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All Journal Lembaran Ilmu Kependidikan Jurnal Pengabdian Masyarakat (ABDIRA) Sevanam: Jurnal Pengabdian Masyarakat SERIBU SUNGAI: Journal of Research and Community Service Journal of Pharmaceuticals and Natural Sciences Jurnal Sains dan Kesehatan Jurnal Riseta Naturafarm
M. Arifuddin, M.
Semarang State University
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Antibacterial Activity of Lactic Acid Bacteria Isolates Mountain Rice Wash Water (Mayas Rice) Against Propionibacterium acnes Arifuddin, M.; Amanda, Rezti; Arifin, Arfiani; Arifin, Arfina Sukmawati; Iswahyudi, Iswahyudi; Samsul, Erwin; Riki, Riki; Rija'i, Hifdzur Rashif; Hikmawan, Baso Didik; Ibrahim, Arsyik; Rijai, Laode
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.42

Abstract

This study aims to explore the antibacterial activity potential of fermented dragon fruit peel juice (Hylocereus polyrhizus) fermented using Lactic Acid Bacteria (LAB) isolated from rice washing water (Beras Mayas). The process begins with the preparation of dragon fruit peel samples, which are washed, peeled, and mashed to obtain the juice. The juice is pasteurized and inoculated with a 5% LAB starter, with the addition of a 10% sugar solution before being incubated for 3, 7, 12, and 17 days at 37ºC. pH measurements were taken during fermentation, showing a significant decrease in pH, reaching the lowest value of 3.76 on day 17. The antibacterial activity was measured using the well-diffusion method with the fermented juice at a concentration of 100%, showing a very strong inhibition zone (>20 mm) against Propionibacterium acnes on day 7. The results indicate that the pH changes during fermentation are closely related to the antibacterial activity
Toxicity of Extracts and Fractions of Bangkal Leaves (Nauclea subdita (Korth.) Steud.) and Genjer (Limnocharis flava (L.) Buch) on the Bioindicator Artemia salina Leach Ibrahim, Arsyik; Salea, Sealti Puji; Windarti, Sri; Ramadhan, M. Rahmad; Rija'i, Hidfdzur Rashif; Arifuddin, M.; Rijai, Laode
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.47

Abstract

A study was conducted on the secondary metabolite content and toxicity testing of Artemia salina leach larvae using extracts from Bangkal leaves (Nauclea subdita (Korth.) Steud.) and Genjer plants (Limnocharis flava (L.) Buch). The objective of this study is twofold: firstly, to ascertain the compounds present in Bangkal leaf extract and Genjer plant extract, and secondly, to assess the toxicity levels of the extracts and fractions from Bangkal leaves and Genjer plants on Artemia salina Leach larvae. In this study, the extraction method employed was maceration with 96% ethanol as the solvent. The crude 96% ethanol extract was fractionated in stages using n-hexane, ethyl acetate, and n-butanol solvents based on polarity levels. The toxicity testing was conducted using the Brine Shrimp Lethality Test (BSLT) method, with Artemia salina Leach larvae serving as the bioindicator. A range of test concentrations were utilised, with each concentration having three replicates. The mortality of Artemia salina was observed after a 24-hour period and was analysed using the Reed and Muench method to determine the LC50 value. The results of the study demonstrated that the secondary metabolites present in the 96% ethanol extract of bangkal leaves com-prised the following groups of compounds: steroids, and triterpenoids, phenols, quinones, and saponins. The toxicity test results of the bangkal leaf extract and fractions yielded LC50 values of 418.79 ppm for the 96% ethanol extract; 716.14 ppm for the n-hexane fraction; 263.03 ppm for the ethyl acetate fraction; and 70,79 ppm for the extract n-buthanol fraction. Meanwhile, the toxicity test results of the genjer plant extract and fractions obtained an LC50 value of 490.23 ppm for the 96% ethanol extract; n-hexane fraction 551.31 ppm; ethyl acetate fraction 425.01 ppm; and n-butanol fraction extract 46.02 ppm. These results indicate that the n-butanol fraction of bangkal leaves and genjer plants have stronger cytotoxic activity than other fraction extracts.
Co-Authors Ahmad Sofwan Almeida, Maria Amanda, Rezti Arifian, Hanggara Arifin, Arfiani Arifin, Arfina Sukmawati Azmi, Fatur Rahman Badawi, Satriani Baso Didik Hikmawan Bone, Mahfuzun Bulan, Adisty Sindi Erwin Samsul Farrah, Harra Ismi Herman Herman Ibrahim, Arsyik Islamudin Ahmad ISWAHYUDI ISWAHYUDI Junaidin, Junaidin Laode Rijai Lasiani, Lasiani Lestari, Seftya Ayu Lizma Febrina Mastuang Mastuang Maulidha, Faizatun Muhammad Faisal Mus, Nurul Muhlisa Pasaribu, Handayani Prabowo, Wisnu Cahyo Qamariah, Qamariah Ramadhan, M. Rahmad Ridhotulloh, Yusuf Isro Rija'i, Hidfdzur Rashif Rija'i, Hifdzur Rashif Rijai, Hifdzur Rashif Riki RIKI RIKI, RIKI Rolan Rusli Rusman, Arman Saiyidah Mahtari Salea, Sealti Puji Sari, Indah Dewi Sulistyarini, Riski Suyidno Suyidno Windarti, Sri Zainuddin, Zainuddin