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All Journal Indonesian Journal of Cancer The Indonesian Biomedical Journal Nusantara Medical Science Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Majalah Patologi Indonesia Poltekita : Jurnal Ilmu Kesehatan Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Indonesian Journal of Cancer
UPIK ANDERIANI MISKAD, UPIK ANDERIANI
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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PERBANDINGAN KARAKTERISTIK KLINIKOPATOLOGIS ANTARA ADENOKARSINOMA KOLOREKTAL MUCINOUS DAN NON-MUCINOUS DI MAKASSAR TAHUN 2021-2023 Rasyid, Nur Rahmah; Miskad, Upik Anderiani; Cangara, Muhammad Husni; Wahid, Syarifuddin; Achmad, Djumadi; Tawali, Suryani; Mardiati, Mardiati
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 6 No 3 (2024): Desember
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v6i3.248

Abstract

ABSTRAK Adenokarsinoma kolorektal terdiri dari dua subtipe utama, yaitu mucinous dan non-mucinous, dengan karakteristik klinikopatologis yang berbeda. Memahami perbedaan ini penting untuk menentukan prognosis dan pendekatan terapi yang tepat. Penelitian ini bertujuan mengevaluasi perbedaan klinikopatologis, termasuk grading Tumor Infiltrating Lymphocytes (TILs), antara adenokarsinoma mucinous dan non-mucinous. Studi cross-sectional ini melibatkan 24 pasien adenokarsinoma kolorektal di Rumah Sakit Dr. Wahidin Sudirohusodo, Makassar (2021-2023). Sebanyak 12 pasien dengan adenokarsinoma mucinous dan 12 pasien dengan adenokarsinoma non-mucinous dianalisis. Uji Chi-square digunakan untuk menilai perbedaan grading TILs dan variabel klinikopatologis lainnya, dengan p < 0,05 dianggap signifikan. Grading TILs secara signifikan lebih tinggi pada adenokarsinoma non-mucinous dibandingkan mucinous (p = 0,002). Tidak terdapat perbedaan signifikan pada usia (p = 0,640), jenis kelamin (p = 0,667), invasi limfovaskular (p = 1,000), metastasis nodus limfatik (p = 0,372), tumor budding (p = 0,372), pT (p = 0,457), dan lokasi tumor (p = 0,148). Grading TILs yang lebih tinggi pada adenokarsinoma non-mucinous menunjukkan respons imun yang lebih kuat. Hasil ini dapat membantu personalisasi strategi terapi pada adenokarsinoma kolorektal. Kata Kunci: Adenokarsinoma kolorektal, mucinous, non-mucinous, Tumor Infiltrating Lymphocytes (TILs), klinikopatologi. ABSTRACT Colorectal adenocarcinoma consists of two main subtypes: mucinous and non-mucinous, with distinct clinicopathological characteristics. Understanding these differences is important for determining prognosis and appropriate therapeutic approaches. This study aims to evaluate the clinicopathological differences, including Tumor Infiltrating Lymphocytes (TILs) grading, between mucinous and non-mucinous colorectal adenocarcinoma. This cross-sectional study involved 24 colorectal adenocarcinoma patients at Dr. Wahidin Sudirohusodo Hospital, Makassar (2021-2023). Twelve patients with mucinous adenocarcinoma and 12 with non-mucinous adenocarcinoma were analyzed. Chi-square tests were used to assess differences in TILs grading and other clinicopathological variables, with p < 0.05 considered significant. TILs grading was significantly higher in non-mucinous adenocarcinoma compared to mucinous (p = 0.002). No significant differences were found in age (p = 0.640), gender (p = 0.667), lymphovascular invasion (p = 1.000), lymph node metastasis (p = 0.372), tumor budding (p = 0.372), pT classification (p = 0.457), and tumor location (p = 0.148). Higher TILs grading in non-mucinous adenocarcinoma indicates a stronger immune response. These findings may assist in personalizing therapeutic strategies for colorectal adenocarcinoma patients. Keywords: Colorectal adenocarcinoma, mucinous, non-mucinous, Tumor Infiltrating Lymphocytes (TILs), clinicopathological analysis.
Leptin Expression in High-grade Serous Ovarian Carcinoma: The Controversy of Leptin Paradox in Ovarian Cancer Ham, Jonathan; Masadah, Rina; Nasser, Andi Sitti Halija Diawanti; Rauf, Syahrul; Nelwan, Berti Julian; Cangara, Muhammad Husni; Miskad, Upik Anderiani; Mardiati; Tawali, Suryani
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 1 January 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i1.2373

Abstract

Objectives : To analyse the characteristics and expression patterns of Leptin in high-grade serous epithelial ovarian carcinoma (HGSC), and to compare them with the overall serous ovarian carcinoma population. Methods : This was a cross-sectional study. A total of 77 paraffin-embedded tissue samples were collected from patients at the Wahidin Sudirohusodo Hospital over a period of 3 years. Immunohistochemical staining was performed using a polyclonal Leptin antibody. Data were analyzed using SPSS version 22.0. Results: Among HGSC patients, the majority (64.3%) were over 50 years old, and a significant portion (39.3%) were obese. Leptin showed strong cytoplasmic expression in 69.6% of HGSC tumor cells and in 100% of LGSC tumor cells (p-value = 0.004). There was no correlation between lymphovascular space invasion and leptin expression. Interestingly, leptin expression in overall serous ovarian carcinoma patients exhibited a protective effect against metastasis (p-value = 0.047), suggesting a leptin paradox exists in this type of cancer. However, this association was no longer significant when the analysis excluded the LGSC group (p-value = 0.193). Conclusion : This study suggest that leptin expression may not be a significant prognostic factor in HGSC. The appearance of the pseudo-leptin paradox phenomenon in several previous studies was confounded by sample populations with heterogeneous tumor morphology. Keywords: high-grade serous carcinoma, leptin paradox, immunohistochemistry, leptin, obesity
FGFR2 as A Prognostic and Predictive Marker in Colorectal Adenocarcinoma Based on TILs Grade Rianti, Andi Marcha; Cangara, Muhammad Husni; Yamin, Amalia; Dahlan, Haslindah; Ilyasa, Muhammad Riza; Miskad, Upik Anderiani
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3523

Abstract

BACKGROUND: Colorectal cancer remains a serious health problem due to its high incidence and mortality rate each year. Histopathological grades and tumor-infiltrating lymphocytes (TILs) are associated with patient’s outcome. Fibroblast growth factor receptor 2 (FGFR2) overexpression is correlated with a worse prognosis in colorectal adenocarcinoma patients. Unfortunately, there are not many studies investigating the relationship between FGFR2 with histopathological grade and TILs in Indonesia. This study was conducted to analyze the correlation between FGFR2 expression with histopathological grade and TILs grade in colorectal adenocarcinoma.METHODS: Immunohistochemistry examination using FGFR2 rabbit polyclonal antibody was performed on 94 paraffin-embedded colorectal adenocarcinoma blocks and its expression was examined using a light microscope. The relationship between FGFR2 expression with histopathological grade and TILs grade in colorectal adenocarcinoma was statistically analyzed.RESULTS: Of the 94 samples examined, low grade adenocarcinoma was more common (n=76), of which 60.5% showed high FGFR2 expression. While in high grade adenocarcinoma, 83.3% of the samples showed high FGFR2 expression. In low grade TILs (n=30), 80% showed strong FGFR2 expression. While in high grade TILs (n=17), 64.7% showed weak FGFR2 expression. Based on statistical analysis, there was a significant correlation between FGFR2 expression and TILs grade (p=0.008). However, there was no significant association with histopathological grade (p=0.127).CONCLUSION: The significant correlation between FGFR2 expression and TILs grade suggests that FGFR2 may be used as a prognostic and predictive marker in colorectal adenocarcinoma.KEYWORDS: FGFR2, Colorectal adenocarcinoma, TILs, Histopathological grade
The Role of Tumor Budding as a Prognostic Factor in Colorectal Adenocarcinoma Rianti, Andi Marcha; Miskad, Upik Anderiani; Cangara, Muhammad Husni; Wahid, Syarifuddin; Achmad, Djumadi; Tawali, Suryani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i1.1586

Abstract

Background: Colorectal cancer is one of the most prevalent malignancies worldwide. Tumor budding has emerged as a potential prognostic indicator in colorectal adenocarcinoma. Objective: This study aimed to analyze the relationship between tumor budding and histopathological grade, lymphovascular invasion, and lymph node metastasis in colorectal adenocarcinoma, and to assess the potential of tumor budding as a prognostic factor. Methods: A cross-sectional study was conducted using 93 colorectal adenocarcinoma samples. The association between tumor budding and histopathological grade, lymphovascular invasion, and lymph node metastasis was evaluated using the Chi-square and Mann-Whitney tests. Results: Among the 93 samples, a significant difference in tumor budding scores was found between cases with and without lymphovascular invasion (p = 0.003). However, no significant association was observed between tumor budding scores and histopathological grade (p = 0.685) or lymph node metastasis (p = 0.092). Additionally, a significant correlation was found between lymphovascular invasion and lymph node metastasis (p < 0.001). Conclusion: Tumor budding may serve as an important prognostic factor in colorectal adenocarcinoma, particularly in its association with lymphovascular invasion
Characteristics of ER, PR, HER2 and Ki67 Expression in Invasive Breast Cancer Patients at RSUP Dr. Wahidin Sudirohusodo, Makassar 2021-2023 Rahmawani, Surya; Nelwan, Berti J; Miskad, Upik Anderiani; Cangara, Muhammad Husni; Sungowati, Ni Ketut; Yamin, Amalia; Aslam, Muhammad; Mardiati, Mardiati
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i1.1589

Abstract

Background: Invasive breast carcinoma is the most common type of breast cancer among women globally, with high mortality. In Indonesia, it ranks first based on Globocan 2020 data. Objective: To determine the expression of prognostic and predictive markers—Estrogen Receptor (ER), Progesterone Receptor (PR), HER2, and Ki67—in breast cancer cases at RSUP Wahidin Sudirohusodo. Methods: A descriptive study was conducted on 71 samples from 2021–2023. Data on age, histopathologic grade, and marker expression (HER2, ER, PR, Ki67) were analyzed. Samples were stained and examined microscopically. Chi-square tests were performed using SPSS version 27. Results: Among the 71 samples, 47.89% were from patients aged < 50 years and 52.11% from those >/ 50. Grade 2 was most common (59.15%). HER2 expression was negative in 59.15% of samples, ER positive in 83.10%, PR positive in 67.61%, and Ki67 expression was low in 52.11%. Conclusion: Most cases showed negative HER2 and positive ER/PR expression with low Ki67, indicating the relevance of hormonal receptors and proliferation rate as prognostic indicators. These markers are crucial for prognosis and treatment planning in breast carcinoma.
Thyroid Leiomyosarcoma: A Rare Case Report Juanita; Maulana, Aries; Yamin, Amalia; prihatni, Imeldi; Sungowati, Ni Ketut; Miskad, Upik Anderiani
Majalah Patologi Indonesia Vol. 34 No. 1 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i3.553

Abstract

Background Primary thyroid leiomyosarcoma is a very rare tumor. The incidence is less than 0.01% of all primary thyroid tumors. Thyroid leiomyosarcoma are tumours showing smooth muscle differentiation, originating from thyroid gland vascular smooth muscle. Case Description Female, 47 years old, with lump on the left neck since 1 year ago, getting bigger in the last 3 months, no shortness of breath, no history of previous surgery. Physical examination revealed a mass was 13x6 cm in size, solid, firm.  Cytological features from fine needle aspiration biopsy (FNAB) showed cellular spindle cells with atypical, pleomorphic, hyperchromatic nuclei and  several normal thyroid follicles among them, sugesting  malignant thyroid tumor (Bethesda VI). Total thyroidectomy was performed, followed by histopathological examination. Microscopically showed proliferation of atypical, pleomorphic, hyperchromatic spindle cells with eosinophilic cytoplasm. The spindle cells arranged in fascicular and interlacing pattern. Several follicular thyroid are entrapped within this atypical spindle cells. Based on these finding, this case was diagnosed as anaplastic thyroid carcinoma. To confirm the diagnosis, immunohistochemical examination with cytokeratin, desmin and Ki-67 were performed and the result showed negative for cytokeratin, positive for desmin and Ki-67 was highly positive. Based on these results, a diagnosis of thyroid leiomyosarcoma was made. Discussion and Conclusion Differential diagnosis with other primary mesenchymal thyroid  tumors should be considered in the cases with atypical spindle cells microscopic appearance. The diagnosis of thyroid leiomyosarcoma based on cytology and histopathology is difficult to establish, therefore immunohistochemical staining is required to establish the accurate final diagnosis.
PD-1 and PDL-1 Immune Checkpoint Inhibitors: Emerging Hope for the Future of Lung Cancer Immunotherapy Ilyasa, Muhammad Riza; Ramadhani, Muhammad Zulmi; Santoso, Rex Jeremy; Hutasoit, Gina Andyka; Miskad, Upik Anderiani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i3.1723

Abstract

Background: Lung cancer is the leading cause of cancer-related deaths worldwide, with Non-Small Cell Lung Cancer (NSCLC) being the most common type. Despite advances in treatment, the prognosis remains poor. Immune checkpoint inhibitors targeting PD-1 and PD-L1 have emerged as a promising first-line treatment approach in combating cancer. Objectives: This literature review aims to evaluate the effectiveness of PD-1 and PD-L1 immune checkpoint inhibitors in the treatment of NSCLC. It also explores the potential of these inhibitors to improve patient survival rates compared to conventional therapies. Methods: A systematic literature search was conducted using databases such as PubMed, Google Scholar, ScienceDirect, and NCBI, with keywords including "PD-1," "PD-L1," "NSCLC," "lung cancer," and "immunotherapy." Results: All four inhibitors significantly improve survival rates compared to traditional chemotherapy. Atezolizumab and pembrolizumab show high effectiveness in patients with high PD-L1 expression. Durvalumab, when combined with chemotherapy, overcomes resistance mechanisms. Nivolumab, enhancing survival rates. Conclusion: PD-1 and PD-L1 inhibitors provide substantial benefits in the treatment of NSCLC, including increased survival rates and reduced need for aggressive therapies. Further research should focus on optimizing combination therapies to expand the therapeutic benefits of these inhibitors.
Snail Expression is Positively Correlated with Depth of Invasion in Colorectal Carcinoma Miskad, Upik Anderiani; Akil, Fardah; Cangara, Muhammad Husni; Dahlan, Haslindah; Hutasoit, Gina Andyka; Ilyasa, Muhammad Riza
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3392

Abstract

BACKGROUND: Colorectal carcinoma ranks as the second deadliest and third most prevalent cancer globally. The depth of tumor invasion and the presence of tumor-infiltrating lymphocytes (TILs) are linked to survival rates in this disease. Meanwhile, Snail expression is positively correlated with tumor grade, recurrence, metastasis and poor prognosis in various tumors. However, not many studies discuss the correlation of Snail expression with invasion depth and TILs in Indonesia. Therefore, this study was conducted to investigate the correlation between Snail expression and both the depth of invasion and TIL scoring in colorectal carcinoma.METHODS: A cross-sectional study was conducted to evaluate 70 paraffin-embedded blocks of colorectal carcinoma patients. Snail expression was measured with immunohistochemistry using Snail rabbit polyclonal antibody. Stromal TILs were assessed on a single full-face hematoxylin and eosin (H&E) slide, and classified into high, intermediate, and low TILs.RESULTS: The results showed that the most invasion was to the muscularis propria (42.9%) and the least invasion was to the submucosa (4.3%). In scoring TILs, the most samples with intermediate TILs (58.6%) and the least samples with low TILs (4.3%). The analysis employing a Spearman Rank coefficient shows significant positive correlation between the expression of Snail with depth of invasion (r=0.273; p=0.022) but there was no significant correlation with TILs scoring (p=0.892).CONCLUSION: Even though, there is no significant correlation between Snail expression with TILs, there is, however, a significant positive correlation between Snail expression with depth of invasion in colorectal carcinoma. Therefore, Snail expression might be potentially used as a prognostic factor in colorectal carcinoma.KEYWORDS: Colorectal, carcinoma, Snail, depth of invasion and TILs
Co-Authors Abdul Qadar Punagi Achmad, Djumadi Andi Fachruddin Benyamin Arsyadi, Gunawan Askandar Tjokroprawiro Aslam, Muhammad Cahyono Kaelan, Cahyono Cangara, Husni Christinahadi, Agnes Dyah Dahlan, Haslindah Djimahit, Tarsisia Truly Fardah Akil Fatmawati Arsyad Said Freddy George Kuhuwael Gina Andyka Hutasoit Ham, Jonathan Ilyasa, Muhammad Riza Juanita Mahmud Ghaznawie Mardiana Ahamad Mardiati Mardiati Mardiati Maulana, Aries Muh. Nasrum Massi Muhammad Fadjar Perkasa, Muhammad Fadjar Nasser, Andi Sitti Halija Diawanti Nelwan, Berti J Nelwan, Berti Julian Ni Ketut Sungowati, Ni Ketut prihatni, Imeldi Rahmawani, Surya Rahmawati Minhajat Rajia Ramadhani, Muhammad Zulmi Rasyid, Nur Rahmah Rianti, Andi Marcha Rina Masadah Santoso, Rex Jeremy Sharvianty Arifuddin Sharvianty Arifuddin SHARVIANTY ARIFUDDIN, SHARVIANTY Sudin, Asmirani Syahrul Rauf Syamsiar, Syamsiar Syarifuddin Wahid Tawali, Suryani Tutik Harjianti Yamin, Amalia