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All Journal HAYATI Journal of Biosciences VALENSI Farmaka International Journal of Integrated Health Sciences Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Pharmacology and Clinical Pharmacy Research FITOFARMAKA: Jurnal Ilmiah Farmasi Molekul: Jurnal Ilmiah Kimia JFIOnline Indian Journal of Forensic Medicine & Toxicology

Rizky Abdulah

Fakultas Farmasi, Universitas Padjadjaran

Author-ID : 604744

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Peran Employee Engagement sebagai Mediasi Budaya Organisasi Karyawan Instalasi Farmasi Rumah Sakit Hilmi, Indah L.; Supriyatna, Supriyatna; Widianto, Sunu; Abdulah, Rizky
Indonesian Journal of Clinical Pharmacy Vol 2, No 1 (2013)
Publisher : Indonesian Journal of Clinical Pharmacy

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Penelitian ini bertujuan untuk menganalisis hubungan antara budaya organisasi terhadap kinerja individual dan kepuasan pelanggan serta peran employee engagement sebagai pemediasi di instalasi farmasi rumah sakit. Sebanyak 100 karyawan dan 100 pelanggan instalasi farmasi rumah sakit menjadi responden. Penelitian ini menggunakan kuesioner dan teknik partial least square. Hasil penelitian menunjukkan terdapat signifikansi antara budaya organisasi terhadap employee engagement (nilai t (18,16)>ttabel (1,64)), budaya organisasi terhadap kepuasan pelanggan (nilai t (2,37)>t-tabel (1,64)), employee engagement terhadap kinerja individual (nilai t (2,24)>t-tabel (1,64)) dan employee engagement terhadap kepuasan pelanggan (nilai t (3,26)>t-tabel (1,64)). Selain itu hasil penelitian menunjukkan bahwa tidak ada pengaruh yang signifikan antara budaya organisasi dan kinerja individual (nilai t (1,17)<t-tabel (1,64)). Employee engagement memediasi hubungan antara budaya organisasi dan kinerja individual.Kata kunci: Budaya organisasi, employee engagement, kinerja individual, kepuasan pelangganÂ The Roles of Employee Engagement as Organization Culture Mediator in Hospital Pharmacy EmployeesThe aims of the study are to analyze the relationship of organization culture on individual performance, customer satisfaction and employee engagement as mediation role in the installation of the hospital pharmacy. A total of 100 employees and 100 customers of the hospital pharmacy become participants in this study. The study used questioner and partial least square techniques. The study results show that there are significance between the organization culture and employee engagement (t value (18.16)>ttable (1.64)), organization culture and customer satisfaction (t values (2.37)>t-table (1.64)), employee engagement and customer satisfaction (t value (3.26)>t-table (1.64)). In addition, the results show that there is no significant influence between organization culture and individual performance (t values (1.17)<t-table (1.64)). Employee engagement mediates the relationship between organization culture and individual performance.Key words: Organization culture, employee engagement, individual performance, customer satisfaction

Potensi Interaksi Obat Resep Pasien Geriatri: Studi Retrospektif pada Apotek di Bandung Annisa, Nurul; Abdulah, Rizky
Indonesian Journal of Clinical Pharmacy Vol 1, No 3 (2012)
Publisher : Indonesian Journal of Clinical Pharmacy

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Usia geriatri merupakan kelompok usia yang rentan terhadap masalah-masalah yang terkait denganpenggunaan obat, salah satunya adalah kejadian interaksi obat-obat. Dalam penelitian ini dilakukan studi untuk mengetahui interaksi potensial obat-obat. Data diproses melalui www.drugs.comdatabase.Evaluasi ini memaparkan prevalensi dan mengklasifikasikan jenis interaksi potensial berdasarkan level interaksi dan spesialisasi medik. Dari total 29.839 resep dari tujuh apotek di kota Bandung diperoleh 334 lembar resep geriatri (1,12%). Dari resep geriatri tersebut, tedapat 4 lembar resep (1,20%) dengan jumlah 1 R/ yang artinya pada resep ini tidak berpotensi untuk terjadi interaksi. Sedangkan jumlah R/pada lembar resep yang mengandung lebih dari 1 R/ adalah 1.136 dengan rata-rata jumlah R/ pada setiap lembar resep adalah 3,40. Sebanyak 131 lembar resep terdapat interaksi potensial obat-obat sebesar 39,22%. Total interaksi potensial yang terjadi adalah 210 interaksi. Interaksi potensial moderate adalah sebanyak 187 (89,05%) sedangkan severe sebanyak 23 (10,95%). Kejadian potensi interaksi moderate dan severe pada kelompok spesialisasi medik umum adalah sebanyak 85,00%, penyakit dalam 8,40%, kardiologi 2,30%, THT 2,30%, syaraf 0,76% dan gigi 0,76%.Kata kunci: Interaksi obat-obat, apotek, geriatriÂ Potency of Drugs Interaction among Geriatric Patients Prescribing: Retrospective Study in Pharmacies in BandungAbstractGeriatric age is an age group that vulnerable to the problems which associated with drug use, one of them is the incidence of drug-drug interactions. This research, conducted to determine potential drugdruginteractions. Data processed through www.drugs.comdatabase. This evaluation explain the prevalence and classify types of potential interactions based on the level of interactions and medical specialities. Based on the total of 29.839 prescriptions from seven pharmacies in the Bandung city obtained 334 prescription sheet of geriatrics (1.12%) and from that geriatric prescriptions, there are 4 prescriptionssheets (1.20 %) that contain 1 R/, which means that in this prescriptions is do not have any potential forinteraction. The number of R/ on prescription sheets which contain more than 1 R / is 1.136 with an average number of R/ on each sheet prescriptions is 3.40. Total of 131 (39.22%) sheets of prescriptionscontain potential drug-drug interaction. Total potential interactions that occur are 210 interactions. Themoderate interaction potential is 187 (89.05%), while severe as much as 23 (10.95%). The incidence ofmoderate and severe potential interaction in the group of medical specialities are 85.50% interactionsin general practitioners, 8.40% in internist, 2.30% in cardiologist, 2.30% in ENT, 0.76% in neurologistsand 0.76% in dentist.Key words: Drug-drug interactions, community pharmacies, geriatrics

Permasalahan Terkait Obat (Drug Related Problems/DRPs) pada Penatalaksanaan Penyakit Ginjal Kronis dengan Penyulit Penyakit Arteri Koroner Furqani, Winda H.; Zazuli, Zulfan; Nadhif, Nabilah; Saidah, Siti; Abdulah, Rizky; Lestari, Keri
Indonesian Journal of Clinical Pharmacy Vol 4, No 2 (2015)
Publisher : Indonesian Journal of Clinical Pharmacy

Masalah terkait obat (DRPs) didefinisikan sebagai setiap kondisi dalam penatalaksanaan terapi pasien yang menyebabkan atau berpotensi menyebabkan tidak tercapainya hasil terapi yang optimal. Penelitian ini dilakukan di salah satu rumah sakit di Kota Cimahi pada bulan Mei 2014. Pada penelitian ini dilakukan identifikasi DRPs pada pasien wanita berusia 59 tahun yang didiagnosis penyakit ginjal kronis dengan penyulit penyakit arteri koroner dan gangren di tangan kiri (jari ke-3). Pasien diketahui mempunyai riwayat diabetes melitus sejak dua hingga tiga tahun yang lalu. Melalui kajian DRPs ditemukan permasalahan terkait obat, yaitu adanya terapi obat yang tidak diperlukan (pemberian kalsium polistiren sulfonat), ketidaktepatan pemilihan antibiotik, Ketidaktepatan dosis (pemberian amoksisilin dan kaptopril), dan risiko interaksi obat-obat merugikan (interaksi kaptoprilâfurosemid, kaptoprilâisosorbid dinitrat, dan kaptoprilânatrium bikarbonat). Pasien penyakit ginjal kronis dengan penyulit penyakit arteri koroner menerima terapi obat yang kompleks sehingga meningkatkan risiko terjadinya DRPs. Keterlibatan apoteker klinis di rumah sakit dalam penatalaksanaan penyakit yang kompleks diperlukan untuk mengoptimalkan terapi, meminimalisir risiko DRPs, dan meningkatkan kualitas hidup pasien.Kata kunci: Drug related problems, penyakit ginjal kronis, penyakit arteri koronerDrug Related Problems in the Management of Chronic Kidney Disease with Coronary Artery DiseaseDrug related problems were defined as conditions on patientâs therapy management that caused, or potentially caused unsuccessful therapy. This study was conducted at a hospital in Cimahi City in May 2014. In this study, DRPs were identified on a 59 years old woman who was diagnosed with chronic kidney disease and coronary artery disease with gangrene on the left hand (the third finger). The patient also had a diabetes mellitus for two until three years ago. Drug related problems (DRPs) were found in this patient. Unnecessary drug therapy (administration of calsium polystirene sulfonate), inappropriate choosen antibiotic, inappropriate dosing (administration of amoxicillin and captopril), and risks drug interactions (captoprilâfurosemide, captoprilâisosorbide dinitrate, and captoprilâsodium bicarbonate). Patients with chronic kidney disease and coronary artery disease received complex drug therapy. These condition lead to higer risk of DRPs. The involvement of clinical pharmacist in interdisciplinary team for management of complex diseases was needed to monitor drug therapy to optimizing the therapy, minimalizing the risk of DRPs, and improving patientâs quality of life.Key words: Chronic kidney disease, coronary artery disease, drug related problems

Analisis Efektivitas Biaya Penggunaan Kombinasi Antipsikotik pada Pasien Rawat Inap Skizofrenia Abdulah, Rizky; Siregar, Riska F; Alfian, Sofa D.
Indonesian Journal of Clinical Pharmacy Vol 6, No 1 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2017.6.1.61

Skizofrenia merupakan salah satu gangguan jiwa dengan biaya tinggi dan risiko morbiditas seumur hidup. Studi farmakoekonomi pada pasien skizofrenia perlu dilakukan untuk mengetahui efisiensi pemilihan kombinasi antipsikotik. Penelitian ini bertujuan untuk menganalisis efektivitas biaya (cost-effectiveness) penggunaan kombinasi antipsikotik klozapin-haloperidol dan klozapin-risperidon pada pasien skizofrenia rawat inap di Rumah Sakit Jiwa Provinsi Jawa Barat tahun 2012â2013. Pengumpulan data dilakukan secara retrospektif dari rekam medis pasien yang meliputi komponen biaya langsung, antara lain biaya terapi antipsikotik, biaya penunjang, biaya tindakan medis, biaya rawat inap, dan biaya administrasi. Rata-rata rasio efektivitas biaya pada kombinasi antipsikotik klozapin-haloperidol sebesar Rp126.898/hari sedangkan pada kombinasi klozapin-risperidon sebesar Rp132.781/hari. Dengan mempertimbangkan waktu rawat inap sebagai efektivitas terapi, kombinasi antipsikotik klozapin-haloperidol lebih cost-effective dibandingkan klozapin-risperdion.

Peresepan Obat-obat Off-Label pada Pasien Anak Usia 0 Hingga 2 Tahun di Apotek Kota Bandung Pratiwi, Ami A.; Khairinnisa, Miski A.; Alfian, Sofa D.; Priyadi, Akhmad; Pradipta, Ivan S.; Abdulah, Rizky
Indonesian Journal of Clinical Pharmacy Vol 2, No 2 (2013)
Publisher : Indonesian Journal of Clinical Pharmacy

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Obat off-label merupakan obat yang diresepkan tetapi tidak sesuai dengan informasi resmi obat seperti indikasi obat yang tidak sesuai dengan yang dinyatakan oleh izin edar serta dosis, umur pasien, dan rute pemberian yang tidak sesuai. Penelitian ini dilakukan untuk mengetahui persentase jumlah resep pasien dokter spesialis anak yang mengandung obat off-label pada pasien anak usia 0 hingga 2 tahun di Apotek Kota Bandung serta mengetahui pola penggunaannya melalui studi observasional dengan pengambilan data secara retrospektif. Identifikasi obat yang diresepkan termasuk kategori off-label atau tidak berdasarkan Pediatric Dosage Handbook 2007, Drug Information Handbook (DIH) 2012, British National Formulary (BNF) 2009, MIMS USA 2013, MIMS Indonesia 2013, dan ISO 2012â2013. Berdasarkan hasil penelitian diperoleh 542 lembar resep off-label (19,77%) dari 2741 total lembar resep, serta sebanyak 699 (7,89%) item obat off-label dari 8861 obat, dengan persentase kategori off-label usia 70,53%, off-label dosis 19,74% dan off-label kontraindikasi 9,73%. Penelitian ini menunjukkan bahwa potensi peresepan obat off-label di apotek di Kota Bandung pada tahun 2012 tinggi sehingga perlu pemilihan obat yang tepat serta pengawasan dalam penggunaan obat pada anak.Kata kunci: Obat off-label, pediatri, peresepan, BandungÂ The Prescription of Off-Label Drugs towards 0â2 Years Old Pediatric Patients in Community Pharmacy in Bandung CityOff-label drug is a drug which is not prescribed in accordance with official drug information, including patient age, drug indications didnât match with the marketing authorization, dosage and route ofadministration are not appropriate. This study was conducted to determine the percentage of patients pediatrician who prescribed with containing drugs off-label in pediatric patients aged 0 to 2 years at pharmacy in Bandung and determine the pattern of use through an observational study with retrospective data collection. Identification of medications that are prescribed off-label category or not based on the Pediatric Dosage Handbook 2007, Drug Information Handbook (DIH) in 2012, the British NationalFormulary (BNF) in 2009, MIMS USA 2013, MIMS Indonesia in 2013, and ISO 2012â2013. Based on the results obtained 542 pieces of off-label prescriptions (19.77%) of the 2741 total pieces recipes, as well as 699 (7.89%) of off-label drug items from 8861 drug, the percentage of off-label age category 70.53%, off-label doses of 19.74% and off-label contraindication 9.73%. The results of this study indicate that the uses of off-label drugs for children is high at Pharmacy in Bandung. This study is expected to be basicconsideration in examining the efficacy and safety in off-label drug uses for children aged 0 to 2 years.Key words: Off-label drug, pediatric, prescription, Bandung

Kualitas Hidup Pasien Kanker Payudara dengan Terapi Kombinasi Fluorouracil, Doxorubicin, dan Cyclofosfamide Agustini, Dewi D.; Surahman, Emma; Abdulah, Rizky
Indonesian Journal of Clinical Pharmacy Vol 4, No 3 (2015)
Publisher : Indonesian Journal of Clinical Pharmacy

Pengobatan pada kanker payudara dengan kemoterapi kombinasi Fluorouracil, Doxorubicin, dan Cyclofosfamide (FAC) menimbulkan perbedaan kualitas hidup pasien yang penting untuk diketahui karena dapat menunjang keefektifan pengobatan. Tujuan penelitian ini adalah untuk mengukur perbedaan dan mengetahui dimensi yang memengaruhi kualitas hidup pasien kanker payudara dari setiap siklus kemoterapi di RS Hasan Sadikin Bandung. Jenis penelitian ini adalah observasional analitik dengan pedekatan potong lintang. Sebanyak 200 pasien kanker payudara dipilih secara purposive dan dipisahkan berdasarkan siklus terapi. Penilaian kualitas hidup dilakukan secara multidimensional menggunakan instrumen EORTC QLQ (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire) C30 dan BR23. Analisis data dihitung menggunakan uji t independen dan regresi linier berganda. Hasil penelitian menunjukkan terdapat perbedaan kualitas hidup yang sangat signifikan antara skala fungsi QLQ-C30 baseline dengan terapi ke-5, skala gejala QLQ-C30 baseline dengan terapi ke-5, skala fungsi QLQ-BR23 baseline dengan terapi ke-1, 2, 3, 4, dan 5, skala gejala QLQ-BR23 baseline dengan terapi ke-4, kemudian perbedaan signifikan antara skala gejala QLQ-BR23 baseline denganterapi ke-1, 3, dan 5. Dimensi yang berpengaruh signifikan terhadap kualitas hidup adalah fungsi sosial, mual dan muntah, gangguan pernapasan, gangguan tidur, dan kesulitan keuangan.Kata kunci: BR23, EORTC QLQ C30, kanker payudara, kualitas hidupQuality of Life Patients with Breast Cancer Therapy Combination Fluorouracil, Doxorubicin, and CyclofosfamideTreatment of breast cancer with combination chemotherapy Florouracil, doxorubicin, and Cyclofosfamide (FAC) lead to differences in the quality of life of patients is important to know because it can support the effectiveness of patient treatment. The aim of the study was to measure the difference and know the dimensions that affect the quality of life of breast cancer patients from each cycle of chemotherapy in Hasan Sadikin Hospital. This research is an observational analytic cross sectional approach. A sample of 200 breast cancer patients who were selected purposively and separated based on cycles of therapy. Assessment of quality of life of patients is done using a multidimensional instrument EORTC QLQ (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire) C30 and BR23. Data analysis was calculated using independent t test and linear regression. The results showed that there are differences in quality of life is very significant between QLQ-C30 functioning scale baseline with treatment 5, the QLQ-C30 symptom scale baseline therapy 5th, QLQ-BR23 function scale baseline with therapy 1st, 2nd, 3rd, 4th, and 5th, QLQ-BR23 symptoms scale baseline with therapy 4th, then a significant difference between scale symptoms of QLQ-BR23 baseline therapy with the 1st, 3rd, and 5th. Dimensions have a significant effect on quality of life is a social function, nausea and vomiting, dyspnea, sleep disorders and financial difficulties.Key words: BR23, breast cancer, EORTC QLQ C30, quality of life

Pengaruh Pelayanan Informasi Obat terhadap Keberhasilan Terapi Pasien Diabetes Melitus Tipe 2 Insani, Widya N.; Lestari, Keri; Abdulah, Rizky; Ghassani, Salma K.
Indonesian Journal of Clinical Pharmacy Vol 2, No 4 (2013)
Publisher : Indonesian Journal of Clinical Pharmacy

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pemahaman mengenai instruksi pengobatan merupakan permasalahan utama dalam pengobatan DMT2. Ketidakpatuhan pasien terhadap regimen obat hipoglikemik oral yang kompleks serta ketidaktepatan dalam cara dan waktu pengonsumsiannya merupakan barrier tercapainya keberhasilan terapi DMT2. Hal ini sangat berkaitan dengan kualitas pelayanan kefarmasian yang diberikan kepada pasien, khususnya pelayanan informasi obat. Penelitian ini bertujuan untuk mengevaluasi pengaruh intervensi pelayanan informasi obat terhadap parameter keberhasilan terapi diabetes yaitu glukosa 2 jam postprandial, HDL dan trigliserida. Penelitian ini merupakan nonrandomized concurrent control trial secara prospektif. 14 subjek uji direkrut selama 4 bulan selama MeiâAgustus 2013 kemudian dibagi menjadi dua grup. Kedua grup mendapat terapi pengobatan diabetes berupa hipoglikemik oral. Grup intervensi mendapatkan pelayanan informasi obat dan edukasi mengenai diabetes, sedangkan grup kontrol tidak mendapatkannya. Data dianalisis menggunakan uji t independen dengan Î± 0,05. Walau belum berbeda signifikan, nilai keberhasilan terapi dengan intervensi pelayanan informasi obat pada parameter glukosa 2 jam postprandial, HDL dan trigliserida memberikan hasil yang lebih tinggi 17,01%; 6,73%; dan 6,31% untuk masing-masing parameter dibandingkan terapi tanpa pelayanan kefarmasian tersebut.Kata kunci: Pelayanan informasi obat, diabetes, obat hipoglikemik oralÂ Effect of Pharmaceutical Information Care on Clinical Outcomes of Patients With Type 2 Diabetes MellitusPoor adherence to medication and lack of understanding about medication instructions are the main problems in the treatment of type 2 diabetes mellitus. Poor adherence to oral hypoglicemic drugs which have complex regiment and unappropriate consumption of them are the obstacles to reach good clinical outcomes. These problems are highly related to the quality of pharmaceutical care given to patients. The aim of this study was to evaluate the effect of pharmaceutical information care towards the outcome of type 2 diabetes mellitus including 2 hours postprandial glucose, HDL and tryglicerides. This study used nonrandomized concurrent control trial prospectively. 14 subjects were recruited during 4 months from MayâAugust 2013 and were divided into two groups. Both of group were given oral hypoglycemic drugs. The intervention group received pharmaceutical information care and diabetes education, whilecontrol group did not receive these. Data were then analysed with independent t test using Î± 0,005. Although the difference were not significant yet, pharmaceutical information care intervention on diabetes treatment gave higher improvement by 17,01%; 6,73%; and 6,31% respectively in 2 hours postprandial glucose, HDL and tryglicerides parameters, compared with the treatment without pharmaceutical care.Key words: Pharmaceutical information care, diabetes, oral hypoglicemic drugs

Profil Penggunaan Antituberkulosis di Apotek di Kota Bandung Periode 2008â2010 Alfian, Sofa D.; Tarigan, Eva S.; Puspitasari, Irma M.; Abdulah, Rizky
Indonesian Journal of Clinical Pharmacy Vol 1, No 4 (2012)
Publisher : Indonesian Journal of Clinical Pharmacy

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Penyakit infeksi masih merupakan penyakit utama yang paling banyak terjadi di negara berkembang seperti Indonesia. Salah satu tempat pelayanan kesehatan yang banyak mendistribusikan antibiotik adalah apotek. Oleh karena itu, studi penggunaan antibiotik di apotek sebagai salah satu komunitas farmasi sangat diperlukan. Tujuan penelitian ini adalah untuk mengetahui profil penggunaan antibiotik antituberkulosis di Apotek di Kota Bandung tahun 2008â2010. Penelitian ini merupakan penelitian observasional dengan pengambilan data secara retrospektif. Penelitian ini dilakukan dengan menggunakan metode Anatomical Therapeutic Chemical/ Defined Daily Dose (ATC/DDD) dan Drug Utilization 90% (DU90%). Hasil penelitian menunjukkan bahwa total penggunaan antibiotik untuk terapi tuberkulosis mengalami penurunan. Nilai DDD/1000 KPRJ tahun 2008, 2009, dan 2010 berturut-turut sebesar 1559,026; 1484,936; dan 1048,111. Selama periode 2008â2010, tingkat penurunan pada tahun 2009 tidak terlalu signifikan, yaitu sebesar 17.783 DDD/1000 Kunjungan Pasien Rawat Jalan (KPRJ), tetapi pada tahun 2010 penurunannya sangat signifikan sebesar 169.416 DDD/1000 KPRJ. Penelitian menyimpulkan bahwa total penggunaan antibiotik antituberkulosis di Apotek di Kota Bandung periode 2008â2010 cenderung mengalami penurunan.Kata kunci: Antibiotik, farmasi, ATC/DDD (Anatomical Therapeutic Chemical/Defined Daily Dose), Drug Utilization 90% (DU90%), infeksiProfile of Antituberculosis Use in Community Pharmacistof Bandung City 2008â2010AbstractInfectious disease is still a major disease in developing countries such as in Indonesia. As one of the healthcare providers which has privilege to distribute antibiotics, it is very important to control the use of antibiotics in pharmacy. The aim of this study is to conduct a profile of anti-tuberculosis use, in all pharmacies in Bandung during the period from 2008â2010. This study was performed using an observational method and retrospective approach. In this study we applied the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) and Drug Utilization 90 % (DU90%) method. The result showed that the use of anti-tuberculosis tends to decrease. During the period from 2008 to 2010, the use of antituberculosis decreased by 17,783 and 169,416 DDD/1000 inhabitants in 2009 and 2010, respectively. It can be concluded that the totaluse of anti-tuberculosis in all pharmacies in Bandung during the period from 2008 to 2010 tends to decrease.Key words: Antibiotic, pharmacy, ATC/DDD (Anatomical Therapeutic Chemical/Defined DailyDose), Drug Utilization 90% (DU90%), infection

Analisis Minimalisasi Biaya Antibiotik Pasien Sepsis Salah Satu Rumah Sakit Kota Bandung Purwanti, Okky S.; Sinuraya, Rano K.; Pradipta, Ivan S.; Abdulah, Rizky
Indonesian Journal of Clinical Pharmacy Vol 2, No 1 (2013)
Publisher : Indonesian Journal of Clinical Pharmacy

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Terapi antibiotik empirik merupakan salah satu komponen penunjang keberhasilan terapi sepsis, khususnya sepsis sumber infeksi pernapasan. Ketidaktepatan pemilihan terapi antibiotik empirik akan menimbulkan dampak buruk berupa munculnya resistensi bakteri terhadap antibiotik, perawatan pasien menjadi lebih lama, kematian, biaya pengobatan menjadi lebih mahal dan bagi rumah sakit akan menurunkan kualitas pelayanan rumah sakit bersangkutan. Tujuan penelitian ini adalah untuk mengetahui kelompok kombinasi antibiotik empirik yang paling efisien secara biaya yang digunakan pada pasien sepsis sumber infeksi pernapasan yang dirawat di salah satu rumah sakit di Kota Bandung periode tahun 2010â2012. Penelitian ini merupakan studi observasional analisis dengan pengumpulan data secara retrospektif. Data diambil dari rekam medis pasien rawat inap sepsis sumber infeksi pernapasan dan mendapat terapi antibiotik empirik seftazidim-levofloksasin atau sefotaksim-eritromisin. Komponen biaya yang dikumpulkan meliputi biaya antibiotik empirik, biaya tindakan, biaya penunjang, biaya rawat inap, dan biaya administrasi. Hasil penelitian menunjukkan bahwa total biaya perawatan kombinasi antibiotik seftazidim-levofloksasin sebesar Rp 12.751.082,49 dan kombinasi sefotaksim-eritromisin sebesar Rp 21.641.678,02. Berdasarkan hasil penelitian dapat disimpulkan bahwa kombinasi antibiotik seftazidim-levofloksasin lebih efisien dibanding kombinasi sefotaksim-eritromisin.Kata kunci: Antibiotik empirik, infeksi pernapasan, minimalisasi biaya, farmakoekonomi, sepsisÂ Cost Minimization Analysis of Antibiotic Used by Sepsis Patients at a Hospital in Bandung Empirical therapy is one of the important supporting therapies for successful sepsis management including, sepsis with respiratory infection. Inappropiate empirical antibiotic therapy leads to resistance of antibiotics which results increases length of stay, mortality and subsequently higher the cost of healthcare and decreases the quality of hospitalâs service. This studyâs objective was to determine which the antibiotic combination group used for the treatment of sepsis with respiratory infection is the most efficient in cost minimization at a hospital in Bandung. Observational analitycal study is conducted by retrospective data. Data were collected from medical record of inpatients sepsis with respiratory infection who received empirical antibiotic therapy of ceftazidime-levofloxacin or cefotaxime-erythromycin. Direct medical cost were calculated from empirical antibiotic costs, costs of medical treatment, medical expenses, hospitalization costs, and administrative costs. The results showed that total cost of the combination of ceftazidime-levofloxacin is 12,751,082,49 IDR and cefotaxime-erythromycin is 21,641,678,02 IDR. It can be conclude that the combination of ceftazidime-levofloxacin is more efficientthan cefotaxime-erythromycin.Key words: Empirical antibiotics, respiratory infection, cost minimization, pharmacoeconomy, sepsis

Hepatotoxicity Effects of Alcohol Consumption during Paracetamol Therapy of Malaria Patients Dinge, Fonny; Alfian, Sofa D.; Abdulah, Rizky; Sumiwi, Sri A.
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

The risk of paracetamol induced hepatotoxicity could increase with alcohol consumption.Paracetamol was usually given to tropical malaria patients to treat fever. The aim of this studywas to determine the hepatotoxicity effect of alcohol consumption in malaria tropica patientsreceiving paracetamol. This study was a cross-sectional study which was conducted duringApril-June 2015 at a hospital in Jayapura, Indonesia. The data were obtained from questionnairesand medical records. Alcohol status was determined by Short Michigan Alcoholics ScreeningTest (SMAST) questionnaire. Level of ALT, AST and bilirubin were observed before and afterreceiving paracetamol therapy for 5 days. Based on the results, the ALT and bilirubin levels ofalcoholic group were higher than in non-alcoholic. However, chi-square test showed that alcoholstatus did not have a significant influence in ALT, AST, and bilirubin levels. Otherwise,logistic regression analysis showed that age gave a significant effect on AST level (P=0.067).Keywords: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alcohol,malaria

Co-Authors . Supriyatna, . Ace Tatang Hidayat Agustini, Dewi D. Ahmad Faried Aisha K. Nur Ajeng Diantini, Ajeng Akhmad Priyadi Ami A. Pratiwi Anas Surbanas Andreas Ciokan Angga Prawira Kautsar Arifah, Gina Asep Supriadin Barliana, Melisa I. Barliana, Melisa I. Carissa P. Purabaya Cherry Rahayu Cherry Rahayu Cherry Rahayu Cinthya, Sindy E. Ciokan, Andreas Desi Harneti Putri Huspa Destiani, Dika P. Desyandri Desyandri Devinna Kang Dewi D. Agustini DIANTINI, AJENG - Dika P. Destiani Dinge, Fonny Dyah A. Perwitasari Eka W. Suradji Eli Halimah Eli Halimah, Eli Eli Mirdayani Emma Surahman Emma Surahman, Emma Eni Indrawati Ernestine Arianditha Pranasti Eva S. Tarigan Fajar, Mohamad Febriyanti, Maya Febriyanti, Maya Finisanti, Ratih Fonny Dinge Fonny Dinge Furqani, Winda H. Ghassani, Salma K. Gina Arifah Haafizah Dania Hanny Hafiar Hasriana Hasriana Hasriana Hasriana, Hasriana Hasrianna Hasrianna Hasrianna, Hasrianna Henry Ng Hersa Milawati Hersa Milawati Hilmi, Indah L. Hiroshi Koyama Imam A. Wicaksono Imaniar N. Faridah Imas Maesaroh Indah L. Hilmi Indah Laily Hilmi Indrawati, Eni Insani, Widya N. Intan Barliana, Melisa Irma M. Puspitasari Irma M. Puspitasari Irma M. Puspitasari, Irma M. Ivan S. Pradipta Ivan S. Pradipta Kang, Devinna Katherine A.Tjenggal Keri Lestari Khairinnisa, Miski A. Khansa F. Rahmah Kumamba, Raine D. Kusuma, Sri A. F. Leri Septiani Marline Abdassah, Marline Maya Febriyanti Meilani Jayanti Melisa I. Barliana Melisa I. Barliana Melisa I. Barliana Melisa I. Barliana Melisa Intan Barliana Melisa Intan Barliana, Melisa Intan Milawati, Hersa Miski A. Khairinnisa Mohamad Fajar Mohamad Fajar Mohamad Nurul Azmi Mohamad Nurul Azmi bin Mohamad Taib Muhaimin Muhaimin Muhammad Rivai Mutakin Mutakin Nabilah Nadhif Nabilah Nadhif Ng, Henry Norisca A. Putri Nunung Kurniasih Nunung Kurniasih Nunung Kurniasih, Nunung Nurul Annisa Nurul Annisa NURUL ANNISA Okky S. Purwanti Pradipta, Ivan S. Pratiwi, Ami A. Priyadi, Akhmad Purabaya, Carissa P. Purwanti, Okky S. Rahayu, Cherry Raine D. Kumamba Rano K. Sinuraya Rano K. Sinuraya Rano K. Sinuraya RANO KURNIA SINURAYA Ratih Finisanti Rika Yulianti, Rika Riska F Siregar Salma K. Ghassani SILVIA PERMATA SARI Sindy E. Cinthya Sinuraya, Rano K. Siregar, Riska F Sitepu, Annisa Ayu Ningtyas Carolina Siti Saidah Siti Saidah Sofa D. Alfian Sofa D. Alfian Sofa D. Alfian Sofa D. Alfian, Sofa D. Sofa Dewi Alfian Sri A. F. Kusuma Sri A. Sumiwi Sri M. Wahyuningrum Sumiwi, Sri A. Sunu Widianto Sunu Widianto Supriyatna Supriyatna Surachman, Emma Surachman, Emma Suradji, Eka W. Tarigan, Eva S. TIANA MILANDA Tina Rostinawati Unang Supratman Wahyuningrum, Sri M. Widianto, Sunu Widya N. Insani Winda H. Furqani Yudi Mulyana Hidayat Zulfan Zazuli

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