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All Journal Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Majalah Obat Tradisional Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Pharmaceutical Journal of Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Indonesian Journal of Pharmaceutical and Clinical Research Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Insan Farmasi Indonesia Jurnal Penelitian Inovatif Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Media Farmasi Indonesia Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Journal Pharmacy of Tanjungpura
Liza Pratiwi
Department Of Pharmaceutical Technology, Faculty Of Medical, Tanjungpura University Pontianak
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Physics Public Health Social Sciences Other

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Pengaruh Pemberian Lozenges Kombinasi Kulit Pisang dan Kulit Nanas terhadap Tikus Putih (Rattus norvegicus L.) galur Wistar Adelita Ahyanurri; Liza Pratiwi; Hadi Kurniawan; Inarah Fajriaty; Siti Nani Nurbaeti; Nugraha Fajar; Pratiwi Apridamayanti
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13811

Abstract

Banana peel and pineapple peel have high potassium content. The banana peel and pineapple peel combination can be used as lozenges in potassium supportive therapy. The safety of banana peel and pineapple peel combination lozenges must be ensured by the acute toxicity test. One of the parameters observed during toxicity testing is the organ index. This study aims to determine the relationship between dose and toxicity in acute oral administration of banana peel and pineapple peel combination lozenges on the heart, lungs, liver, spleen, and kidneys organ index in white rats (Rattus norvegicus L.) Wistar strain. Acute toxicity based on OECD 425 guidelines for the Up-and-Down Procedure (UDP) method. Rats were grouped into 2000 mg/kg BW and 5000 mg/kg BW dose groups, consisting of 5 rats. Organ indexes were analyzed using SPSS Independent Sample T-test with 95% confidence level (p0.05). The result showed no significant difference between both doses (P0.05) in heart, lungs, liver, spleen, and kidneys organ index. Based on the results, it can be concluded that banana peel and pineapple peel combination lozenges did not affect white rats’ heart, lungs, liver, spleen, and kidney organ index.
Analisis Tingkat Pengetahuan Mahasiswa Program Studi Farmasi Terhadap Swamedikasi Obat Bebas dan Bebas Terbatas Felisitas Feli; Liza Pratiwi; Shoma Rizkifani
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14027

Abstract

Over-the-counter and over-the-counter drugs are the two classes of drugs commonly used for self-medication. The high risk caused by irrational use of drugs must be considered by each individual in order to increase knowledge and good behavior in self-medication. This study aims to analyze the level of knowledge and behavior level of the students of the Pharmacy Study Program, Tanjungpura University and analyze the relationship between the semester level and the two variables. This research method uses the Spearman rank correlation test with the SPSS Version 26 application in the bivariate analysis test with a cross-sectional approach. Respondents used as many as 232 people with the method of taking Statified Random Sampling. The results showed that the majority of respondents were female, aged 17-22 years, and mostly used paracetamol purchased at pharmacies without a doctor's prescription to treat fever. Respondents have a level of knowledge that falls into the category of less (40.5%) with appropriate self-medication behavior (97.4%). The variable level of knowledge and level of behavior has a significant relationship (p-value = 0.006). The semester level variable and the level of knowledge have a significant relationship (p-value = 0.000). Semester level and behavioral level variables have a significant relationship (p-value = 0.026). The conclusion is that there is a relationship between the semester level and the level of knowledge and behavior of the students of the Pharmacy Study Program at Tanjungpura University towards the use of over-the-counter and over-the-counter drugs in self-medication.
Pengaruh Ekstrak Kulit Pisang dan Kulit Nanas terhadap Aktivitas Motorik dan Perilaku Tikus Wistar Novia Novia; Fajar Nugraha; Siti Nani Nurbaeti; Inarah Fajriaty; Pratiwi Apridamayanti; Hadi Kurniawan; Liza Pratiwi
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13908

Abstract

Banana peel and pineapple peel are organic wastes that contain potassium, so it can potentially be developed into lozenges form as supportive antihypertensive therapy. Banana peel and pineapple peel as health supplement ingredients must meet safety requirements. The study of subchronic toxicity test was aimed to determine the toxic effect of repeated administration of a combination of banana peel and pineapple peel extract on motor activity and behavior of Wistar rats. The study was conducted by giving the test preparations repeatedly for 28 days in the control group, doses of 100 mg/KgBW, 400 mg/KgBW, 1000 mg/KgBW, control satellite, and satellite at 1000 mg/KgBW dose, as well as additional 14 days of observation in the satellite group to observe the reversibility effect. The test results showed that administering a combination of banana peel and pineapple peel extract showed normal observation on motor activity and behavior of Wistar rats. This study concludes that the combination of banana peel and pineapple peel did not give toxic effect on motor activity and behavior of Wistar rats.
Analisis Tingkat Pengetahuan Mahasiswa Program Studi Farmasi terhadap Swamedikasi Influenza Yulnalia Mariella Delavega; Liza Pratiwi; Shoma Rizkifani
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14024

Abstract

The percentage of the population using self-medication to treat minor illnesses, such as influenza, continues to increase. Self-medication using over-the-counter drugs or without a doctor's prescription is not a completely safe treatment, so knowledge about the influenza and the drugs to be used is required. The purpose of this study was to determine the percentage of knowledge and behavior of self-medication for influenza, to determine the relationship between semester level and level of knowledge and behavior, and to determine the relationship between the level of knowledge and behavior of self-medication for influenza in Pharmacy students, Tanjungpura University. This method with a cross-sectional approach that is descriptive analytic. Respondents involved as many as 232 people including inclusion and exclusion criteria taken by stratified random sampling technique and the data were analyzed using Spearman rank correlation test. The results indicated that the respondents' knowledge level was good (39.7%), sufficient (50.0%), less (10.3%) and the respondent's behavior was right (96.6%) and inappropriate (3.4%). Relationship between semesters and the level of knowledge obtained sig (2-tailed) 0.000 and the value of r is 0.422; semester on the behavior of sig (2-tailed) 0.004 and the r value is 0.190; the level of knowledge on the behavior of the value of sig (2-tailed) is 0.007 and r is 0.178. The conclusion of this study is that the level of knowledge is in the sufficient category and the behavior is appropriate and there is a moderate undirectional relationship between semesters and the level of knowledge, a very low unidirectional relationship between semesters and behavior and there is a very low unidirectional relationship between the level of knowledge and behavior of influenza self-medication.
Pengaruh Pemberian Kombinasi Ekstrak Kulit Pisang dan Kulit Nanas terhadap Indeks Organ Tikus Wistar Melania Niken Safira; Pratiwi Apridamayanti; Hadi Kurniawan; Inarah Fajriaty; Fajar Nugraha; Siti Nani Nurbaeti; Liza Pratiwi
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13910

Abstract

Banana peel and pineapple peel contain potassium which may be developed into health supplements. The development of banana peels and pineapple peels as ingredients for potassium supplements must meet safety aspects that can be proven by subchronic toxicity tests. This subchronic toxicity test aimed to determine the effect of repeated administration of a combination of banana peel and pineapple peel extract for 28 days on the liver, kidney, kidney, lung, heart, and spleen index of Wistar rats. This research used male and female white rats which were divided into six treatment groups, namely the control group, low dose, middle dose, high dose, satellite control, and high dose satellite. The results showed that there was a significant increase in the liver and kidney organ index, and a significant decrease in the adrenal gland organ index after administration of a combination of banana peel and pineapple peel extract. This research concludes that the combination of banana peel and pineapple peel extract has an effect on the liver, kidney, and adrenal gland organ index in Wistar white rats.
Penggolongan Obat Berdasarkan Peresepan Obat Asma Di Instalasi Rawat Jalan RSUD Dr Agoesdjam Ketapang Defiga Kasrin; Liza Pratiwi; Shoma Rizkifani
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13648

Abstract

Asthma was included in the top ten causes of morbidity and mortality in Indonesia. The priority of asthma treatment so far is to control symptoms. Therefore, the classification of drugs based on asthma drug prescribing is very necessary. This study aims to determine the characteristics and classes of drug prescribing in outpatient asthma patients at RSUD Dr. Agoesdjam Ketapang in 2020. This research method was carried out in December 2021-January 2022 with a retrospective descriptive method, data obtained from medical record cards of outpatient asthma patients at RSUD Dr. Agoesdjam Ketapang in 2020. The data obtained are presented in the form of percentages, average values and tables. The results showed that of the 61 outpatient asthma patient medical records analyzed by the percentage data, the majority of patients were women (59%) and at the age of 42-49 years (31%). The most widely prescribed drug group was beta-2 agonist (48%) with the most common dosage form being inhalers (51%) and the route of drug use was inhalation (51%). The conclusion is that the use of drugs in asthma patients in the outpatient installation of RSUD Dr. The majority of Agoesdjam Ketapang are women. The majority occurred at the age of 42-49 years, the most widely used drug class was the beta-2 agonist group with the inhaler dosage form and the inhalation route was the most widely used.
Identifikasi Penggolongan Obat Berdasarkan Peresepan Obat Hipertensi di Instalasi Rawat Jalan Rumah Sakit Ulfa Sri Mandasari; Liza Pratiwi; Shoma Rizkifani
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14028

Abstract

The cause of hypertension is not clearly known, but risk factors that cause hypertension are found, namely the elderly or the elderly, in the form of a family history of hypertension, excess body weight and excessive salt levels. Hypertension is the third leading cause of death in Indonesia with a CFR (Case Fetality Rate) of 4.81%. Causes of the elderly suffer from hypertension due to reduced work functions in the human body. This study aims to determine the characteristics (gender and age) and classes of drugs prescribed to outpatient hypertension patients at RSUD Dr. Achmad Diponegoro Putussibau. This research is an observational study with a retrospective descriptive research design. From the results of the study, it was found that there were 55 hypertension patients with medical record data, based on gender the number of women was 62% and based on the age of 60-74 years by 80%. The class of drugs that are widely used are ACE-Inhibitors by 31%. Comorbidities that often accompany hypertension patients are diabetes mellitus by 40%. The dosage form is tablets by 90%, with the route of using the drug orally by 100%. The conclusion is that the use of drugs in hypertensive patients in the outpatient installation of RSUD Dr. Achmad Diponegoro Putussibau is mostly women. The majority occur at the age of 60-74 years, the most widely used drug class is the ACE-Inhibitor group with tablet dosage form and the oral route of use is the most widely used.
Ethanol Extract, Ethyl Acetate Extract, Ethyl Acetate Fraction, and n-Heksan Fraction Mangosteen Peels (Garcinia mangostana L.) As Source of Bioactive Substance Free-Radical Scavengers Liza Pratiwi; Achmad Fudholi; Ronny Martien; Suwidjiyo Pramono
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 1, No 2 (2016)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.449 KB) | DOI: 10.20961/jpscr.v1i2.1936

Abstract

Mangosteen peels (Garcinia mangostana L.) is well known as an excellent source of antioxidative compounds. The name of mangosteen is xanthone. Antioxidant of mangosteen  peels can be extracted by ethanol, etyl acetate and can be fractinated by etyl acetate and n-hexane. The aim of this research was to compare the antioxidant activity of the peel extract by ethanol and etyl acetate and fractinated by etyl acetate and n-hexane. Extract and fraction exhibited higher scavenging activity of DPPH. The purpose of this study was to compare antioxidant activity of ethanol extract, ethyl acetate extract, fraction of ethyl acetate and n-hexane fraction. The antioxidant activity test using DPPH method with UV-Vis spectrophotometer. Ethanol extract shown IC50 value 5,03 µg/mL, ethyl acetate extract shown IC50 value 41,56 µg/mL. Ethyl acetate fraction shown IC50 value 2,78 µg/mL, and n-hexane fraction with IC50 22,33 µg/mL. It means peel extract and fraction by mangosteen peels has very strong antioxidant activity and ethyl acetate fraction that its antioxidant activity higher that the other solvent.
UJI EFEKTIVITAS LOSIO EKSTRAK DAUN KEMANGI (Ocimum sanctum Linn.) SEBAGAI REPELAN TERHADAP NYAMUK BETINA Isnindar Isnindar; Willy Hervianto; Liza Pratiwi
Media Farmasi Indonesia Vol. 7 No. 2 (2012): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (227.972 KB)

Abstract

Kemangi (Ocimum sanctum Linn.) is a plant that has the chemical content of essential oils are linalool, estragol, graniol, eugenol, and cineol. The purpose of this research is to know whether extract of kemangi leaves have a effect as mosquito repellent and how about its effectivity when it was formulated in lotion product. Extract test group being used are negative control, n-heksane extract, and methanol extract. Lotion group test being used are negative control, positive control, Lotion A (lotion that contain 2,5 % n-heksane extract) Lotion B (lotion that contain 5% n-heksane extract) Lotion C (lotion that contain 10% n-heksane extract). Effectiviy test was done for six hour with test for 15 minutes every single hour. It was done in three time repetition on one people. Stability test carried out for 31 days includes organoleptic, viscosity, ability of spreading and sticking and pH. The results shows that n-heksane extract give the best repellent effect than methanol extract so it was formulated in lotion product with different concentration. The results of the effectivity test and stability test was analized statistically by use One Way ANOVA with confidence level 95% and then it analized with Post Hoc Tukey. The result repelensi percentages are Lotion A (53,97%), Lotion B (69,67%), Lotion C (85,97%). The results shows that Lotion C give the best repellent effect between Lotion A and Lotion B. The result shows that Lotion C has a few change in all variables of stability test, so Lotion C better than Lotion A and Lotion B.
Efektivitas SNEDDS Ekstrak Kulit Manggis Terhadap Bakteri P. mirabilis dan S. epidermidis yang Terdapat pada Ulkus Diabetik Sari, Rafika; Pratiwi, Liza; Apridamayanti, Pratiwi
Pharmaceutical Sciences and Research Vol. 3, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Mangosteen rind possesses the ability to conduct antibacterial activity. Under the development relating to drug delivery system, SNEDDS were known to boost the penetration of active compound. The aim of this research is to compare the effectiveness of the antibacterial activity at both SNEDDS preparation and the ethanol extract of mangosteen rind as the antibacteria against the bacteria that cause diabetic ulcers with the most prevalence whether it was Gram positive or Gram negative bacteria like Proteus mirabilis and Staphylococcus epidermidis. The research started by maceration process with the crude extract as the result continued with the phytochemical screening which subsequently prepared as SNEDDS preparations. The SNEDDS preparation prepared earlier were then analyzed to see the content of the active compound using spectrophotometer UV-Vis and the measuring of antibacteria activity with bacteria growth inhibitory parameter at ethanol extract SNEDDS preparations of mangosteen rind then compared to ciprofloxacin and were analyzed the data afterwards using ANOVA. The results shows that SNEDDS preparation of mangosteen extract have an activity against both typed of bacteria that cause diabetic ulcers shows by significant differences between both group which is P.mirabilis bacteria group and S.epidermidis bacteria group in ANOVA test with significant number of 0,000 and shows significant differences between both group.
Co-Authors Achmad Fudholi Achmad Fudholi Adelita Ahyanurri Agvina Felicia Esperanza Andhi FAHRURROJI Anjani, Ayu Paramitha Apridamayanti, Pratiwi Bambang WIJIANTO Berliana Simbolon, Intan Damanik, Virna Helena Defiga Kasrin Dermawan, Abdurraafi Maududi Diah Ismarani Diah Ismarani Diah Ismarani, Diah Dwi Nurahmanto Evi Umayah Ulfa Fahrauk Faramayuda, Fahrauk Fajar Nugraha Fajar Nugraha Fajriaty, Inarah Felisitas Feli Fitri, Aulia Kemala Gazzali, Amirah Mohd Hadi Kurniawan Harum Nadyanti Usman Hervianto, Willy Indri Kusharyanti Isnindar Isnindar Istiqomah, Rifqi Lina Winarti Luliana, Sri Melania Niken Safira Mufidah, Fania Mufti Nera Umilia Purwanti, Nera Umilia Novia Novia Pratiwi Apridamayanti Pratiwi Apridamayanti Pratiwi Apridamayanti Pratiwi Apridamayanti, Pratiwi Rafika Sari Rafika Sari Rafika Sari Ronny Martien Ronny Martien Safrilla Anggraeni Shinta Nia Putri Shoma Rizkifani Siti Nani Nurbaeti Sri Wahdaningsih Suhartaty, Lindy Suwidjiyo Pramono Suwidjiyo Pramono SYF. OCTY NOVY FISSY Tendianus, Tendianus Ulfa Sri Mandasari Utami, Amanda Yanasari Wendy Wendy Wijianto, Bambang Wijianto Willy Hervianto Yulnalia Mariella Delavega Yuswar, Muhammad Akib Zelika Hitri, Indry