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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Jurnal Sains dan Teknologi Farmasi Indonesian Journal of Pharmaceutical Science and Technology Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Farmasains : Jurnal Ilmiah Ilmu Kefarmasian PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmamedika (Pharmamedica Journal) Indonesian Journal of Pharmaceutical Education Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Sciences of Pharmacy Journal of Pharmaceutical and Sciences. Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Ni Made Dwi Sandhiutami
Fakultas Farmasi Universitas Pancasila
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Animal Models of Acute Exacerbations COPD: Mechanistic Insights and Translational Challenges Dewi, Rika Sari; Wuyung, Puspita Eka; Louisa, Melva; Sandhiutami, Ni Made Dwi; Pratomo, Irandi Putra
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501482

Abstract

Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) represent critical events in disease progression, yet their complex pathophysiology remains incompletely understood. Understanding the mechanisms underlying these exacerbations is essential for developing effective therapeutic strategies and improving patient outcomes. This literature review aims to synthesize current knowledge on the cellular and molecular mechanisms driving acute exacerbations of COPD, highlighting the importance of utilizing appropriate animal models for future research. This review identified rodent models, particularly mice (C57BL/6 strain) and rats (Sprague-Dawley) are predominantly employed due to their genetic tractability and physiological relevance, with occasional use of guinea pigs for airway hyperresponsiveness studies. Combined approaches using cigarette smoke exposure followed by inflammatory triggers (LPS, viral infections) showed the highest translational relevance. Key pathophysiological mechanisms studied include neutrophilic inflammation, oxidative stress, airway remodelling, and mucus hypersecretion. Current animal models provide valuable insight into AECOPD pathophysiology but face limitations in fully recapitulating human disease complexity. Future directions should focus on incorporating comorbidities, aging, and standardized outcome measures.
POTENSI EKSTRAK ETANOL 70% DAUN JAMBU BOL (SYZYGIUM MALACCENSE (L.) MERR. & L.M. PERRY) TERHADAP KADAR MALONDIALDEHID DAN AKTIVITAS ANTIOKSIDAN ENZIM SUPEROKSIDA DISMUTASE PADA MENCIT Rika Sari Dewi; Ni Made Dwi Sandhiutami; Inneke Tasya K. Siagian
Jurnal Farmamedika (Pharmamedica Journal) Vol. 10 No. 2 (2025): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v10i2.353

Abstract

Daun Jambu bol (Syzygium malaccense (L.) Merr. & L.M.Perry) memiliki senyawa polifenol seperti flavonoid, asam fenolat dan tannin telah dianggap sebagai antioksidan. Penelitian ini bertujuan menguji aktivitas antioksidan ekstrak etanol 70% daun jambu bol (Syzygium malaccense (L.) Merr. & L.M.Perry) berdasarkan parameter kadar malondialdehid (MDA) dan aktivitas superoksida dismutase (SOD). Mencit dibagi menjadi 6 kelompok yaitu: kelompok kontrol normal, kelompok kontrol negatif, kelompok kontrol positif diberikan vitamin C (2,6 mg/20gBB), dan 3 kelompok dosis ekstrak etanol 70% daun jambu bol (5; 10; 20 mg/20gBB). Pengukuran kadar MDA dilakukan dengan metode TBARs dan pengukuran aktivitas SOD dilakukan dengan metode Adrenochrome Assay. Hasil pengukuran kadar MDA pada kelompok normal, kelompok kontrol negatif, kelompok kontrol positif, kelompok dosis 5 mg/20gBB; 10 mg/20gBB; 20 mg/20gBB secara berturut-turut adalah 2,4814 nmol/mL; 5,0557 nmol/mL; 3,0153 nmol/mL; 4,7122 nmol/mL; 4,1289 nmol/mL; 3,5013 nmol/mL sedangkan untuk hasil pengukuran aktivitas SOD pada hati mencit adalah 124,9967 U/mL; 60,34 U/mL; 188,76 U/mL; 129,31 U/mL; 148,85 U/mL; 168,9667 U/mL. Kesimpulan hasil yang didapatkan adalah ekstrak etanol 70% daun jambu bol (Syzygium malaccense (L.) Merr. & L.M.Perry) memiliki potensi antioksidan dengan menurunkan kadar MDA dan meningkatkan aktivitas SOD.
Ethanol Extract of Nigella sativa Attenuates Eosinophilic Inflammation and Epithelial Remodeling in an Ovalbumin-Induced Rat Model Dewi, Rika Sari; Sandhiutami, Ni Made Dwi; Desmiaty, Yesi; Dwiantika, Ajeng Sunthi
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 2 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i2.67195

Abstract

Allergic airway inflammation is commonly associated with eosinophilic infiltration and epithelial remodeling, which impair respiratory function and contribute to tissue damage. This study investigated the therapeutic potential of the ethanol extract of Nigella sativa in an ovalbumin-induced rat model of allergenic airway response. Ethanol extracts were tested in an ovalbumin-induced rat model using Sprague-Dawley rats (n=36), comparing normal, negative controls, 0.009 mg/g BW salbutamol (positive control), and three inhaled extract doses (12.25, 24.50, 49 g/kg BW). Comprehensive analysis included physiological parameters (oxygen saturation), inflammatory biomarkers (lung eosinophil count), and pulmonary histopathology (epithelial thickness). The highest dose (49 g/kg) matched salbutamol in improving oxygen saturation (86.75% vs. 88%, p=0.9917) and reducing epithelial thickness (81.50 µm vs. 81.75 µm, p=0.9999), while suppressing eosinophil infiltration (0.73 vs. 1.45 cells/field, p=0.3348). These results confirm Nigella sativa’s efficacy in attenuating airway inflammation via eosinophil-targeted mechanisms without structural epithelial alterations. The study validates traditional applications of Nigella sativa and proposes an evidence-based framework for integrating phytotherapy into respiratory medicine.
INCREASING ANTIOXIDANT ACTIVITY OF SUPEROXIDE DISMUTASE AND DECREASING MALONDIALDEHYD LEVELS FROM Ethanol Extract of Radish (Raphanus Sativus L.) LEAVES IN SWIMMING MICE Sondang Khairani; Ni Made Dwi Sandhiutami; Ika Permata Sari
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 10 No. 1 (2023)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v10i1.8261

Abstract

Daun lobak (Raphanus sativus L.) mengandung senyawa flavonoid yang memiliki aktivitas sebagai antioksidan. Penelitian ini bertujuan untuk menguji efek antioksidan ekstrak etanol 70% daun lobak (Raphanus sativus L.) berdasarkan parameter kadar malondialdehid (MDA) dan aktivitas superoksida dismutase (SOD). Penelitian menggunakan mencit dibagi menjadi 6 kelompok yaitu: kelompok kontrol normal (I), kelompok kontrol negative (II), kelompok kontrol positif (III) (vitamin C 2,6 mg/20 gBB), dan 3 kelompok (IV,V,VI)dosis ekstrak etanol 70% daun lobak (Raphanus sativus L.) (5,6; 11,2; 22,4 mg/20 gBB). Pengukuran kadar MDA dilakukan dengan metode Wills dan pengukuran aktivitas SOD dilakukan dengan metode Adrenochrome Assay dan Analisa menggunakan uji ANOVA. Hasil pengukuran kadar MDA pada kelompok normal, kelompok kontrol negatif, kelompok kontrol negatif, kelompok kontrol positif, kelompok dosis 5,6 mg/20 gBB; 11,2 mg/20 gBB; 22,4 mg/20 gBB secara berturut-turut adalah 2,1617 nmol/mL; 5,3075 nmol/mL; 2,3331 nmol/mL; 4,5583 nmol/mL; 3,5957 nmol/mL; 2,6702 nmol/mL sedangkan untuk hasil pengukuran aktivitas SOD hati mencit adalah 124,2383 U/mL; 65,64 U/mL; 176,7583 U/mL; 106,045 U/mL; 134,34 U/mL; 153,53 U/mL. Kesimpulan penelitian ini adalah terdapat perbedaan bermakna antara kelompok III dengan kelompok IV,V,VI  dalam peningkatan aktivitas SOD dan penurunan kadar MDA (p<0,05) yaitu memiliki potensi antioksidan yang sama seperti vitamin C.
Co-Authors AFIZZA ANBAR Agung Wiwiek Indrayani Ali Timucin Atayoglu Alya Fariha Anita Rahmi Pradani Apriliana, Amalia Zahra Bakhtiar, Muhammad Taher Ciang, Windy Deni Rahmat Dianita Ayu Noviastuti Dwiantika, Ajeng Sunthi Dyavaprathivi, Made Anindya Ayu Engita, Elvira Erna Kristin Errol Rakhmad Noordam Evangelia, Beatrix Melani Fahleni Fahleni Fahri Muhammad Griselda, Agnes Gumilar Adhi Nugroho Handayani, Rizqya Cahya Ika Permata Sari Inneke Tasya K. Siagian Ira Ningtiyas Purpranoto Irandi Putra Pratomo Irtan, Levina Diva Isti Atika Kharinta Adella Meynderth Lestari Rahayu LIBERT MORY Liliek Nurhidayati Maisa, Yustrida Marvel, Nadya Sekar Melva Louisa Milla Fitri Amalia Moordiani Moordiani Muzakar, Cholid Nancy Dewi Yuliana Nattika Sari Darmastuti Ngatidjan Ngatidjan Noor, Siti Umrah Okta , Fauzia Noprima Okta, Fauzia Noprima Prayoga, Tria Priyanti, Ike Ari Puspita Eka Wuyung Rafif Fadhlurrahman Ahmad RAHMAT, DENI Ramadaniati, Hesty Utami Reczky Muhammad Ramdhan Hasan Rika Sari Dewi Rika Sari Dewi RIKA SARI DEWI Rizky Adam Hidayat ROS SUMARNY S.Farm., M.Farm., Apt, Sondang Khairani Sang Ayu Made Widyadari Sriyono, Bimantoko Hadi SULISTYO RAHARJO Sumiyati , Yati Tasya K. Siagian , Inneke Wawaimuli Arozal Yati Sumiyati Yati Sumiyati, Yati Yesi Desmiaty, Yesi Yuslia Noviani Zainur Rahman Hakim