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Optimasi Kombinasi Karbopol 940 dan HPMC Terhadap Sifat Fisik Gel Ekstrak dan Fraksi Metanol Daun Kesum (Polygonum minus Huds.) dengan metode Simplex Lattice Design Sari, Rafika; Nurbaeti, Siti Nani; Pratiwi, Liza
Pharmaceutical Sciences and Research Vol. 3, No. 2
Publisher : UI Scholars Hub

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Indonesia especially Kalimantan Barat well known by its biodiversity, one of the potential resource is Kesum leaves. Kesum leaves are potential by its antibacterial effect, so that it can be formulated into pharmaceutical dosage form, especially gel. This research aims to know the best comparison between Carbopol 940 and Hydroxypropyl methylcellulose (HPMC) gel base affecting the physical stability of methanol extract and fraction of kesum leaves gel by Simplex Lattice Design (SLD) method. Gels were prepared into three variation base such as gel A (100% Carbopol - 0% HPMC); gel B (0% Carbopol - 100% HPMC); and gel C (50% Carbopol – 50% HPMC). According to SLD method, the optimum combination obtained among the basis were 100% Carbopol - 0% HPMC for Kesum leaves methanol extract gel and 10% Carbopol – 90% HPMC for Kesum leaves methanol fraction gel. Then , the gels were tested their physical stability including adhesive ability spreadability and pH. Results were analyzed using One sample t- test and was known there was no difference of the physical stability between Kesum leaves methanol extract gel and Kesum leaves methanol fraction gel.

Formulasi Gel Pacar Air (Impatiens balsamina Linn.) terhadap Propionibacterium acnes dan Staphylococcus epidermidis Ismarani, Diah; Pratiwi, Liza; Kusharyanti, Indri
Pharmaceutical Sciences and Research Vol. 1, No. 1
Publisher : UI Scholars Hub

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Acnes vulgaris is a chronic inflammatory disease of sebaceous follicles caused by Propionibacterium acnes and Staphylococcus epidermidis. The antibacterial activity of Impatiens balsamina L. has been studied for many years. The aims of this study are to find out the antiacne effect from methanolic extract of stems and leaves of Impatiens balsamina L. that formulated in gel. Simplicia were extracted using soxhlet technique bu using methanol as solvent. Extracts were then formulated in gel in three variations of HPMC 4000 and Carbopol 934 as gel base with ratio of 70:30 (F1), 50:50 (F2) and 30:70 (F3). The determination of antiacne effect was done using disc diffusion method. Evaluation of physical and chemical properties of those gels includes organoleptic examination, spreadability testing, adhesion testing and pH testing. Data were analyzed using R version 2.14.1 package R-commander. Determination results showed the diameter of inhibition zone from FI, FII and FIII for P.acnes are 6.46 ±0.15 mm; 12.16 ± 0.35 mm; 16.13 ± 0.35 mm and for S. epidermidis sebesar 14.5 ± 0.47 mm; 16.56 ± 0.651 mm; 17.13 ± 0.44 mm. Analysis results showed that gel of FIII gave optimal antiacne effect, and significantly different from positive control (p < 0,05). The evaluation of gel showed that they have homogeny texture, good spreadability and adhesion, as well as the pH.

Analisis Efektivitas Biaya Penggunaan Kortikosteroid Inhalasi Pada Pasien Asma Rawat Jalan di Rumah Sakit Shinta Nia Putri; Liza Pratiwi; Shoma Rizkifani
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15452

West Kalimantan is in the 6th highest order whose prevalence of asthma exceeds the national rate of 2.4% in 2018. Asthma therapy with inhaled corticosteroids that take a long time needs to be cost-effective so as not to increase the patient's immediate medical costs. This study aims to determine the cost-effectiveness of using inhaled corticosteroids given to outpatients at Dr. Agoesdjam Hospital, Ketapang Regency. The study was conducted in a cross-sectional retrospective manner by taking data on patient medical records for the January-December 2020 period. The sampling technique is carried out by purposive sampling. The pharmacoeconomic analysis carried out is Cost Effectiveness Analysis (CEA). The Average Cost Effectiveness Analysis (ACER) and Incremental Cost Effectiveness Analysis (ICER) methods are used to analyze the most cost-effective inhaled corticosteroids. The results of the study were obtained with the characteristics of the study subjects based on gender the number of male patients n=23 (39%) and female n=36 (61%). The conclution of this research are the percentage of effectiveness of the use of inhaled corticosteroids at Dr. Agoesdjam Hospital, Ketapang Regency in 2020 is 33-100% and the most effective inhaled corticosteroids are flutiase combinations; Brotec; Combivent with an effectiveness of 100% with an ACER value of Rp. 731.45.

Characterization and Antioxidant Activity of Banana Peels, Pineapple Peels, and Combination Extracts of both Peels as Raw Materials in the Development of Hard Candy Pratiwi Apridamayanti; Hadi Kurniawan; Fajar Nugraha; Inarah - Fajriaty; Siti Nani Nurbaeti; Liza Pratiwi
Majalah Obat Tradisional Vol 27, No 3 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.77474

Kepok banana and pineapple are horticultural commodities found in West Kalimantan. The two fruits are generally used as processed foods such as fried bananas and pineapple jam. The use of fruit as food often leaves the peel as a by-product, which can produce waste twice the weight of the food consumed. Meanwhile, waste utilization is an innovation in food processing into functional products which are developed into hard candy. Therefore, this research aims to the specific and non-specific characterization of raw materials for making candy, namely the combination of banana and pineapple peel extract (KP-KN). The characterization is organoleptic tests on the content of ethanol-soluble and water-soluble extracts. The Total phenolic content was determined by the Follin ciocalticeu method with UV/Vis spectrophotometry. Furthermore, antioxidant activity tests with DPPH and FRAP methods using UV/Vis spectrophotometry and ELISA to determine antioxidant activity. The mineral content was observed using the molybdate vandalate method with UV/vis spectrophotometry and ICP-MS, Heavy metal contamination using the ICP-MS tool, and microbial contamination using the plate method. Moreover, the infundation process was carried out on banana and pineapple peels, and the results were evaporated using a food dehydrator to obtain a combination extract. The results showed that the organoleptically KP-KN combination extract had a bitter taste, pineapple smells, 15.57% ash content, ethanol soluble extract content of 55.10%, and 47.99% water-soluble extract. Also, the total phenolic of 6.22 g/Kg, as well as the mineral content of Potassium (K), Calcium (Ca), Iron (Fe), Magnesium (Mg), Zinc (Zn), and Phosphorus (P), which were 47.23 g/Kg, 291.43 mg/Kg, <1x10-6 g/Kg, 2.59x10-3 g/Kg, and 2.38 g/Kg, respectively. Meanwhile, the heavy metal and bacterial contamination test showed that Arsenic (As), Sn, Mercury (Hg), and lead (Pb) were <1x10-6 g/Kg and Cadmium (Cd) was 0.0293. In the microbial contamination test with bacterial components including the ALT test, a value of 4.83 x 103 cfu/g was found, and there was no contamination from E.coli, mold, and yeast bacteria, DPPH and FRAP methods showed antioxidant activity combination extract banana peels and pineapple peels with values of 1390.96±2.83 mg/L and 4542.81±1.10 mg/L compare antioxidant activity of ascorbic acid as standard is 2.13 mg/L and 4.83 mg/L. The test with the KP-KN combined extract can be used as a raw material for making hard candy because it contains minerals needed by the body, meets the safety and quality requirements of traditional medicines, and has antioxidant activity in vitro.

Pengolahan Ampas Kopi Arabika (Coffea arabica L.) menjadi Masker Face Pack Powder di Desa Punggur Besar, Kuburaya: Processing of Arabica Coffee Dregs (Coffea arabica L.) into Face Pack Powder Masks in Punggur Besar Village, Kuburaya Liza Pratiwi; Pratiwi Apridamayanti; Rafika Sari
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 8 No. 2 (2023): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v8i2.4230

Cosmetics are preparations that are popularly used. Face pack is claimed to rejuvenate the skin and remove dirt and excess oil on the skin. Coffee grounds in Punggur Besar Village have only been thrown away and become waste, so a new breakthrough is needed to process coffee grounds so that they can be utilized and not wasted. This PKM activity will be carried out offline using the Health protocol. The purpose of the Community Service Program (PKM) is product innovation by utilizing coffee grounds waste into masks. This PKM activity began with making masks in the laboratory, training activities for making coffee grounds face packs including exposure of material on cosmetic face pack powder treatments, training with health protocols with the number of participants limited to 20 people with a room capacity of 50 people, exposure on labels and face packaging. pack powder, discussion and question and answer. Evaluation and monitoring activities are carried out using a questionnaire (pretest and post-test). The results of the activity showed significant differences in the results of the questionnaire analysis before and after the activity on each question item. The PKM activity targeting PKK women in Punggur Besar Village succeeded in increasing the ability of PKK women in utilizing coffee grounds waste into face pack powder masks. The next activity is expected to be able to provide assistance so that the resulting product obtains a distribution permit so that the coffee grounds face pack powder product can be marketed with a wider market share.

Cosmetic Serum Loaded Arabica Coffee (Coffea arabica) Extract: Formulation and Antioxidant Study Harum Nadyanti Usman; Liza Pratiwi; Bambang Wijianto
Majalah Obat Tradisional Vol 28, No 2 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.83120

Arabica coffee (Coffea arabica) is a natural antioxidant that can be used in the prevention of skin aging. This study was conducted to determine the comparison of variations in the composition of HPMC, CMC-Na, and Carbomer in the optimum formula of arabica coffee serum, then to determine the physical properties of the preparation, as well as the IC50 value ofarabica coffee extract and arabica coffee serum in the DPPH test. Arabica coffee extract was obtained by maceration method using 70% ethanol. Determination of the optimum formula of arabica coffee serum using the Simplex Lattice Design method. The optimum formula of arabica coffee serum was evaluated for physical properties including organoleptic test, homogeneity test, pH test, spreadability test, and adhesion test. The antioxidant activity of arabica coffee extract and the optimum formula of arabica coffee serum was tested using the DPPH method. Data analysis used SPSS One sample T-test statistics. The results showed that the composition variation of HPMC, CMC-Na, and Carbomer in the optimum formula of arabica coffee serum using the Simplex Lattice Design method was 0.1%:0.8%:0.1%. The resulting predicted values are a pH value of 4.88 and a spreadability value of 7.95 cm. The optimum formula of arabica coffee serum has the physical properties of the preparation, namely brown color, coffee aroma, light texture, a cool sensation when applied to the skin, homogeneous, has a spreadability of 7.93 cm, stickiness of 1 second, and pH value of 4.9. The IC50 value of arabica coffee extract and the optimum formula of arabica coffee serum are 8.13 ppm and 250 ppm. The results of the SPSS One sample T-test statistical analysis showed that there was no significant difference between the prediction response and the results of the optimum formula evaluation.

SERUM OF EXTRACT Onchidium Typhae USES HYDROXYETHYL CELLULOSE AND CARBOXYMETHYL CELLULOSE NATRIUM BASE AS ANTIOXIDANT Bambang Wijianto; Liza Pratiwi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1113

Antioxidants can prevent premature aging (anti-aging) and various types of cancer and increase body immunity. Empirically, Onchidiid slugs have been used as natural antioxidants. This study aimed to determine the antioxidant potency of the serum of Onchidiid slug ethanolic extract. The Onchidiid slug extract was obtained by maceration and was prepared to create two effective serum formulations. Formula A involved hydroxyethyl cellulose (HEC), while Formula B employed sodium carboxymethyl cellulose (Na-CMC) as gelling agent. The second serum formula was rigorously evaluated and subjected to antioxidant activity testing by the diphenyl-2-picrylhydrazyl (DPPH) method. The serum preparation with the best physical properties and antioxidant activity was serum A at a concentration of 1%. Physical test results showed that serum A had a yellow color with a distinctive smell and was homogeneous with a soft texture. The test results for the spreadability and stickiness properties of serum A were 6 cm2 and 1'55'' second. The serum A antioxidant activity test results showed moderate free-radical scavenging activity, with an IC50 value of 277 ppm. Keywords: Anti-aging, 2,2-diphenyl-1-pikrilhidrazyl, Onchidium typhae, Antioxidant

Efektivitas SNEDDS Kombinasi Fraksi Etil Asetat Daun Cengkodok (Melasthoma malabathricum)-Antibiotik terhadap Bakteri Hasil Isolat dari Pasien Ulkus Diabetik Sari, Rafika; Apridamayanti, Pratiwi; Pratiwi, Liza
Pharmaceutical Journal of Indonesia Vol. 7 No. 2 (2022)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2022.007.02.5

Diabetic ulcer is a condition where there are neurological abnormalities and peripheral arterial vascular disease that causes infection, ulceration, and/or damage to the deepest skin tissue on the feet of people with diabetes mellitus (DM). The long duration of wound healing is due to the wrong use of antibiotics for a long time, and bacteria tend to become resistant to antibiotics. Antimicrobial compound fraction of cengkodok combined with gentamicin and ciprofloxacin antibiotics for prevention and reduction of antibiotic resistance in the cause of diabetic ulcers. The drug preparation is in the form of self nanoemulsifiying drug delivery system (SNEDDS), which is the optimum combination of cengkodok leaf fraction with gentamicin and ciprofloxacin antibiotics. The use of SNEDDS in this study is because the SNEDDS made from nanoemulsion formulations has small particle size, large surface absorption, and good dispersion, so that it can be evenly dispersed on the skin and penetrates the skin layer. This study aims to determine the effectiveness of the formulation cengkodok leaf fraction with gentamicin and ciprofloxacin antibiotics against B. cereus and S. aureususing the SNEDDS drug delivery system. The test uses the spotless diffusion method without using paper discs. The results showed that the combination of cengkodok leaf fraction with gentamicin and ciprofloxacin antibiotics had better activity against B. cereus and S. aureus than cengkodok leaf fraction, gentamicin and ciprofloxacin only.

Efektivitas SNEDDS Kombinasi Fraksi Etil Asetat Daun Cengkodok (Melasthoma malabathricum)-Antibiotik terhadap Bakteri Hasil Isolat dari Pasien Ulkus Diabetik Sari, Rafika; Apridamayanti, Pratiwi; Pratiwi, Liza
Pharmaceutical Journal of Indonesia Vol. 7 No. 2 (2022)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2022.007.02.5

Diabetic ulcer is a condition where there are neurological abnormalities and peripheral arterial vascular disease that causes infection, ulceration, and/or damage to the deepest skin tissue on the feet of people with diabetes mellitus (DM). The long duration of wound healing is due to the wrong use of antibiotics for a long time, and bacteria tend to become resistant to antibiotics. Antimicrobial compound fraction of cengkodok combined with gentamicin and ciprofloxacin antibiotics for prevention and reduction of antibiotic resistance in the cause of diabetic ulcers. The drug preparation is in the form of self nanoemulsifiying drug delivery system (SNEDDS), which is the optimum combination of cengkodok leaf fraction with gentamicin and ciprofloxacin antibiotics. The use of SNEDDS in this study is because the SNEDDS made from nanoemulsion formulations has small particle size, large surface absorption, and good dispersion, so that it can be evenly dispersed on the skin and penetrates the skin layer. This study aims to determine the effectiveness of the formulation cengkodok leaf fraction with gentamicin and ciprofloxacin antibiotics against B. cereus and S. aureususing the SNEDDS drug delivery system. The test uses the spotless diffusion method without using paper discs. The results showed that the combination of cengkodok leaf fraction with gentamicin and ciprofloxacin antibiotics had better activity against B. cereus and S. aureus than cengkodok leaf fraction, gentamicin and ciprofloxacin only.

USE D-OPTIMAL MIXTURE DESIGN IN FORMULATION OF ONCHIDIID SLUG (ONCHIDIUM TYPHAE) INSTANT POWDER AS FUNCTIONAL FOODS Wijianto, Bambang; Tendianus, Tendianus; Pratiwi, Liza
Jurnal Farmasi Sains dan Praktis Vol 10 No 2 (May-August 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i2.11107

Onchidiid slug (Onchidium typhae) is an animal with bioactive compounds with high nutritional value and the potential to be used as a functional food product. The study aimed to optimize the onchidiid slug instant powder formula, analyze its proximate content, and determine its hedonic level. The formula of instant powder was made with a comparison of the composition of maltodextrin and dextrose based on the run in the D-Optimal Mixture Design (DMD) program, namely run 1 (20%:10%), run 2 (10%:20%), run 3 (13.33%: 16.67%), run 4 (16.67%:13.33%), run 5 (15%:15%), run 6 (12.5%:17.5%), run 7 (10%: 20%), run 8 (20%:10%). The powder is tested for water content and dissolution time, and the optimal formula is analyzed using One Sample T-Test in SPSS. The results showed that the composition of maltodextrin and dextrose significantly affected the characteristics of instant powder. The optimal instant powder formula combines 18.690% maltodextrin and 11.310% dextrose with a water content of 4.892% and a soluble time of 118.052 seconds. The results of statistical analysis in verifying the optimal formula show a p-value > 0.05 (not significant). The results of the proximate content test were 8.21% water content, 0.42% ash content, 0.85% crude fiber, 3.54% protein, and 1.54%. They had a preference level in the like and acceptable in terms of color, taste, texture, and scent.

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