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FORMULATION AND ANTIOXIDANT ACTIVITY EMULGEL SENGGANI LEAF (Melastoma malabathricum L.) WATER FRACTIONS WITH VARIATIONS OF GELLING AGENT USING DPPH METHOD Sultan, Andi Rizka Walyanda; Ropiqa, Meri; Apridamayanti, Pratiwi; Anastasia, Desy Siska
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1289

Abstract

The senggani plant is reported to have antioxidant activity owing to its flavonoid content, which is a free radical scavenger. The water fraction of senggani leaves needs to be prepared for use, one of which is the emulgel. An important additional ingredient in emulgels is the gelling agent, and the most commonly used is carbopol 940. This study aimed to determine the formulation of emulgel preparations with the most stable variation in carbopol 940 and to test the antioxidant activity of water fraction emulgel preparations from senggani leaves (Melastoma malabatricum L.). The preparations were made by varying the concentrations of Carbopol 940 to 0.5% (F1), 1.25% (F2), and 2% (F3). Physical stability evaluations included organoleptic, homogeneity, pH, spreadability, adhesive power, viscosity, and antioxidant tests for 28 days. The results of the research showed that the emulgel that tested the physical stability of emulgel preparations with each concentration produced the best emulgel, F3 with an emulgel concentration of 2%, with a pH of 5.32-5.19, spreadability of 4.47-5.53 cm, adhesive power of 31. 21 -25.64 seconds, and viscosity of 47520-34853 cP. The IC50 value of the emulgel preparation is 17870.83-14851.28 ppm, with statistical test results of sig. (p-value) > 0.05, which means that storage has no effect on the emulgel preparation. The conclusion of this research is the best concentration of Carbopol as gelling agent of emulgel is 2% with the antioxidant activity is very weak Keywords:  emulgel; senggani leaf water fraction; carbopol 940; IC­50
Penyuluhan dan Pendampingan Pembuatan Jamu Serbuk Instan Imunostimulan di Desa Tebang Kacang IH, Hariyanto; Isnindar, Isnindar; Nurbaeti, Siti Nani; Luliana, Sri; Yuswar, Muhammad Akib; Kurniawan, Hadi; Ropiqa, Meri
Jurnal Pengabdi Vol 7, No 2 (2024): Oktober 2024
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/jplp2km.v7i2.72379

Abstract

Abstrak: Masyarakat indonesia telah lama menggunakan tanaman obat keluarga (TOGA) sebagai upaya pencegahan timbulnya penyakit dan menjaga kesehatannya. Salah satunya adalah meniran (Phillanthus niruri L.) dan jahe (Zingiber Officinale) dimana kombinasi tanaman tersebut telah terbukti dapat meningkatkan daya tahan tubuh. Namun dalam pegolahannya masih dalam bentuk yang sederhana, oleh karena itu diperlukan edukasi dan pendampingan pemanfaatan TOGA menjadi bentuk yang lebih praktis, mudah dan memiliki nilai ekonomi yang tinggi seperti serbuk instan. Oleh karena itu tujuan dari kegiatan pengabdian masyarakat ini adalah memberikan edukasi dan pendampingan pembuatan meniran dan jahe menjadi serbuk instan sebagai imunostimulan di desa tebang kacang. Sasaran dari kegiatan PKM ini adalah ibu-ibu kader PKK yang ada di Desa Tebang Kacang. Metode dari PKM ini adalah penyuluhan dan workshop dengan tahapan kegiatan yaitu persiapan kegiatan, pelaksanaan kegiatan (penyuluhan dan workshop atau pendampingan pembuatan jamu serbuk instan), serta evaluasi kegiatan. Hasil kegiatan menunjukkan  adanya peningkatan pengetahuan peserta yang ditunjukkan dari nilai post-test rata-rata peserta, yaitu 65, jika dibandingkan terhadap nilai rata-rata pre-test, yaitu sebesar 53,33. Evaluasi kepuasan peserta dari kuesioner juga menunjukkan bahwa, materi yang disampaikan mudah dipahami, bermanfaat, menambah keterampilan, produk yang dihasilkan memiliki rasa yang enak dan dapat meningkatkan perekonomian desa.  Kata Kunci:  Serbuk Instan, Imunostimulan , Meniran, Jahe dan Desa Tebang Kacang  Abstract: Indonesians have long used family medicinal plants (TOGA) to prevent disease and maintain health. A few of them are meniran (Phillanthus niruri L.) and ginger (Zingiber Officinale). Their combination has been proven to increase the body's immune system. However, their processing was still in a simple form; therefore, education and assistance are needed to use TOGA in a more practical, easier, and highly economical value, such as instant powder. Therefore, this community service activity aims to educate and assist in making meniran and ginger into instant powder as an immunostimulant in the Tebang Kacang village. The targets of this program are PKK cadre mothers in Tebang Kacang Village. The method of this PKM is counseling and workshops with activity stages, namely preparation of activities, implementation of activities (counseling and workshops or assistance in making instant powdered herbal medicine), and evaluation of activities. The activity results showed an increase in participants' knowledge as indicated by the participants' average post-test score, which was 65%, compared to the average pre-test score, which was 53.33.% Evaluation of participant satisfaction from the questionnaire also shows that the material presented is easy to understand, valuable, increases skills, the product produced has a good taste, and can improve the village economy.  Keywords: Instant Powder, Immunostimulant, Meniran, Ginger and Tebang Kacang Village.  
Edukasi Imunisasi Dasar Lengkap pada Anak bagi Anggota PKK Wajok Hilir Kecamatan Jongkat Kabupaten Mempawah: Basic Immunization Education in Children for PKK Members at Wajok Hilir, Jongkat District, Mempawah Regency Ropiqa, Meri; Wahdaningsih, Sri; Nurbaeti, Siti Nani; Rizkifani, Shoma; Agustriangga, Muhammad Rafly; Indriyani, Risa
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 3 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i3.6426

Abstract

Immunization is a safe and effective method to protect a person from dangerous diseases before exposure to disease-causing agents. Immunization for children is essential to strengthen the body's defense system so it's immune to disease attacks. Community Service Activities (PKM) aim to equip the Wajok Hilir cadres or PKK mothers with information, education, and skills regarding complete basic immunization information for children. This PKM activity consists of several activities, including designing educational methods, creating complete basic immunization educational media, administering pretest and posttest, and evaluating the level of understanding. The results show that there has been an increase in the understanding of cadres or PKK mothers with the indicator that the average pretest score is 39.58 and the average posttest score is 65.72. The conclusion, there has been an increase in the understanding of the Wajok Hilir cadres or PKK mothers.
FORMULASI SABUN TRANSPARAN BERBASIS MINYAK KELAPA MURNI (VCO) Ropiqa, Meri; Azmi, Khulul; Septina, Diani Ria
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p89-93

Abstract

VCO has been widely used as a base of soap formulation. It was used due to its high fatty acid contain resists to oxidation causing stinky smell. The highest abundant of fatty acid in VCO was reported as lauric acid (52%). Lauric acid was known contribute to moisturize the skin. Hence widely used as a base of soap manufacture. The type of soap formulate in this study was the transparent soap due its appealing appearance. To find the best formulation of transparent soap according to SNI. Methods: transparent soap was formulated using hot process technique with two different concentrations of VCO which were 20% and 30%. The obtained soaps were then tested using SNI criteria such as organoleptic, pH, foam stability, and fatty acid. According to T-test, it was resulted p value>0,05 showing those two formulation did not have significance differentiation on pH test and foam stability test. The fatty acid concentration test of those two formulation showed different result significantly but it was still fulfilling the SNI requirement (≤ 2,5%). The formulas obtained of transparent soap using VCO as the base was known fulfill the quality standard of SNI.
Uji Antioksidan dan Toksisitas Ekstrak Batang Polygonum Minus Huds Ginjal Tikus Wistar Sukandiarsyah, Fadli; Ropiqa, Meri; Riska, Bella
ARTERI : Jurnal Ilmu Kesehatan Vol 6 No 2 (2025): Februari
Publisher : Puslitbang Sinergis Asa Professional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/arteri.v6i2.500

Abstract

Kesum plants have demonstrated robust antioxidant activity and possess the potential to function as antiviral, antibacterial, antifungal, anticancer, and antiulcer agents. Further research is necessary to investigate the activity and toxicity of kesum stem preparations. The objective of this study is twofold: first, to ascertain the antioxidant activity of an ethanol extract of kesum stem; and second, to determine the level of acute toxicity in the kidneys of Wistar rats. The extraction process was conducted using the maceration method, employing 70% ethanol as the solvent. The antioxidant activity test demonstrated that the ethanol extract of kesum stem exhibited an IC50 value of 72.03 ppm, thereby classifying it as a strong antioxidant. The acute toxicity test demonstrated that the ethanol extract of kesum stem (Phyllanthus emblica) at doses of 500 mg/kg, 1000 mg/kg, and 2000 mg/kg did not induce toxic effects on the kidneys. This finding was substantiated by the observation that the levels of ureum and creatinine remained within the normal range. The findings of this study, derived from statistical analysis employing the analysis of variance (ANOVA) method, indicated a p-value of 0.632 (p > 0.05) for serum urea examination and 0.06 (p > 0.05) for serum creatinine examination. These findings suggest that there is no statistically significant difference between the treatment groups. The safety of all three doses has been demonstrated by the absence of toxicity effects on rat kidney organs.
Edukasi pemanfaatan tanaman obat tradisional dalam rangka self-medication Rizkifani, Shoma; Wahdaningsih, Sri; Najini, Robby; Ropiqa, Meri; Putri, Alifa Rapaella Fadia Tito; Fahmi, Ayu Aulia Uly; Chang, Samuel Crishanzen
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 9, No 1 (2025): January
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v9i1.28929

Abstract

AbstrakSelf-medication atau pengobatan mandiri merupakan praktik umum di kalangan pelajar, namun pemanfaatan obat tradisional masih terbatas akibat kurangnya edukasi terkait manfaat dan penggunaannya. Indonesia memiliki kekayaan biodiversitas dan pengetahuan tradisional yang melimpah, yang berpotensi besar untuk dikembangkan sebagai sumber obat tradisional. Meskipun regulasi terkait obat tradisional di Indonesia sudah baik, diperlukan penelitian lebih lanjut untuk memastikan efektivitas dan keamanan penggunaannya dalam pengobatan mandiri. Penelitian ini bertujuan untuk meningkatkan pengetahuan siswa SMK Kesehatan mengenai manfaat, jenis, dan penggunaan tanaman obat tradisional dalam praktik self-medication. Metode yang digunakan meliputi pre-test, edukasi melalui presentasi, video, flyer, diskusi, dan post-test untuk mengukur peningkatan pemahaman siswa. Hasil pre-test menunjukkan distribusi nilai dengan skor tertinggi 90 dan terendah 50, sedangkan hasil post-test menunjukkan peningkatan signifikan dengan skor tertinggi mencapai 100. Rata-rata skor pre-test adalah 70,4 dan rata-rata skor post-test meningkat menjadi 96,8; mencerminkan peningkatan pengetahuan sebesar 27,4%. Evaluasi kegiatan menunjukkan kepuasan tinggi dari peserta terkait metode penyampaian dan relevansi materi. Hasil menunjukkan bahwa edukasi tentang tanaman obat tradisional efektif dalam meningkatkan pengetahuan siswa dan diharapkan dapat mendorong praktik self-medication yang bijak dan bertanggung jawab di kalangan siswa SMK Kesehatan. Kata kunci: pengobatan mandiri; obat tradisional; edukasi; pelajar; SMK AbstractSelf-medication is a common practice among students, but the utilization of traditional medicine is still limited due to lack of education regarding its benefits and uses. Indonesia has an abundance of biodiversity and traditional knowledge, which has great potential to be developed as a source of traditional medicine. Although regulations related to traditional medicine in Indonesia are good, further research is needed to ensure the effectiveness and safety of its use in self-medication. This study aims to improve the knowledge of vocational health students regarding the benefits, types, and uses of traditional medicinal plants in self-medication practices. The methods used include pre-test, education through presentations, videos, flyers, discussions, and post-test to measure the improvement of students' understanding. The pre-test results showed a distribution of values with the highest score of 90 and the lowest score of 50, while the post-test results showed significant improvement with the highest score reaching 100. The average pre-test score was 70.4 and the average post-test score increased to 96.8, reflecting a 27.4% increase in knowledge. Evaluation of the activity showed high satisfaction from participants regarding the delivery method and relevance of the material. The results show that education about traditional medicinal plants is effective in improving students' knowledge and is expected to encourage wise and responsible self-medication practices among vocational health students. Keywords: self-medication; traditional medicine; education; students; vocational schools
Formulasi Mouthwash Kulit Jeruk Pontianak (Citrus nobilis Lour. Var. microcarpa) dan Uji Aktivitas terhadap Bakteri Streptococcus mutans Ropiqa, Meri; Kurniawan, Hadi; Mayesa, Sabila
Sinteza Vol. 5 No. 2 (2025): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i2.31603

Abstract

Preserving dental and oral hygiene is essential to maintain the overall function of the oral cavity. Essential oil extracted from Pontianak orange peel shows potential as a safe and effective component for oral healthcare when incorporated into a mouthwash formulation. This research was conducted to evaluate the potential of Pontianak orange peel essential oil as an antibacterial mouthwash effective against Streptococcus mutans. The study was conducted by formulating mouthwash preparations using different concentrations of Pontianak orange peel essential oil: 3%, 4%, and 5%, followed by evaluation of physical properties including organoleptic characteristics, homogenity, pH level, sedimentation, specific gravity, and viscosity. The antibacterial properties were tested using  the disc diffusion method.The physical evaluation results showed that the mouthwash had a sweet taste, green color, a citrus peel aroma with a hint of mint; it was homogeneous, with no sedimentation; had a pH value ranging from 5.13 ± 0.02 to 5.25 ± 0.02; specific gravity ranging from 0.9968 ± 0.06 to 1.0424 ± 0.00 g/ml; and viscosity ranging from 1.717 ± 0.02 to 1.920 ± 0.01mPa.s. All formulations met the physical property requirements of a good mouthwash to ensure comfort during use. The largest inhibition zone was observed at the highest essential oil concentration (5%), with a diameter of 8.04 ± 1.05 mm, which falls under the category of moderate antibacterial activity. This study indicates that a mouthwash containing 5% Pontianak orange peel essential oil is effective in inhibiting the growth of Streptococcus mutans.
OPTIMIZATION TYPE OF STIFFENING AGENT IN FORMULATION CREAM Melastoma malabathricum L. LEAF WATER FRACTION Hasya Nadhira, Raden; Siska Anastasia, Desy; Apridamayanti, Pratiwi; Ropiqa, Meri
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 3 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i3.1607

Abstract

The skin is one of the visible outer parts of the body, and cosmetics are used for its care. Senggani (Melastoma malabathricum) leaves contain flavonoids, saponins, alkaloids, tannins, and polyphenols. The polyphenol content found in M. malabathricum leaves has high antioxidant activity and has the potential to be used as a sunscreen that can block the negative effects of UVA and UVB rays. These secondary metabolites can be obtained from the water fraction and used as antioxidants in cream preparations. Cream formulations require compounds that can maintain the consistency of the preparation to produce good physical properties and stability. This study aimed to analyze the type of stiffening agent in the formulation of cream preparation of aqueous fraction of senggani leaf (Melastoma malabathricum L.) using organoleptical tests, homogeneity, pH, spreadability, adhesiveness, and viscosity of cream preparation. The results showed that cetyl alcohol (FII) has different physical properties, and the evaluation and accelerated stability test (cycling test) resulted in the most physically stable preparation, as evidenced by the sig. (p value) > 0.05, indicating that storage did not affect the cream preparation.  Keywords: senggani leaf (Melastoma malabathricum L.), water fraction, cream, cycling test
KKN Tematik: Membangun Kesadaran Pencegahan dan Pengendalian Penyakit Demam Berdarah Dengue (DBD) di Desa Jeruju Besar: KKN Tematik: Building Awareness to The Prevention and Control of Dengue Hemorrhagic Fever (DHF) in Jeruju Besar Village Ropiqa, Meri; Wijianto, Bambang; Angellica, Grecya; Yanastya, Salsa Yoana; Putri, Alifa Rapaella Fadia Tito
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 7 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i7.6666

Abstract

Dengue hemorrhagic fever (DHF) is caused by the bite of the female Aedes aegypti mosquito. Dengue hemorrhagic fever cases that occurred in Kubu Raya have reached 1,061 cases with 4 deaths, as of November 22 2023. The importance of preventing and controlling dengue fever needs to be done to reduce the increasing number of dengue fever cases that occur so that this problem is raised as KKN theme in Jeruju Besar Village. The KKN implementation was carried out in Jeruju Besar Village with a program to prevent and control dengue hemorrhagic fever which included socialization, training in making larvicide and wall magazine, also providing larvicide products, posters and platelet-increasing food. The results of evaluation show that there was an influence of the socialization carried out on increasing knowledge and understanding regarding dengue prevention and control among village residents from an average value of 59.24 to 87.83 and among elementary school students from an average value of 55.09 to 82 .61 which is supported by the Paired Sample T Test. The result of questionnaires also showed a good level of satisfaction from residents, where 82.61% felt that the were useful. Overall, the program implemented went well according to plan and received a very good response so that it was able to increase understanding and knowledge, also increase awareness in preventing and controlling the spread of dengue hemorrhagic fever among the residents of Jeruju Besar Village.
EDUKASI KEAMANAN DALAM PENGGUNAAN OBAT SIRUP BAGI KADER PUSKESMAS ALIANYANG DI KOTA PONTIANAK Rizkifani, Shoma; Nurbaeti, Siti Nani; Wahdaningsih, Sri; Ropiqa, Meri; Indriyani, Risa; Agustriangga, Muhammad Rafly
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 7, No 4 (2023): December
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v7i4.19282

Abstract

ABSTRAKCemaran etilen glikol pada obat sirup disinyalir sebagai salah satu penyebab gangguan ginjal akut yang berujung kematian pada anak. Gangguan ginjal akut progresif atipikal (Atypical Progressive Acute Kidney) merupakan gangguan yang gempar dibicarakan sebab menewaskan seratus lebih anak di Indonesia. Gangguan ginjal akut yang menyebabkan kematian tersebut diduga kuat terjadi karena adanya kandungan senyawa ethyleme glycol (EG), diethylene glycol (DEG) dan ethylene glycol butyl ether (EGBE) pada obat sirup. BPOM mengimbau masyarakat untuk lebih waspada, menjadi konsumen cerdas, dan memperoleh obat melalui sarana resmi, yaitu di apotek, toko obat berizin, puskesmas atau rumah sakit terdekat. Masalah tersebut tidak saja dipandang sebagai masalah kesehatan, tetapi telah menjadi tanggung jawab bersama diantaranya dari institusi pendidikan seperti Fakultas Kedokteran. Kegiatan Pengabdian Kepada Masyarakat (PKM) bertujuan untuk membekali kader Puskesmas Alianyang dengan informasi, edukasi dan keterampilan terkait informasi penggunaan obat sirup yang aman. Dalam pelaksanaan kegiatan PKM ini terdiri dari beberapa kegiatan diantaranya adalah perancangan metode edukasi, pembuatan media edukasi penggunaan obat sirup yang aman, dan pemberian pre-test, post-tes. Hasil menunjukkan terjadi peningkatan pemahaman kader dengan indikator nilai rata-rata pre-test adalah 56,67 dan nilai rata-rata post-test adalah 58,75. Kesimpulannya trerjadi peningkatan pemahaman kader Puskesmas Alianyang Kata Kunci: sirup; edukasi; puskesmas; kemanan ABSTRACTEthylene glycol contamination in drug syrup is suspected as one of the causes of acute kidney failure which leads to death in children. Atypical Progressive Acute Kidney Disorder (Atypical Progressive Acute Kidney) is a disorder that is being talked about because it kills more than one hundred children in Indonesia. The acute kidney disorder that caused the death is strongly suspected to have occurred because of the compounds ethylene glycol (EG), diethylene glycol (DEG) and ethylene glycol butyl ether (EGBE) in the syrup. BPOM urges the public to be more vigilant, to be smart consumers, and to obtain medicines through official means, namely at pharmacies, licensed drugstores, health centers or the nearest hospital. This problem is not only seen as a health problem, but has become a shared responsibility, including from educational institutions such as the Faculty of Medicine. Community Service Activities (PKM) aim to equip Alianyang Health Center cadres with information, education and skills related to information on the safe use of syrup drugs. In carrying out this PKM activity, it consists of several activities including designing educational methods, making educational media on the safe use of syrup drugs, and administering pre-test, post-test. The results showed an increase in understanding of cadres with an indicator of the average pre-test score of 56.67 and the average post-test score of 58.75. In conclusion, there has been an increase in the understanding of Alianyang Health Center cadres. Keywords: syrup; education; public health center