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All Journal HAYATI Journal of Biosciences VALENSI Farmaka International Journal of Integrated Health Sciences Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Pharmacology and Clinical Pharmacy Research FITOFARMAKA: Jurnal Ilmiah Farmasi Molekul: Jurnal Ilmiah Kimia JFIOnline Indian Journal of Forensic Medicine & Toxicology
Rizky Abdulah
Fakultas Farmasi, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Hypoglicemia Risk Factors on Hospitalized Type 2 Diabetes Mellitus Patients Jayanti, Meilani; Lestari, Keri; Abdulah, Rizky
Pharmacology and Clinical Pharmacy Research Vol 3, No 2 (2018)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (434.595 KB)

Abstract

Hypoglycemia is one of the most important complications of diabetes treatment and it becomes an obstacle in hypoglycemia medication. Besides, hypoglycemia can cause nerve damage and impaired cognitive function so that it influences the patients mortality, morbidity, and quality of life. Recognition of hypoglycemia risk factors, blood glucose monitoring, selection of appropriate regimens and educational programs for healthcare professionals and patients with diabetes are the major issues to maintain good glycemic control, minimize the risk of hypoglycemia, and prevent long-term complications. This research employs retrospective method and the design of the research is case control.  The sample of this research is 72 patients with type 2 diabetes which is divided into two groups.  The first group is case and It consists of 23 patients (31,9%) getting hypoglycemia. Then, the second group is control and it consists of 49 patients (68,1%). In the second group the 49 patients do not get hypoglycemia and they do not receive any hypoglycemia medication in the hospital. The Results of multivariate logistic regression analysis shows that there is a significant different between the variables reduction in food intake (p 0,011) and lower laboratory result of HbA1C (p 0,003) on the incidence of hypoglycemic, where the variable reduction in food intake has the strong relationship with most major hypoglycemic (OR 9,329). On the other hand, other variables such as the use of antidiabetic drugs, diabetes duration, age, comorbidities and polypharmacy showed no significant association with hypoglycemic events. Thus, the hypoglycemic risk factors in patients with type 2 diabetes receiving antidiabetic therapy due to reduction in food intake and lower laboratory results of HbA1C. Patients with reduction in food intake at risk of hypoglycemic events nine times greater than patients with normal food intake. Keywords: type 2 diabetes mellitus, hypoglycemia, food intake, HbA1C
Polymorphism of pfcrt K76T and pfatpase6 S769N Genes in Malaria Patients at Papua, Indonesia Suradji, Eka W.; Ng, Henry; Finisanti, Ratih; Indrawati, Eni; Ciokan, Andreas; Barliana, Melisa I.; Abdulah, Rizky
Pharmacology and Clinical Pharmacy Research Vol 1, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (773.927 KB) | DOI: 10.15416/pcpr.v1i1.15192

Abstract

Indonesia is one of the country with the highest prevalence of malaria infections. In order to achieve malaria control as an act to support Millenium Development Goals, complete eradication of Plasmodium parasites needs to be conducted. Drugs resistance has been a hindrance in this act. This study aimed to assess Plasmodium parasite resistance towards chloroquine (CQ) and artemisinin combined therapy (ACT) through the determination of polymorphism on pfcrt K76T and pfatpase6 S769N genes, respectively. Subjects of this study were 16 adult patients positively diagnosed with malaria infection caused by P. falciparum or cross infection. DNA obtained from patient blood samples were amplified using polymerase chain reaction (PCR) and then the fragment of pfcrt and pfatpase6 were then digested using ApoI and DdeI, respectively. The results showed that 81% of the pfcrt K76T polymorphism was occured on the samples, which indicated the resistance of CQ. Meanwhile, 87% of the patient samples did not showed any polymorphism of pfatpase6 S769N gene, which indicated no resistance of ACT. This study showed that CQ was no longer effective as the first line therapy of antimalarial drugs due to the resistance of P. falciparum to CQ. However, the used of ACT still can be maintained in the antimalarial drug therapy regimen. In conclusion, the polymorphism of both genes negatively influenced the effectivity of antimalarial therapy using artemisinin.Keywords: antimalarial drugs, resistance, polymorphism, endemic area
Evaluation of Prescription Pattern for Internal Medicines Outpatients using World Health Organization Indicators Dinge, Fonny; Abdulah, Rizky; Sumiwi, Sri A.
Pharmacology and Clinical Pharmacy Research Vol 2, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.952 KB) | DOI: 10.15416/pcpr.v2i3.16216

Abstract

Rational use of drugs plays an important role in efficacy and safety. World Health Organization(WHO) developed a set of indicators to assess medicines precribing pattern. The aim ofthis study was to evaluate the rational use of drugs among internal medicines outpatients ata hospital in Papua, Indonesia, using WHO prescribing indicators. This study was a retrospectiveobservational study conducted during January-March 2014. The data were obtainedfrom patients medical prescriptions. From each prescriptions, data regarding the the totalnumber of drugs, generic, antibiotics, parenteral, and essential drugs were extracted. A totalof 2025 medical precriptions were included in this study. We found out that the averagenumber of drugs per prescription was 2.3. Majority of the prescribed drugs were generic(84.14%). The use of antibiotics, parenteral drugs, and essential drugs were 33.43%, 3.40%,and 60.13%, respectively. Polypharmacy was relatively low among the subjects. The medicinesprescribing patterns among internal medicines outpatients were in accordance withWHO recommendation.Keywords: prescribing indicator, polypharmacy, essential drugs
The Effect of Anti-Tuberculosis Drugs on the Effectiveness of Anti-Retroviral Therapy in HIV-AIDS Patients Hasriana, Hasriana; Alfian, Sofa D.; Milanda, Tiana; Abdulah, Rizky
Pharmacology and Clinical Pharmacy Research Vol 2, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.201 KB) | DOI: 10.15416/pcpr.v2i1.16214

Abstract

patients who infected by Humman Immunodeficiency Virus (HIV) in developing countries. The purpose of this study was to determine the effect of anti-tuberculosis drugs (ATB) on the effectiveness of anti-retroviral (ARV) therapy in HIV–AIDS infected patients.This study was a prospective cohort study conducted at outpatient clinic of Abepura Hospital during April-June 2015. The data were taken from medical records, which include CD4 level, gender, age, education and stage of disease. Statistical analysis was performed using bivariate and multiple regression analysis. A total of 28 subjects was included in this study (7 HIV patients and 21 TB-HIV patients). The results of bivariate analysis showed that there was no significant difference on general characteristics of patients using ARV-ATB and without ATB. Gender, age, occupation, education and the stage of disease did not affect the value of CD4 patients (p>0.005). The result from paired t-test showed that there was no significant difference in the level of CD4 cell, before and after treatment using ARV (p˃0.912), while therapy with ARV-ATB showed significant differences (p˂0.002). In conclusion, this study showed that the combination of ATB and ARV could increase CD4 level up to 72%. Thus, the use of ATB drugs on ARV patients who infected by TB is recommended to reduce disease burden.Keywords: anti-retroviral therapy , HIV- AIDS, tuberculosis
Comparison of Effectiveness between Combination of Beta-Lactam with Azyhtromycin or Levofloxacin for Adult Pneumonia Patients Arifah, Gina; Halimah, Eli; Abdulah, Rizky
Pharmacology and Clinical Pharmacy Research Vol 3, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (312.673 KB) | DOI: 10.15416/pcpr.v3i1.16451

Abstract

Treatment for pneumonia has always been a challenge due to the difficulties in diagnosis and the growing incidence of antibiotic resistance. Beta-lactam antibiotics are the first line treatment for pneumonia. The combination of beta-lactam with other antibiotics are preferred than single antibiotic therapy. However, there was limited information regarding the effectiveness of combination between beta-lactam with either macrolides or fluoroquinolone for the treatment of pneumonia.The purpose of this study was to determine the most effective combination of antibiotics for hospitalized adults pneumonia patients. This was a cross-sectional study with prospective data collection. The data source was the medical record of the subjects. We included adult pneumonia patients hospitalized at Dr. Hasan Sadikin General Hospital during June-August 2015. We found that mean reduction of body temperature in group who received combination of a beta-lactam antibiotic and azithromycin was 1.53 0C, while in levofloxacin group, the reduction was 1.22 0C (p=0.210). Reduction in leukocytes and respiratory rate were 7800 and 2.29 times/minute, respectively, in the former group, while in the latter group the reduction of leukocytes and respiratory rate were 2600 and 5 times/minute. The differences were not statistically significant in both parameters (p=0.036 and 0.149, respectively). In conclusion, better clinical outcomes were observed in patients treated with combination of beta-lactam and azithromycin compared to combination of beta-lactam and levofloxacin, although the difference was not statistically significant.Keywords: pneumonia, pneumonia therapy, combination therapy for pneumonia
SITOTOKSISITAS KOMBINASI EKSTRAK PUSPA (Schiima wallichii) DANKECAMBAH BROKOLI iv (Brassica olerasea) TERHADAP SEL KANKER PAYUDARA MCF-7 Diantini, Ajeng; Febriyanti, Maya; Intan Barliana, Melisa; Abdulah, Rizky
FITOFARMAKA | Jurnal Ilmiah Farmasi Vol 3, No 1 (2013): FITOFARMAKA
Publisher : Universitas Pakuan

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Abstract

Puspa (Schiima wallichii) diketahui memiliki aktivitas antikanker melalui mekanisme menginduksi apoptosis pada sel kanker payudara MCF-7, sedangkan kecambah brokoli (Brassica olerasea) dilaporkan dapat menghambat proliferasi sel-sel kanker kandung kemih dan prostat secara in vitro. Pada penelitian ini dilakukan pengujian sitotoksisitas kombinasi ekstrak puspa (EP) dan ekstrak kecambah brokoli (EKB) terhadap sel kanker payudara MCF-7. EP memberikan nilai IC 50 60,76 µg/ml, sedangkan EKB tidak memberikan persentasi inhibisi lebih besar dari 50% pada rentang konsentrasi uji. Sitotoksisitas kombinasi EP-EKB dengan perbandingan IC 50 1:2 memiliki nilai Indeks Kombinasi < 0,9 menunjukkan bahwa kombinasi EP-EKB memberikan efek sinergisme. Kata kunci :puspa, kecambah brokoli, sinergisme, MCF-7
Kandungan Kimia dan Aktivitas Sitotoksik Ekstrak dan Fraksi Herba Anting-anting terhadap Sel Kanker Payudara MCF-7 Febriyanti, Maya; Supriyatna, .; Abdulah, Rizky
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 1 (2014)
Publisher : Indonesian Research Gateway

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Abstract

Acalupha indica, belongs to Euphorbiaceae family, is annual herb which distributed widely in Asia, including Indonesia. Extract and fraction of Acalypha indica were sreened for phytochemical constituents and investigated for its cytotoxicity against human breast cancer MCF-7 using MTT assay. Ethanolic extract of A.indica showed cytotoxicity against MCF-7 with an IC50 225 μg/ml. While for the fraction, ethyl acetate fraction showed best cytotoxicity compared to n-hexane and water fraction with an IC50 387 μg/ml. Phytochemical screening to the ethyl acetate fraction showed that the fraction contain flavonoids, polyphenols, monoterpenes and sesquiterpenes, triterpenoids, and quinones.Keywords : Acalypha indica, cytotoxicity, MCF-7, MTT assay
Gel Kombinasi Ekstrak Daun Sirsak dan Daun Jambu Biji Sebagai Obat Anti Jerawat Yulianti, Rika; Abdassah, Marline; Abdulah, Rizky; Surachman, Emma
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 3 (2015)
Publisher : Indonesian Research Gateway

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Abstract

This study aims to determine the formulation and testing of anti-acne combination gel activity of ethanol extract of leaves of soursop (Annona muricata L.) and leaves of guava (Psidium guajava L ) in in - vitro and in - vivo. Soursop leaf is traditionally used to treat acne . It is known that asetogenin soursop leaves contains compounds acetogenin, tannins, phytosterols, calcium oxalate, murisin alkaloids, ????la- vonoids and steroid. Research on anti- acne activity of guava leaf extract has been carried out by Qa’dan et al in 2005. Samples were obtained from a combination of extracts of leaves of soursop (Annona muricata L.) and leaves of guava (Psidium guajava L ) using the method of maceration with 96 % ethanol. The preparation is formulated in the form of a gel and tested the minimum inhibitory concentration and antibacterial activity against Propionibacterium acne using Cindala ® gel for comparison. In-vivo studies conducted using rats (Rattus novergicus) galus Wistar as test animals by administration of Propionibacterium acne bacteria colonies suspense as inducers.The results showed that the combination gel of soursop leaf extract and guava leaf extract has anti bacterial activity against Propionibacterium acne with carbomer gel formulation using as a base. In vivo testing results show that the gel has anti acne activity and statistically signi????icantly different to the negative control.
Gel Kombinasi Ekstrak Daun Sirsak dan Daun Jambu Biji Sebagai Obat Anti Jerawat Yulianti, Rika; Abdassah, Marline; Abdulah, Rizky; Surachman, Emma
Jurnal Farmasi Indonesia Vol 7, No 3 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (199.433 KB) | DOI: 10.35617/jfi.v7i3.308

Abstract

This study aims to determine the formulation and testing of anti-acne combination gel activity of ethanol extract of leaves of soursop (Annona muricata L.) and leaves of guava (Psidium guajava L ) in in - vitro and in - vivo. Soursop leaf is traditionally used to treat acne . It is known that asetogenin soursop leaves contains compounds acetogenin, tannins, phytosterols, calcium oxalate, murisin alkaloids, ô°la- vonoids and steroid. Research on anti- acne activity of guava leaf extract has been carried out by Qaâ??dan et al in 2005. Samples were obtained from a combination of extracts of leaves of soursop (Annona muricata L.) and leaves of guava (Psidium guajava L ) using the method of maceration with 96 % ethanol. The preparation is formulated in the form of a gel and tested the minimum inhibitory concentration and antibacterial activity against Propionibacterium acne using Cindala ® gel for comparison. In-vivo studies conducted using rats (Rattus novergicus) galus Wistar as test animals by administration of Propionibacterium acne bacteria colonies suspense as inducers.The results showed that the combination gel of soursop leaf extract and guava leaf extract has anti bacterial activity against Propionibacterium acne with carbomer gel formulation using as a base. In vivo testing results show that the gel has anti acne activity and statistically signiô°icantly different to the negative control.
Kandungan Kimia dan Aktivitas Sitotoksik Ekstrak dan Fraksi Herba Anting-anting terhadap Sel Kanker Payudara MCF-7 Febriyanti, Maya; Supriyatna, .; Abdulah, Rizky
Jurnal Farmasi Indonesia Vol 7, No 1 (2014)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.469 KB) | DOI: 10.35617/jfi.v7i1.152

Abstract

Acalupha indica, belongs to Euphorbiaceae family, is annual herb which distributed widely in Asia, including Indonesia. Extract and fraction of Acalypha indica were sreened for phytochemical constituents and investigated for its cytotoxicity against human breast cancer MCF-7 using MTT assay. Ethanolic extract of A.indica showed cytotoxicity against MCF-7 with an IC50 225 μg/ml. While for the fraction, ethyl acetate fraction showed best cytotoxicity compared to n-hexane and water fraction with an IC50 387 μg/ml. Phytochemical screening to the ethyl acetate fraction showed that the fraction contain flavonoids, polyphenols, monoterpenes and sesquiterpenes, triterpenoids, and quinones.Keywords : Acalypha indica, cytotoxicity, MCF-7, MTT assay
Co-Authors . Supriyatna, . Ace Tatang Hidayat Agustini, Dewi D. Ahmad Faried Aisha K. Nur Ajeng Diantini, Ajeng Akhmad Priyadi Ami A. Pratiwi Anas Surbanas Andreas Ciokan Angga Prawira Kautsar Arifah, Gina Asep Supriadin Barliana, Melisa I. Barliana, Melisa I. Carissa P. Purabaya Cherry Rahayu Cherry Rahayu Cherry Rahayu Cinthya, Sindy E. Ciokan, Andreas Desi Harneti Putri Huspa Destiani, Dika P. Desyandri Desyandri Devinna Kang Dewi D. Agustini DIANTINI, AJENG - Dika P. Destiani Dinge, Fonny Dyah A. Perwitasari Eka W. Suradji Eli Halimah Eli Halimah, Eli Eli Mirdayani Emma Surahman Emma Surahman, Emma Eni Indrawati Ernestine Arianditha Pranasti Eva S. Tarigan Fajar, Mohamad Febriyanti, Maya Febriyanti, Maya Finisanti, Ratih Fonny Dinge Fonny Dinge Furqani, Winda H. Ghassani, Salma K. Gina Arifah Haafizah Dania Hanny Hafiar Hasriana Hasriana Hasriana Hasriana, Hasriana Hasrianna Hasrianna Hasrianna, Hasrianna Henry Ng Hersa Milawati Hersa Milawati Hilmi, Indah L. Hiroshi Koyama Imam A. Wicaksono Imaniar N. Faridah Imas Maesaroh Indah L. Hilmi Indah Laily Hilmi Indrawati, Eni Insani, Widya N. Intan Barliana, Melisa Irma M. Puspitasari Irma M. Puspitasari Irma M. Puspitasari, Irma M. Ivan S. Pradipta Ivan S. Pradipta Kang, Devinna Katherine A.Tjenggal Keri Lestari Khairinnisa, Miski A. Khansa F. Rahmah Kumamba, Raine D. Kusuma, Sri A. F. Leri Septiani Marline Abdassah, Marline Maya Febriyanti Meilani Jayanti Melisa I. Barliana Melisa I. Barliana Melisa I. Barliana Melisa I. Barliana Melisa Intan Barliana Melisa Intan Barliana, Melisa Intan Milawati, Hersa Miski A. Khairinnisa Mohamad Fajar Mohamad Fajar Mohamad Nurul Azmi Mohamad Nurul Azmi bin Mohamad Taib Muhaimin Muhaimin Muhammad Rivai Mutakin Mutakin Nabilah Nadhif Nabilah Nadhif Ng, Henry Norisca A. Putri Nunung Kurniasih Nunung Kurniasih Nunung Kurniasih, Nunung Nurul Annisa Nurul Annisa NURUL ANNISA Okky S. Purwanti Pradipta, Ivan S. Pratiwi, Ami A. Priyadi, Akhmad Purabaya, Carissa P. Purwanti, Okky S. Rahayu, Cherry Raine D. Kumamba Rano K. Sinuraya Rano K. Sinuraya Rano K. Sinuraya RANO KURNIA SINURAYA Ratih Finisanti Rika Yulianti, Rika Riska F Siregar Salma K. Ghassani SILVIA PERMATA SARI Sindy E. Cinthya Sinuraya, Rano K. Siregar, Riska F Sitepu, Annisa Ayu Ningtyas Carolina Siti Saidah Siti Saidah Sofa D. Alfian Sofa D. Alfian Sofa D. Alfian Sofa D. Alfian, Sofa D. Sofa Dewi Alfian Sri A. F. Kusuma Sri A. Sumiwi Sri M. Wahyuningrum Sumiwi, Sri A. Sunu Widianto Sunu Widianto Supriyatna Supriyatna Surachman, Emma Surachman, Emma Suradji, Eka W. Tarigan, Eva S. TIANA MILANDA Tina Rostinawati Unang Supratman Wahyuningrum, Sri M. Widianto, Sunu Widya N. Insani Winda H. Furqani Yudi Mulyana Hidayat Zulfan Zazuli