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All Journal Farmaka Jurnal Farmasi Klinik Indonesia Jurnal Penelitian Kesehatan Suara Forikes Majalah Farmasetika Journal of Pharmaceutical and Sciences. Media Penelitian dan Pengembangan Kesehatan Journal of Pharmaceutical and Natural Resources
RANO KURNIA SINURAYA
Departemen Farmakologi Dan Farmasi Klinik, Fakultas Farmasi, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Dampak Klinis Interaksi Obat antara Clopidogrel dan Inhibitor Pompa Proton : Tinjauan Naratif Ideasha Aslama; Rano Kurnia Sinuraya; Neily Zakiyah; Triwedya Indra Dewi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1040

Abstract

Dual antiplatelet therapy (DAPT), consisting of aspirin and P2Y12 receptor antagonists such as clopidogrel, is the mainstay treatment for patients with acute coronary syndrome (ACS). However, its widespread use can increase the risk of gastrointestinal bleeding. Proton pump inhibitors (PPIs) are often used as prophylaxis to prevent bleeding. On the other hand, PPIs are suspected of reducing the effectiveness of clopidogrel due to pharmacokinetic drug interactions. Nevertheless, findings from various studies regarding the clinical impact of this interaction remain inconsistent and controversial. The aim of this narrative review is to evaluate the effectiveness and safety of using PPIs concurrently with clopidogrel. The method used was a literature review of international journal articles discussing the interaction between PPIs and clopidogrel. The review findings indicate that certain PPIs, such as omeprazole, can inhibit the CYP2C19 enzyme involved in clopidogrel activation, potentially reducing its effectiveness. Conversely, some PPIs such as pantoprazole have minimal effects on CYP2C19 and are considered safer for concomitant use with clopidogrel. Overall, the use of PPIs can reduce the risk of gastrointestinal bleeding; however, the selection of PPI type must be carefully considered to minimize drug interactions that may compromise clopidogrel’s efficacy.
Identifikasi Potensi Interaksi Obat pada Resep Umum di Salah Satu Apotek Kota Bandung Periode Oktober 2025–Maret 2026 Zahra, Citra Aulia; Septyadi, Rendy; Sinuraya, Rano Kurnia
Indonesian Journal of Clinical Pharmacy Vol 15, No 2 (2026)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2026.v15i2.70822

Abstract

Interaksi obat adalah perubahan efek obat akibat penggunaan dua atau lebih obat secara bersamaan yang dapat meningkatkan risiko efek samping maupun menurunkan efektivitas terapi. Penelitian ini bertujuan untuk mengidentifikasi potensi interaksi obat pada resep umum berdasarkan tingkat keparahan interaksi (mayor, moderat, dan minor) serta mekanisme interaksinya. Penelitian dilaksanakan di salah satu apotek di Kota Bandung pada periode Oktober 2025–Maret 2026 dengan desain noneksperimental menggunakan pendekatan deskriptif analitik secara retrospektif. Sampel penelitian berupa resep yang memenuhi kriteria inklusi, yaitu resep dengan ≥2 jenis obat. Pengambilan sampel dilakukan menggunakan teknik total sampling. Analisis potensi interaksi obat dilakukan menggunakan Drug Interaction Checker dari Drugs.com. Dari 2.371 resep yang ditelaah, sebanyak 1.106 resep memenuhi kriteria inklusi dan dianalisis lebih lanjut. Hasil penelitian menunjukkan terdapat 687 potensi interaksi obat, terdiri atas 73 interaksi minor (10,63%), 517 interaksi moderat (75,25%), dan 97 interaksi mayor (14,12%). Interaksi moderat menjadi kategori paling dominan, salah satunya kombinasi obat antihiperlipidemia dengan obat antiinflamasi nonsteroid (NSAID), yaitu celecoxib dan fenofibrate, yang berpotensi meningkatkan risiko efek samping akibat peningkatan kadar celecoxib dalam plasma. Sementara itu, interaksi mayor ditemukan pada kombinasi sesama obat antihiperlipidemia, yaitu fenofibrate dan rosuvastatin yang berisiko menyebabkan miopati hingga rhabdomiolisis. Potensi interaksi farmakokinetik paling banyak ditemukan pada kombinasi suplemen mineral, yaitu kalsium dan zat besi, sedangkan interaksi farmakodinamik paling sering terjadi pada kombinasi antidiabetes oral, yaitu glimepiride dan metformin. Tingginya potensi interaksi obat pada resep menunjukkan pentingnya peran aktif apoteker dalam mengidentifikasi, memantau, dan mencegah interaksi obat guna meningkatkan keamanan terapi pasien.Kata kunci: apotek, interaksi obat, mekanisme interaksi, resep, tingkat keparahan Identification of Potential Drug Interactions in General Prescriptions at a Pharmacy in Bandung City During the Period of October 2025–March 2026AbstractDrug interactions are changes in drug effects caused by the concurrent use of two or more medications, which may increase the risk of adverse effects or reduce therapeutic effectiveness. This study aimed to identify potential drug interactions in general prescriptions based on severity level (major, moderate, and minor) and interaction mechanisms. The study was conducted at a pharmacy in Bandung City during October 2025–March 2026 using a nonexperimental retrospective descriptive-analytic design. The samples were polypharmacy prescriptions meeting the inclusion criterion of containing ≥2 medications and were collected using a total sampling technique. Potential drug interactions were analyzed using the Drug Interaction Checker from Drugs.com. Of the 2,371 prescriptions reviewed, 1,106 prescriptions met the inclusion criterion and were further analyzed. The results identified 687 potential drug interactions, consisting of 73 minor interactions (10.63%), 517 moderate interactions (75.25%), and 97 major interactions (14.12%). Moderate interactions were the most common, including the combination of celecoxib and fenofibrate, which may increase the risk of adverse effects due to elevated plasma levels of celecoxib. Major interactions were found between fenofibrate and rosuvastatin, which may increase the risk of myopathy and rhabdomyolysis. Pharmacokinetic interactions were most commonly observed with calcium and iron supplements, whereas pharmacodynamic interactions were most frequently identified between glimepiride and metformin. The high prevalence of potential drug interactions in polypharmacy prescriptions highlights the important role of pharmacists in identifying, monitoring, and preventing drug interactions to improve patient safety.Keywords: drug interactions, pharmacy, polypharmacy, prescriptions, severity level
Co-Authors A, Adrian Abednego Kristande Abib Latifu Fatah Abib Latifu Fatah Adham Rizki Ananda Afifah Tri Ambarwati AJENG RATNA NINGTYAS ALIA RESTI AZURA AMALIA OCTA PERMATASARI Ameilia Ameilia Amelia, Nisa Ayu ANNIESAH RAHAYU SAKINAH Annisa Atusholihah Annisa Tamara Panjaitan Apriyandi, Restu Amelia Arifa, Irbah Arista, Dwi Yuri Asep Sukohar Bashirah, Danaparamita Berliana, Nadila Billy Dwi Saputra Cecep Suhandi Dede Jihan Oktaviani Destiana, Dika Pramita Destiani, Dika P. DEVI MEILANI Dewi Ria Oktarina Dewi Sarah, Dewi Dewi, Triwedya Indra DHEANDA, HILALLYA MAURIZKA DIAH SITI FATIMAH Dian Amalia Maharani Dika Pramita Destiani, Dika Pramita Dinda Meviansyah Dwi Aulia Ramdini Dwi Yuri Arista Dwi, Fanny Seftiani El Yahya, Idzni Rusydina Elisabeth, Erlin Elisha Wianatalie ELLENA MAGGYVIN Erica Willy Ersa Fadhilah Faizah, Ulfa Rahmatul Fatah, Abib Latifu Firda Riska Rahayu Firda Silvia Pramashela Gabriella Josephine Maranatha Gabriella Livia Amanda GALUH AYU WANDITA Hadad, Nur Diana Hafida Aulia Qodrina Hanifa Rifdah Aiman Hidayatun Nisa Hidayatun Nisa, Hidayatun HILDA VILDAYANTI HILMI, HANNY LATIFA Ideasha Aslama Imam Adi Wicaksono Imam Adi Wicaksono Imam Adi Wicaksono IMAM ADI WICAKSONO, IMAM ADI Irawan, Aurizal Risandy Irma Melyani Puspitasari Irsarina Rahma Izzah Al Mukminah JAMES PRASETYO LAKSONO JESSICA TRISTI Josephine, Gabriella JOSHUA JOSHUA Kamila, Rezkia Azka KENNY DWI SIDHARTA KIARA DIRGANTARA Kiara Puspa Dhirgantara Latifa, Hanny Listiani, Nita Lokajaya, Trifena Mamay Krisman Maulida, Putri Kholilah MAURA SYAFA ISLAMI MAYA, IRA Mochamad Rizky Fauzy Mukminah, Izzah Al Nadila Berliana Nadila Berliana Nadira Hasna Putri Natasha Salsabila Neily Zakiyah Nia Kurniasih Nida Adlina Fadhilah NISA MAULANI NURALIYAH Norisca Aliza Putriana Nurfianti Silvia NURHAYATI . Nurhayati Nurhayati Nurlatifah, Anggun Pardosi, Yessica Pramashela, Firda S Puri, Tri N. S. QUINZHEILLA PUTRI ARNANDA Rachmawati, Afina Dwi Rahmawati Witriani Witriani, Rahmawati Witriani RAHMAWATI, NURUL FITRI Ramadhana, Aslamnur Fikri Randy Rassi Prayoga Rania Aisha Nuralisa Riana Kamer Rizky Abdulah Salsabilla, Rifa Alya Saputra, Billy Dwi SAQILA ALIFA RAMADHAN Septyadi, Rendy Shela Sandra Kirana SHELLA WIDIYASTUTI SHINTA LESTARI Sidharta, Kenny Dwi Sifa Muhammad Yusuf Soleh, Soleh Sri Indrayani, Sri Suharmanto Sumedhi, Herdina Mayangsari Syara Nur Fitri Balqist Triwedya Indra Dewi UTARI YULIA ALFI UZLIFATUL ZANNAH Wijayanti, Sinthiya Eka Zahra, Citra Aulia Zakiyah, Neily