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All Journal Jurnal Pendidikan Biologi Undiksha Wahana-Bio: Jurnal Biologi dan Pembelajarannya Jurnal Pembelajaran dan Biologi Nukleus Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Konservasi Hayati BERNAS: Jurnal Pengabdian Kepada Masyarakat Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Medical Chemistry and Bioinformatics Maximus: Journal of Biological and Life Sciences Jurnal Bioteknologi & Biosains Indonesia (JBBI) Indonesian Journal of Jamu Jurnal Bioteknologi & Biosains Indonesia
Khaerunissa Anbar Istiadi
Program Studi Biologi, Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia 35365
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Phytochemical Compound, Antioxidant and Antibacterial Properties of Sargassum sp. Extracts from Pahawang Island, Lampung Province Khairani, Iffa Afiqa; Istiadi, Khaerunissa Anbar; Restiawati, Nawang
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 1: Jurnal Pembelajaran Dan Biologi Nukleus March 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i1.6558

Abstract

Pahawang Island, located in Lampung Bay, has a variety of potential natural resources, one of which is macroalgae. One of the abundant brown macroalgae is Sargassum sp., with phytochemical components (flavonoids, steroids, tannins, and glycosides) that have potential as antioxidants, antibacterial, antitumor, anticancer, antifouling, and others. Sargassum sp. from Lampung waters, especially Pahawang Island still lacks scientific studies on its bioactive content and properties. This study aims to examine the phytochemical compounds (qualitatively and quantitatively), antioxidant activity (DPPH method) and antibacterial potential of Sargassum sp. extract (MIC/MBC method) against Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The results of phytochemical assay  showed that Sargassum sp. extract contained phenolic compounds, flavonoids, tannins, and saponins. Quantification results on total phenolic content were 0.56 mgGAE/g extract, total tannins were 4.27 mgTAE/g extract, total flavonoids were 14.19 mgQE/g extract, and total saponins were 5.54 %. Sargassum sp. extract classified as a very weak antioxidant with IC50 value of 964.10 ppm, and moderate antibacterial activity at a concentration of MIC/MBC 250/250 ppm against B. subtilis, E. coli, P. aeruginosa, and S. aureus
Biodegradation of Oil Palm Empty Fruit Bunch Waste by Pleurotus ostreatus and Volvariella volvacea Using Solid-State Fermentation Jannah, Umi Nur; Chusniasih, Dewi; Suryanti, Erma; Istiadi, Khaerunissa Anbar
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 2: Jurnal Pembelajaran Dan Biologi Nukleus June 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i2.7327

Abstract

Background: Oil palm empty fruit bunches (OPEFB) represent the largest form of solid waste generated from palm oil production, comprising approximately 23 % of the weight of every ton of fresh fruit bunches (FFB) processed. Untreated OPEFB waste causing pollution problems and increase toxicity due to methane emission. This study aims to evaluate the potential of OPEFB as a growth substrate for the cultivation of Pleurotus ostreatus and Volvariella volvacea, as well as to assess the reduction in lignocellulosic content following fungal biodegradation. Methodology: The experiment was conducted using solid-state fermentation (SSF), and lignocellulose content was analyzed using the Chesson method and SNI 0429:2008 through descriptive quantitative analysis. Findings: Over a 21-day incubation period, mycelial growth of both fungi successfully colonized the OPEFB baglogs, resulting in a 1–2 % reduction in baglog weight. Both P. ostreatus and V. volvacea demonstrated the ability to degrade lignocellulose by secreting lignin peroxidase (LiP), manganese peroxidase (MnP), laccase, cellulase, and hemicellulase enzymes. Initial lignocellulose levels of OPEFB were 18 % lignin, 57 % cellulose, and 20 % hemicellulose. After 21 days of incubation, P. ostreatus reduced these levels to 10 %  lignin, 47 % cellulose, and 19 % hemicellulose, while V. volvacea reduced them to 11 % lignin, 52 % cellulose, and 18 % hemicellulose. Contribution: These findings indicate that OPEFB is a viable substrate for mushroom cultivation and can be effectively biodegraded by these fungi, offering a sustainable approach to managing palm oil industry waste. The treated OPEFB can be used as organic fertilizer, animal feed, and briquettes
Unveiling the Antimicrobial of Lactic Acid Bacteria from Gatot Cassava Against Escherichia coli and Salmonella typhi Chusniasih, Dewi; Alfauzia, Nadia; Suryanti, Erma; Istiadi, Khaerunissa Anbar
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 2: Jurnal Pembelajaran Dan Biologi Nukleus June 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i2.7161

Abstract

Background: Lactic Acid Bacteria (LAB) as probiotics provide many benefits to the body, including suppressing the growth of pathogens in the digestive tract. Antibacterial compounds from LAB can inhibit the presence of pathogenic bacteria. This study aimed to determine the ability of antibacterial compounds from Gatot LAB to inhibit the growth of Escherichia coli and Salmonella typhi bacteria. Methodology: LAB was isolated from cassava gatot, and The LAB isolates obtained were then tested for several LAB characteristics and antibacterial activity against E. coli and S. typhi. LAB characterization based on colony morphology, Gram staining, biochemical testing, coaggregation, and autoaggregation. Findings: There were 7 LAB isolates obtained, namely isolates with codes GNK1, GNK3, GNR2, GNR4, GUR1, GUR3, and GUR5. Isolate GUR3 can inhibit E. coli with the highest inhibition zone of 21.31 ± 3.98 mm. In the antibacterial test against S. typhi, 4 isolates had an inhibitory activity with the highest inhibition diameter by isolate GNK3 of 28.23±3.91 mm. LAB isolates from gatot have the ability to autoaggregate and coaggregate against E. coli and S. typhi. There are 5 isolates that show inhibitory activity against E. coli, namely GNK1, GNK3, GNR2, GNR4, GUR1, and GUR3. Inhibitory activity against S. typhi is shown by 4 LAB isolates, namely GNK1, GNK3, GNR2, and GNR4. Contribution: This research shows that LAB isolates from gatot have potential as probiotic agents with significant antibacterial activity against E. coli and S. typhi, so it can be developed as a natural alternative to control intestinal pathogens.
Ectoparasites Identification on Spiny Lobster (Panulirus homarus) Cultivated Controlled Tanks and Floating Net Cages (KJA) at the Lampung Marine Aquaculture Center (BBPBL) : Identifikasi Ektoparasit Lobster Pasir (Panulirus homarus) pada Bak Terkendali dan Keramba Jaring Apung (KJA) di Balai Besar Perikanan Budidaya Laut (BBPBL) Lampung Fatimatuzzahra, Izza; Istiadi, Khaerunissa Anbar; Garbono, Andrian
Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Vol. 12 No. 1 (2025)
Publisher : Department of Biology Faculty of Mathematics and Natural Sciences Universitas Lampung in collaboration with The Indonesian Association of Biology (PBI) Lampung Branch.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jbekh.v12i1.411

Abstract

Ectoparasites can infect aquatic biota, including spiny lobster (Panulirus homarus), which causes failure of spiny lobster cultivation, such as death, bacterial infection, and decreased cultivation quality. One of the failures of spiny lobster cultivation is often caused by ectoparasite disorders. Environmental conditions influence the growth and distribution of ectoparasites. This study aims to identify the types of ectoparasites and factors that influence the presence of ectoparasites in spiny lobsters and determine the intensity and dominance of spiny lobster ectoparasites. The study was conducted in floating net cages (KJA). It controlled Lampung Marine Aquaculture Center (BBPBL) tanks by purposive random sampling with 18 spiny lobsters, each taken from KJA and controlled tanks. The stages of the study included taking mucus samples on the tail and swimming legs (pleopods), microscopic examination of ectoparasites, calculating the intensity and dominance of ectoparasites, and measuring water quality parameters. The study results obtained three ectoparasites infecting the Spiny lobster, including the Protozoa phylum and the Ciliata class: Vorticella sp., Zoothamnium sp., and Epistylis sp. The intensity of Vorticella sp. ectoparasite attacks was 11.5/lobster. The most dominant ectoparasite was the Vorticella sp. type at 53.90%. The difference in the number of ectoparasites in controlled tanks and floating net cages was due to differences in temperature, size of the cultivation container, and depth, which affected water quality.
Molecular Insights into the Therapeutic Potential of Curcuma amada Rhizome: A Network Pharmacology and Docking Approach Fatriani, Rizka; Istiadi, Khaerunissa Anbar; Khairani, Iffa Afiqa
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.397

Abstract

The rhizome of Curcuma amada (ginger mango) has traditionally been used for various medicinal purposes. However, its molecular targets and mechanisms of action are still poorly understood. This study aimed to predict the potential bioactive compounds and target proteins of C. amada using network pharmacology and molecular docking approaches. A total of 110 compounds were identified, and their predicted targets were analyzed through a protein-protein interaction (PPI) network, enrichment, and disease analysis. Key targets include phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) and tyrosine-protein kinase JAK2 (JAK2), both of which are closely related to cancer-related pathways. Four compounds, β-eudesmol, (E,Z)-farnesol, spathulenol, and τ-muurolol, were selected for molecular docking studies. Validation of the docking protocol through re-docking showed low RMSD values ​​(0.667 Å for PIK3CA and 0.474 Å for JAK2), confirming the reliability of the method. The docking results demonstrated that the native ligands and selected compounds formed multiple hydrogen bonds and extensive hydrophobic interactions with key residues in the active site. Notably, most of the interactions were hydrophobic, which is consistent with the volatile nature of the ligands. The binding affinity was below –5 kcal/mol for all tested compounds. These findings suggest that C. amada rhizomes contain bioactive compounds capable of modulating cancer-related targets, thus providing a molecular basis for their potential therapeutic effects. 
PEMBUATAN BIOCHAR-SLOW-RELEASE-FERTILIZER DARI LIMBAH PELEPAH KELAPA SAWIT Satria, Arysca Wisnu; Ariyanto, Dika Ariyanto; Anisa, Hida Arliani Nur; Istiadi, Khaerunissa Anbar; Sari, Dian Anggria; Muhyi, Abdul; Alawiyah, Alawiyah
MAXIMUS: Journal of Biological and Life Sciences Vol. 1 No. 2 (2023)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/maximus.v1i2.1578

Abstract

Industri kelapa sawit dapat menyebabkan dampak yang buruk bagi lingkungan terkait dengan limbah cair dari industri pengolahan maupun limbah padat dari perkebunan. Limbah padat dari perkebunan kelapa sawit, seperti pelepah sawit, sesungguhnya dapat dimanfaatkan ulang menjadi biochar yang digunakan sebagai bahan pelapis slow-release-fertilizer. Penelitian ini bertujuan untuk mempelajari pengaruh variasi komposisi, bahan pelapis, dan bahan perekat terhadap daya lepas nitrogen pada biochar-slow-release-fertilizer, serta mempelajari kinetika pelepasannya. Variasi yang digunakan adalah rasio biochar/bentonite 20%:80% – 80%:20%, jenis perekatnya asap cair dan minyak jarak, dan jumlah pupuk urea 30% massa total. Hasil penelitian menunjukan bahwa hasil optimum yang diperoleh untuk bahan perekat asap cair dan minyak jarak adalah berturut-turut pada rasio biochar/bentonite 50%:50% dan 60%:40%. Sedangkan hasil uji pelindian mendapatkan bahwa kedua formula tersebut mampu mempertahankan pelepasan nitrogen total hingga 28 hari, dibanding 13 hari untuk formulasi yang tidak dimodifikasi. Uji kinetika pelepasan menggunakan model Korsmeyer-Peppas menunjukkan bahwa mekanisme pelepasan kedua sampel tersebut mengikuti difusi Fickian. Kata kunci : Biochar Pelepah Sawit, Pupuk Pelepasan Lambat, Asap Cair, Minyak Jarak, Model Pelepasan
INOVASI MEDIA TANAM ANGGREK DARI LIMBAH PELEPAH KELAPA SAWIT Satria, Arysca Wisnu; Siragih, Rajuman S; Amelia, Tiara; Nur Anisa, Hida Arliani; Istiadi, Khaerunissa Anbar; Sari, Dian Anggria; Alawiyah, Alawiyah
MAXIMUS: Journal of Biological and Life Sciences Vol. 1 No. 1 (2023)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/maximus.v1i1.1580

Abstract

Anggrek merupakan salah satu tanaman hias dengan keanekaragaman yang tinggi, khususnya di Pulau Sumatera. Permintaan serta nilai komersial anggrek menjadikan budidaya anggrek semakin berkembang. Media tanam yang umumnya digunakan merupakan cacahan tanaman pakis, namun status pakis yang hampir punah menjadikan tanaman pakis menjadi salah satu tanaman yang perlu dilindungi. Limbah pelepah sawit dengan kandungan unsur hara yang beragam merupakan salah satu bahan potensial dalam pengembangan media tanam. Penelitian bertujuan untuk mengembangkan alternatif media tanam anggrek dari limbah pelepah sawit terfortifikasi dan menganalisis kelayakan ekonominya. Cacahan limbah pelepah sawit difortifikasi dengan pupuk serta direkatkan menggunakan getah damar kemudian dicetak dalam bentuk pellet. Hasil penelitian terbaik ditunjukkan pada pelet dengan rasio sawit/pakis sebesar 60%:40% dimana komponen N-P-K yang terekstrak berturut-turut sebesar 6,0; 4,4; dan 4,2 ppm/g pelet. Hasil uji tekan juga menunjukkan bahwa penambahan 60% serbuk pelepah sawit mampu memberikan kekuatan tekan tertinggi pada media pelet sehingga mampu memberikan penahanan nutrisi dan air tertinggi. Sementara itu, hasil analisis ekonomi menujukkan bahwa pabrik pelet media tanam layak didirikan, yang ditunjukkan oleh nilai Internal Rate of Return 16,47%; Pay Back Period 2,26 tahun, Break Even Point 58,86%; Return On Investment 44,26%; dan Net Present Value Rp 1.236.691.035,00.
UTILIZATION OF PINEAPPLE PROCESSING LIQUID WASTE IN BIODEGRADATION OF DISPOSABLE FACE MASK BY BACTERIA FROM LAMPUNG BAY Deviany, Deviany; Zhofiroh, Nawrah Meisyah Muthi'ah; Febrina, Yane Fita; Yusuf, Reggina Aulia; Achmad, Feerzet; Yuniarti, Reni; Istiadi, Khaerunissa Anbar
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.8192

Abstract

The designation of COVID-19 as a global pandemic led to an increased use of single-use face masks, which result in waste that is difficult to degrade and has the potential to release microplastic fibers into the environment. This study aims to examine the im-pact of adding pineapple peel liquid waste (LCN) as a growth medium for the biodeg-radation of single-use face masks by bacterial isolates obtained from the waters of the Lampung Bay. The study investigates how LCN affects the efficiency of mask degra-dation by microorganisms, as well as how the ratio of LCN mixed with other growth media, such as Nutrient Broth (NB), influences the degradation process. The biodeg-radation process was carried out using a biostimulation technique, where bacterial iso-lates were incubated in media containing LCN at a 1:1 ratio. The degradation process lasted for 15 days, with the results being analyzed using gravimetry and Fourier-Transform Infrared Spectroscopy (FTIR). Gravimetric results showed a greater weight reduction in treated masks compared to the control masks. FTIR analysis also indicat-ed changes in the intensity of functional groups in the degraded layers of the masks, as well as the emergence of C≡C functional groups in the second and third layers. This study demonstrates that the addition of LCN can accelerate the biodegradation of sin-gle-use face masks, offering a new approach for managing mask waste.
Co-Authors Aji Hafidz Talaga Alawiyah, Alawiyah Alfauzia, Nadia Amelia, Tiara Andreas Dwi Nugroho Andriani, Silvia Aniesti, Frigia Rafilia Anisa, Hida Arliani Nur Ariyanto, Dika Ariyanto Astuti, Ayu Widia Desi Budiono Deviany Deviany, Deviany Dewi Chusniasih DINA ANGGRAINI Dini Meilinda Dwi Anita Suryandari Erma Suryanti Fajri Arif Wibawa Fatimatuzzahra, Izza Fatriani, Rizka Febrina, Yane Fita Feerzet Achmad Ferdinanda, Thierry Garbono, Andrian Gres Maretta, Gres Hadi Sunaryo Handayani, Catie Hariyandi, Yopi Hida Arliani Nur Anisa Iffa Afiqa Khairani Imaniar, Lisana Husna Irandi Putra Pratomo Jannah, Umi Nur Luluk Yunaini Muhyi, Abdul Mulyana, Jeane Siswitasari Nur Anisa, Hida Arliani Puji Sari Reni Yuniarti Restiawati, Nawang Sari, Dian Anggria Satria, Arysca Wisnu Siragih, Rajuman S Suryanti, Erma Triya Yuli Andini Yuni Sukmawati Yusuf, Reggina Aulia Zhofiroh, Nawrah Meisyah Muthi'ah