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All Journal Majalah Kedokteran Bandung Althea Medical Journal Damianus Journal of Medicine The Indonesian Biomedical Journal Makara Journal of Health Research Journal of Urban Health Research
Zita Arieselia
Department Of Pharmacology And Pharmacy, School Of Medicine And Health Sciences, Atma Jaya Catholic University Of Indonesia, Jakarta
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Antioxidant, Antimicrobial, Anti-Inflammatory, and Gut Microbiota Modulation Effects of Kombucha: a Literature Review Hananta, Linawati; Kurniawan, Sandy Vitria; Lonah; Arieselia, Zita; Surjono, Edward; Setiawan, Jonny; Lieputra, Andrew Adhytia; Puspa Bunardi, Dewi; Prayoga Tjendratama, Jason; Vallerie Satyadi, Richelle; Dewi, Rita
Journal of Urban Health Research Vol. 3 No. 2 (2025): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i2.6445

Abstract

Introduction: The interest in probiotics has increased significantly in recent years. While most probiotic-containing foods are dairy-based, an increasing number of non-dairy probiotic products have emerged, including kombucha. Kombucha is a fermented tea beverage originating from China, known for its high polyphenol content and potential health benefits. Methods: This literature review aims to provide a comprehensive understanding of the health benefits of kombucha. A systematic search of published studies was conducted using the keywords "kombucha," "antioxidant," "anti-inflammatory," "antimicrobial," and "gut microbiota modulation." Only English-language articles were included, and there was no restriction on publication date to capture the full spectrum of research on kombucha. Results: Kombucha exhibits significant antioxidant capacity, with green tea kombucha demonstrating the highest Ferric Ion Reducing Antioxidant Power (FRAP) due to its high polyphenol content. Additionally, kombucha possesses antimicrobial properties attributed to organic acids, lactones, aldehydes, fatty acids, and alkaloids, which act synergistically. It also exhibits anti-inflammatory effects by inhibiting nitric oxide production and downregulating pro-inflammatory cytokines such as IL-1β and TNF-α. Furthermore, kombucha modulates gut microbiota composition by inhibiting the growth of Gram-negative bacteria, leading to reduced systemic inflammation and oxidative stress. Conclusion: Kombucha, a traditional fermented tea, has notable health benefits, including antioxidant, antimicrobial, anti-inflammatory, and gut microbiota-modulating properties. These findings highlight its potential as a functional beverage for health promotion. Keywords: kombucha – antioxidant - anti-inflammatory – antimicrobial - gut microbiota modulation
Potensi laktoferin susu sapi sebagai antibiotik tunggal dan kombinasi dengan sefepim terhadap Pseudomonas aeruginosa secara in vitro Prasetya, Alver; Surja, Sem Samuel; Arieselia, Zita
Bahasa Indonesia Vol 23 No 2 (2024): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v23i2.3824

Abstract

Pendahuluan: Pseudomonas aeruginosa merupakan salah satu bakteri yang paling sering resistan terhadap berbagai macam antibiotik, sehingga diperlukannya perkembangan antibiotik terbaru. Sefepim merupakan salah satu antibiotik yang sering digunakan dalam pengobatan terhadap bakteri resistan dengan menghambat pembentukan peptidoglikan. Laktoferin susu sapi merupakan glikoprotein pada susu yang memiliki potensi antimikroba dengan mengikat zat besi dan merusak dinding sel. Dengan demikian, terdapat potensi interaksi sinergisme antara sefepim dan laktoferin dalam menghambat Pseudomonas aeruginosa. Dengan demikian, tujuan dari studi ini adalah untuk mengetahui potensi antimikroba laktoferin susu sapi dan potensi interaksinya dengan sefepim dalam menghambat Pseudomonas aeruginosa. Metode: Sampel bakteri yang digunakan adalah Pseudomonas aeruginosa ATCC 27853. Uji suseptibilitas dilakukan menggunakan uji difusi cakram dan mikrodilusi secara in vitro berdasarkan pedoman Clinical and Laboratory Standards Institute. Sefepim dan cakram kosong digunakan sebagai kontrol. Untuk mengetahui interaksi antara laktoferin susu sapi dengan sefepim dilakukannya uji metode checkerboard. Hasil: Pada uji difusi cakram dan mikrodilusi, laktoferin susu sapi tidak dapat menghambat pertumbuhan Pseudomonas aeruginosa ATCC 27853. Hal ini sudah dilakukan dengan berbagai macam konsentrasi sampai dengan 0,5 g/ml. Pada uji checkerboard tidak ditemukan interaksi antara sefepim dan laktoferin susu sapi. Simpulan: Laktoferin susu sapi tidak dapat menghambat pertumbuhan bakteri Pseudomonas aeruginosa ATCC 27853 secara in vitro.
Self-Protection against UV Exposure: Behavioral Patterns and Phototype Correlations among Medical Students in North Jakarta, Indonesia Alvina, Jesslyn; Arieselia, Zita; Regina, Regina
Journal of Urban Health Research Vol. 3 No. 3 (2025): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i3.6631

Abstract

Introduction: Exposure to ultraviolet (UV) rays can cause significant skin damage, including cancer. This study examines sun protection behaviors among medical students in North Jakarta, despite their knowledge of UV risks, and correlates these behaviors with Fitzpatrick skin types. Understanding these behaviors helps inform targeted interventions to promote sun safety among future healthcare professionals. Methods: An observational study with a cross-sectional approached on 230 respondents consisting of medical students, conducted through online questionnaires within 3-month period on a systematic random sampling method. Data on demographic data, Fitzpatrick skin type scale, and 5 questions on self-protection behavior obtained was analyzed using Spearman’s rank correlation and chi-square analysis, p < 0.05 indicating a significant relationship. Results: Type III, IV, and V are the most common Fitzpatrick’s phototypes found on subjects where 69.6% of students had low sun protection behavior. Male exhibit lower sun protection behavior than female, and there was no relationship between students’ Fitzpatrick's skin type and sun protection behavior, (p = 0.112). Conclusions: Sun protection behavior among medical students at FKIK UAJ is low. There is a correlation between gender and sun protection behavior, but no correlation between Fitzpatrick's skin type and sun protection behavior among the students. The study reveals that medical students, especially males, exhibit low sun protection behaviors despite their knowledge of UV risks, emphasizing the need for targeted educational interventions. These findings are crucial for medical education and public health, making them relevant for journals focused on preventive medicine, dermatology, and medical education.  
Relationship between Knowledge and Attitude toward BSE Behavior for Early Breast Cancer Detection among Atma Jaya Hospital Nurses Zita Arieselia; Kurniawan, Sandy Vitria; Lonah; Linawati Hananta; Freggy Spicano Joprang; Edward Surjono; Jonny Setiawan; Andrew Liputra; Jennifer
Journal of Urban Health Research Vol. 3 No. 3 (2025): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i3.7114

Abstract

Introduction : Breast cancer is a frequently occurring type of cancer in Indonesia, with symptoms of rapid and invasive growth of abnormal cells. Deaths due to this cancer can be reduced by avoiding risk factors and early detection, such as through breast self-examination (BSE). Assessing knowledge, attitudes, and behavior regarding BSE is important for early detection, especially for nurses as health workers. This study assessed the relationship between knowledge and attitudes towards BSE behavior among Atma Jaya Hospital nurses.  Methods: This is an analytical observational study employing a cross-sectional design, involving 105 samples selected through purposive sampling according to established inclusion and exclusion criteria. The variables in this study include knowledge, attitude, and behavior regarding breast self-examination (BSE). Data were collected through the distribution of questionnaires to respondents and will be statistically analyzed using the Chi-Square test (x2) with a significance level (a) = 5%, and the analysis will be conducted using STATA software. Results: Based on the data analysis, there is no correlation between knowledge and attitude toward the practice of breast self-examination (BSE), with p-values of 0.623 and 0.994. Conclusion: There is no significant relationship between Knowledge and Attitude towards BSE Behavior. Keywords:  BSE Attitude - BSE Behavior - BSE Knowledge
Transcriptional Regulation of CYP2D6 by Nrf2 and Its Implications in Breast Cancer Therapy: Bioinformatics and Experimental Evidence Siswanto, Ferbian Milas; Handayani, Maria Dara Novi; Lonah, Lonah; Dewi, Rita; Arieselia, Zita; Hananta, Linawati; Andarisuta, Putu Suwarastra
The Indonesian Biomedical Journal Vol 17, No 1 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i1.3194

Abstract

BACKGROUND: Tamoxifen (TAM) resistance in patient with breast cancer is the leading cause of mortality among women globally. Cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of TAM, and recently NF-E2-related factor 2 (Nrf2) has recently been found as its regulator. However, the impact of Nrf2-mediated CYP2D6 regulation in the context of breast cancer and TAM resistance are currently unknown. Therefore, this study was conducted to examine the role of CYP2D6 and Nrf2 in breast cancer prognosis. MEDTHODS: The roles of CYP2D6 and Nrf2 were investigated in the T47D breast cancer cell line and T47D-derived TAM-resistant cells by examining the gene expression, cell viability, and transcriptional regulation by quantitative reverse transcription polymerase chain reaction (qRT-PCR), MTT, and reporter gene assay, respectively. Additionally, comprehensive in silico analysis of the transcriptomic and clinical data from The Cancer Genome Atlas database were performed to uncover the prognostic role of CYP2D6 and its regulator in breast cancer patients. RESULTS: CYP2D6 mRNA was low and Nrf2 protein was high in TAM-resistant T47D cells compared to parental cells. Nrf2 knockdown upregulated CYP2D6 mRNA levels and enhanced the cytotoxicity of TAM. Similarly, in silico analysis revealed that low CYP2D6 mRNA and high Nrf2 protein were related to a lower probability of survival. The rs1238662089 within the identified Nrf2-binding site was found to greatly affect CYP2D6 expression levels, indicating its role as predictor for better prognosis. CONCLUSION: This study revealed for the first time that Nrf2 regulates CYP2D6expression in breast cancer and is involved in TAM sensitivity; thus, plays a role in breast cancer patient prognosis.KEYWORDS: breast cancer, CYP2D6, Nrf2, pharmacoepigenetics, SNPs
Potential Antihyperlipidemia Effect of Lactoferrin in Hyperlipidemia-Induced Male Sprague–Dawley Rats Jusni, Louis Fabio Jonathan; Chandra, Valencia; Djuartina, Tena; Notario, Dion; Arieselia, Zita; Hananta, Linawati
Makara Journal of Health Research Vol. 26, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Hyperlipidemia is a condition that is characterized as an increase in total cholesterol and triglyceride levels in the blood. Lactoferrin is a protein that can serve as an antioxidant. This study aims to determine whether lactoferrin can reduce total cholesterol and triglyceride levels. Methods: This study used 24 Sprague–Dawley rat strains, which were divided into six groups: normal group; negative control; positive control; and dose groups 1, 2, and 3. The normal group was given standard feed, whereas the other group was given high cholesterol and fat. The positive control group and dose groups 1, 2, and 3 were given 1.5 mg/kg BW of simvastatin and 100, 200, and 400 mg/kg of BW lactoferrin, respectively. After 6 weeks, total cholesterol and triglyceride levels were measured. Results: This study showed that lactoferrin doses of 100, 200, and 400 mg/kg BW could significantly reduce total cholesterol and triglyceride levels (p < 0.05). Lactoferrin could also significantly reduce activated Kupffer cell and steatosis area in the liver (p < 0.05). Conclusions: Lactoferrin can reduce total cholesterol and triglyceride levels. Thus, further research is needed to address the existing bias and confirm that lactoferrin can reduce cholesterol and triglyceride levels.
Effects of Coffee Consumption on Acne Vulgaris Severity in Atma Jaya Medical Students in Jakarta, Indonesia Natasha, Tiffanie; Wijaya, Lorettha; Djuartina, Tena; Arieselia, Zita
Journal of Urban Health Research Vol. 3 No. 1 (2024): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i1.5467

Abstract

Introduction: Acne vulgaris is a common multifactorial skin disease. With diet as one of the possible factors, the rising habit of coffee consumption may have its own effects on acne. In present time, there is a lack of study between coffee consumption and acne vulgaris as well as the relationship between the two topics. This study aimed to analyze the effects of coffee consumption on acne severity. Methods: A cross-sectional study was conducted from September to December 2022 on 106 Atma Jaya medical students in Jakarta, Indonesia, who has acne and consumed coffee in the past month when the study was performed. The students were asked to fill a questionnaire about demographic and filtering questions along with questions about coffee consumption in the past month based on Diet History Questionnaire III (DHQ III). Acne lesion observations on the face, upper back, and chest were then performed on every individual to calculate acne severity based on Global Acne Grading System (GAGS). Results: Students who only drank black coffee tend to have lower acne severity score (mean±SD: 19.69±5.68) than those who drank coffee mixtures beverages (mean±SD: 25.41±5.11) (p-value<0.001). There was a significant negative correlation between acne severity scores and amount of black coffee consumed (p-value=0.001). On the other hand, there was a significant positive correlation between acne severity scores and amount of coffee mixtures beverages consumed (p-value<0.001). Conclusion: The results of this study show that the types and amount of coffee consumed had significant effects on acne vulgaris severity in medical students. Keywords: acne vulgaris - black coffee - coffee mixtures
Co-Authors - Patrick Ali Baziad Alvina, Jesslyn Andarisuta, Putu Suwarastra Andrew Liputra Arini Setiawati Budiyanti, Ecie Chandra, Valencia Dion Notario Divara Ariesta Sekar Suryadi, Made Edward Surjono Edward Surjono, Edward Elisabeth Rukmini Evi Ulina Margaretha Situmorang Fan, Tan Fei Fenny Mariska Ferbian Milas Siswanto Freggy Spicano Joprang Jennifer Jojor Lamsihar Manalu Joneri, Richie Jonny Setiawan Jonny Setiawan Jonny Setiawan Jonny Setiawan Jusni, Louis Fabio Jonathan Kurniawan, Sandy Vitria Lieputra, Andrew Adhytia Linawati Hananta Linawati Hananta, Linawati Lonah, Lonah Lorettha Wijaya Margareta Amelia Maria Dara Novi Handayani, Maria Dara Novi Mariani Santosa, Mariani Maureen Miracle Stella Meiliyana Wijaya Monalisa Heryani Narwati, Yulia Tanti Natasha, Tiffanie Poppy Kristina Sasmita Prasetya, Alver Prayoga Tjendratama, Jason Puspa Bunardi, Dewi Regina Regina Rianto Setiabudy Rita Dewi Rita Dewi Rita Dewi Sem Samuel Surja Sukendar, Billy Tena Djuartina, Tena Vallerie Satyadi, Richelle Via Dolorosa Halilintar Yenna Tasia, Yenna Yohanes Jason Yuliana Yuliana