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All Journal Indonesian Journal of Tropical and Infectious Disease Jurnal Ilmiah Kedokteran Wijaya Kusuma Health Notions Jurnal Ilmiah Universitas Batanghari Jambi Journal of Maternal and Child Health INTERNATIONAL JOURNAL OF NURSING AND MIDWIFERY SCIENCE (IJNMS) Care : Jurnal Ilmiah Ilmu Kesehatan Abdimas Umtas : Jurnal Pengabdian kepada Masyarakat Biomolecular and Health Science Journal Journal of Telenursing (JOTING) Jurnal Layanan Masyarakat (Journal of Public Service) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL Narra J Journal Of Sustainability Perspectives Journal of Scientech Research and Development The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of Sustainability Perspectives Proceeding Of International Conference On Education, Society And Humanity Jurnal Greenation Sosial dan Politik
Muhammad Miftahussurur
Departemen Penyakit Dalam, Rumah Sakit Dr. Seotomo, Jl. Mayjen Prof. Dr. Moestopo No.6-8, Surabaya 60286, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Narra J

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Challenges and adversities among doctors in the era of healthcare disruption: Reflection from COVID-19 pandemic Sugiyatmi, Tri A.; Hadi, Usman; Chalidyanto, Djazuly; Pathak, Yashwant; Miftahussurur, Muhammad
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.134

Abstract

The doctor's profession is noble and tied up with quite strict rules, both in terms of ethics as well as discipline. Naturally, there is a problem of asymmetrical information between doctors and patients, often leading to misunderstandings. The purpose of this review is to map the available evidence related to the challenges and difficulties faced by doctors in the era of disruption. The evidence indicate that disruption of health services has both positive and negative effects. Many aspects related to the use of technology in the medical practices including innovation, cost-effectiveness, and quality improvement. However, psychologically, the doctors often get frustrated by internal or external triggers. The external factors, ranges from the equipment and work procedures, for instance, using high technology, communication with management, inter-professional relationships, patients, and their families. Volatility, uncertainty, complexity, and ambiguity (VUCA) could cause stress and burnout. In this case, doctors are highly vulnerable, and consequently, have the potential to make mistakes. Therefore, the adversity faced by doctors ought to be mapped. Resilience is a barrier against stress and burnout and the ability to adapt in resilience among doctors is important factor in dealing with the disruption era.
Association between COVID-19 severity with liver abnormalities: A retrospective study in a referral hospital in Indonesia Maimunah, Ummi; Kholili, Ulfa; Vidyani, Amie; Sugihartono, Titong; Tanaya, Willa M.; Wessels, Firda I.; Alshawsh, Mohammed A.; Miftahussurur, Muhammad
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.816

Abstract

Coronavirus disease 2019 (COVID-19) is characterized by an acute respiratory infection with multisystem involvement and the association of its severity to liver function abnormalities is not well characterized. The aim of this study was to assess the association between the severity of COVID-19 patients and liver function abnormalities. This retrospective study included adult patients with confirmed COVID-19, which were classified as non-severe or severe according to World Health Organization guidelines. Liver function test results were compared between the severity groups. A total of 339 patients were included of which 150 (44.25%) were severe cases. The male-to-female ratio was 0.9:1 and 3:2 in the non-severe and severe groups, respectively (p=0.031). Aspartate aminotransferase (AST), alanine transaminase (ALT), and total bilirubin levels and acute liver injury (ALI) incidence were significantly higher in the severe group compared to non-severe group (p<0.001, p<0.001, p=0.025, p=0.014, respectively). In contrast, albumin levels were significantly lower (p=0.001). Multivariate analysis showed that ALI was significantly associated with human immunodeficiency virus (HIV) infection (odds ratio (OR): 5.275; 95% confidence interval (CI): 1.165–23.890, p=0.031), hemoglobin level (OR: 1.214; 95%CI: 1.083–1.361, p=0.001), and hypoalbuminemia (OR: 2.627; 95%CI: 1.283–5.379, p=0.008). Pre-existing liver diseases were present in 6.5% of patients. No significant differences were observed between the groups based on COVID-19 severity and ALI presence. Liver function test abnormalities, including ALI, are more prevalent in patients with severe COVID-19 infection. HIV infection, high hemoglobin levels, and hypoalbuminemia may be potential risk factors for ALI.
Helicobacter pylori sabA, hopQ and hom genotypes as potential genetic biomarkers for gastric mucosal inflammation Hunowu, Ramdan; Fauzia, Kartika A.; Alfaray, Ricky I.; Dewi, Selva R.; Juniastuti, Juniastuti; Yamaoka, Yoshio; Miftahussurur, Muhammad
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1917

Abstract

Helicobacter pylori infection drives heterogeneous gastric pathologies, yet genotype-phenotype correlations in diverse populations remain underexplored. The aim of this cross-sectional study was to investigate the associations between H. pylori virulence genotypes (sabA, hopQ, hom family) and histopathological severity in gastric mucosa among 113 Indonesian dyspepsia patients (mean age: 49.6 years; male predominance: 64.6%). Whole-genome sequencing characterized virulence genotypes, while histopathological grading system using the Updated Sydney System assessed inflammation, atrophy, and bacterial density in the antral and corporal gastric regions. Phylogenetic analysis elucidated strain relatedness. Key genotype frequencies included sabA "on" (40.6%, 43/106), hopQ type I (53.7%, 43/80), and homCL (82.4%, 75/91). Statistical analysis revealed sabA "on" status significantly associated with elevated antral bacterial density (odds ratio (OR) 2.70 and 95% confidence interval (95%CI) 1.10–6.60, p=0.027). The homC variants (homCL/homCS) demonstrated robust associations with chronic inflammation severity (OR: 3.04; 95%CI: 0.99–9.36, p=0.046) and atrophy progression (OR: 4.78; 95%CI: 1.00–22.86, p=0.035), in contrast to the hopQ genotype, which showed no histopathological association. These findings indicated that sabA and homC as critical determinants of gastric microenvironment modulation, potentially through sabA-mediated colonization efficiency and homCL-babA synergistic interactions. While histological profiles predominantly indicated mild atrophy, widespread severe chronic inflammation signals latent progression risks.
Co-Authors Adi Pranoto Adinda Juwita Syakila Elizafanti Agoes Soegianto Agus Sulistyono Alfaray, Ricky I. Alpha Fardah Athiyyah Alshawsh, Mohammed A. Amie Vidyani Ana, Devi Andino Maseleno Annisa Zahra Mufida Aryati -, Aryati Astri Dewayani Aswin, R. Haryanto Ayu Citra Gestari Bernadetta Jonan Brian Eka Rahman Budi Prasetyo Budi Widodo Chabib Fachry Albab Dewi, Selva R. Diah Rizki Rahma Dini Dianbudiyanto, Wahid Dita Mega Utami Djazuly Chalidyanto Dominicus Husada Dwiki Noni Armyta Dwiyanti Puspitasari, Dwiyanti Eka Mishbahatul Mar'ah Has Endyka Erye Frety Fauzia, Kartika A. Fauziah Diayu Retnaningtyas Gatut Hardianto, Gatut Gilda Hartecia Hadisuwarno, Wiharjo Hajjarianti, Permata Hamzah Hamzah Hartecia, Gilda Hasan Maulahela Heasty Oktaricha HERAWATI, LILIK Hermanto Tri Joewono Herry Purbayu Hertanto, Carisa Irene Hubur, Aa Hunowu, Ramdan I'tishom, Reny Indra Alfaray, Ricky Ishomatul Faizah Isna Mahmudah Isna Mahmudah Iswan A Nusi Iswan Abbas Nusi Izzatul Fithriyah Jonan, Bernadetta Juniastuti Juniastuti Karnaji, Karnaji Kartika Afrida Fauzia Lionardy Yodianto Mahmudah, Isna Maria Inge Lusida Martono Tri Utomo MISBAKHUL MUNIR Mohammad Anam Al-Ari Nadia Sherli Syafira Natasya Ariesta Selyardi Putri Naufali Rizkiawan Nihayati, Hanik Endang Nurhayati, Fitasari Nidia NUrina Fitriani, NUrina Nurullia Hanum Hilfida Pangestu Adi Pathak, Yashwant Poernomo Boedi Setiawan Purwo Sri Rejek Rejeki, Purwo Sri Riani Widia Parantika Rizkiawan, Naufali Samsriyaningsih Handayani Savitri, Camilia Metadea Aji Soelistijo, Soebagijo Adi Sugiyatmi, Tri A. Sulistiawati Sulistiawati Susanti Susanti Tanaya, Willa M. Thamrin, Husin Titong Sugiharto Titong Sugihartono Tri Purwanti Ucik Nurul Hidayati Ulfa Kholili Ummi Maimunah Usman Hadi Vasa Adi Wisnu Wardana Wahyul Anis Watari, Rekno Wati, Yunita Kholilaili Saras Wessels, Firda I. Widjiati Widjiati Widyaleksono, Trisnadi Willy Sandhika Woro Setia Ningtyas Yoshio Yamaoka Yoshio Yamaoka Yoshio Yamaoka, Yoshio Yudith Annisa Ayu Rezkitha Yudith Annisa Ayu Rezkitha, Yudith Annisa Ayu Zagita, Lauditta Chavia