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All Journal VALENSI Indonesian Journal of Pharmaceutical Science and Technology MPI (Media Pharmaceutica Indonesiana) Jurnal Sains Teh dan Kina Jurnal Kreativitas PKM Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Insan Farmasi Indonesia Jurnal Sains dan Teknologi Farmasi Indonesia EDUCARE: Jurnal Pendidikan dan Kesehatan

Adang Firmansyah

Unknown Affiliation

Author-ID : 634850

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health

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STUDI SPEKTRUM DERIVATIF FTIR DAGING SAPI DAN DAGING BABI SETELAH MELALUI REAKSI ENZIMATIS Adang - Firmansyah; Melvia - Sundalian; Oo - Suprijana; Resti Pahlawati Fauziah
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 7, No 2 (2018)
Publisher : Sekolah Tinggi Farmasi Indonesia

AbstrakKasus pemalsuan daging sapi dengan daging babi masih tetap ditemukan dan memiliki perhatian serius terkait dengan masalah halal terutama di Indonesia yang merupakan negara mayoritas muslim. Analisis spektrum FTIR memungkinkan untuk dapat menganalisis perbedaan kandungan protein pada daging babi dan sapi. Penelitian ini bertujuan untuk menganalisis daging sapi dan daging babi dengan FTIR dengan reaksi enzimatis menggunakan enzim protease. Sampel dibuat dalam beberapa kelompok yaitu sampel daging tanpa penambahan enzim, sampel dengan enzim protease, sampel yang tidak dikeringkan, serta sampel yang dikeringkan. Hasil penelitian menunjukkan FTIR dapat membedakan daging sapi dan daging babi. Spektrum FTIR yang dihasilkan memiliki keterulangan yang baik dan serapan khas dari daging sapi maupun daging babi. Spektrum derivatif pertama FTIR daging babi menghasilkan perbedaan pita-pita serapan pada bilangan gelombang 1318 cm-1, 1019-1066 cm-1, 705 cm-1, 681 cm-1 yang tidak ditemukan pada daging sapi.Kata kunci : daging sapi, daging babi, reaksi enzimatis, spektrofotometri FTIR, spektrumderivatif pertamaAbstractAdulteration case of beef with pork still remain found and had serious attention due to halal issue especially in Indonesia as a moslem majority country. FTIR spectrum analysis makes it possible to analyze differences in protein content in pork and beef. This study aims to analyze the beef and pork with FTIR with enzymatic reaction using protease enzymes. Samples were made in several groups, namely samples without enzyme addition, samples with protease enzymes, non-dried samples, and dried samples. The result of this research indicate that FTIR method successfully differentiate beef to pork. The analysis result showed the measurument using FTIR spectrum were relative repeatable and produced some unique bands both pork or beef. The first derivative spectrum FTIR of pork produced different absorption bands at wave numbers 1318 cm-1, 1019-1066 cm-1, 705 cm-1, 681 cm-1 which were not found in beef.Keywords : beef, pork, denaturation of enzyme, spektrofotometri FTIR, first derivative spectrum

PRODUKSI ASTAXANTHIN DARI MIKROALGA Haematococcus pluvialis MENGGUNAKAN EKSTRAKSI KARBON DIOKSIDA SUPERKRITIKAL YANG DIMODIFIKASI Adang - Firmansyah; Wiwin - Winingsih; Zenith Virgina Ababiel; Nella - Nurmeilasari; Ati - Setiasih
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 8, No 2 (2019)
Publisher : Sekolah Tinggi Farmasi Indonesia

Astaxanthin adalah pigmen karotenoid yang memiliki aktivitas antioksidan lebih tinggi dibandingkan dengan turunan β-karoten lainnya dan vitamin E. Sumber utama astaxanthin alami terdapat dalam mikroalga Haematococcus pluvialis yang dapat ditemukan di berbagai wilayah perairan di Indonesia. Astaxanthin alami dari H. pluvialis dapat diperoleh melalui proses isolasi. Sebagian besar metode isolasi yang telah diteliti menggunakan ekstraksi pelarut yang memiliki efek buruk pada lingkungan dan kesehatan, berbeda dengan ekstraksi superkritis CO2 yang memiliki efek baik pada lingkungan dan kesehatan. Pada penelitian ini, H. pluvialis dikultivasi, diinduksi dengan mengoptimalkan berbagai metode induksi stres, kemudian diisolasi dengan ekstraksi superkritis CO2 yang dimodifikasi menggunakan dry ice CO2 sebagai pelarut. Hasil penelitian menunjukkan bahwa H. pluvialis menghasilkan astaxanthin pada induksi cahaya matahari dengan panjang gelombang maksimum sesuai dengan produk standar yaitu 474 nm. Pengujian terhadap skema isolasi dan uji kesesuaian sistem menunjukkan bahwa pembentukan cairan superkritis dari dry ice CO2 ditentukan oleh massa, volume, dan suhu. Hasil dari uji pendahuluan kemudian dirancang sebuah ekstraktor dari bahan stainless steel dan hasil pengujian menunjukkan bahwa ekstraktor masih perlu dikembangkan, adapun isolasi yang dilakukan pada chamber simulasi menunjukkan tidak terjadi pemisahan.Kata Kunci: Astaxanthin, Haematococcus pluvialis, Ekstraksi CO2 Superkritis.

Antidiabetic activity of of green tea ethanol extract on white mouse Dadan Rohdiana; Adang Firmansyah; Anik Setiawati; Nuni Yunita
Jurnal Penelitian Teh dan Kina Vol 15 No 1 (2012)
Publisher : Research Institute for Tea and Cinchona

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22302/pptk.jur.jptk.v15i1.19

In China, India, United State, and some small other countries, tea has been consumed to prevent various disease, such as diabetes mellitus. A number of recent research revealed that consumption of green tea has an impact on the ability of insulin sensitivity in reducing glucose content in human body. Research to know antidiabetic activity of ethanol extract of green tea on experimental rats has been conducted using glucose tolerance method on rats. Results showed that application of 720 mg/kg BW of ethanol extract of green tea at 120, 180, and 240 minutes after application could reduce glucose content in the body. While applications of 180 mg/kg BW and 360 mg/kg BW of ethanol extract of green tea reduced glucose content of the body at 180 and 240 minutes after application respectively.

Nutritional value and contamination testing assistance for the improvement of the processed food products quality Syarif Hamdani; Adang Firmansyah; Muhammad Ismail Faruqi; Dewi Astriany; Sri Gustini; Wiwin Winingsih; Melvia Sundalian; Nur Asni Setiani; Putri Afiyanti
Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Vol 8, No 4 (2023): November 2023
Publisher : University of Merdeka Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26905/abdimas.v8i4.11295

Micro, Small, and Medium Enterprises (MSMEs) are one of the business sectors driving the country's economy. MSMEs produce many quality products that can compete in the market, where one of the products that is marketed quite a lot is food products. Several MSMEs in the Purwakarta Regency area have not included information on nutritional value and contamination on labels or packaging so these products cannot be widely marketed or traded in official stores and can only be marketed in their production areas. The Community Service activities carried out aim to carry out nutritional value and contamination tests, followed by improving product quality through workshops and mentoring. The food products targeted are simping and instant turmeric drinks produced by MSMEs in Pondoksalam District, Purwakarta Regency. Laboratory test results show that instant turmeric does not meet several SNI standard parameters, so quality improvement is still needed to be able to adapt it to become a product that meets standards. The results of the questionnaire show that several MSME owners in the Purwakarta area have a poor understanding of food product quality standards and ways to improve them. The coaching program for community service activities shows an increase in knowledge and understanding so that food products from Purwakarta MSMEs are expected to meet product quality standards in the future.

ANALISIS KEMOMETRIKA SPEKTRUM Fourier transformed infrared (FTIR) DARI MINYAK NABATI Husein, Sri Gustini; Firmansyah, Adang; Yusuf, Fuzy Fauziah
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 9, No 2 (2020)
Publisher : Sekolah Tinggi Farmasi Indonesia

Minyak nabati adalah minyak yang di ekstraksi dari berbagai tumbuhan. Ada banyak jenis minyak nabati diantaranya minyak kacang, bunga matahari, jagung, kedelai, wijen, kelapa, zaitun dan lain sebagainya. Banyak industri makanan yang menggunakan minyak nabati sebagai bahan baku olahannya seperti margarin, mentega, dan produk lainnya, menyebabkan banyaknya minyak nabati yang beredar dipasaran sehingga memerlukan metode analisis yang tepat untuk mengetahui kualitas dari berbagai jenis minyak nabati tersebut. Pada penelitian ini dilakukan pengembangan metode analisis minyak nabati menggunakan kemometrika spektrum FTIR dari minyak nabati. Kemometrika merupakan salah satu teknik pengukuran yang berhubungan dengan pengukuran data multivariat yaitu data yang dihasilkan dari pengukuran banyak variabel pada satu sampel yang sejenis. Tujuan penelitian ini adalah melakukan analisis terhadap 20 jenis sampel minyak nabati menggunakan Fourier transformed infrared- Attenuated Total Reflectance (FTIR-ATR). Hasil analisis menunjukkan dengan menggunakan metode kemometrika hasil spekrum 20 jenis minyak nabati, di kombinasikan berdasarkan analisis komponen utama atau principal component analysis (PCA) dan analisis klaster atau Cluster Analysis. Hasil penelitian ini menunjukkan bahwa FTIR dapat digunakan untuk uji kualitas terhadap sampel uji 20 jenis minyak nabati secara semi-kuantitatif yang dielaborasi oleh kemometrik. Kemometrika juga mendukung analisis perbedaan spesifik dari kandungan kimia minyak nabati. Kata kunci : Kemometrika, minyak nabati, spektrofotometer FTIR-ATR.

PENENTUAN KELARUTAN KURKUMIN DALAM DELAPAN PELARUT ORGANIK GUNA PENGEMBANGAN SEDIAAN FARMASI BERBAHAN DASAR KURKUMIN MENGGUNAKAN SPEKTROFOTOMETRI VISIBLE DAN GRAVIMETRI Sahari, Yuni; Rahmat, Sendi Dwi; Rahmawati, Sarah Rifka; Firmansyah, Adang; Sundalian, Melvia
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 12, No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58327/jstfi.v12i2.222

Kurkumin merupakan senyawa kurkuminoid terdiri dari demetoksikurkumin, bisdemetoksikurkumin, dan kurkumin yang merupakan hasil isolasi dari rimpang tanaman kunyit (Curcuma Longa Linn). Kurkumin telah terbukti memiliki aktivitas farmakologis, seperti antiinflamasi, antioksidan, antivirus, antimalaria, antiparasit, dan antimikroba dibidang pengobatan. Data kelarutan merupakan salah satu informasi penting yang dibutuhkan dalam proses isolasi, ekstraksi, rekristalisasi dan praformulasi suatu obat di bidang industri, akan tetapi kurkumin belum memiliki data kelarutan yang spesifik. Penelitian ini bertujuan untuk mengetahui kelarutan kurkumin dalam pelarut asetonitril, air, kloroform, metanol, etanol, etil asetat, n-heksana, dan aseton menggunakan metode shake-flask saturation. Konsentrasi kurkumin yang terlarut dalam masing-masing pelarut ditentukan secara spektrofotometri dan gravimetri. Berdasarkan pengujian yang telah dilakukan pada kelarutan kurkumin dalam pelarut etil asetat sebesar 16,69 mg/mL; pada etanol 7,856 mg/mL; pada asetronitril 7,421 mg/mL; pada aseton 7,395 mg/mL; pada methanol 5,568 mg/mL; pada kloroform 3,544 mg/mL; pada air 0,165 mg/mL; dan pada n-heksana 0,101 mg/mL. Berdasarkan hasil penelitian dapat disimpulkan bahwa kelarutan kurkumin tertinggi dalam asetonitril dan terendah dalam pelarut n-heksana.Kata Kunci: Kurkumin, kelarutan, spekrtofotometri, gravimetri

RP-HPLC Method Validation for Purity Assay of α-Mangostin Isolate Ratih, Ratih; Budipramana, Krisyanti; Firmansyah, Adang
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 2 (2023): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i2.6108

The quality of natural products regarding the purity of their active compounds, such as α-mangostin isolate from mangosteen pericarp, may vary depending on cultivation, harvest season, and isolation process. Thus, extensive isolation procedures are involved in obtaining a certain level of purity of the active compounds. Studies on the yield of α-mangostin isolate and its effectiveness as an active compound in health care have been reported. The quality parameter of the isolate as the intended active compound can be indicated by its purity level. Measuring the purity of the active compound is proposed to define the grade α-mangostin isolate as a starting material or even reference standard. The higher the purity level of α-mangostin isolate, the greater its potential as a reference standard candidate. Therefore, a selective analytical method is required to measure the purity level accurately. For this reason, a rapid analytical method to ensure α-mangostin isolate was developed and validated to confirm its purity. Separation condition semployed an X-Terra® C18 column 5 μm, 4.6 x 150 mm under an isocratic system with a mobile phase composition of MeCN:water (85:15) at a flowrate of 0.5 mL/ min and a detector wavelength of 243 nm were selected. Acceptable validation parameters of linearity in the range of 2.6 –52 μg/mL with r2 = 0,9994, Vx0 = 2.64%; accuracy 96.38 – 100.99%; precision 1.36%; and LOD/LOQ = 4.6 μg/mL/ 13.7μg/mL were achieved. The validated method was successfully applied to the purity assay α-mangostinisolate with a run time of less than 9 minutes.

AKTIVITAS IMUNOMODULATOR REGIMEN ISOLAT MANGOSTIN, KURKUMINOID, PIPERIN, METIL SINAMAT DAN VITAMIN C DENGAN METODE CARBON CLEREANCE Fauzi, Novi Irwan; Sari, Nia Kurnia; Fathurrahman, Muhammad Hilmi; Firmansyah, Adang; Ferdiansyah, Rival; Ismayadi, Pupung; Herawati, Irma Erika
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/7sr0rm77

The regimen of test materials consisting of mangostin isolate, curcuminoid, piperine, methyl cinnamate, and vitamin C is combined to help increase body immunity (immunostimulant). Immunostimulant activity testing was carried out using the carbon clearance method. 30 male Wistar rats were randomly divided into 5 groups, namely the normal control group, the comparison drug control, and dose groups I, II and III where the regimen of the test material was given at consecutive doses of 7.2; 72; 720 mg /kg respectively. The treatment was given for 6 days, then a carbon suspension dose of 0.5 mL / BW was given intravenously. Blood samples from the tail vein at 5, 10, and 15 minutes were measured for absorbance using a UV-Vis spectrophotometer at a wavelength of 650 nm. Phagocytosis constant and Phagocytosis Index (IF) were determined to assess immunostimulant activity. The phagocytosis constant in the regimentation of the test material showed a faster pattern in eliminating carbon compared to the normal control group and the reference drug. The regimentation of the test material also had an IF value > 1.5 which is a strong immunostimulant category.

Education and nutrition intervention to mitigate stunting in Cisaranten Wetan, Cinambo District, Bandung Dewi Astriany; Adang Firmansyah; Pupung Ismayadi; Iffa Risfayanti; Rizki Amaludin Mutaqin; Sani Nurlaela Fitriansyah
Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Vol. 9 No. 2 (2024): May 2024
Publisher : University of Merdeka Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26905/abdimas.v9i2.12813

Stunting is a complex problem related to environmental health and the provision of nutritious food. Chronic malnutrition in children results in permanently impaired physical and cognitive growth. Cisaranten Wetan Village, Cinambo District, Bandung has problems with the health conditions of children who are indicated to be stunted. The purpose of this service activity is to provide education to Integrated Healthcare Center (in Indonesia: Posyandu) cadres and the community regarding stunting, as well as assistance with specific nutritional interventions for children indicated as stunted. Education was conducted by the STFI Community Service Team with the theme of balanced nutrition and child development in the form of counseling, videos, and leaflets. Children who are indicated to be stunted are given additional food in the form of egg powder, curcumin honey, and goat milk regularly. The existence of routine education carried out with various media causes a change in the level of knowledge from the moderate category to good in mother respondents with children who are indicated to be stunted. Increased maternal knowledge affects behaviour in parenting and child growth and development.

Formulation of Ethyl p-Methoxycinnamate (EPMC) Clay Mask as an Anti-Acne Agent Using a Box–Behnken Design Andriyannto, Adit; Legowo, Wahyu Priyo; Firmansyah, Adang; Rachmaniar, Revika
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 2 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i2.68948

Jerawat merupakan gangguan kulit yang umum terjadi dan memengaruhi sekitar 80–85% remaja serta dewasa muda di Indonesia. Pada penelitian sebelumnya, ethyl p-methoxycinnamate (EPMC) merupakan senyawa utama dari rimpang kencur (Kaempferia galanga L.) yang memiliki aktivitas antibakteri dengan konsentrasi hambat minimum (KHM) sebesar 1,2% b/v terhadap Cutibacterium acnes, bakteri utama penyebab jerawat. Dalam upaya meningkatkan kemudahan penggunaan dan potensi terapinya, dikembangkan sediaan masker clay sebagai sistem penghantaran topikal yang inovatif. Penelitian ini bertujuan memperoleh formula masker clay yang teroptimasi menggunakan Desain Box–Behnken, dengan kaolin (15–30% b/b), bentonit (1–2% b/b), dan xanthan gum (0,5–1% b/b) sebagai faktor, serta respon yang dievaluasi meliputi pH, viskositas, dan waktu mengering. Optimasi menghasilkan formula optimum yang mengandung 26,925% b/b kaolin, 1,808% b/b bentonit, dan 0,854% b/b xanthan gum dengan nilai desirabilitas 1,000. Masker clay optimum memiliki pH 7,560 ± 0,0899, viskositas 20.583,33 ± 650,85 mPa·s, waktu mengering 25,58 ± 1,36 menit, daya sebar 4,038 ± 0,096 cm, daya lekat 8,80 ± 1,018 detik dan uji antibakteri menunjukkan zona hambat sedang sebesar 6,969 ± 0,896 mm, lebih besar dibandingkan EPMC murni. Secara keseluruhan, formula optimum masker clay EPMC menunjukkan sifat fisik yang baik serta aktivitas antibakteri dalam kategori sedang yang berpotensi mendukung terapi jerawat.

Co-Authors Achmad - Zainuddin Alaris Darasito Damanik Almira Asih Maulani Andriyannto, Adit Anik Setiawati Anik Setiawati, Anik Ati - Setiasih Budipramana, Krisyanti Dadan Rohdiana Deni Deni Dewi Astriany Dewi Astriany Fathurrahman, Muhammad Hilmi Fauzi, Novi Irwan Ferdiansyah, Rival Fitriyani Fitriyani Hamdani, Syarif Haruman - Kartamihardja Husein, Sri Gustini Iffa Risfayanti Irma Erika Herawati Ismayadi, Pupung Legowo, Wahyu Priyo Lina Maudyawati Luh Putu Ratna Sundari Melvia Sundalian Melvia Sundalian Muhammad Ismail Faruqi Nella - Nurmeilasari Novi Irwan Fauzi Nuni Yunita Nuni Yunita, Nuni Nur Asni Setiani O - Suprijana Oo - Suprijana Pupung Ismayadi Putri Afiyanti Putri Yuniar Saraswati Rachmaniar, Revika Rafif Abdikah Utama Rahmat, Sendi Dwi Rahmawati, Sarah Rifka ratih ratih Resti Pahlawati Fauziah Ricky Johanes Hutagaol Rizki Amaludin Mutaqin Sahari, Yuni Sani Nurlaela Fitriansyah Sari, Nia Kurnia Siti Uswatun Hasanah Sohadi - Warya Sri Gustini Tini - Apriliani Umi Baroroh Windari - Syafitri Wiwin - Winingsih Wiwin Winingsih Wiwin Winingsih Yefi Ardyanti Yuanita - Permana Yulia - Riesmawati Yusuf, Fuzy Fauziah Zenith Virgina Ababiel

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