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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Althea Medical Journal Molecular and Cellular Biomedical Sciences (MCBS) IRJE (Indonesian Research Journal in Education) Journal of Health Sciences MEDIC MEdical Dedication Jurnal Karya Abdi Masyarakat Journal of Medical Studies Indonesian Journal of Biomedicine and Clinical Sciences Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Anggelia Puspasari
Fakultas Kedokteran Dan Ilmu Kesehatan Universitas Jambi
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Althea Medical Journal

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Profile of Apoptotic Marker Genes and Histopathology of the Placenta in Pregnancies with Pre-Eclampsia Herlambang, Herlambang; Enis, Rina Nofri; Tarawifa, Susan; Harahap, Huntari; Puspasari, Anggelia; Maharani, Citra; Kusdiyah, Erny
Althea Medical Journal Vol 10, No 2 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n2.3088

Abstract

Background: Pre-eclampsia (PE) is a hypertensive disorder in pregnancy and a significant cause of maternal and perinatal mortality and morbidity. Failure of spiral artery remodeling due to abnormal apoptosis, triggers disturbances in the mother and the baby’s growth. This study aimed to identify the profile of apoptotic marker genes and histopathological features of the placenta in pregnancies with pre-eclampsia.Methods: This study had used case-control method. Samples were taken from normal pregnancies (n=25) and pregnant women with pre-eclampsia (n=25) using a purposive sampling method from several hospitals in Jambi. qRT-PCR was used to examine apoptotic gene expression from placental tissue and hematoxyline eosin staining to view the placenta’s microscopic appearance. The targeted genes were BCL2-associated X (BAX) and B-cell lymphoma 2 (BCL-2). Histopathological changes of the placenta observed were syncytial node, cytotrophoblast, villous edema, hypervascularization, fibrosis stroma, atherosis, infarction, and thrombosis.Results: Relative BAX genes expression were increased once in placenta pre-eclampsia compared to controls, but not statistically significant (p-value>0.05). There was no difference between the decline of BCL-2 gene expression in pre-eclampsia placenta compared to the control (p-value >0.05). Histopathological changes in the placenta were syncytial node and cytotrophoblast (25 of 25), villous edema (19 of 25), hypervascularization (24 of 25), fibrosis stroma (22 of 25), atherosis (12 of 25), infarction (17 of 25), and thrombosis (24 of 25).Conclusion: The expression of BAX genes in pre-eclampsia tends to increase compared to normal pregnancy, and the expression of BCL-2 decreases.  The histopathological features of pre-eclampsia pregnancy placenta are mostly syncytial nodes, cytotrophoblasts, stromal fibrosis, and thrombosis.
Protein Insufficiency Among First-Trimester Pregnant Women in Jambi, Indonesia Herlambang, Herlambang; Puspasari, Anggelia; Maharani, Citra; Enis, Rina Nofri; Fitri, Amelia Dwi; Kusdiyah, Erny; Ibnu, Ismi Nurwaqiah
Althea Medical Journal Vol 12, No 2 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n2.4044

Abstract

Background: Insufficient protein intake or specific patterns of plasma amino acid levels during pregnancy has been associated with adverse maternal and neonatal outcomes. Studies in non-pregnant women have reported an association between protein intake and amino acid levels, however, data in pregnant women remain limited. Jambi, a region rich in freshwater fish, has a traditional dishes based on fish, which may affect maternal protein adequacy. This study aimed to assess protein sufficiency intake, plasma essential amino acid levels, and the relationship between fish consumption and protein intake among first-trimester pregnant women. Methods: A cross-sectional study was conducted in 2022 involving pregnant women at 9-16 weeks of gestation in Jambi, Indonesia, selected through purposive sampling. Protein intake and fish consumption data were collected using Food Frequency Questionnaires. Plasma essential amino acid levels were measured using Liquid Chromatography-Mass Spectrometry. Bivariate analyses were performed using Mann-Whitney and Chi-square tests.Results: Among 30 participants, 23.3% had insufficient protein intake and had lower plasma essential amino acid levels. Lysine levels showed a statistically significant difference between groups (p=0.010). Women with adequate protein intake reported significant higher fish consumption, particularly of freshwater fish (p=0.033).Conclusion: Adequate protein intake during early pregnancy is related to higher plasma essential amino acid levels. Consumption of local freshwater fish contributes to maintaining sufficient protein intake. These findings emphasize the importance of integrating healthy dietary patterns and locally sourced nutrient-rich foods into prenatal care to support maternal wellness and long-term health outcomes.
Co-Authors Ahmad Hamim Sadewa Ahmad Syauqy Ahmad Syauqy Alya Dwiva Juhari Amalia, Fenny Amatullah, Afifah Ameli Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri, Amelia Dwi Amelia Minarfah Anati Purwakanthi, Anati Annissa Delfira Arif, Cut Wulan Armaidi Darmawan Aryanti, Nindya Asro Hayani Harahap Ave Olivia Rahman Betty Marlina Budi Justitia Charles Apul Simanjuntak Citra Maharani Citra Maharani Devy Afriyanti dewi, hasna Dhea Assyifa Effendi, Ian Ekaputri, Tia Wida Elfiani Elfiani Elfiani Erny Kusdiyah Esa Indah Ayu, Esa Indah Fairuz, Fairuz Farrah Balqis Fitriyanti Gading, Patrick Wiliam Hana Nurul Qur’ani Harahap, Asro Hayani Hasmita, Debby Herlambang Herlambang HERLAMBANG HERLAMBANG Herlambang Herlambang Herlambang Herlambang Huntari Harahap Ika Setyawati Irawan Anasta Irlianissa, Mutiara Iskandar, Mirna Marhami Ismi Nurwaqiah Ibnu Khairunnisa, Dhia Fairuz Maharani, Amrina Mus, Rosdiana Nadilla Sitepu Neldi, Vina Nindya Aryanty Nurul Fitriani Nyimas Natasha Ayu Shafira Nys. Natasha Ayu S Pramudji Hastuti Priskila, Loury Rina Nofri Enis Rini Kartika Rita Halim Rita Halim S, Nys. Natasha Ayu Simanjuntak, Charles Apul Suhaimi, Novadian Suprapti Suprapti Susan Tarawifa Suzan, Raihanah Syatria Esa Putra Syukur, Astian Nathaniel Tarawifa, Susan Tarigan, Nadir Putra Indra Tengku Arief Buana Perkasa Tia Wida Ekaputri Utami, Erisca Ayu Virginsia, Sonya Vivekanantharasa, Raveenthiran Wahyu Indah Dewi Aurora Widyawati, Dwi Zulkhair Ali