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Efek Anti-Agregasi Platelet Ekstrak Etanol Daun Salam (Syzygium polyanthum (Wight) Walp.) pada Men RIKA SARI DEWI; NI MADE DWI SANDHIUTAMI; SULISTYO RAHARJO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (244.291 KB)

Salam leaves (Syzygium polyanthum (Wight) Walp.) contains flavonoids, volatile oil and phenolic acid that can inhibiting platelet aggregation induced by ADP (adenosine diphospate), arachidonic acid, epinephrine, thrombin, collagen and aff ecting the activity enzyme ectonucleotidase so it can be used as anti-platelet drug. The purpose of this study was to investigated 70% ethanol extract of salam leaves have anti-platelet aggregation eff ect and increase of dose can also increase anti-platelet aggregation. This study was performed in 5 groups, each group consisted of 5 mice there were: groups of positive control, normal control, 70% ethanol extract leaves doses (150, 300, 450) mg/ kg, each group is given orally once daily during 8 days and measurements of parameters at day-0 and day-9th. The results of this study was 70% ethanol extract of leaves of salam leaves doses (150,300, 450) mg/kgBW showed the effects prolong bleeding time, coagulation time, enhance the decreased plasma absorbance after the addition of ADP. From the measurement parameter bleeding time, coagulation time and measurement decreased plasma absorbance after the addition of ADP that 70% ethanol extract of salam leaves doses 150, 300 and 450 mg/kgBW have anti-platelet aggregation eff ect and increase of dose was able to increase the eff ect anti-platelet aggregation.

Efek Sari Buah Terong Belanda (Solanum betaceum Cav.) terhadap Perubahan Profil Lipid pada Mencit Dislipidemia Ni Made Dwi Sandhiutami; Sondang Khairani; Moordiani Moordiani; Ira Ningtiyas Purpranoto
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 02 Desember 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i2.10302

Buah terong belanda (Solanum betaceum Cav.) mengandung antosianin, isoflavon, karotenoid, serat, vitamin-vitamin seperti vitamin E, vitamin A, vitamin C dan vitamin B6, banyak digunakan secara empiris untuk tekanan darah tinggi, aterosklerosis, membantu metabolisme, meningkatkan imunitas, sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui efek perubahan profil lipid dari pemberian sari buah terong belanda terhadap mencit dislipidemia. Pengujian efek perubahan profil lipid dilakukan dengan cara mengiduksi mencit dengan pemberian kuning telur, sukrosa dan lemak hewan sehingga mencit mengalami dislipidemia. Setelah 14 hari, penginduksian dihentikan dan dilanjutkan dengan pemberiaan sediaan uji setiap hari selama 7 hari (i) kontrol positif (atorvastatin dosis 2,6 mg/kgBB), sari buah terong belanda (ii) dosis 14 g/kgBB, (iii) dosis 21 g/kgBB dan (iv) dosis 28 g/kgBB, (v) kontrol normal dan (vi) kontrol negatif. Pemeriksaan kadar kolesterol total, trigliserida, LDL dan HDL pada darah mencit dilakukan dengan metode kalorimetri enzimatik pada hari ke-0, ke-14, dan ke-21. Sari buah terong belanda dosis 14, 21, 28 g/kgBB dapat menurunkan kadar kolesterol total dengan persentase penurunan secara berturut-turut sebesar 21,08; 25,50; dan 29,94%. menurunkan kadar trigliserida sebesar 20,28; 31,69; dan 38,54%; menurunkan kadar LDL sebesar 28,43; 28,76; dan 42,83%; dan meningkatkan kadar HDL sebesar 16,67; 17,50; 30,13%. Sari buah terong belanda dengan dosis 28 g/kgBB perhari efektif menurunkan kadar kolesterol total, trigliserida, LDL dan meningkatkan kadar HDL mencit dislipidemia.

The effectiveness of avocado (Persea americana M.) leaves infusion as urinary stones dissolving in rats Ni Made Dwi Sandhiutami; Rika Sari Dewi; Alya Fariha
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Urolithiasis is a pathological condition marked by the formation of urinary stones (calculi) in the urinary tract. Avocado leaf (Persea americana M.) contains substances that play crucial roles in the solubility of calcium in urinary stones, such as flavonoids, alkaloids, saponins, and magnesium. Empirically, avocado leaves are used to make urinating easier and break stones in the urinary tract. This study aims to determine the effect of avocado leaf infusion to dissolve urinary stones in white male rats. According to the experiment, 24 male white rats were divided into four groups; the negative control group (not given infusion), the 1 g/kg BW dose group, the 2 g/kg BW dose group, and the 3 g/kg BW dose group of avocado leaves infusion. The infusion was administered orally for seven consecutive days after 28 days of planting black silk thread as the stone core in the urinary tract. Then, the stone formed is taken. The weight and volume are measured. The urinary stones were tested qualitatively in terms of calcium and oxalate. The results showed that there were significant differences among treatment groups in weight and volume of urinary stones. The effect of bladder stone dissolving was best in the 3 g/kg BW group. The qualitative test also shows that urinary stones contain the same calcium and oxalate as urinary stones that form in humans. Avocado leaves infusion can have a urinary stone dissolving effect on white male rats. Increasing the dose of avocado leaves infusion increases its effectiveness as a urinary stone dissolution.

Karakteristik Beberapa Biji Kopi Arabika Komersil di Indonesia Yesi Desmiaty; Liliek Nurhidayati; Ni Made Dwi Sandhiutami; Reczky Muhammad Ramdhan Hasan; Kharinta Adella Meynderth; Dianita Ayu Noviastuti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1277

Arabica coffee is one of the mainstay commodities in the Indonesian plantation sector. Geographical differences and the environment where coffee grow can affect the characteristic, phytochemical content and antioxidant activity of the beans. The aim of this study was to determine the phytochemical characteristics and antioxidant activity of 10 items of commercial Arabica coffee beans in Indonesia. The extraction of 10 coffee beans was carried out by kinetic maceration in 1 hour with 70% ethanol, then evaporated. Each extract was examined for morphology, phytochemical screening, assay of caffeine content using HPLC method, levels of flavan-3-ol, total flavonoid content (TFC), total polyphenolic content (TPC), antioxidant determination using DPPH and FRAP methods. All bean samples showed the presence of flavonoids, alkaloids, triterpenoids, coumarins, and tannins. The chemical content determination showed caff eine content of 1.5-2.9%; flavan-3-ol content 4.85-12.38cat/g extract; TFC 9.71–23.67QE/g extract; and TPC 21.8–76.26GAE/g extract. Tests of antioxidant capacity using the DPPH reveal an inhibiting effect with varying IC₅₀ values from 19.49-81.41g/mL and using the FRAP method gave IC₅₀ values from 18.01-61.2g/mL. This study indicates that coffee samples have the same phytochemical characteristics and also have an important antioxidant activity, which justifies its potential to be developed into antioxidant nutraceuticals.

ANTI-HIPERGLIKEMIK TEH CELUP HERBAL KOMBINASI Fragaria x ananassa, Camellia sinensis, Stevia rebaudiana MELALUI MEKANISME ANTIOKSIDAN PADA MENCIT GANGGUAN METABOLIK YANG DIINDUKSI ALOXAN: ANTI-HYPERGLYCEMIC HERBAL TEA COMBINATION OF Fragaria x ananassa, Camellia sinensis, Stevia rebaudiana THROUGH ANTIOXIDANT MECHANISM IN ALLOXAN-INDUCED METABOLIC DISORDERS MICE Ni Made Dwi Sandhiutami; Yuslia Noviani; Milla Fitri Amalia; Rafif Fadhlurrahman Ahmad
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 1 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i1.551

Daun stroberi (Fragaria x ananassa), teh (Camellia sinensis), dan stevia (Stevia rebaudiana) mengandung flavonoid, epigallocatechin gallate, steviosida, dan rebaudiosida yang memiliki aktivitas tinggi sebagai antioksidan dan secara empiris digunakan sebagai pengobatan alternatif Diabetes Millitus (DM). Penelitian ini bertujuan untuk menentukan aktivitas antioksidan dan anti-hiperglikemik dari teh herbal celup kombinasi daun stroberi, teh dan stevia melalui mekanisme antioksidan. Uji aktivitas anti-hiperglikemik dilakukan dengan metode induksi aloksan (300 mg/kgBB) pada hewan coba mencit yang dibagi menjadi 6 kelompok, yaitu kelompok normal, kelompok negatif, kelompok positif (glibenklamid), dan 3 kelompok dosis teh celup herbal kombinasi daun stroberi, teh dan stevia (15,6; 31,2; 62,4 mg/20 gBB). Pengukuran kadar malondialdehid dilakukan dengan metode TBARs (Wills) dan SOD dengan metode Adrenochrome Assay Kadar glukosa darah mencit diamati pada hari ke-0, 4, 11 dan 18 dengan metode enzimatik glucose oxidase strip glucometer. Histopatologi pankreas dilakukan menggunakan pewarnaan Hematoksilin-Eosin. Hasil pengujian menunjukkan bahwa persentasi penurunan kadar glukosa darah teh celup herbal kombinasi daun stroberi, teh, stevia kelompok dosis uji 15,6 mg/20gBB; 31,2 mg/20gBB; 62,4 mg/20gBB secara berturut-turut yaitu 9,74%; 13,79%; 20,76%. Dosis 62,4 mg/20gBB memiliki aktivitas sebagai antioksidan dan anti-hiperglikemik yang lebih baik daripada dosis lain dan pada gambaran histopatologi menunjukkan bahwa teh celup herbal kombinasi tiga daun tersebut dapat memperbaiki Pulau Langerhans mencit. Berdasarkan hasil penelitian dapat disimpulkan bahwa teh celup herbal kombinasi daun stroberi, teh, dan stevia dapat menurunkan kadar glukosa darah dan memperbaiki gambaran histopatologi Pulau Langerhans pada pankreas mencit.

Kombinasi Colocasia esculenta L. dan Zingiber officinale Potensial Menghambat Inflamasi dan Nyeri Ni Made Dwi Sandhiutami; Ali Timucin Atayoglu; Yati Sumiyati; Yesi Desmiaty; Rizky Adam Hidayat
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1373

The active metabolites of Colocasia esculenta L. and Zingiber officinale L. have been reported to reduce pain and exert anti-inflammatory effects. This study aimed to examine the anti-inflammatory and analgesic effects of a combination of C. esculenta and Z. officinale extract. Thirty rats and mice were each divided into 6 groups (n=5), namely the normal group, negative control, positive control (Nadiclofenac), and 3 test groups were given a extract combination (dose 1.3 mg/20 gBW, 2.6 mg/20 gBW, and 5.2 mg/20 gBW). Winter's method was used for anti-inflammatory tests by inducing carrageenan in rat paws, and Sigmund's method was used for analgesic tests by the intraperitoneal induction of acetic acid in mice. The percentage of inhibition of leg edema in rats was 11.33%, 18.90%, and 19.10% for the three doses of the combined extracts of C. esculenta and Z. officinale, and 22.72% for Na-diclofenac (p<0.05). The percentage inhibition in the analgesic test in the positive control group and the three test groups was 61.17%, 41.19%, 51.79%, and 52.35%, respectively (p<0.05). The combination of the C. esculenta and Z. officinale extracts exhibited anti-inflammatory and analgesic effects. Dose of 2.6 mg/20 gBW and 5.2 mg/20 gBW as effective as Na-diclofenac.

INCREASING ANTIOXIDANT ACTIVITY OF SUPEROXIDE DISMUTASE AND DECREASING MALONDIALDEHYD LEVELS FROM Ethanol Extract of Radish (Raphanus Sativus L.) LEAVES IN SWIMMING MICE Sondang Khairani; Ni Made Dwi Sandhiutami; Ika Permata Sari
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 10 No. 1 (2023)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v10i1.8261

Daun lobak (Raphanus sativus L.) mengandung senyawa flavonoid yang memiliki aktivitas sebagai antioksidan. Penelitian ini bertujuan untuk menguji efek antioksidan ekstrak etanol 70% daun lobak (Raphanus sativus L.) berdasarkan parameter kadar malondialdehid (MDA) dan aktivitas superoksida dismutase (SOD). Penelitian menggunakan mencit dibagi menjadi 6 kelompok yaitu: kelompok kontrol normal (I), kelompok kontrol negative (II), kelompok kontrol positif (III) (vitamin C 2,6 mg/20 gBB), dan 3 kelompok (IV,V,VI)dosis ekstrak etanol 70% daun lobak (Raphanus sativus L.) (5,6; 11,2; 22,4 mg/20 gBB). Pengukuran kadar MDA dilakukan dengan metode Wills dan pengukuran aktivitas SOD dilakukan dengan metode Adrenochrome Assay dan Analisa menggunakan uji ANOVA. Hasil pengukuran kadar MDA pada kelompok normal, kelompok kontrol negatif, kelompok kontrol negatif, kelompok kontrol positif, kelompok dosis 5,6 mg/20 gBB; 11,2 mg/20 gBB; 22,4 mg/20 gBB secara berturut-turut adalah 2,1617 nmol/mL; 5,3075 nmol/mL; 2,3331 nmol/mL; 4,5583 nmol/mL; 3,5957 nmol/mL; 2,6702 nmol/mL sedangkan untuk hasil pengukuran aktivitas SOD hati mencit adalah 124,2383 U/mL; 65,64 U/mL; 176,7583 U/mL; 106,045 U/mL; 134,34 U/mL; 153,53 U/mL. Kesimpulan penelitian ini adalah terdapat perbedaan bermakna antara kelompok III dengan kelompok IV,V,VI dalam peningkatan aktivitas SOD dan penurunan kadar MDA (p<0,05) yaitu memiliki potensi antioksidan yang sama seperti vitamin C.

Anti-Inflammatory and Analgesic Activity of Musa balbisiana Peels In Vivo Ni Made Dwi Sandhiutami; Sondang Khairani; Rika Sari Dewi; Zainur Rahman Hakim; Anita Rahmi Pradani
Borneo Journal of Pharmacy Vol. 5 No. 2 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i2.3169

Musa balbisiana Peels (MBP) contains high levels of flavonoids, alkaloids, tannins, saponins, and triterpenoids. Flavonoids function to slow down the inflammatory process by inhibiting the arachidonic acid, forming prostaglandins, and releasing histamine. This study aimed to examine the anti-inflammatory and analgesic effects of MBP decoction. This study used the Winter method for anti-inflammatory assay by induction of carrageenan on the soles of rat's feet and Sigmund's method for analgesic assay with intraperitoneal induction of acetic acid in mice. Group I as a negative control, group II as a positive control with diclofenac sodium, group III as a low dose (200 mg/kg BW of MBP), group IV as a medium dose (400 mg/kg BW of MBP), and group V as a high dose (800 mg/kg BW of MBP decoction). The percentage of inhibition in the anti-inflammatory test in rats for groups II, III, IV, and V was 34.43%, 17.68%, 25.53%, and 25.4%, and the percentage of effectiveness for the anti-inflammatory test, respectively, was 51.35%, 74.15%, and 74.01%. The results of the percentage inhibition of the analgesic test in mice for groups II, III, IV, and V were 55.25%, 38.52%, 44.53%, and 49.31%, and the percentage of effectiveness for the analgesic test, respectively, followed by 69.71%, 80.59%, and 89.24%. Based on the results, it can be concluded that the decoction of the MBP has an anti-inflammatory and analgesic effect.

ANTI-HIPERGLIKEMIK TEH CELUP HERBAL KOMBINASI Fragaria x ananassa, Camellia sinensis, Stevia rebaudiana MELALUI MEKANISME ANTIOKSIDAN PADA MENCIT GANGGUAN METABOLIK YANG DIINDUKSI ALOXAN: ANTI-HYPERGLYCEMIC HERBAL TEA COMBINATION OF Fragaria x ananassa, Camellia sinensis, Stevia rebaudiana THROUGH ANTIOXIDANT MECHANISM IN ALLOXAN-INDUCED METABOLIC DISORDERS MICE Ni Made Dwi Sandhiutami; Yuslia Noviani; Milla Fitri Amalia; Rafif Fadhlurrahman Ahmad
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 1 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i1.551

Daun stroberi (Fragaria x ananassa), teh (Camellia sinensis), dan stevia (Stevia rebaudiana) mengandung flavonoid, epigallocatechin gallate, steviosida, dan rebaudiosida yang memiliki aktivitas tinggi sebagai antioksidan dan secara empiris digunakan sebagai pengobatan alternatif Diabetes Millitus (DM). Penelitian ini bertujuan untuk menentukan aktivitas antioksidan dan anti-hiperglikemik dari teh herbal celup kombinasi daun stroberi, teh dan stevia melalui mekanisme antioksidan. Uji aktivitas anti-hiperglikemik dilakukan dengan metode induksi aloksan (300 mg/kgBB) pada hewan coba mencit yang dibagi menjadi 6 kelompok, yaitu kelompok normal, kelompok negatif, kelompok positif (glibenklamid), dan 3 kelompok dosis teh celup herbal kombinasi daun stroberi, teh dan stevia (15,6; 31,2; 62,4 mg/20 gBB). Pengukuran kadar malondialdehid dilakukan dengan metode TBARs (Wills) dan SOD dengan metode Adrenochrome Assay Kadar glukosa darah mencit diamati pada hari ke-0, 4, 11 dan 18 dengan metode enzimatik glucose oxidase strip glucometer. Histopatologi pankreas dilakukan menggunakan pewarnaan Hematoksilin-Eosin. Hasil pengujian menunjukkan bahwa persentasi penurunan kadar glukosa darah teh celup herbal kombinasi daun stroberi, teh, stevia kelompok dosis uji 15,6 mg/20gBB; 31,2 mg/20gBB; 62,4 mg/20gBB secara berturut-turut yaitu 9,74%; 13,79%; 20,76%. Dosis 62,4 mg/20gBB memiliki aktivitas sebagai antioksidan dan anti-hiperglikemik yang lebih baik daripada dosis lain dan pada gambaran histopatologi menunjukkan bahwa teh celup herbal kombinasi tiga daun tersebut dapat memperbaiki Pulau Langerhans mencit. Berdasarkan hasil penelitian dapat disimpulkan bahwa teh celup herbal kombinasi daun stroberi, teh, dan stevia dapat menurunkan kadar glukosa darah dan memperbaiki gambaran histopatologi Pulau Langerhans pada pankreas mencit.

Edukasi Peningkatan Aspek Mutu Obat Tradisional bagi Pengguna dan Pelaku Usaha Obat Tradisional Desmiaty, Yesi; Nugroho, Gumilar Adhi; Okta, Fauzia Noprima; Sandhiutami, Ni Made Dwi; Sumiyati, Yati; Priyanti, Ike Ari
Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Vol 6, No 2 (2023): Agustus 2023
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Bina Sarana Informatika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31294/jabdimas.v6i2.14627

Adanya pandemi covid-19 membuat masyarakat berusaha lebih untuk menjaga kesehatan salah satunya dengan menggunakan obat herbal, sehingga terjadi peningkatan penggunaan obat herbal di Indonesia. Hal ini tentu harus diimbangi dengan mutu yang terjamin dari obat herbal di pasaran. Kegiatan pengabdian kepada masyarakat ini dalam rangka mengedukasi masyarakat sebagai pengguna obat herbal maupun pelaku usaha herbal agar memperhatikan aspek mutu obat herbal. Saat ini masih terdapat obat herbal yang beredar di masyarakat dan tidak memenuhi persyaratan. Metode edukasi dilakukan secara daring dengan menyebarkan kuisioner untuk mengetahui pengetahuan masyarakat, dilanjutkan dengan edukasi dan diskusi interaktif. Dari hasil survey menunjukkan responden umumnya belum terlalu memahami aspek mutu obat herbal sehingga perlu untuk dilakukan edukasi agar dapat memilih obat herbal yang bermutu baik serta bagi pelaku usaha herbal dapat meningkatkan mutu produknya sesuai dengan persyaratan yang diberlakukan oleh regulator yaitu Badan Pengawas Obat dan Makanan Republik Indonesia (BPOM RI).

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