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Journal : Media Farmasi

Tinjauan Literatur Sistematis; Pemanfaatan Teknologi CRISPR-CAS9 Untuk Pengobatan Penyakit Huntington’s Sari, Meliana; Kasasiah, Ahsanal
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.704

Abstract

Huntington's Disease (HD) is a neurodegenerative disorder caused by a CAG triple expansion (>36) in the first exon of the HTT gene encoding the huntingtin protein. Advances in gene editing technologies, such as CRISPR-Cas9, provide new hope for correcting the genetic mutations underlying HD. This review article aims to review the potential and effectiveness of CRISPR-Cas9 technology as a therapeutic tool for HD. The writing method used was Systematic Literature Review, with literature searches conducted using three databases: PubMed, ScienceDirect, and SpringerLink. This study reviewed several studies that used in vivo and in vitro models to evaluate the impact of HTT gene editing on mutant huntingtin protein expression and HD symptoms. Results showed that CRISPR-Cas9 can effectively reduce mutant huntingtin protein expression, reduce neuronal toxicity, and improve motor symptoms in mouse models of HD. Although these results are promising, further studies are needed to optimize the safety and effectiveness of using CRISPR-Cas9 in genetic therapy for HD.
Co-Authors ABDUL BASHIR, ABDUL ABRIANO, NOVA Abubakar, Rafeah Abubakar, Rafeah Ahmed, Shakib Ahsanal Kasasiah Alvinesar , Muhammad Habib Amalina Amalina, Amalina Amiruddin Amiruddin Andriani, Lia Anna Yulianita Aristi, Dela Astuti , Rahayu Azizah Azizah Azizah, Faiha Bambang Wispriyono Cahyani, Aprilia Dwi Camila, Putri Data, Mulya Rahman Desnawita, Desnawita Dwi Wahyuni Fatma Nabila, Dinda Ferifina, Liska Fety Fathimah Firdaus Firdaus Gusmita, Deri Husni, Suci Nisaul Idris, T Indah Puspita Sari, Indah Puspita Isa, Yamanto Ismandela, Afriyane Iswarini, Harniatun Iting Shofwati Jhoni Warmansyah Kadir Naffari, Abdul Khairunnisa Khodarsih, Delma Komalasari, Elis Latif, Nurdin Masril Masril Mastanora, Refika Meida, Hafsah Murti, Firda Aulya mutiara mutiara Nabila, Dinda Fatma Nabila, Putri Nova Yulia Nurazizah, Diyah Ayu Nurhasanah Nurhasanah Nurlaila Nurlaila Pérez, Carlos Pramudita, Arif Saiful Pusaka, Semerdanta Putri Wahyu, Widia Putri Yanti, Elsa Putri, Anis Putri, Hafifa Putri, Irawati Anindya Putri, Santi Virdaus Putri, Widya Rahmadani, Widia Rahmadina, Sabrina Rahman Data, Mulia Restu Yuningsih Retno Wulandari Safna, Aisyah Salsabila, Dhiva Sanniyah, Zahra Satriani Satriani Saufika, Alka Sinuraya, Bachtiar Siregar, Rahayu Yandira Siregar, Rahayu Yandira S Solin, Saobil Sobri Soniati, Soniati Syaharra, Salsya Iffana Tri Yuliani, Tri Trimelia Utami, Winda Urrahmah, Nisa Utami, Winda Trimelia Wahidah Fitriani WIJAYA, JOHAN EKA Wiliani, Sherly Wiliany, Sherly Wiska Bela, Sandora Wulandari, Tiara Yandira S Siregar, Rahayu Yandira, Rahayu YUNIARTI, SETIAFITRIE Yusmar, Sherly Aini Zalzabila, Zakiah