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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Pharmaciana: Jurnal Kefarmasian Al-Kimia Majalah Farmaseutik Pharmacology and Clinical Pharmacy Research Pharmaceutical Journal of Indonesia Jurnal Mandala Pharmacon Indonesia JURNAL FARMASIMED (JFM) BERNAS: Jurnal Pengabdian Kepada Masyarakat Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Pengabdian UNDIKMA Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Eureka Herba Indonesia Natural Sciences Engineering and Technology Journal Jurnal Pengabdian Masyarakat Madani Jurnal Pengabdian Masyarakat Journal of Agropharmacy Dirya : Journal of Economic Management Halal Science
Wardhani, Firdha Aprillia
Departement Of Clinical And Community Pharmacy, Faculty Of Pharmacy, University Of Jember
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Quantitative Mapping of Phytochemical Synergy in Psidium guajava and Piper betle for Antidiarrheal Therapy: A Systematic Review and Meta-Analysis Using Radar Chart Analysis and AUC Kintoko; Cendekiawan, Khrisna Agung; Sapto Yuliani; Firdha Aprillia Wardhani
Eureka Herba Indonesia Vol. 7 No. 1 (2026): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v7i1.133

Abstract

Infectious diarrhea constitutes a massive global health burden defined by severe gastrointestinal hypermotility, profound fluid hypersecretion, and aggressive mucosal inflammation. Conventional pharmacotherapy, including antimotility agents and broad-spectrum antibiotics, presents significant clinical limitations, including the exacerbation of antimicrobial resistance and adverse systemic effects. Phytochemical interventions utilizing Psidium guajava and Piper betle offer a robust complementary approach. However, the exact quantitative magnitude of their combined pharmacological synergy requires rigorous statistical integration. A systematic review and meta-analysis were executed utilizing PRISMA protocols. Comprehensive literature screening across major databases identified primary research manuscripts reporting precise quantitative parameters on the antidiarrheal, antimicrobial, and antioxidant properties of the targeted extracts. Extracted data variables included sample sizes, mean outcomes, and standard deviations. The Standardized Mean Difference (SMD) and 95% Confidence Intervals (CI) were calculated using a random-effects model. The multidimensional therapeutic capacity was further mapped and quantified using Radar Chart Analysis (RCA) and geometric Area Under Curve (AUC) mathematical integration. The statistical synthesis indicated that Psidium guajava profoundly suppressed gastrointestinal motility and intestinal fluid accumulation (Pooled SMD = -2.45; 95% CI: -3.10 to -1.80). Concurrently, Piper betle demonstrated immense broad-spectrum bactericidal activity and superlative free radical scavenging capacity (Pooled SMD = 3.85; 95% CI: 2.95 to 4.75). The subsequent AUC integration revealed that combining the specific phytochemical profiles of both botanical sources mathematically expanded the total therapeutic coverage by 42%. The quantitative framework confirms a highly potent synergistic mechanism. Psidium guajava selectively targets the physiological symptoms of hypermotility and secretory failure, while Piper betle aggressively eradicates the underlying pathogenic etiology and neutralizes oxidative tissue damage. This dual-action synergy provides a formidable, evidence-based foundation for the development of advanced botanical therapeutics.
Peningkatan Pengetahuan Pemanfaatan Tanaman Obat Daun Sirih (Piper Betle) Pada Masyarakat Suku Osing Kabupaten Banyuwangi Khrisna Agung Cendekiawan; Nafisah Isnawati; Shinta Mayasari; Neny Poerwahyuningrum; Firdha Aprillia Wardhani; Dea Maulidi Saputri
Jurnal Pengabdian Masyarakat Madani Vol 6 No 1 (2026): Jurnal Pengabdian Masyarakat Madani (JPMM)
Publisher : Sekolah Tinggi Ekonomi Bisnis Syariah Bina Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51805/jpmm.v6i1.218

Abstract

Pulau Jawa merupakan “pulau yang kaya keanekaragaman hayati. Obat tradisional pada etnis Suku Osing umumnya masih dalam bentuk yang sederhana. Bahan baku yang diambil dari alam setelah dibersihkan biasanya langsung digunakan dalam bentuk segar dengan cara direndam atau direbus, kemudian diminum, diolah dengan cara dihaluskan dan ditumbuk/dipanaskan dalam bungkusan daun. Pengetahuan dan pemanfaatan tanaman obat masih minim, terutama dalam pengolahannya menjadi sediaan yang efektif dan efisien agar mudah digunakan. Sirih hijau (Piper betle) merupakan tumbuhan yang dapat dimanfaatkan sebagai obat tradisional terutama pada bagian daunnya. Tujuan dari kegiatan ini adalah untuk meningkatkan pengetahuan warga tentang khasiat tanaman sirih hijau sekaligus mendorong warga memanfaatkan lahan pekarangan rumah untuk menanam tanaman tersebut sebagai tanaman obat keluarga serta dapat mengolah simplisia sirih hijau sebagai teh herbal untuk digunakan sebagai minuman berkhasiat obat. Metode yang digunakan adalah sosialisasi, edukasi materi tentang daun sirih hijau, dan pelatihan pembuatan teh herbal. Edukasi dilakukan dengan mengukur tingkat pengetahuan menggunakan kuesioner yang dibagikan sebelum (pretest) dan sesudah (post-test) pemberian materi. Hasil pretest menunjukkan bahwa pengetahuan dan minat warga untuk membudidayakan tanaman sirih hijau masih kurang. Namun, hasil post-test menunjukkan bahwa pengetahuan mereka menjadi meningkat. Kesimpulan dari kegiatan ini adalah terdapat peningkatan pengetahuan warga tentang tanaman berkhasiat obat daun sirih hijau (Piper betle).”
The Role of Pharmacy Personnel in Ensuring Appropriate Diarrhea Self-Medication in an Agro-Coastal Community in Jember, Indonesia Wardhani, Firdha Aprillia; Nur Sepdianto, Bagas; Rachmawati, Ema; Pontanar, Mae Quenie; Afifah Machlaurin
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 11 No. 1 (2026)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v11i1.44285

Abstract

Background: Self-medication for diarrhea is a common self-care practice because diarrhea is often perceived as a mild, self-limiting condition. However, its high prevalence in Indonesia, particularly in Jember Regency, raises concerns about inappropriate medicine selection and use, including the unsupervised use of prescription-only drugs such as loperamide and antibiotics. Pharmacists and pharmacy personnel play a key role in promoting safe and rational self-medication. Method: This cross-sectional study was conducted in 15 pharmacies in Agro-Coastal Jember from August 2025 to January 2026. Using purposive sampling, 200 eligible respondents were recruited. Data were collected using a structured questionnaire and analyzed using univariate analysis and Chi-square analysis with the contingency coefficient test to assess the significance and strength of the relationship between variables. Result: Most respondents were female (67%), aged 26–35 years (46.5%), had a senior high school education (71%), and had a monthly income of < IDR 2,500,000 (86%). Loperamide was the most frequently used medication (46.36%), and more than half of the medications used were prescription-only (53.18%). The appropriateness of diarrhea self-medication remained low for both medicine selection (46.8% appropriate) and medicine use (28.2% appropriate). A significant association was found between the role of pharmacists/pharmaceutical staff and the appropriateness of diarrhea self-medication (p < 0.05), although the strength of the relationship was weak (r = 0.233 and r = 0.184). Conclusion: In conclusion, diarrhea self-medication in the Agro-Coastal Jember community was still dominated by inappropriate medication practices. Strengthening pharmacy-based counseling in community pharmacy and service quality is essential to improve the safety and rational use of medicines in diarrhea self-medication.
Detection of Porcine Gelatin in Jelly Soft Candies Using Near-Infrared Spectroscopy and Chemometrics Cendekiawan, Khrisna Agung; Wardhani, Firdha Aprillia; Anggraeni, Linda Suci; Anggraeni, Lutvi
Halal Science Volume 1 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/halal0101342

Abstract

Gelatin, commonly used in jelly soft candies, is often derived from porcine sources, which Islam prohibits. This study developed a rapid and reliable method for detecting porcine gelatin using near-infrared (NIR) spectroscopy combined with chemometric analysis to support halal verification. Twenty samples were analyzed: 10 with 100% bovine gelatin and 10 containing 10–100% porcine gelatin. Spectral data were processed using partial least squares (PLS) regression and linear discriminant analysis (LDA). The PLS model showed high predictive accuracy (RMSEC = 2.87, R²cal = 0.9931; RMSEP = 0.0124, R²val = 0.9919), while LDA classified samples with over 90% accuracy. Results were consistent with the Xema Pork Detection Kit, confirming the method’s reliability. This approach offers a fast, accurate tool for halal compliance in food products.
Co-Authors Adelia Firandi Amalia Wardatul Firdaus Amalia Wardatul Firdaus Anggraeni, Linda Suci Anggraeni, Lutvi Aryani, Dhita Aryani, Dhita Evi Dea Maulidi Saputri Dian Agung Pangaribowo Didik Hasmono Dwi Koko Pratoko Dyan Wigati Ema Rachmawati Eryani, Mikhania Christiningtyas Fifteen Aprila Fajrin Firandi, Adelia Hasana, Siti Nur Ika Norcahyanti Khrisna Agung Cendekiawan Kintoko Kintoko Kintoko Kusumaningrum , Yunita Dyah Lina Winarti Linda Suci Anggraeni Machlaurin, Afifah Nafisah Isnawati Nafisah Isnawati NANANG MUNIF YASIN Neny Poerwahyuningrum Nia Kristiningrum Ningrum, Lailatul Fitria Nur Sepdianto, Bagas Poerwahyuningrum, Neny Pontanar, Mae Quenie Ramadhani, Nuril Izzati Farihatur Rina Fitriana RR. Ella Evrita Hestiandari Sapto Yuliani Sapto Yuliani Shinta Mayasari Shinta Mayasari Sinta Rachmawati Syafika, Devina Sarah Zulkarnain Permana ZULLIES IKAWATI