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All Journal Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Jambura Journal of Health Sciences and Research Journal of Pharmaceutical and Health Research JUKESHUM: Jurnal Pengabdian Masyarakat FORTE JOURNAL Mejuajua Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Jurnal Abdi Masyarakat Multidisiplin Jurnal Riset Rumpun Matematika dan Ilmu Pengetahuan Alam (JURRIMIPA) Jurnal Natural Journal of Pharmaceutical and Sciences. Jurnal Indah Sains dan Klinis
Salman Salman
Universitas Tjut Nyak Dhien
Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Education Energy Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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POTENSI ANTIBAKTERI AIR REBUSAN SERBUK, EKSTRAK n-HEKSANA DAN EKSTRAK KLOROFORM CACING TANAH ( Perionyx sp.) TERHADAP BAKTERI Salmonella typhosa Meutia Indriana; salman salman
Journal of Pharmaceutical and Sciences Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i1.89

Abstract

Earthworms are animals that have many benefits and are easy to find—results of information from people consume boiled water of earthworms three times a day for 7 days is used as a typhus medicine, other information is obtained from electronic media, many people also consume earthworms as a typhoid medicine in powder form which is filled into capsules Which can be found in Chinese drug stores, but until now scientific research on earthworms (Perionyx sp.) as an anti-bacterial has not been done. Extraction is done by maceration. Multilevel maceration using chloroform and n-hexane as solvent. The class of chemical compounds was determined on the ethyl acetate extract and the n-hexane extract of the earthworm Perionyx sp.), including alkaloids, glycosides, steroids/triterpenoids, flavonoids, saponins, and tannins. Testing of antibacterial activity of chloroform extract and n-hexane extract against Salmonella typhosa was carried out in vitro by agar diffusion method using metal buffer at a concentration of 500 mg/ml; 400 mg/ml; 300 mg/ml; 200 mg/ml; 100 mg/ml and 50 mg/ml. The results of determining the class of chemical compounds from the chloroform extract of earthworms (Perionyx sp.) showed the presence of chemical compounds belonging to the alkaloid group, while the n-hexane extract did not indicate the presence of chemical compounds detected. The n-hexane extract of tar h (Perionyx sp.) had an inhibitory effect on the growth of Salmonella typhosa at a minimum inhibitory concentration of 400 mg/ml of 10.9mm, while the chloroform extract had a minimum inhibitory concentration of 300 mg/ml with an inhibitory diameter of 12.87 mm.
PENETAPAN KADAR DILTIAZEM HCI DALAM SEDIAAN TABLET SECARA SPEKTROFOTOMETR ULTRAVIOLET salman salman; Meutia Indriana
Journal of Pharmaceutical and Sciences Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i1.84

Abstract

The rhizome of mango Curcuma is empirically used as a traditional medicine for the treatment of gastric pain, pain, and inflammation due to hemorrhoids, sore throat, bronchitis, and asthma. The aim of this study was to determine the chemical compound content of secondary metabolites and the activity of the ethanol extract of Temu Mango (Curcuma mangga Val.) on the reduction of carrageenan-induced rat paw edema. The results of a preliminary examination of the chemical content of the rhizome of Intersection mango (Curcuma mango Val.) showed the presence of glycosides, flavonoids, saponins, essential oils, and steroids. In general, the suspension of the ethanol extract of Temu Mango at doses of 50, 100, 200 mg/kg BW gave an anti-inflammatory effect that began to appear in the first half-hour and continued to increase with increasing time. An increase of 2 times the dose of the ethanol extract of Temu Mango showed an anti-inflammatory effect that was not significantly different, but with an increased dose of 4 times, it showed a significant difference. Even the ethanol extract of Intersection mango at a dose of 200 mg/kg BW gave almost the same effect as indomethacin.
PEMANFAATAN KULIT BATANG MIMBA SEBAGAI ANTITUBERKULOSIS DIBANDINGKAN DENGAN RIFAMPISIN DAN ETAMBUTOL Meutia Indriana; salman salman
Journal of Pharmaceutical and Sciences Vol 3 No 2 (2020): JPS Volume 3 Nomor 2 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i2.92

Abstract

Indonesia ranks third in the number of tuberculosis, after India and China. Treatment of tuberculosis takes a long time, and the lack of discipline in taking medication has caused the Mycobacterium tuberculosis to be resistant to many synthetic drugs that have been used so far. In contrast, the discovery of new synthetic drugs is very slow. Traditionally, neem bark (Azadirachta indica JUSS.) has been used to treat coughing up blood and phlegm, and the results of previous studies show that ethanol extract of neem bark in vitro can inhibit the growth of Mycobacterium tuberculosis. This study was conducted to determine the toxicity of neem bark extract, formulation of neem bark ethanol extract into tablet preparations, and the potential of this tablet preparation as anti-tuberculosis in vivo in animals. Neem bark extract was made by percolation using an ethanol extractor. Toxicity test was carried out in the form of an acute toxicity test on mice to calculate the LD50 value and histopathological observations of the liver, lungs, and intestines. The tablets were made by wet granulation. The potential test of tablet preparations as anti-tuberculosis was performed in vivo on animals infected with Mycobacterium tuberculosis H37Rv using a nebulizer. The results showed LD 50 = 11.85 ± 0.571, including mild toxic. The ethanolic extract of neem bark can be formulated into tablets using a 6% gelatin binder, Manihot starch and primojel as a binder, and a mixture of starch and lactose as a filler. Neem bark extract tablets can cure tuberculosis of experimental animals that have been infected with Mycobacterium tuberculosis H37RV, which is given a dose of 3 times a day two tablets (50 mg/tablet) for six weeks seen tuberculosis bacteria from +3 to negative, and a dose of 3 times a day once a day. Tablet looks from +3 to +1.
PENENTUAN KADAR PARASETAMOL DALAM SEDIAAN TABLET DAN LARUTAN ORAL SECARA KROMATOGRAFI CAIR KINERJA TINGGI (KCKT) salman salman; Meutia Indriana
Journal of Pharmaceutical and Sciences Vol 3 No 2 (2020): JPS Volume 3 Nomor 2 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i2.85

Abstract

According to RI Law no. 36 of 2009, determining the level of efficacious substances from a drug preparation is one of the requirements that must be carried out to ensure the quality of the drug preparation. Drug preparations of good quality will provide the expected effect and one of the parameters is the level of the active substance of the drug must meet the level requirements listed in the Indonesian Pharmacopeia or other standard books. The purpose of this study was to determine the levels of Paracetamol in tablet preparations and oral solution by high-performance liquid chromatography. The determination of the concentration was carried out by the HPLC method using a 2.5 mm x 25 cm VP-ODS shim pack column with water-methanol as a mobile phase (3:1), a flow rate of approximately 1.5 ml/minute, and the detection was carried out at a wavelength of 243 nm. The advantage of the HPLC method is the separation system with high speed and efficiency because it is supported by advances in column technology, high-pressure pump systems, and highly sensitive and diverse detectors so that they are able to analyze various samples qualitatively and quantitatively, back in single or mixed components. The results showed that all the specified samples met the content requirements according to the Indonesian Pharmacopeia IV edition 1995, namely not less than 90.0% and not more than 110.0% of the amount stated on the label. The results of the Validation test method carried out obtained a recovery percent of 99.96% with an RSD (Relative Standard Deviation) of 1.81% so that it can be concluded that this method has good sensitivity and accuracy, with a LOD (limit of detection) 0.76 g/ml and LOQ (limit of quantitation) 2.56 g/ml.
PENGARUH INTERESTERIFIKASI LEMAK SAPI TERHADAP PROFIL LIPIDA MARMUT Meutia Indriana; salman salman
Journal of Pharmaceutical and Sciences Vol 4 No 1 (2021): JPS Volume 4 Nomor 1 (2021)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v4i1.91

Abstract

Properties of fats are determined by the composition and position (sn-1,2,3) of fatty acids in the fat molecule. Palmitic acid is one of the most atherogenic fatty acids in the sn-2. Interesterification will change the position of palmitic acid in the fat molecule. This study aimed to determine the effect of interesterification on the atherogenic properties of fat. The fat used was beef, extracted by dry rendering, and chemically interesterified using a Na-methoxide catalyst for 20, 30, 60, 90, and 120 minutes. The melting point of the fat was measured using a melting point apparatus then given to guinea pigs. For 21 days, the propyl lipid was measured using the enzymatic method using a micro lab 300 spectrophotometers. The melting point of beef fat from interesterification for 60 minutes was constant, meaning the reaction was complete. Interesterification of beef fat showed an increase in atherogenicity seen from the increase in total cholesterol, triglyceride, LDL and decreased HDL levels after interesterification, respectively 69.20 ± 20.24; 68.60 ± 18.81; 40.43 ± 15.18; 14.33 ± 3.01 mg/dl compared with no interesterification 62.27 ± 16.02; 62.87 ± 14.08; 37.84 ± 13.41; 11.80 ± 2.15 mg/dl (ANOVA, P < 0.05).
SKRINING FITOKIMIA DAN UJI KEMAMPUAN SEBAGAI ANTIOKSIDAN DARI DAUN JAMBU BIJI salman salman; Meutia Indriana
Journal of Pharmaceutical and Sciences Vol 4 No 1 (2021): JPS Volume 4 Nomor 1 (2021)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v4i1.87

Abstract

Free radicals are molecules that have free electrons, very harmful to health. One of the efforts to overcome it is with antioxidants. Naturally, in the body, there are antioxidants, namely superoxide dismutase, glutathione, and catalase, but depending on food intake, especially containing phenolics and flavonoids. Traditionally, guava leaves are used to treat diarrhea, dysentery, lower cholesterol, irregular menstruation, wounds, and canker sores. Judging from these various properties, it is possible that guava leaves contain chemical compounds that have the potential as antioxidants, especially phenolic compounds, the authors tested the ability of guava leaves as antioxidants. Guava leaves were prepared into ethanol extract, fractionated with n-hexane, ethyl acetate, and water, and phytochemical screening was carried out on the ethanol extract and each fraction. Antioxidant testing was carried out using the Radical Scavenger using 1,1-diphenyl-2-picrylhydrazyl. The test results showed that the ethanol extract contained alkaloids, tannins, flavonoids, steroids, saponins, and glycosides. The n-hexane fraction contains alkaloids and glycosides. the ethyl acetate fraction contains tannins. the water fraction contains tannins and glycosides. As antioxidants, ethanol extract and water fraction were categorized as strong with IC50 ethanol = 42.06 g/ml, water fraction = 49.41 g/mL, n-hexane and ethyl acetate fractions were categorized as medium with IC50 fraction n-hexane = 58.15 g /mL, ethyl acetate fraction = 51.60 g/ml.
AKTIVITAS ANALGESIK EKSTRAK ETANOL DAUN MAHKOTA DEWA (Phaleria macrocarpa (Scheff.) Boerl) SECARA IN VIVO salman salman; Muharni Saputri; Ika Mustika
Journal of Pharmaceutical and Sciences Vol 4 No 1 (2021): JPS Volume 4 Nomor 1 (2021)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v4i1.57

Abstract

Pain is a feeling of discomfort caused by intense or destructive stimuli, which, if left untreated, can affect your daily routine. Pain can be treated with analgesics. One of the plants that are thought to have analgesic effects is the leaves of the mahkota dewa. The purpose of this study was to determine the analgesic effect and dosage of the ethanol extract of mahkota dewa leaves and to determine the effectiveness of the ethanol extract of the mahkota dewa leaves as an analgesic using the stretching method. The study began with the collection and processing of the leaves of the mahkota dewa into ethanol extract using the maceration method; then, the research was continued within in vivo analgesic activity testing of 25 mice that had been induced by pain using 1% acetic acid. The induced mice were divided into five treatment groups, where the mice in the first group served as a negative control group; in this group, they were given CMC at a dose of 0.5%. The second group of mice, which were positive controls, were given mefenamic acid at a dose of 500 mg. In contrast, in mice, the third, fourth, and fifth groups, which were the treatment group, were given ethanol extract of the leaves of mahkota dewa with consecutive doses of 0.25 g/kg BW, 0.50 g/kg BW, 0.75 g/kg BW. Parameters measuring the effectiveness of the extracts used in this study included the amount of stretching, the percentage of analgesic power, and analgesic effectiveness. The results showed that the positive control group had the highest percentage of analgesic power at 59.9%. At EEDMD 0.75 g/kg BW gained 55.5%. EEDMD at a dose of 0.25 g/kg BW obtained 46.33%. Furthermore, EEDMD at a dose of 0.50 g/kg BW amounted to 55.06%. Furthermore, the percent effectiveness showed that EEDMD 0.75 g/kg BW had the highest percentage effectiveness, namely 92.65%. Whereas at EEDMD 0.25 g/kg BW is 77.29% and in EEDMD 0.50 g/kg BW is 91.91%. Based on the results of statistical analysis using ANOVA, it was found that the ethanol extract of the leaves of the mahkota dewa dosage of 0.75 g / kg BW had analgesic activity close to 500 mg of mefenamic acid.
PENGGUNAAN EKSTRAK BIJI BUAH KESUMBA (Bixa orellana L.) SEBAGAI PEWARNA LIPSTIK Meutia Indriana; salman salman
Journal of Pharmaceutical and Sciences Vol 4 No 2 (2021): JPS Volume 4 Nomor 2 (2021)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v4i2.76

Abstract

Recently, there have been hundreds of lip color cosmetics on the market in various colors. However, not all lip colors are safe to use. Without realizing it, there are lip dyes that contain dyes that are dangerous and are prohibited because they can cause irritation to the skin and respiratory tract. Therefore, it is better to use natural dyes. One of the sources of natural dyes is the fruit of kesumba. Extracts from simplicia of kesumba seeds were made by percolation using 96% ethanol as a solvent. The lipstick formulation formula consists of Cera alba, vaseline alba, lanolin, carnauba wax, cetyl alcohol, oleum ricini, propylene glycol, titanium dioxide, butylhydroxytoluene, tween 80, rose oil (oleum rosae), and nipagin, as well as the addition of kesumba seed extract with concentrations of 15%, 17.5%, 20%, 22.5%, and 25%. Tests on the preparations made included examination of the melting point, homogeneity, lipstick strength, stability test against changes in shape, color, and odor during 30 days of storage at room temperature, smear test, and pH examination, and irritation test preference test (Hedonic test). The results of the research that the extract of the kesumba fruit seed can be formulated in lipstick preparations with a light yellow to dark maroon color. The formulation of the kesumba seed extract in the lipstick preparation shows that the preparation is relatively stable homogeneous, the melting point is 58°C, has a good lipstick strength, the pH ranges from 6.3 to 5.7 (according to the pH of the skin) easy to apply with an even color. , does not irritate, so it is safe to use; the pretty preferred preparations are preparations 2, 3, and 4, namely the formula with extracts of kesumba seeds with concentrations of 17.5%, 20%, and 22.5%.
AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DARI BUNGA TUMBUHAN KECOMBRANG (Etlingera elatior Jack.) SECARA IN VITRO salman salman; Meutia Indriana
Journal of Pharmaceutical and Sciences Vol 4 No 2 (2021): JPS Volume 4 Nomor 2 (2021)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v4i2.75

Abstract

Traditionally, kecombrang flowers have been used to treat various diseases, including colds, earaches, blood purifiers, treat festering wounds and eliminate body odor. Various bacteria may cause ear diseases, purulent wounds, and body odor, so the kecombrang flower, which has been used traditionally to treat this disease, maybe due to its anti-bacterial activity against both Gram-positive and Gram-negative, so it is necessary to do research with the aim of ensuring the presence of anti-bacterial activity. This research includes collecting kecombrang flowers, plant identification, making Simplicia, phytochemicals, making kecombrang flower extracts by percolation with 96% ethanol extract. Testing anti-bacterial activity in vitro by diffusion method with punch holes on Mueller Hinton Agar medium, and used Ampicillin sulfate 20 g/ml as a control against Staphylococcus aureus, Streptococcus pneumonia, Escherichia coli, and Pseudomonas aeruginosa bacteria. Phytochemical screening showed the presence of the same group of compounds, namely alkaloids, flavonoids, steroids, glycosides, and essential oils. The results of the anti-bacterial activity test of the ethanol extract of the excellent kecombrang flower against Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, and less suitable for Pseudomonas aeruginosa.
EKSTRAK KULIT BUAH ANGGUR (Vitis vinifera L) SEBAGAI PEWARNA PADA FORMULASI LIPSTIK salman salman; Meutia Indriana
Journal of Pharmaceutical and Sciences Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v5i1.90

Abstract

Grapes (Vitis vinifera L.) belong to the family Vitaceae. The color of the fruit varies. There are red, green and purple. The color of this wine contains anthocyanin dyes that can be used as natural dyes to replace synthetic dyes, the colors they contain are pretty intensive, so the researchers aimed to make lipstick formulations using natural dyes from grape skins. The lipstick formulation consisted of Cera alba, lanolin, vaseline alba, cetyl alcohol, oleum ricini, carnauba wax, propylene glycol, titanium dioxide, oleum rosae, butylhydroxytoluene, tween 80, and nipagin, as well as the addition of grape skin extract with a concentration of 15 %, 20%, 25%, 30%, and 35%. Tests on the preparations made include inspection of homogeneity, melting point, lipstick strength, stability test against changes in shape, color, and odor during 30 days of storage at room temperature, smear test, pH examination, and irritation test preference test (Hedonic test). From the research results, grape skin extract can be formulated into lipstick preparations with pink to dark red colors. Lipstick preparations with grape skin extract as a dye are pretty stable, homogeneous, melting point 59°C, have good lipstick strength, pH ranges from 3.7 to 3.9 (close to the pH of the lip skin) are easy to apply with an even color, and do not irritate. Irritation the preparation preferred by 30 panelists was preparation with a concentration of 25%.
Co-Authors . Saiful Agustina Magdalena alma Handayani Lubis Aprilia Ulfa Asri Ainun Bunga Rimtam Barus Dea Anggraini Desy Natalia Siahaan Dewi Lestari Erfan Wahyudi Erna Juliana Munthe Eva Sartika Dasopang FENNY HASANAH IDA FAUZIAH Ika Julianti Tambunan Ika Julianti Tambunan IKA MUSTIKA Irene Maria Clarita Zebua Jazilul Amira Jhesica Elsa Febriani Daeli Kanne Dachi Kanne Dachi Kurniawan Sinaga Lisda Wardani Mahmudi Mahmudi Majda Rofiah Mariani Razali Mariany Razali Meutia Indriana Meutia Indriana Muflihah Fujiko Muhammad Iskandar Muharni Saputri Muharni Saputri Mutia Farida Muzakir Muzakir Muzakkir Muzakkir Nadhira, Ahmad Nerdi Nerdi Nerdy Nerdy Nilsya Febrika Zebua, Nilsya Febrika Nilya Febrika Zebua Nurfazila Nurfazila Nurmala Sari Nurmala Sari Nurul Afwa Yustika Sari Pinte Peteri Melisa Pravil Mistriyanto Tambunan Priska Noveranni Zebua Putri Febrianti Syakila Quizha Axyvia Rahma Yulia Rama Mulya Dwi Safita Rili Meilita Sari Rina Kurniaty Said Haikal Alfajar Saiful Azhari Salmah Handayani sari khalidya putri Silvia Primastuti Daeli siti muliani julianty siti rahmi ningrum Siti Saleha Sri Maharani Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sumardi Supran Hidayat Sihotang Supran Hidayat Sihotang Syarifah Nadia TEDY KURNIAWAN BAKRI Vivi Sofia Vriezka Mierza Vriezka Mierza Windi Anggraini Yessi Febriani Yessi Febriani Yessi Febriani Yessi Febriani Yettrie Simarmata Zulfikar Zulfikar