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Efektivitas Krim Ekstrak Metanol Batang Dan Daun Pacar Air (Impatiens balsamina L.) terhadap Bakteri Propionibacterium acnes Wendy Wendy; Liza Pratiwi; Indri Kusharyanti
Journal of Tropical Pharmacy and Chemistry Vol. 2 No. 4 (2014): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v2i4.66

Abstract

Colonization of Propionibacterium acnes is one of factors that causes acne vulgaris. The present study was conducted to evaluate antiacne effect from cream of methanolic extract from stems and leaves of Impatiens balsamina L. towards Propionibacterium acnes, concentration that gives greatest antiacne effect and to evaluate physical and chemical properties of creams. Simplicia were extracted using soxhlet technique and methanol as solvent. Extract then formulated in cream in three variations of concentration as following 10%(F1), 15%(F2) and 20%(F3). The determination of antiacne effect was done using disc diffusion method. Evaluation of physical and chemical properties of those creams includes organoleptic examination, spreadability, adhesion and pH testing. Determination results showed the diameter of inhibition zone from F1, F2 and F3 were 8,37±2,205; 10,78±2,551; and 17,42±3,029 mm respectively. Analysis results showed that cream of F3 gave significantly greatest antiacne effect compared to F1 and F2 (p<0,05), and not significantly different to the positive control (p>0,05). The evaluation of creams showed that they had homogenous texture, nongreasy, easily washed, spreadability of 10,18±0,285 to 11,55±0,687 cm2, adhesion force of 33,299±2,821 to 60±0 minutes, and pH of 6,07±0,058 to 6,37±0,115, this showed that creams have good physical and chemical properties. Keywords: Antiacne, Impatiens balsamina L. stems and leaves extract, Propionibacterium acnes ABSTRAK Kolonisasi bakteri Propionibacterium acnes merupakan salah satu penyebab terjadinya jerawat. Penelitian ini dilakukan untuk mengetahui efek antijerawat krim ekstrak metanol batang dan daun pacar air (Impatiens balsamina L.) terhadap bakteri Propionibacterium acnes, mengetahui konsentrasi krim yang memberikan efek antijerawat yang paling besar serta mengevaluasi sifat fisik dan kimia krim. Simplisia disokletasi menggunakan pelarut metanol. Ekstrak diformulasikan ke dalam sediaan krim dengan variasi konsentrasi ekstrak yaitu 10%(F1), 15%(F2) dan 20%(F3). Pengujian efektivitas krim dilakukan dengan metode difusi cakram. Evaluasi sifat fisik dan kimia sediaan krim yang dilakukan meliputi pemeriksaan organoleptis, pengujian daya sebar, daya lekat dan pH. Hasil penelitian menunjukkan daya hambat krim F1, F2 dan F3 terhadap bakteri masing-masing sebesar 8,37 ± 2,205; 10,78 ± 2,551; dan 17,42 ± 3,029 mm. Hasil analisis menunjukkan bahwa F3 memberikan efek antijerawat yang paling besar dan berbeda signifikan dibandingkan dengan F1 dan F2 (p<0,05) serta tidak berbeda signifikan dibandingkan dengan kontrol positif (p>0,05). Hasil evaluasi menunjukkan sediaan homogen, tidak berminyak, mudah tercuci, memiliki daya sebar sebesar 10,18±0,285 hingga 11,55±0,687 cm2 dan daya lekat sebesar 33,299±2,821 hingga 60±0 menit, serta pH antara 6,07±0,058 hingga 6,37±0,115, menunjukkan bahwa sediaan memiliki sifat fisik dan kimia yang baik. Kata kunci: Antijerawat, ekstrak batang dan daun pacar air, Propionibacterium acnes
Analisis Kadar Kalium Ekstrak Kombinasi Kulit Pisang (Musa paradisiaca L.) dan Kulit Nanas (Ananas comosus (L.) Merr) Secara Spektrofotometri Serapan Atom: Analysis of Potassium Levels in Combination Extracts of Banana Peels (Musa paradisiaca L.) and Pineapple Peels (Ananas comosus (L.) Merr) by Atomic Absorption Spectrophotometry Fajar Nugraha; Pratiwi Apridamayanti; Hadi Kurniawan; Inarah Fajriaty; Siti Nani Nurbaeti; Liza Pratiwi; Safrilla Anggraeni
Jurnal Sains dan Kesehatan Vol. 3 No. 6 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i6.791

Abstract

Penggunaan buah pisang dan nanas yang banyak untuk berbagai olahan makanan akan menghasilkan penumpukan limbah kulit. Limbah kulit pisang dan nanas diketahui mengandung unsur kalium yang dapat diolah kembali untuk menjadi produk yang bermanfaat. Oleh karena itu, penelitian ini dilakukan untuk melihat kadar kalium terhadap ekstrak kombinasi kulit pisang dan kulit nanas dengan menggunakan spektrofotometer serapan atom. Metode: pembuatan ekstrak kental dilakukan dengan metode infundasi atau infusa yang dikeringkan. Ekstrak kental didestruksi dengan cara pengabuan menggunakan tanur. Kemudian dilakukan pengujian kadar kalium menggunakan spektrofotometer serapan atom pada panjang gelombang 766,5 nm. Hasil penelitian menunjukkan kalium pada ekstrak kental didapatkan sebanyak 47,483 mg/g ekstrak. Kesimpulan: ekstrak kombinasi kulit pisang dan kulit nanas mengandung kalium yang berpotensi dalam menunjang kebutuhan kalium di dalam tubuh.
Analisis Tingkat Pengetahuan dan Perilaku Swamedikasi Diare terhadap Mahasiswa Farmasi Universitas Tanjungpura: Knowledge and Behaviour Assessment of Diarrhea Self-Medication among Pharmacy Undergraduate in Tanjungpura University Agvina Felicia Esperanza; Liza Pratiwi; Shoma Rizkifani
Jurnal Sains dan Kesehatan Vol. 5 No. 4 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i4.1277

Abstract

Self-medication is done to treat minor illnesses, such as diarrhea. Knowledge and behaviour of drugs usage in each individual affect self-medication so that irrational drugs usage can be prevent. This study determines the relationship between semester, knowledge and behaviour about diarrhea self-medication of pharmacy students at Tanjungpura University 2021/2022. The research method was carried out retrospectively in the form of a cross-sectioned questionnaire. Stratified random sampling method was used for sample selection. Rank-spearman analysis was used to analyze the relationship between semester level, knowledge and behaviour of diarrhea self-medication. Based on research, out of 232 respondents, majority of respondents were women, aged 21, obtained drugs from pharmacies without prescription (81,03%) and used adsorbent class for antidiarrheal drugs. Knowledges are classified from good (9,91%), moderate (28,45%) and low (61,64%). Behaviours are classified as appropiate (79,74%) and inappropriate (20,26%). The p-value results show the relationship between semester and knowledge 0,142; relationship between semester and behaviour 0,256 and relationship between knowledge and behaviour 0,318. The conclusion of this study is the relationship between semester and knowledge are categoried very low with positive significant relationship. Relationship between semester and behaviour and relationship between knowledge and behaviour are categoried low with positive significant relationship. Keywords: behaviour, diarrhea, knowledge, self-medication Abstrak Swamedikasi dilakukan untuk mengatasi keluhan atau penyakit ringan seperti penyakit diare. Tingkat pengetahuan dan perilaku individu dalam penentuan dan penggunaan obat diare dapat mempengaruhi swamedikasi diare sehingga tidak terjadi penggunaan obat yang tidak rasional. Penelitian ini bertujuan mengetahui hubungan tingkat semester, pengetahuan dan perilaku mahasiswa farmasi Universitas Tanjungpura tahun 2021/2022 terhadap swamedikasi diare. Metode penelitian dilakukan secara retrospektif potong lintang berbentuk kuesioner. Metode stratified random sampling digunakan untuk pemilihan sampel. Analisis rank-spearman digunakan untuk menganalisis hubungan tingkat semester, pengetahuan dan perilaku responden terhadap swamedikasi diare. Berdasarkan penelitian menunjukkan bahwa dari 232 responden, mayoritas responden adalah perempuan, berusia 21 tahun, memperoleh obat dari apotek tanpa resep (81,03%), dan menggunakan obat diare golongan adsorben. Responden memiliki tingkat pengetahuan yang baik (9,91%), cukup (28,45%) dan kurang (61,64%) dan tingkat perilaku tepat (79,74%) dan tidak tepat (20,26%). Hasil p-value menunjukkan hubungan tingkat semester terhadap pengetahuan yaitu 0,142; hubungan tingkat semester terhadap perilaku 0,256 dan hubungan tingkat pengetahuan dan perilaku 0,318. Kesimpulan dari penelitian ini adalah terdapat hubungan signifikan positif berkategorikan sangat rendah pada tingkat semester terhadap pengetahuan dan hubungan signifikan positif berkategorikan rendah pada tingkat semester terhadap perilaku dan hubungan tingkat pengetahuan terhadap perilaku berkategorikan rendah. Kata Kunci: diare, pengetahuan, perilaku, swamedikasi
EFEKTIVITAS EKSTRAK ETANOL DAN EKSTRAK KLOROFORM SIPUT ONCHIDID (Onchidium thyphae) SEBAGAI PENUMBUH RAMBUT PADA TIKUS (Rattus norvegicus) Wijianto, Bambang; Wijianto, Bambang Wijianto; Pratiwi, liza; Utami, Amanda Yanasari
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/fba2x720

Abstract

Hair loss is a problem that can affect appearance. A natural ingredient that can address hair loss treatment is the extract of the onchidiid snail. This study aims to test the hair growth effectiveness of ethanol and chloroform extracts of the onchidiid snail on white rats (Rattus norvegicus). The test groups of rats were divided into several groups: the Negative Group (CN), the Positive Group (CP) with candlenut oil, Treatment Group I (K1) with Chloroform Extract of the Onchidiid Snail, and Treatment Group II (K2) with Ethanol Extract of the Onchidiid Snail. Hair growth length was measured daily and processed using Image J software. The hair growth effectiveness test showed that over 14 days, the chloroform extract (K1) produced faster results compared to the other three groups, with a hair growth result of 1.61 cm on the 14th day. The findings of this study conclude that the chloroform extract of the onchidiid snail effectively promotes hair growth in male Wistar strain white rats.
Pelatihan Pembuatan Nano Liquid Aromaterapi bagi Kader PKK Desa Wajok Hilir di Kabupaten Mempawah: Training on Manufacturing Aromatherapy Nano liquid for PKK Cadres in Wajok Hilir Village in Mempawah District Pratiwi, Liza; Wijianto, Bambang; Fahrurroji, Andhi; Yuswar, Muhammad Akib
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 3 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i3.6251

Abstract

So far, essential oils have only been used as perfume and sold as raw material. On average, residents of Wajok Hilir village have yards covered with essential oil-producing plants such as lavender, lemongrass, and coconut. The aim of the PKM Program is training in utilizing community resources to make essential oils for aromatherapy in nano-liquid preparations. The development of this product must be oriented towards developing a practice that is easy to apply and environmentally friendly without ignoring environmental health. The solution to overcome existing problems is to provide knowledge to partners about the benefits of nano liquid preparations as aromatherapy and mosquito repellent and training on using essential oils as aromatherapy. Pharmacists provided training on making "nano liquid" products. This training activity will involve PKK cadres from Wajok Hilir village. The output target of this activity is to increase the level of quality empowerment of partners by driving sustainable activity programs from product results. This service activity showed that the 31 participants comprised the majority of women and homemakers, 77.4% with a high school education level. The results of measuring participants' knowledge and skills showed an increase in the pre-test and post-test scores, which were 55.5 and 78.33, respectively. In conclusion, the service activities that have been carried out have increased the knowledge and abilities of participants regarding the use of essential oils as aromatherapy in the form of nano-liquid preparations.
FORMULATION OF FACE PACK POWDER USING SIMPLEX LATTICE DESIGN METHOD Fitri, Aulia Kemala; Pratiwi, Liza; Nurbaeti, Siti Nani
Journal Pharmacy Of Tanjungpura Vol 1, No 2 (2024): APRIL
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Face pack powder is a cosmetic preparation that has been developed in the pharmaceutical industry. In powder dosage formulations, the important components used are binders. This study aimed to obtain an optimal formulation of face pack powder with a combination of binders. The binders combined in this study were carbopol, hydroxypropyl methylcellulose (HPMC), and sodium carboxymethyl cellulose (CMC-Na). The binder combination in the formula was predicted with simplex lattice design (SLD) mehod of Design-Expert ® software. The applied method for making the face pack powder was wet granulation based on 13 runs of software with responses in the form of pH and moisture content. The results showed that the pH of the preparations was in the range of 5.2-6.3 and that the water content was 1.54-2.87%. The pH and water content data were then entered into the software to obtain the optimum composition with a carbopol : HPMC : CMC-Na ratio of 3:1:1. The optimum formulation of the face pack powder is with white color, smooth texture, vanilla scent, pH 5.4, and 1.64% moisture content. The optimum formula data was then analyzed using one-sample t-test to verify that the predicted formula and the experimental results do not differ significantly (p0.05) so that it could be used to design the optimum formula
Formulasi NLC-Stick Ekstrak Bunga Telang (Clitoria ternatea L.) Dengan Variasi Konsentrasi Shea Butter dan Asam Stearat Damanik, Virna Helena; Pratiwi, Liza; Wijianto, Bambang
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 1 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i1.16719

Abstract

NLC of telang flower extract has an effect as a sunscreen to protect the skin from sunlight. Stick preparation in NLC formulation can facilitate the use of sunscreen. This study aims to determine and compare variations in the concentration of Shea Butter (as a Base) and stearic acid (as a Harding Agent) and obtain the results of physical evaluation of variations in the concentration of Shea butter and Stearic Acid. NLCs of telang flower extract were formulated into formulas with varying concentrations of shea butter and stearic acid in the ratio of 80:20; 50:50; 20:80. Furthermore, the physical properties of NLC-Stick of bay flower extract were evaluated, including organoleptic test, homogeneity test, pH test, melting time test, and spreadability test. The results showed that the optimal variation of shea butter and stearic acid concentration was 50:50. The optimum formula of NLC-Stick of telang flower extract has a colour like the active substance, solid shape, soft aroma, homogeneous, pH of 4.56 ± 0.3, melting time test of 21 minutes, and spreadability test of 3 cm. NLC-Stick with varying concentrations of shea butter:stearic acid (50:50) has a physical evaluation that meets the stick requirements.