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All Journal Biotropika Wahana-Bio: Jurnal Biologi dan Pembelajarannya Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Konservasi Hayati BERNAS: Jurnal Pengabdian Kepada Masyarakat Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Medical Chemistry and Bioinformatics Maximus: Journal of Biological and Life Sciences Bioeksperimen Jurnal Bioteknologi & Biosains Indonesia (JBBI) Indonesian Journal of Jamu Jurnal Bioteknologi & Biosains Indonesia
Khaerunissa Anbar Istiadi
Program Studi Biologi, Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia 35365
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Molecular Insights into the Therapeutic Potential of Curcuma amada Rhizome: A Network Pharmacology and Docking Approach Fatriani, Rizka; Istiadi, Khaerunissa Anbar; Khairani, Iffa Afiqa
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.397

Abstract

The rhizome of Curcuma amada (ginger mango) has traditionally been used for various medicinal purposes. However, its molecular targets and mechanisms of action are still poorly understood. This study aimed to predict the potential bioactive compounds and target proteins of C. amada using network pharmacology and molecular docking approaches. A total of 110 compounds were identified, and their predicted targets were analyzed through a protein-protein interaction (PPI) network, enrichment, and disease analysis. Key targets include phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) and tyrosine-protein kinase JAK2 (JAK2), both of which are closely related to cancer-related pathways. Four compounds, β-eudesmol, (E,Z)-farnesol, spathulenol, and τ-muurolol, were selected for molecular docking studies. Validation of the docking protocol through re-docking showed low RMSD values ​​(0.667 Å for PIK3CA and 0.474 Å for JAK2), confirming the reliability of the method. The docking results demonstrated that the native ligands and selected compounds formed multiple hydrogen bonds and extensive hydrophobic interactions with key residues in the active site. Notably, most of the interactions were hydrophobic, which is consistent with the volatile nature of the ligands. The binding affinity was below –5 kcal/mol for all tested compounds. These findings suggest that C. amada rhizomes contain bioactive compounds capable of modulating cancer-related targets, thus providing a molecular basis for their potential therapeutic effects. 
PEMBUATAN BIOCHAR-SLOW-RELEASE-FERTILIZER DARI LIMBAH PELEPAH KELAPA SAWIT Satria, Arysca Wisnu; Ariyanto, Dika Ariyanto; Anisa, Hida Arliani Nur; Istiadi, Khaerunissa Anbar; Sari, Dian Anggria; Muhyi, Abdul; Alawiyah, Alawiyah
MAXIMUS: Journal of Biological and Life Sciences Vol. 1 No. 2 (2023)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/maximus.v1i2.1578

Abstract

Industri kelapa sawit dapat menyebabkan dampak yang buruk bagi lingkungan terkait dengan limbah cair dari industri pengolahan maupun limbah padat dari perkebunan. Limbah padat dari perkebunan kelapa sawit, seperti pelepah sawit, sesungguhnya dapat dimanfaatkan ulang menjadi biochar yang digunakan sebagai bahan pelapis slow-release-fertilizer. Penelitian ini bertujuan untuk mempelajari pengaruh variasi komposisi, bahan pelapis, dan bahan perekat terhadap daya lepas nitrogen pada biochar-slow-release-fertilizer, serta mempelajari kinetika pelepasannya. Variasi yang digunakan adalah rasio biochar/bentonite 20%:80% – 80%:20%, jenis perekatnya asap cair dan minyak jarak, dan jumlah pupuk urea 30% massa total. Hasil penelitian menunjukan bahwa hasil optimum yang diperoleh untuk bahan perekat asap cair dan minyak jarak adalah berturut-turut pada rasio biochar/bentonite 50%:50% dan 60%:40%. Sedangkan hasil uji pelindian mendapatkan bahwa kedua formula tersebut mampu mempertahankan pelepasan nitrogen total hingga 28 hari, dibanding 13 hari untuk formulasi yang tidak dimodifikasi. Uji kinetika pelepasan menggunakan model Korsmeyer-Peppas menunjukkan bahwa mekanisme pelepasan kedua sampel tersebut mengikuti difusi Fickian. Kata kunci : Biochar Pelepah Sawit, Pupuk Pelepasan Lambat, Asap Cair, Minyak Jarak, Model Pelepasan
INOVASI MEDIA TANAM ANGGREK DARI LIMBAH PELEPAH KELAPA SAWIT Satria, Arysca Wisnu; Siragih, Rajuman S; Amelia, Tiara; Nur Anisa, Hida Arliani; Istiadi, Khaerunissa Anbar; Sari, Dian Anggria; Alawiyah, Alawiyah
MAXIMUS: Journal of Biological and Life Sciences Vol. 1 No. 1 (2023)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/maximus.v1i1.1580

Abstract

Anggrek merupakan salah satu tanaman hias dengan keanekaragaman yang tinggi, khususnya di Pulau Sumatera. Permintaan serta nilai komersial anggrek menjadikan budidaya anggrek semakin berkembang. Media tanam yang umumnya digunakan merupakan cacahan tanaman pakis, namun status pakis yang hampir punah menjadikan tanaman pakis menjadi salah satu tanaman yang perlu dilindungi. Limbah pelepah sawit dengan kandungan unsur hara yang beragam merupakan salah satu bahan potensial dalam pengembangan media tanam. Penelitian bertujuan untuk mengembangkan alternatif media tanam anggrek dari limbah pelepah sawit terfortifikasi dan menganalisis kelayakan ekonominya. Cacahan limbah pelepah sawit difortifikasi dengan pupuk serta direkatkan menggunakan getah damar kemudian dicetak dalam bentuk pellet. Hasil penelitian terbaik ditunjukkan pada pelet dengan rasio sawit/pakis sebesar 60%:40% dimana komponen N-P-K yang terekstrak berturut-turut sebesar 6,0; 4,4; dan 4,2 ppm/g pelet. Hasil uji tekan juga menunjukkan bahwa penambahan 60% serbuk pelepah sawit mampu memberikan kekuatan tekan tertinggi pada media pelet sehingga mampu memberikan penahanan nutrisi dan air tertinggi. Sementara itu, hasil analisis ekonomi menujukkan bahwa pabrik pelet media tanam layak didirikan, yang ditunjukkan oleh nilai Internal Rate of Return 16,47%; Pay Back Period 2,26 tahun, Break Even Point 58,86%; Return On Investment 44,26%; dan Net Present Value Rp 1.236.691.035,00.
UTILIZATION OF PINEAPPLE PROCESSING LIQUID WASTE IN BIODEGRADATION OF DISPOSABLE FACE MASK BY BACTERIA FROM LAMPUNG BAY Deviany, Deviany; Zhofiroh, Nawrah Meisyah Muthi'ah; Febrina, Yane Fita; Yusuf, Reggina Aulia; Achmad, Feerzet; Yuniarti, Reni; Istiadi, Khaerunissa Anbar
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.8192

Abstract

The designation of COVID-19 as a global pandemic led to an increased use of single-use face masks, which result in waste that is difficult to degrade and has the potential to release microplastic fibers into the environment. This study aims to examine the im-pact of adding pineapple peel liquid waste (LCN) as a growth medium for the biodeg-radation of single-use face masks by bacterial isolates obtained from the waters of the Lampung Bay. The study investigates how LCN affects the efficiency of mask degra-dation by microorganisms, as well as how the ratio of LCN mixed with other growth media, such as Nutrient Broth (NB), influences the degradation process. The biodeg-radation process was carried out using a biostimulation technique, where bacterial iso-lates were incubated in media containing LCN at a 1:1 ratio. The degradation process lasted for 15 days, with the results being analyzed using gravimetry and Fourier-Transform Infrared Spectroscopy (FTIR). Gravimetric results showed a greater weight reduction in treated masks compared to the control masks. FTIR analysis also indicat-ed changes in the intensity of functional groups in the degraded layers of the masks, as well as the emergence of C≡C functional groups in the second and third layers. This study demonstrates that the addition of LCN can accelerate the biodegradation of sin-gle-use face masks, offering a new approach for managing mask waste.
Isolation and screening of halotolerant protease-producing bacteria from Lampung fermented shrimp paste Istiadi, Khaerunissa Anbar; Ningsih; Suryanti, Erma; Imaniar, Lisana Husna
Bioeksperimen: Jurnal Penelitian Biologi March 2026
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v12i1.14593

Abstract

Protease are class of degradative enzymes that hydrolyze proteins, breaking its peptide bond, into smaller peptides and amino acids. Microbial proteases have gained increasing attention due to its productivity and utilization in various industries. Proteolytic bacteria derived from fermented shrimp paste from Lampung have great potential to meet this need. However, studies on these bacteria are still limited, so further research is needed to explore and optimally utilize their potential. This study aims to explore the diversity of proteolytic bacteria from Lampung terasi.. The methods employed included isolation stages using Nutrient Agar supplemented with 5% and 10% NaCl (w/v), followed by proteolytic screening properties using Skim Milk Agar media. A total of 20 bacterial isolates were obtained from terasi using Nutrient Agar supplemented with 5% (w/v) NaCl, and 15 isolates were obtained from Nutrient Agar (NA)  supplemented with 10% (w/v) NaCl. Screening results showed that 85% and 67% of the isolates obtained from NA supplemented with 5% and 10% NaCl, respectively, exhibited proteolytic activity. Halotolerant bacterial isolates isolated using NA + 5% NaCl exhibited a proteolytic index ranging from 0.3 – 3.0, while those isolated with NA + 10% NaCl showed values ranging from 0.18 to 3.06. The screening results revealed that isolates BTCL5-07 and BTCL10-05 exhibited the highest proteolytic activity, with proteolytic indices of 3.0 and 3.06, respectively. These findings indicate that halotolerant bacteria from Lampung terasi represent a promising source of potential proteolytic enzymes. Further research is required to optimize enzyme production.
Integrated Metabolite Profiling and Network Pharmacology Reveal the Multitarget Therapeutic Potential of Curcuma amada Rhizome Fatriani, Rizka; Istiadi, Khaerunissa Anbar; Khairani, Iffa Afiqa; Anisa, Hida Arliani Nur
Biotropika: Journal of Tropical Biology Vol. 14 No. 1 (2026)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Curcuma amada Roxb. (mango ginger) is a medicinal plant traditionally known for its antioxidant, anti-inflammatory, and anticancer effects, however, the underlying molecular mechanisms are not fully understood. In this study, we combined metabolite profiling with in silico analysis (network pharmacology and molecular docking) to understand the bioactivity of C. amada. Gas chromatography-mass spectrometry (GC-MS) revealed a diverse metabolite composition with fifty-two compounds detected in the ethanol extract. Target prediction of the compounds was performed using SwissTargetPrediction, BindingDB, and ChEMBL. Hub genes were identified using Maximum Clique Centrality (MCC), which identified ESR1, PPARG, and NR3C1 as the main hub genes. Enrichment analysis showed a strong association with cancer-related pathways, particularly the PI3K–Akt signalling, endocrine resistance, and cell senescence pathways, as well as the biological processes regulating apoptosis, stress response, and intracellular signalling. Molecular docking studies of PPARG and ESR1 showed that the metabolites retinal, coronarin E, and 1H-cycloprop[e]azulene derivatives had stable binding affinities and interacted with residues in the ligand-binding domain (LBD) of the target proteins. Our findings suggest that C. amada exerts therapeutic effects through multiple mechanisms. Not a single molecule or pathway, but a coordinated network of metabolites acting on multiple targets. This integrative approach provides a scientific basis for the traditional use of C. amada and highlights its potential as a promising resource for drug discovery, particularly in the field of cancer therapy.
Co-Authors Aji Hafidz Talaga Alawiyah, Alawiyah Amelia, Tiara Andreas Dwi Nugroho Aniesti, Frigia Rafilia Anisa, Hida Arliani Nur Ariyanto, Dika Ariyanto Astuti, Ayu Widia Desi Budiono Deviany Deviany, Deviany Dewi Chusniasih DINA ANGGRAINI Dini Meilinda Dwi Anita Suryandari Erma Suryanti Fajri Arif Wibawa Fatimatuzzahra, Izza Fatriani, Rizka Febrina, Yane Fita Feerzet Achmad Ferdinanda, Thierry Garbono, Andrian Gres Maretta, Gres Hadi Sunaryo Handayani, Catie Hariyandi, Yopi Hida Arliani Nur Anisa Iffa Afiqa Khairani Imaniar, Lisana Husna Irandi Putra Pratomo Luluk Yunaini Muhyi, Abdul Mulyana, Jeane Siswitasari Ningsih Nur Anisa, Hida Arliani Puji Sari Reni Yuniarti Sari, Dian Anggria Satria, Arysca Wisnu Siragih, Rajuman S Suryanti, Erma Triya Yuli Andini Yuni Sukmawati Yusuf, Reggina Aulia Zhofiroh, Nawrah Meisyah Muthi'ah