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All Journal JURNAL PHARMASCIENCE INDONESIAN JOURNAL OF PHARMACY Pharmascience Jurnal Surya Medika Journal of Dedicators Community PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Biomedika Cendekia Journal of Pharmacy Avicenna : Journal of Health Research SEMAR (Jurnal Ilmu Pengetahuan, Teknologi, dan Seni bagi Masyarakat) Jurnal Farmasi Indonesian Journal of Pharmaceutical Education Bengawan :Jurnal Pengabdian Masyarakat Jurnal Kesehatan Farmasi Jurnal Sains dan Kesehatan

Mamik Ponco Rahayu

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Author-ID : 6466992

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Aktivitas Antihipertensi dari Ekstrak Etanol Daun Dewandaru (Eugenia uniflora L.) pada Tikus Putih Jantan yang Diinduksi Adrenalin Eka Umayasari; Lucia Vita Inandha Dewi; Mamik Ponco Rahayu
Jurnal Farmasi Indonesia Vol 12 No 1 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Hypertension is a condition in which an individual develops above normal blood pressure, when systolic blood pressure exceeds 140 mmHg and diastolic exceeds 90 mmHg. Hypertension becomes health problem in the world. Dewandaru leaves contained flavonoid, saponin and tannin. This research aimed to find out the antihypertensive activity of dewandaru leaves ethanol extract and to find out the most optimum dose of dewandaru ethanol extract (Eugenia uniflora L.). Dewandaru leaves ethanol extract was obtained through extraction using maceration method and using ethanol 96% solvent. This study employed 25 male white rats divided into 5 groups: groups I (control with kontrol negatif, II (control with captopril), III (ethanol extract at 0.3 mg/200 gBW dose), IV (ethanol extract at 0.6 mg/200 g BW dose), V (ethanol extracts at 1.2 mg/200 g BW dose). The tested animal was made hypertensive with adrenaline induction intraperitoneally. The blood pressure measurement was conducted on the week-3 using blood pressure analyzed. The analysis used in this research was ANOVA with Dunnet T3 advanced test. From the result of research, it could be found that all doses of dewandaru leaves ethanol extract had antihypertensive activity. Dose 1.2 mg/200 g BW had effect equivalent to captoprilâ€™s.

AKTIVITAS ANTIBAKTERI DAN ANTIJAMUR KULIT BATANG KRANGEAN(Litsea cubeba Pers.) Mamik Ponco Rahayu; Ismi Rahmawati; Wahyu Listiantoro; Wayndy Chrisantoso
Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Litsea cubeba Pers or Krangean is a traditional medicinal plant widely used as an antidiarrheal, skin diseases, as well as antiseptic agent. In addition to essential oils, this herb also contains various components such as tannins, saponins, flavonoids and alkaloids. The purpose of the study was to determine the activities of n-hexane fraction, ethyl acetate, and water from the ethanolic extract of the Krangean stem bark as antibacterial and antifungal properties against E. coli ATCC 25922, S. aureus ATCC 25923 and C. albicans ATCC 1023. Krangean stem bark extraction was conducted by maceration method using 70% ethanol as solvent, followed by fractionation with n-hexane, ethyl acetate, and water as solvent. Antibacterial and antifungal activities were determined by diffusion and dilution method. Diffusion method was used to measure the diameter of the inhibitory area against bacteria colonies with concentrations used were 50%, 25%, as well as 12.5%. Dilution method (dilution tubes), was conducted in serial dilutions of various concentrations, 50%, 25%; 12.5%, 6.25%; 3.12%; 1.56%; 0.78%; 0.39%; and 0.195%. The results showed that n-hexane fraction of the ethanolic extract of the Krangeanâ€™ stem bark had the highest activity against E. coli ATCC 25922 and C. albicans ATCC 10231 compared to other fractions, based on the average of diameter inhibition values. The diffusion method showed that nhexane fraction at concentration of 50% had inhibitory activity against E. coli ATCC 25922, and C. albicans ATCC 10231 with the average inhibitory power were 30 Â± 0,00 mm and 20,4 Â± 0,58 mm, respectively. n-Hexane fraction could kill E. coli ATCC 25922, and C. albicans ATCC 10231 with the Minimum Killing Inhibitory Concentration (MKC) value were 1.56%, and 0.39%, respectively.The presence of essential oils and triterpenoid in n-hexane fraction were detected in the preliminary phytochemical tests.

Optimasi Proporsi Polisorbat 80 dan Sorbitan 80 dalam Formulasi Krim Ekstrak Etil Asetat Daun Jengkol (Pithecollobium lobatum Benth) Sebagai Antibakteri dengan Metode Desain Faktorial Ghani Nurfiana Fadma Sari; Ilham Kuncahyo; Mamik Ponco Rahayu
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Jengkol leaves ethyl acetate extract shows to have antibacterial activity because it contains saponins, flavonoids and tannins. The use of jengkol leaves ethyl acetateextract directly assessed less well, so that it made cream preparations to make it more convenient to use. This study aimed to obtain the optimum formula of cream of jengkol leavesethyl acetate extract using additional materials polysorbate 80 and sorbitan 80 by Factorial Design method. The Jengkol leaves extract obtained by soxhletation using n-hexane solvent followed by ethyl acetate was then evaporated to obtain a viscous extract. Jengkol leaves extract ethyl asetat cream was made four made in four formulas based on factorial design method. The resulting cream conducted stability tests including organoleptic test, viscosity, adhesiveness, and dispersive power. Optimum formulation parameters based on physical properties, namely: viscosity, viscosity shift, and dispersive power, using Design EaseÂ® Software version 7.1.6. Optimum formula was determined the physical properties and the data were analyzed using t-test. Antibacterial activity was tested by diffusion method. Optimum formula cream of jengkol leaves ethyl acetate extract obtained from proportion polysorbate 80 of 0.44 g and sorbitan 80 of 1.15 g with the physical properties of the response of the optimum formula predictions and experimental result showed no significant difference. Optimum cream showed antibacterial activity presented as inhibition diameter of 14 mm after one day incubation, more potential than formulation 1 (12.8 mm), formulation A (13,8 mm), formulation B (13,2 mm), and formulation AB (13 mm) against Staphylococcus aureus bacteria.

Optimasi Pelarut Ekstraksi, Aktivitas Anthelmintika terhadap Ascaris lumbricoides Suis., dan Telaah Fitokimia Bunga Ekor Kucing (Acalypha hispida Burm. F.) MAMIK PONCO RAHAYU; ESTU SYA’BANA; AROFATUL HIDAYAH
Jurnal Farmasi Indonesia Vol 9 No 1 (2012): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Red hot cat's tail (Acalypha hispida Burm. F.) flowers is a traditional medicinal plant which can be used as an antelmintic. The aim of present study was to determine the solvent extraction of Red hot cat's tail flowers that produce the highest yield, to determine antelmintic activity against roundworms (Ascaris lumbricoides Suis.) and to determine the compounds in the extract. The powder was extracted by maceration with ethanol with four variations concentration. Extract was analyzed the soluble in ethanol extract concentration and the yield. The highest yield extract was tested on roundworms by in vitro. The worms were grouped into 12 groups randomly without regard to gender. The group consists of one negative control group was be given distilled water, the positive control group was be given piperazine citrate in 5 different concentrations, and the red hot cat's tail flowers group with 6 variations of concentration. Observation of the worm is done after 24 hours of treatment. Data were analyzed by probit method to determine the LC50. The results of this study were solvent extraction that produces the highest yield was 70% ethanol. The 70% ethanol extract had an antelmintic activity against roundworms with 6,61% w/v as LC50 values that equivalent to 0,12% w/v piperazine citrate. The 70% ethanol extract contained saponins, flavonoids, and tannins.

OPTIMASI FORMULA KRIM DAUN JENGKOL (Pithecollobium lobatum Benth) SEBAGAI ANTIBAKTERI MENGGUNAKAN DESAIN FAKTORIAL Kiki Puspitasary; Ilham Kuncahyo; Mamik Ponco Rahayu
Avicenna : Journal of Health Research Vol 3, No 1 (2020): MARET
Publisher : STIKES Mamba'ul 'Ulum Surakarta

Latar belakang : Daun jengkol (Pithecollobium lobatum Benth) merupakan bahan obat tradisional yang digunakan oleh masyarakat sebagai obat eksim, kudis, luka dan bisul, kulit buahnya untuk borok. Daun jengkol mengandung saponin, flavonoid dan tanin. Menurut Salni (2011) fraksi etil asetat daun jengkol pada konsentrasi 160 ppm mempunyai aktivitas antibakteri terhadap Staphylococcus aureus ATCC 25923. Tujuan Penelitian : Penelitian ini untuk mendapatkan formula optimum krim ekstrak daun jengkol dan mengetahui aktivitas antibakteri terhadap Staphylococcus aureus ATCC 25923. Metode : Ekstraksi diawali dari pelarut n-heksan kemudian etil asetat. Ekstrak etil asetat dipekatkan dengan evaporator kemudian digunakan sebagai zat aktif dalam pembuatan krim. Krim ekstrak daun jengkol dibuat empat formula berdasarkan metode desain faktorial. Krim yang dihasilkan diuji sifat fisiknya meliputi organoleptis, viskositas, daya sebar, daya lekat. Formula optimum berdasarkan parameter sifat fisik krim yaitu: viskositas, daya sebar, daya lekat diperoleh menggunakan software Design Ease® versi 7.1.6. Formula optimum yang diperoleh dibuat dan diuji sifat fisiknya selama 4 minggu serta aktivitas antibakterinya menggunakan metode difusi. Hasil : Formula optimum krim ekstrak daun jengkol diperoleh pada proporsi polisorbat 60 sebesar 0,41 g dan sorbitan 60 sebesar 1,19 g. Respon sifat fisik formula optimum dari hasil prediksi dan percobaan menunjukkan tidak ada beda signifikan. Aktivitas antibakteri krim optimum sebesar 15,3 mm. Simpulan : Ekstrak daun jengkol dapat dibuat krim dengan formula optimum dengan sifat fisik yang baik melalui pengujian beberapa formula menggunakan desain faktorial.

Pelatihan Pembuatan Minyak Telon Antinyamuk Sebagai Upaya Perawatan Kesehatan Anak dan Perintisan Home Industri di Surakarta Ghani Nurfiana Fadma Sari; Endang Sri Rejeki; Mamik Ponco Rahayu; Nuraini Harmastuti; Taufik Turahman; Supriyadi Supriyadi
Journal of Dedicators Community Vol 5, No 1 (2021)
Publisher : Universitas Islam Nahdlatul Ulama Jepara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34001/jdc.v5i1.1192

Telon oil and children have been an inseparable unity. The making of telon oil from easy-to-find traditional ingredients can encourage home industry ideas for economic growth. The use of essential oils (orange oil/ lavender oil) as components of the making of telon oil is expected to avoid mosquito bites causing itching and even dengue fever. The community service activity program aims to provide training of anti-mosquito telon oil making to keep children healthy. The participants of the program include a cadre of PKK (Family Welfare Movement) members in RW (Community Unit) 21, Nusukan Village, Banjarsari Sub-district, Surakarta. The community service activity began with the explanation of natural ingredients used to make telon oil as well as their benefits. Afterward, the training was conducted through several stages including a tutorial, technical assistance by the community service team, and evaluation of the activity. The results of the activity are: 1) the participants have an understanding of the benefits of the ingredients used; 2) the participants understand the procedure to make the anti-mosquito telon oil; 3) the participants can make the anti-mosquito telon oil by themselves.

AKTIVITAS FAGOSITOSIS MAKROFAG DARI FRAKSI N-HEKSAN HERBA SAMBILOTO (Andrographis paniculata, (Burm.F) Nees) TERHADAP MENCIT YANG DIINDUKSI VAKSIN HEPATITIS B Mamik Ponco Rahayu
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 11 No. 02 Desember 2014
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v11i2.837

ABSTRAK Herba sambiloto (Andrographis paniculata Burm. Nees) mengandung komponen senyawa kimia yang mempunyai aktivitas sebagai imunomodulator. salah satu kandungan zat aktifnya adalah andrographolida yang aktif sebagai hepatoprotektor. Penelitian ini bertujuan untuk mengetahui aktivitas dari A. paniculata sebagai imunomodulator terhadap mencit Balb/c yang telah diinduksi vaksin hepatitis B. Ekstraksi herba sambiloto menggunakan alat Soxhlet dengan pelarut yang berseri. Vaksin hepatitis B digunakan sebagai penginduksi mencit Balb/c. Sebagai tolak ukur imunostimulator adalah peningkatan aktivitas fagositosis makrofag. Hasil penelitian menunjukkan bahwa tiga fraksi aktif dengan peningkatan aktifitas fagositosis makrofag tertinggi sampai terendah yaitu F2, F3, dan F1. Hasil analisis fitokimia menunjukkan kandungan golongan senyawa dari fraksi FI adalah terpenoid, F2 adalah steroid, terpenoid, dan flavonoid; F3 dan F5 adalah terpenoid; serta fraksi F4 mengandung alkaloid. Kata kunci: hepatitis B, herba sambiloto (A. paniculata Burm. Nees), imunomodulator, vaksin. ABSTRACT Andrographis herbs (Andrographis paniculata Burm. Nees) contains many active compounds and showed imunomodulatory activity. One of its component, andrograpolide, has hepatoprotector activity. Therefore, the aim of this study was to find out the immunomodulator compounds from A. paniculata in the BALB/c mice induced by hepatitis B vaccine. Andrographis herbs was extracted using Soxhlet by series of solvents. The isolation process was guided by in vivo imunommodulatory activity in in Balb/c mice induced by hepatitis B vaccine. The imunostimulant activity was assesed through the phagocytic activity of macrophage. The most active extract was fractionated by vaccum column chromatography and further phytochemically identified. The fraction enhanced phagocyte activities of macrophage were F2, F3, and F1. The results of phytochemical analysis showed that the group of compounds from F1 was terpenoid, F2 were steroid, terpenoid, and flavonoid; F3 and F5 were terpenoid; and F4 was alkaloid. Key words: andrographis herbs (Andrographis paniculata Burm. Nees), imunomodulator, hepatoprotector, hepatitis B vaccine.

Pengaruh Konsentrasi Asam Stearat Terhadap Mutu Fisik Losion Ekstrak Daun Nangka (Arthocarpus heterophyllus) Sebagai Antioksidan Natasya Sava Agasta; Siti Aisiyah; Mamik Ponco Rahayu
Jurnal Farmasi (Journal of Pharmacy) Vol 11, No 1 (2022)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v11i1.173

Jackfruit leaf extract was developed into a lotion preparation to increase skin moisture and prevent the skin from being exposed to free radicals. The purpose of this study was to determine the effect of variations in stearic acid base on physical quality, differences in antioxidant activity in jackfruit leaf extract and preparations, best formula that can provide antioxidant activity.Jackfruit leaf extract was obtained by maceration using 70% ethanol and then formulated with a concentration of 6% jackfruit leaf extract and variations in stearic acid base 2%, 3%, and 4%. This study used the DPPH method to determine antioxidant activity and ANOVA for statistical analysis. This study obtained the IC50 value of jackfruit leaf extract of 64.5616 ppm. Variations of stearic acid have an effect on the physical quality and value of antioxidant activity. The IC50 value of jackfruit leaf extract and lotion was different due to the presence of additional ingredients in the lotion. The best formula from this research, formula has the best physical quality value, with the IC50 value of the extract in the formula 70.6862 ppm and the IC50 value of the base in the formula 1179.3357 ppm.

Antibacterial Activity of Karanda (Carissa Carandas) Leaf and Fruit Extract to Against Streptococcus mutans, Escherichia coli, Staphylococcus aureus Destik wulandari; Mamik Ponco Rahayu; Fransiska Leviana
Jurnal Kesehatan Farmasi Vol 4, No 1 (2022)
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Tanaman karanda (Carissa carandas) memiliki aktivitas antimikroba. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak daun dan buah karandas sebagai antibakteri terhadap Streptoccocus mutans, Escherichia coli, Staphylococcus aureus. Daun dan buah karandas diekstraksi menggunakan metode maserasi dengan pelarut methanol. Ekstrak daun dan buah karanda diuji aktivitas antibakterinya menggunakan metode difusi seumuran. Hasil penelitian menunjukkan bahwa ekstrak daun Carissa carandas mampu menghambat bakteri S. aureus dan E. coli dan ekstrak buah mampu menghambat bakteri S. mutans dengan optimal.

Uji Aktivitas Antiinflamasi Ekstrak Batang Karamunting (Rhodomyrtus tomentosa) Terhadap Tikus Jantan Galur Wistar: Test of Antiinflamatory Activity Extract of Karamunting (Rhodomyrtus tomentosa) Stem to Male Rat Wistar Strain Rika Arfiana Safitri; Mamik Ponco Rahayu; Gunawan Pamudji Widodo
Jurnal Surya Medika (JSM) Vol. 9 No. 1 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i1.5202

Inflammation is a response to tissue damage due to various adverse stimuli, both chemical and mechanical, infections and foreign bodies such as bacteria and viruses. This study aims to determine the effect of the anti-inflammatory effect of ethanol extract of karamunting stems. Karamunting stems were extracted by maceration method using 96% ethanol solvent. Each anti-inflamatory test was divided into five groups, namely the negative control group (CMC Na), the positive control group (Diclofenac Na), the Karamunting stem extract test group (dose of 100 mg/kg BW, 200 mg/Kg BW, and 400 mg/kg). kg BW). Anti-inflammatory test using the Rat hind paw edema method induced by 1% carrageenan. Data analysis used the Shapiro-Wilk test and then continued with a one-way ANOVA test. The results showed that the ethanol extract of karamunting stems had an anti-inflammatory effect at doses of 200 mg/Kg BW and 400 mg/Kg BW.the karamunting stem could provide an analgesic effect at a dose of 200 mg/Kg BW.

Co-Authors Aditya Prasetyo AROFATUL HIDAYAH Asaddah Dwi Mulyani Bunga Yuniasakti Desi Ratna Dewi, Lucia Vita Inandha Dyah Susilowati Eka Umayasari Endang Sri Rejeki Endang Sri Rejeki ESTU SYA’BANA Fransiska Leviana Ghani Nurfiana Fadma Sari Gunawan Pamudji Gunawan Pamudji Widodo Hilda Khairunnisa Ika Purwidyaningrum Ilham Kuncahyo, Ilham Ismi Rahmawati Kartinah Wiryosoenjoyo Kiki Puspitasary Nainggolan, Rully Mukti Natasya Sava Agasta Nuraini Harmastuti Purnamasari, Nur Aini Dewi Reslely Harjanti Rika Arfiana Safitri Rini Prastiwi Rosa Juwita Hesturini Siti Aisiyah Supriyadi Supriyadi Supriyadi Tri Wijayanti Turahman, Taufik Turahman, Taufik Wahyu Listiantoro Wayndy Chrisantoso Wulandari, Destik

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