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All Journal VALENSI Indonesian Journal of Pharmaceutical Science and Technology Jurnal Kimia Riset Chimica et Natura Acta Jurnal Pengabdian Pada Masyarakat Indonesian Journal of Chemistry Jurnal Kreativitas PKM JURNAL FARMASI GALENIKA Pharmacoscript Indonesia Natural Research Pharmaceutical Journal (INRPJ) Science Midwifery Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pengabdian Pada Masyarakat Jurnal Farmasi Indonesia Edukasi Masyarakat Sehat Sejahtera (EMaSS) Karya Kesehatan Siwalima Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Galenika Jurnal Pengabdian kepada Masyarakat (PEMAS)
Deden Indra Dinata, Deden Indra
Fakultas Farmasi, Universitas Bhakti Kencana
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Molecular Docking and Molecular Dynamics Study of Phlorotannin-Derived Metabolites from Brown Macroalgae (Sargassum sp.) as Potential α-Amylase Inhibitors Asnawi, Aiyi; Silviana, Lilis; Andriansyah, Ivan; Kurnia, Dewi; Febrina, Ellin; Dinata, Deden Indra
Jurnal Kimia Riset Vol. 10 No. 2 (2025): December
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkimris.v10i2.75900

Abstract

Type 2 diabetes mellitus (T2DM) is a widespread global health issue, characterized by insulin resistance and impaired a-amylase activity—an enzyme essential for carbohydrate metabolism. Phenolic compounds derived from brown macroalgae have been identified as potential a-amylase inhibitors and are promising candidates for the development of novel antidiabetic agents. This study aimed to explore the molecular interactions between phlorotannin-derived metabolites from Sargassum sp. and the α-amylase enzyme (PDB ID: 1B2Y) through in silico approaches, including molecular docking and molecular dynamics simulations. Molecular docking was performed using AutoDock 4.2, followed by molecular dynamics (MD) simulations using GROMACS to assess the stability of the ligand–enzyme complexes. The results revealed that dieckol (S06) and 6,6′-bieckol (S07) showed the strongest binding affinity with a docking score of -9.57 and -8.95 kcal/mol, respectively and the most favorable binding free energy (ΔTOTAL -56.87 kcal/mol), suggesting its strong potential for stable interaction with the enzyme. These results highlight the potential of dieckol and 6,6′-bieckol as effective α-amylase inhibitors.
Herbal-Based Community Training For Hypertension Prevention Using TENSITEA Vina Juliana Anggraeni; Asep Roni; Siti Saidah Mutmainah; Anne Yuliantini; Deden Indra Dinata
Karya Kesehatan Siwalima Vol. 4 No. 2 (2025): September
Publisher : Lembaga Penerbitan Fakultas Kesehatan, Universitas Kristen Indonesia Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54639/kks.v4i2.1687

Abstract

Hypertension remains one of the most prevalent non-communicable diseases worldwide and is increasingly becoming a health burden in Indonesian communities. Limited knowledge about hypertension and the lack of access to preventive strategies contribute to its high incidence in rural areas. This community empowerment program was conducted to improve public understanding of hypertension and to provide practical training on the production of a herbal tea formulation, known as Tensi Tea, using locally available ingredients such as breadfruit leaves, bay leaves, and cinnamon. The activity took place in Mandalawangi Village and involved community members, local health cadres, and students. The program was implemented in several stages, including educational sessions on hypertension prevention, interactive discussions, and hands-on training in harvesting, processing, and packaging herbal ingredients into tea bags. Participants were actively engaged, demonstrated high enthusiasm, and were able to produce the herbal tea product independently by the end of the training. The results showed an increase in community knowledge regarding risk factors and prevention of hypertension, as well as enhanced skills in producing a simple herbal preparation that has the potential to support both health promotion and local economic opportunities. In conclusion, education on hypertension prevention, accompanied by training on herbal tea, is an effective strategy to empower communities. It is recommended that similar programs be expanded to other rural areas and supported by local health services to ensure sustainability.
Kromatografi Lapis Tipis Video Densitometri sebagai Alternatif Analisis Simultan Rifampisin dan Isoniazid dalam Sediaan Kombinasi Fauzan Zein; Yusril Panji; Deden Indra Dinata
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 1 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i1.1018

Abstract

Rifampicin and isoniazid are first-line antituberculosis drugs widely used in tuberculosis therapy. Simultaneous determination of both compounds is required to ensure the quality and safety of pharmaceutical preparations. This study aimed to develop a Thin-Layer Chromatography (TLC) Video Densitometry method as an alternative approach for the simultaneous analysis of rifampicin and isoniazid in combination tablets. Separation was performed using silica gel GF254 as the stationary phase and methanol:ammonia (10:1) as the mobile phase. Spot visualization was carried out under UV light at 254 nm and analyzed using ImageJ software to obtain the area under curve (AUC) values. Method validation included selectivity, linearity, sensitivity, accuracy, and precision tests. The results showed that the Rf values of rifampicin and isoniazid were 0.78 and 0.66, respectively, with a selectivity factor of 1.18. The calibration curves demonstrated good linearity with determination coefficients of 0.9987 for rifampicin and 0.9992 for isoniazid. The recovery values ranged from 99.20–99.70% for rifampicin and 99.56–99.80% for isoniazid, while the %RSD values were less than 2% for both compounds. The assay results of combination tablets showed rifampicin levels of 82.42–82.46% and isoniazid levels of 78.00–78.47%. Based on the validation results, the TLC video densitometry method fulfilled the validation parameters and can be used as an alternative method for the simultaneous analysis of rifampicin and isoniazid in combination preparations.
EVALUASI TURUNAN PHLOROTANNIN DALAM MAKROALGA COKELAT (Sargassum sp.) UNTUK POTENSI MODULASI HUMAN PPAR-GAMMA SEBAGAI INHIBITOR ANTI-DIABETES: KAJIAN PENAMBATAN MOLEKUL Lilis Silviana; Muhamad Ilham Bintang; Ivan Andriansyah; Deden Indra Dinata; Aiyi Asnawi
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 9, No 1 (2024)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/inrpj.v9i1.7335

Abstract

Diabetes Mellitus merupakan masalah kesehatan global dengan jumlah kasus yang terus meningkat, khususnya Diabetes Mellitus Tipe 2. Salah satu intervensi pengobatannya melalui penghambatan PPAR (Peroxisome proliferator-activated receptor). Di sisi lain, penggunaan akarbosa jangka panjang dapat menyebabkan gangguan pencernaan, hati, dan ginjal. Makroalga cokelat, khususnya Sargassum sp., mengandung senyawa bioaktif florotanin yang berpotensi memberikan manfaat kesehatan, namun turunannya belum dilaporkan. Tujuan penelitian ini untuk menyelidiki potensi afinitas dan interaksi pengikatan senyawa turunan florotann dari makroalga cokelat dengan reseptor Human PPAR-Gamma melalui simulasi penambatan molekul. Prosedur penambatan molekul divalidasi secara cermat dengan melakukan penambatan molekul ulang ligan alami ((2S)-2-Etoksi-3-[4-(2-{4-[(Methylsulfonyl) oxy]Phenyl}Ethoxy)Phenyl]Propanoic Acid) ke dalam enzim situs aktif, menghasilkan nilai Root Mean Square Deviation (RMSD) rendah di bawah 2 Å. Langkah validasi ini memastikan keandalan algoritma penambatan molekul yang dipilih, AutoDock 4.2.6, dan parameternya untuk evaluasi penambatan ligan uji. Simulasi penambatan molekul selanjutnya dilakukan untuk sembilan ligan phlorotannin, mengungkapkan beragam afinitas pengikatan dan profil interaksi. Khususnya, senyawa seperti Dieckol, 7-phloroeckol, Phlorofucofuroeckol A, dan Eckol menunjukkan energi pengikatan yang kuat dan interaksi yang menjanjikan dengan residu utama, yang menunjukkan potensinya sebagai ligan efektif untuk enzim Human PPAR-Gamma. Analisis rinci ikatan hidrogen dan interaksi hidrofobik memberikan gambaran tentang mekanisme molekuler ligan dalam situs pengikatan enzim terutama residu B:Ser 289 dan B:His449, diidentifikasi sebagai kontributor penting dalam interaksi ligan-enzim. Dapat disimpulkan, Dieckol merupakan kandidat senyawa pemandu dari penambatan senyawa turunan florotanin dari makroalga cokelat dan Human PPAR-Gamma.
Pemberdayaan Komunitas PILAR SAP melalui Penerepan Pengendalian Mutu Sederhana pada Produk Herbal Rumah Tangga Vina Juliana Anggraeni; Asep Roni; Deden Indra Dinata; Anne Yuliantini; Ilyas Nur Fatahillah
Jurnal Pengabdian kepada Masyarakat (PEMAS) Vol. 3 No. 2 (2026): Mei 2026
Publisher : Yayasan Ran Edu Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63866/pemas.v3i2.128

Abstract

Produksi minuman herbal rumah tangga di tingkat komunitas terus berkembang sebagai bagian dari pemanfaatan bahan alam lokal dan penerapan gaya hidup sehat. Namun, proses pengolahan produk herbal masih banyak dilakukan secara tradisional tanpa penerapan pengendalian mutu sederhana, sehingga berpotensi memengaruhi kualitas, keamanan, dan konsistensi produk. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan kapasitas komunitas PILAR SAP dalam menerapkan pengendalian mutu sederhana pada produk herbal rumah tangga. Metode yang digunakan adalah pendekatan Asset Based Community Development (ABCD) melalui identifikasi potensi komunitas, penyuluhan, pelatihan praktik, pendampingan, dan evaluasi partisipatif. Kegiatan diikuti oleh 33 peserta yang terdiri atas orang tua dan anggota komunitas Sekolah Alam Purwakarta. Program meliputi pelatihan pembuatan minuman herbal serta penerapan uji pH dan uji organoleptik sebagai bentuk pengendalian mutu sederhana. Hasil kegiatan menunjukkan adanya peningkatan pemahaman dan keterampilan peserta dalam menjaga mutu, higienitas, dan konsistensi produk herbal rumah tangga. Peserta juga mampu menerapkan analisis sederhana secara mandiri pada produk yang dibuat. Kegiatan ini menunjukkan bahwa penerapan pengendalian mutu sederhana dapat menjadi pendekatan aplikatif dalam pemberdayaan komunitas untuk mendukung pengembangan produk herbal yang lebih aman dan berkualitas.
Co-Authors Abdillah, Lutfi Abdul Mulki Irpani Abdul Mulki Irpani Achmad Fadjar Aiyi Asnawi Aiyi Asnawi Aiyi Asnawi Aiyi Asnawi Andriansyah, Ivan Anggraeni, Vina Juliana Arif Rubianto Baharudin Lutfi Darwati Darwati Darwati Darwati Dewi Kurnia Dewi Kurnia Dinayanti, Westi Nur Ellin Febrina Fadjar, Achmad Farizan Nur Fazrina Fauzan Zein Fauzan Zein Muttaqien Fenti Fatmawati Fikri Mourly Wahyudi Firdaus, Oktri Muhammad Garnadi Jafar, Garnadi Hani Oktafiani Hardhi Suryatno Hardhi Suryatno, Hardhi Helena, Deni Fransisca Heni Nurakilah Ida Musfiroh Ida Musfiroh -, Ida Musfiroh Idar, Idar Ilyas Nur Fatahillah Irfani, Abdul M. Jajang Japar Sodik Kosasih Kosasih KOSASIH KOSASIH, KOSASIH Lilis Silviana Lilis Silviana Lutfi Abdillah Meda Yuliani Meti Sulastri Mohamad Nurul Azmi Muhamad Ilham Bintang Mutmainah, Siti Saidah Muttaqin, Fauzan Z. Muttaqin, Fauzan Zein Nani, Shinta Ayu Nenden Ayu Lisniawati Nurdiansyah, Ilyas Nurul Qomarilla Oktri Muhammad Firdaus Pertiwi, Nisa Indah Qomarilla, Nurul R Nety Rustikayanti Rahmat Santoso Rani Maharani Rani Maharani Rinjani, Santi Roni, Asep Sari Nurmala Septianti, Regina Dwi Shelvy E Suherman Shelvy E Suherman, Shelvy E Silviana, Lilis Siti Rokhmah SITI SAIDAH Siti Saidah Mutmainah Sodik, Jajang J. Soni Muhsinin Sri Lestari Kartikawati Suherdin Tenny Putri Wikayani Tenny Putri Wikayani, Tenny Putri Tri Mayanti Unang Supratman Vina Juliana Anggraeni Widhya Aligita Winasih Rachmawati Yoshihito Shiono Yuliantini, Anne Yusril Panji