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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Jurnal Respirasi (JR) Jurnal Ilmiah Kesehatan Jurnal Layanan Masyarakat (Journal of Public Service) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology International Journal of Social Service and Research Jurnal Ilmiah Kesehatan (JIKA) Jurnal Widya Medika
Rebekah Setiabudi, Rebekah
Clinical Microbiology Specialist Program, Faculty Of Medicine, Universitas Airlangga − Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Positive Blood Culture as a Marker of Sepsis and MODS Risk in Critically Ill Children A Narrative Literature Review Rafly Bayu Surya Wardhana; Arina Setyaningtyas; Rebekah Juniati Setiabudi; Neurinda Permata Kusumastuti
Jurnal Ilmiah Kesehatan Vol 17 No 2 (2025): Jurnal Ilmiah Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/jik.v17i2.3063

Abstract

Blood culture is an essential examination for establishing the diagnosis of bloodstream infection (BSI) in critically ill children, as it enables the detection of causative pathogens and guides appropriate antimicrobial therapy. This study aims to examine the association between positive blood culture results and disease severity in children admitted to the pediatric intensive care unit (PICU). A literature review was conducted by searching articles in PubMed, Google Scholar, NCBI, and ScienceDirect over the past 15 years, which were then selected based on topic relevance and methodological quality. Analysis of ten studies revealed that positive blood cultures were strongly associated with increased mortality, longer hospital stay, and a higher incidence of multiple organ dysfunction. Frequently reported risk factors included younger age, the use of central venous catheters, immunocompromised conditions, and infections caused by drug-resistant Gram-negative bacteria. Parameters such as time to positivity (TTP), procalcitonin levels, and organ dysfunction scores (PELOD-2) were identified as important prognostic indicators reflecting infection severity. Thus, a positive blood culture serves not only as a diagnostic tool but also as a crucial prognostic marker for risk stratification and clinical decision-making in critically ill children.
Co-Authors Achmad Ardianto Adhima, Fauziah Afif Hidayati Agung Dwi Wahyu Widodo Alimsardjono, Lindawati Anindita Rehana Arina Setyaningtyas Awalia Ayu Rahmanita Putri Soetrisno Ayurveda Zaynabila Heriqbaldi Azzahra, Safira Deby Kusumaningrum Dewi Setyowati Diah Mira Indramaya Didik Didik Handijatmo, Didik Dwiyanti Puspitasari, Dwiyanti Eko Budi Koendhori, Eko Budi Evy Ervianti Farah Meriana Fajrin Hammam Izza Rofiqi Hasan, Helmia Indiastuti, Danti Nur Juniastuti Juniastuti Khairunnida Rahma Laksmi Wulandari M. Kharis Khamdan M. Yulianto Listiawan Mahrumi Dewi Tri Utami Manik R Wahyunitisari ManikRetno Wahyunitisari Mariska Nuriana Marsha Zahrani Maya Wardiana Neurinda Permata Kusumastuti Ni Made Mertaniasih Nunuk Mardiana, Nunuk Pepy Dwi Endraswari, Pepy Dwi Prasanti, Siva Allysha Purwanto, Satiti Palupi Putri S Wulandari Rafly Bayu Surya Wardhana Rahmadewi Rahmadewi Rehana, Anindita Resti Yudhawati Retno Asih Setyoningrum Risky Vitria Prasetyo Rochmanti, Maftuchah Rochmanti Rossyanti, Lynda Sawitri Sawitri Silvia Sutandhio Sri Ratna Dwiningshih Suhintam Pusarawati Sulistiawati Sulistiawati Sulistiawati Sulistiawati Titiek Sulistyowati Utami Meilanie Putri Wahyunitisari, Manik Retno Wardhany, Atiqah Nurul Warella, Juen Carla Yuri Widia, Yuri