Hernaningsih YUNI YAMASARI