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All Journal HAYATI Journal of Biosciences VALENSI Farmaka International Journal of Integrated Health Sciences Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Pharmacology and Clinical Pharmacy Research FITOFARMAKA: Jurnal Ilmiah Farmasi Molekul: Jurnal Ilmiah Kimia JFIOnline Indian Journal of Forensic Medicine & Toxicology

Rizky Abdulah

Fakultas Farmasi, Universitas Padjadjaran

Author-ID : 604744

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Articles

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Efficiency Fast-Moving Drug Plan with Reorder Point Intervention at a Private Hospital in Bandung Aisha K. Nur; Angga P. Kautsar; Indah L. Hilmi; Rizky Abdulah
Pharmacology and Clinical Pharmacy Research Vol 4, No 3
Publisher : Universitas Padjadjaran, Indonesia

Drug supplies are the major portion of the hospital expenses. The rising of drugs cost directly affect the total expenses of the hospital. Thus, their procurement, especially for fast-moving drugs, should be managed effectively. This study aimed to examine the efficiency of fast-moving drug plan after reorder point (ROP) intervention at a private hospital in Bandung. We conducted a pre-experimental study and used turn-over ratio (TOR) as a parameter. Data were taken from the stock of antibiotics in May-June of 2013 and May-June 2014. Cost components were collected; included the amount of stock, the cost of goods sold, and daily drug use. We did pre-test and post-test analysis to check the efficiency of intervention. The results showed that ROP intervention increased the efficiency of fast-moving drug plan. The comparison of pre- and post- intervention resulted a lower inventory value and a greater TOR value. We concluded that the increase in efficiency will eventually require a smaller budget of drug expenses.

Hepatotoxicity Effects of Alcohol Consumption during Paracetamol Therapy of Malaria Patients Fonny Dinge; Sofa D. Alfian; Rizky Abdulah; Sri A. Sumiwi
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

The risk of paracetamol induced hepatotoxicity could increase with alcohol consumption.Paracetamol was usually given to tropical malaria patients to treat fever. The aim of this studywas to determine the hepatotoxicity effect of alcohol consumption in malaria tropica patientsreceiving paracetamol. This study was a cross-sectional study which was conducted duringApril-June 2015 at a hospital in Jayapura, Indonesia. The data were obtained from questionnairesand medical records. Alcohol status was determined by Short Michigan Alcoholics ScreeningTest (SMAST) questionnaire. Level of ALT, AST and bilirubin were observed before and afterreceiving paracetamol therapy for 5 days. Based on the results, the ALT and bilirubin levels ofalcoholic group were higher than in non-alcoholic. However, chi-square test showed that alcoholstatus did not have a significant influence in ALT, AST, and bilirubin levels. Otherwise,logistic regression analysis showed that age gave a significant effect on AST level (P=0.067).Keywords: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alcohol,malaria

Comparison of Effectiveness between Combination of Beta-Lactam with Azyhtromycin or Levofloxacin for Adult Pneumonia Patients Gina Arifah; Eli Halimah; Rizky Abdulah
Pharmacology and Clinical Pharmacy Research Vol 3, No 1
Publisher : Universitas Padjadjaran, Indonesia

Treatment for pneumonia has always been a challenge due to the difficulties in diagnosis and the growing incidence of antibiotic resistance. Beta-lactam antibiotics are the first line treatment for pneumonia. The combination of beta-lactam with other antibiotics are preferred than single antibiotic therapy. However, there was limited information regarding the effectiveness of combination between beta-lactam with either macrolides or fluoroquinolone for the treatment of pneumonia.The purpose of this study was to determine the most effective combination of antibiotics for hospitalized adults pneumonia patients. This was a cross-sectional study with prospective data collection. The data source was the medical record of the subjects. We included adult pneumonia patients hospitalized at Dr. Hasan Sadikin General Hospital during June-August 2015. We found that mean reduction of body temperature in group who received combination of a beta-lactam antibiotic and azithromycin was 1.53 0C, while in levofloxacin group, the reduction was 1.22 0C (p=0.210). Reduction in leukocytes and respiratory rate were 7800 and 2.29 times/minute, respectively, in the former group, while in the latter group the reduction of leukocytes and respiratory rate were 2600 and 5 times/minute. The differences were not statistically significant in both parameters (p=0.036 and 0.149, respectively). In conclusion, better clinical outcomes were observed in patients treated with combination of beta-lactam and azithromycin compared to combination of beta-lactam and levofloxacin, although the difference was not statistically significant.Keywords: pneumonia, pneumonia therapy, combination therapy for pneumonia

Hypoglicemia Risk Factors on Hospitalized Type 2 Diabetes Mellitus Patients Meilani Jayanti; Keri Lestari; Rizky Abdulah
Pharmacology and Clinical Pharmacy Research Vol 3, No 2
Publisher : Universitas Padjadjaran, Indonesia

Hypoglycemia is one of the most important complications of diabetes treatment and it becomes an obstacle in hypoglycemia medication. Besides, hypoglycemia can cause nerve damage and impaired cognitive function so that it influences the patients mortality, morbidity, and quality of life. Recognition of hypoglycemia risk factors, blood glucose monitoring, selection of appropriate regimens and educational programs for healthcare professionals and patients with diabetes are the major issues to maintain good glycemic control, minimize the risk of hypoglycemia, and prevent long-term complications. This research employs retrospective method and the design of the research is case control. The sample of this research is 72 patients with type 2 diabetes which is divided into two groups. The first group is case and It consists of 23 patients (31,9%) getting hypoglycemia. Then, the second group is control and it consists of 49 patients (68,1%). In the second group the 49 patients do not get hypoglycemia and they do not receive any hypoglycemia medication in the hospital. The Results of multivariate logistic regression analysis shows that there is a significant different between the variables reduction in food intake (p 0,011) and lower laboratory result of HbA1C (p 0,003) on the incidence of hypoglycemic, where the variable reduction in food intake has the strong relationship with most major hypoglycemic (OR 9,329). On the other hand, other variables such as the use of antidiabetic drugs, diabetes duration, age, comorbidities and polypharmacy showed no significant association with hypoglycemic events. Thus, the hypoglycemic risk factors in patients with type 2 diabetes receiving antidiabetic therapy due to reduction in food intake and lower laboratory results of HbA1C. Patients with reduction in food intake at risk of hypoglycemic events nine times greater than patients with normal food intake. Keywords: type 2 diabetes mellitus, hypoglycemia, food intake, HbA1C

Polymorphism of pfcrt K76T and pfatpase6 S769N Genes in Malaria Patients at Papua, Indonesia Eka W. Suradji; Henry Ng; Ratih Finisanti; Eni Indrawati; Andreas Ciokan; Melisa I. Barliana; Rizky Abdulah
Pharmacology and Clinical Pharmacy Research Vol 1, No 1
Publisher : Universitas Padjadjaran, Indonesia

Indonesia is one of the country with the highest prevalence of malaria infections. In order to achieve malaria control as an act to support Millenium Development Goals, complete eradication of Plasmodium parasites needs to be conducted. Drugs resistance has been a hindrance in this act. This study aimed to assess Plasmodium parasite resistance towards chloroquine (CQ) and artemisinin combined therapy (ACT) through the determination of polymorphism on pfcrt K76T and pfatpase6 S769N genes, respectively. Subjects of this study were 16 adult patients positively diagnosed with malaria infection caused by P. falciparum or cross infection. DNA obtained from patient blood samples were amplified using polymerase chain reaction (PCR) and then the fragment of pfcrt and pfatpase6 were then digested using ApoI and DdeI, respectively. The results showed that 81% of the pfcrt K76T polymorphism was occured on the samples, which indicated the resistance of CQ. Meanwhile, 87% of the patient samples did not showed any polymorphism of pfatpase6 S769N gene, which indicated no resistance of ACT. This study showed that CQ was no longer effective as the first line therapy of antimalarial drugs due to the resistance of P. falciparum to CQ. However, the used of ACT still can be maintained in the antimalarial drug therapy regimen. In conclusion, the polymorphism of both genes negatively influenced the effectivity of antimalarial therapy using artemisinin.Keywords: antimalarial drugs, resistance, polymorphism, endemic area

Evaluation of Prescription Pattern for Internal Medicines Outpatients using World Health Organization Indicators Fonny Dinge; Rizky Abdulah; Sri A. Sumiwi
Pharmacology and Clinical Pharmacy Research Vol 2, No 3
Publisher : Universitas Padjadjaran, Indonesia

Rational use of drugs plays an important role in efficacy and safety. World Health Organization(WHO) developed a set of indicators to assess medicines precribing pattern. The aim ofthis study was to evaluate the rational use of drugs among internal medicines outpatients ata hospital in Papua, Indonesia, using WHO prescribing indicators. This study was a retrospectiveobservational study conducted during January-March 2014. The data were obtainedfrom patients medical prescriptions. From each prescriptions, data regarding the the totalnumber of drugs, generic, antibiotics, parenteral, and essential drugs were extracted. A totalof 2025 medical precriptions were included in this study. We found out that the averagenumber of drugs per prescription was 2.3. Majority of the prescribed drugs were generic(84.14%). The use of antibiotics, parenteral drugs, and essential drugs were 33.43%, 3.40%,and 60.13%, respectively. Polypharmacy was relatively low among the subjects. The medicinesprescribing patterns among internal medicines outpatients were in accordance withWHO recommendation.Keywords: prescribing indicator, polypharmacy, essential drugs

Analisis Interaksi Obat Dari Resep di Salah Satu Apotek Kota Bandung Pada Periode Mei - Juli 2023 Sitepu, Annisa Ayu Ningtyas Carolina; Abdulah, Rizky
Farmaka Vol 22, No 2 (2024): Farmaka (Juli)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v22i2.52888

Interaksi obat-obat menggambarkan situasi di mana satu obat dapat mempengaruhi aktivitas obat lain. Kombinasi berbagai jenis obat dapat menyebabkan reaksi yang kompleks, termasuk peningkatan atau penurunan efek terapeutik, interaksi farmakokinetik, atau bahkan munculnya efek samping yang tidak terduga. Oleh karena itu, penelitian dan pemahaman yang terus menerus terkait interaksi obat menjadi kunci dalam meningkatkan kualitas perawatan kesehatan. Artikel ini bertujuan untuk mengidentifikasi interaksi obat dari resep yang masuk ke salah satu apotek di Kota Bandung pada bulan Mei - Juli 2023 dan memberikan solusi yang tepat untuk interaksi yang teridentifikasi. Metode yang digunakan dalam penulisan artikel ini yaitu pengambilan data secara langsung ke lapangan dan metode analisa resep yang dilakukan dengan tinjauan literatur. Data resep diperoleh dari dokter umum, dokter spesialis penyakit dalam, dokter spesialis telinga hidung tenggorokan, dan dokter spesialis anak yang melakukan praktik di salah satu apotek di Kota Bandung. Resep yang diambil yaitu resep yang masuk pada bulan Mei - Juli 2023 serta berisikan obat polifarmasi, minimal terdapat 3 R/. Dari 100 resep yang telah dianalisa, terdapat sebanyak 50 obat yang berinteraksi, dengan interaksi minor sebanyak 13 interaksi, moderate sebanyak 33 interaksi dan major sebanyak 4 interaksi. Obat-obatan yang berintekasi secara major diantaranya spironolakton dengan kandesartan, spironolakton dengan ramipril, isoniazid dengan rifampicin, rifampicin dengan pyrazinamide. Obat – obatan tersebut berinteraksi dengan berbagai mekanisme yang berbeda.Kata kunci : Interaksi obat, resep, apotek di Kota Bandung

Anticancer Activities and Metabolite Profiling of UHPLC-HRMS Method from Chrysanthemum x morifolium (Ramat.) Hemsl Leaves Maesaroh, Imas; Barliana, Melisa Intan; Abdulah, Rizky; Muhaimin, Muhaimin
HAYATI Journal of Biosciences Vol. 33 No. 1 (2026): January 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.1.167-180

The Chrysanthemum morifolium Ramat, traditionally used for cancer treatment, including breast cancer, possesses anticancer properties. The aim of this study is metabolite profiling using ultra-high-performance liquid chromatography in conjunction with the high-resolution mass spectrometry (UHPLC-HRMS) technique and its correlation with the cytotoxic activity of the extract and ethyl acetate fraction of Chrysanthemum x morifolium (Ramat.) Hemsl leaves on cancer cells. The ethyl acetate fraction from the hydrolyzed ethanol extract of (Chrysanthemum x morifolium (Ramat.) Hemsl) leaves has anticancer activity against the MCF-7 breast cancer cells. Metabolite profiling was used to understand the presence of metabolites that have anticancer activity. UHPLC-HRMS was used to profile their metabolites. Compound Discoverer 3.3 software finished data processing and metabolite annotation. Anticancer activity was performed using the 2-[2-methoxy-4-nitrophenyl]-3[4-nitrophenyl]-5[2,4-disulfophenyl]-2H-tetrazolium (WST-8) assay. As many as 57 secondary metabolites were identified by UHPLC-HRMS analysis. Secondary metabolites that have the potential as anti-breast cancer are glycitein, diosmetin, kaempferol, esculetin, scopoletin, dihydroartemisinin, and Chrysin, with successive percentages of 31.39%, 19.91%, 5.61%, 2.63%, 0.82%, 0.14%, and 0.05%. Ethyl acetate fraction showed stronger cytotoxic activity than ethanol extract against MCF-7 cells with IC50 values of 66.31 ppm at 24 hours incubation and 40.35 ppm at 48 hours. Further research can be conducted on the isolation of flavonoids from the ethyl acetate fraction, as well as the analysis of cell cycle apoptosis stimulation and gene expression mechanisms.

Co-Authors . Supriyatna, . Ace Tatang Hidayat Agustini, Dewi D. Ahmad Faried Aisha K. Nur Ajeng Diantini, Ajeng Akhmad Priyadi Ami A. Pratiwi Anas Surbanas Andreas Ciokan Angga Prawira Kautsar Arifah, Gina Asep Supriadin Barliana, Melisa I. Barliana, Melisa I. Carissa P. Purabaya Cherry Rahayu Cherry Rahayu Cherry Rahayu Cinthya, Sindy E. Ciokan, Andreas Desi Harneti Putri Huspa Destiani, Dika P. Desyandri Desyandri Devinna Kang Dewi D. Agustini DIANTINI, AJENG - Dika P. Destiani Dinge, Fonny Dyah A. Perwitasari Eka W. Suradji Eli Halimah Eli Halimah, Eli Eli Mirdayani Emma Surahman Emma Surahman, Emma Eni Indrawati Ernestine Arianditha Pranasti Eva S. Tarigan Fajar, Mohamad Febriyanti, Maya Febriyanti, Maya Finisanti, Ratih Fonny Dinge Fonny Dinge Furqani, Winda H. Ghassani, Salma K. Gina Arifah Haafizah Dania Hanny Hafiar Hasriana Hasriana Hasriana Hasriana, Hasriana Hasrianna Hasrianna Hasrianna, Hasrianna Henry Ng Hersa Milawati Hersa Milawati Hilmi, Indah L. Hiroshi Koyama Imam A. Wicaksono Imaniar N. Faridah Imas Maesaroh Indah L. Hilmi Indah Laily Hilmi Indrawati, Eni Insani, Widya N. Intan Barliana, Melisa Irma M. Puspitasari Irma M. Puspitasari Irma M. Puspitasari, Irma M. Ivan S. Pradipta Ivan S. Pradipta Kang, Devinna Katherine A.Tjenggal Keri Lestari Khairinnisa, Miski A. Khansa F. Rahmah Kumamba, Raine D. Kusuma, Sri A. F. Leri Septiani Marline Abdassah, Marline Maya Febriyanti Meilani Jayanti Melisa I. Barliana Melisa I. Barliana Melisa I. Barliana Melisa I. Barliana Melisa Intan Barliana Melisa Intan Barliana, Melisa Intan Milawati, Hersa Miski A. Khairinnisa Mohamad Fajar Mohamad Fajar Mohamad Nurul Azmi Mohamad Nurul Azmi bin Mohamad Taib Muhaimin Muhaimin Muhammad Rivai Mutakin Mutakin Nabilah Nadhif Nabilah Nadhif Ng, Henry Norisca A. Putri Nunung Kurniasih Nunung Kurniasih Nunung Kurniasih, Nunung Nurul Annisa NURUL ANNISA Nurul Annisa Okky S. Purwanti Pradipta, Ivan S. Pratiwi, Ami A. Priyadi, Akhmad Purabaya, Carissa P. Purwanti, Okky S. Rahayu, Cherry Raine D. Kumamba Rano K. Sinuraya Rano K. Sinuraya Rano K. Sinuraya RANO KURNIA SINURAYA Ratih Finisanti Rika Yulianti, Rika Riska F Siregar Salma K. Ghassani SILVIA PERMATA SARI Sindy E. Cinthya Sinuraya, Rano K. Siregar, Riska F Sitepu, Annisa Ayu Ningtyas Carolina Siti Saidah Siti Saidah Sofa D. Alfian Sofa D. Alfian Sofa D. Alfian Sofa D. Alfian, Sofa D. Sofa Dewi Alfian Sri A. F. Kusuma Sri A. Sumiwi Sri M. Wahyuningrum Sumiwi, Sri A. Sunu Widianto Sunu Widianto Supriyatna Supriyatna Surachman, Emma Surachman, Emma Suradji, Eka W. Tarigan, Eva S. TIANA MILANDA Tina Rostinawati Unang Supratman Wahyuningrum, Sri M. Widianto, Sunu Widya N. Insani Winda H. Furqani Yudi Mulyana Hidayat Zulfan Zazuli

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