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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Penelitian Pendidikan IPA (JPPIPA) Biolearning Journal Jurnal Abdimasa Jurnal Ners Jurnal Promotif Preventif Jurnal Kesehatan Tambusai Jurnal EduHealth Journal of Pharmaceutical and Sciences. Jurnal Etnofarmasi
A. M. Muslihin
Universitas Pendidikan Muhammadiyah Sorong
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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Studi Fitokimia Senyawa Aktif Ekstrak Batang Nelambo suon (Rubiaceae) Rossardy, Marzella Dea; Muslihin, A.M.; Watora, Wahyuni; Budiyanto, Angga Bayu; Hardia, Lukman; Irwandi, Irwandi; Aponno, Alyssa Mileta; Utami, Hikmahtul Putri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1333

Abstract

Background: Papua has high biodiversity with significant potential as a source of traditional medicinal plants, including Nelambo suon (Rubiaceae), which has been empirically used by local communities. However, scientific information regarding the active compounds in its stem bark remains limited. Objective: This study aimed to identify the secondary metabolite groups present in the ethanol extract of Nelambo suon stem bark through phytochemical screening. Methods: The research was conducted experimentally using the maceration method with 80% ethanol as the solvent. The stem bark simplicia was extracted and qualitatively screened for alkaloids, flavonoids, tannins, and saponins using specific reagents. Results: The results showed that the ethanol extract of Nelambo suon stem bark contained alkaloids, flavonoids, tannins, and saponins, indicated by characteristic color changes, precipitate formation, and foam production. Conclusion: These findings suggest that Nelambo suon stem bark is a potential source of bioactive compounds and may be further developed as a herbal medicinal material based on local wisdom.
Antioxidant The Effect of Solvent Variation on Antioxidant Activity in Red Fruit Extract (Pandanus Conoideus Lam) Using UV-Visible Spectrophotometry Liwen Vinesia Bilat Werluka; Ratih Arum Astuti; AM Muslihin
Jurnal EduHealth Vol. 17 No. 01 (2026): Jurnal EduHealt, January-March 2026
Publisher : Sean Institute

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Abstract

This study aims to determine the effect of different solvents on the antioxidant activity of red fruit seed extract (Pandanus conoideus Lam). It was analysed using the DPPH assay and UV–Vis spectrophotometry. Samples were extracted using the maceration method with various solvents, namely 96% ethanol, n-hexane, and ethyl acetate. The yield results showed that ethanol, n-hexane, and ethyl acetate extracts yielded 18%, 12%, and 11%, respectively. Phytochemical screening tests showed that ethanol extracts contained flavonoids, alkaloids, tannins, and saponins. The n-hexane extract contained alkaloids, while the ethyl acetate extract contained alkaloids and saponins. Antioxidant activity was assessed based on the IC₅₀ value of the ethanol extract, which showed antioxidant activity with an IC₅₀ value of 54.67 μg/mL, categorised as a very strong antioxidant. The ethyl acetate extract had an IC₅₀ value of 19.92 μg/mL, categorised as strong, while the n-hexane extract showed the highest IC₅₀ of 9.40 μg/mL, categorised as very strong. These differences indicate that solvent polarity affects the amount and type of bioactive compounds extracted, thereby affecting the ability to capture free radicals. Thus, these results indicate that n-hexane solvent provides the strongest antioxidant activity in red fruit seed extractsc.
Efficacy of Akway (Drymis sp.) Bark Extract in Restoring Hemoglobin Levels: A Preclinical Study in a Sodium Nitrite-Induced Anemia Mice Model Lukman Hardia; Fabanyo, Syahrul H.; Budiyanto, Angga Bayu; Muslihin, A. M.; Rossardy, Marzella Dea; Irwandi, Irwandi; Watora, Wahyuni
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 11 No. 1 (2026)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v11i1.44062

Abstract

The high prevalence of anemia prompted us to explore the potential of local herbs in Papua, Indonesia, which is known for its rich natural resources. In this study, we aim to conduct preclinical tests on anemia model test animals to validate the effectiveness of akway bark extract (ABE) as the basis for the development of effective and safe herbal antianemia drugs in the future. This study employs a quantitative analytical approach, utilizing an experimental design with a pre-posttest with a control group design. The research sample used 20 mice test animals, divided into 5 groups consisting of 4 animals each, namely: the control group (positive and negative), and the intervention group using ABE doses of 10, 30, and 50mg/kg. This study was approved by the Health Research Ethics Committee of STIFAR Makassar (Number: 299/EC.1.1.B/III/KEPK/2024). Data analysis showed that a 14-day intervention using ABE was able to increase Hb levels (D% = 52.00±27.13 [ABE dose 10mg/kg]; 49.72±7.86 [ABE dose 50mg/kg] and 42.82±12.75 [ABE dose 30mg/kg]) significantly (p<0.05) when compared with the negative control (D% = 4.54±5.14), but when compared with the positive control (D% = 52.57±10.85) the average increase in Hb levels was not significant (p>0.05). In conclusion, our study showed that mice of the anemia model, intervened using ABE at doses of 10, 30, and 50mg/kg once daily for 14 days, experienced increased Hb levels.
Formulasi Dan Aktivitas Antioksidan Sirup Air Kelapa Tua (Cocos nucifera L) Dan Ekstrak Buah Merah (Pandanus conoideus L) Dengan Metode DPPH Siti Mun Muhliza Ahmad; Ratih Arum Astuti; A.M. Muslihin
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1496

Abstract

Background: Mature coconut water (Cocos nucifera L.) has the potential as a health drink but is often discarded as waste. Red fruit (Pandanus conoideus L.) is an endemic plant of Papua that is rich in antioxidants. The combination of both is expected to produce a beneficial herbal syrup preparation. Objective: To formulate a combination syrup of mature coconut water and red fruit extract and to determine its antioxidant activity using the DPPH method. Methods: Red fruit extract was obtained by maceration using 96% ethanol. Phytochemical screening was performed on both ingredients. The syrup was prepared with the addition of sugar, citric acid, vanilla, and CMC. Physical evaluation included organoleptic, homogeneity, pH, viscosity, and clarity tests. Antioxidant activity was tested using the DPPH method at a wavelength of 517 nm using a UV-Vis spectrophotometer. Results: Phytochemical screening showed that mature coconut water contains alkaloids, while red fruit extract contains flavonoids, tannins, saponins, and alkaloids. The syrup evaluation met SNI requirements: organoleptic (reddish-orange color, characteristic odor, sweet taste), homogeneous, pH 5–6, viscosity 250 mPa·s, and clear. The IC50 values of the syrup in three consecutive replicates were 550.34 μg/mL, 2282.3 μg/mL, and 2863.4 μg/mL, which are classified as weak antioxidant activity (IC50 > 200 ppm). Conclusion: The combination syrup of mature coconut water and red fruit extract exhibits weak antioxidant activity but meets the physical quality standards of the preparation. This preparation has the potential to be developed as a herbal health drink.
Aktivitas Sedatif Ekstrak Etanol Batang Tali Kuning (Anamirta cocculus (L.) Wight & Arn.) Terhadap Mencit (Mus musculus) Jantan Wiwit Ayu Fitrianti; A.M. Muslihin; Ratih Arum Astuti
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1513

Abstract

Mental health is a state of well-being that includes where individuals recognize their personal potential, enabling them to manage life's pressures and be able to work productively. Treatment of mental health disorders usually involves the use of sedative drugs such as benzodiazepines, barbiturates, and several other drugs. This study aims to evaluate the sedative activity of the ethanol extract of tali kuning (A. cocculus (L.) Wight & Arn.) stem in male mice as an alternative therapy requiring sedative effects. The study was conducted using a quantitative experimental approach with a pretest–posttest control group design and the rotarod method. The experimental animals were divided into five groups: positive control, negative control, and three extract dose groups treated with the ethanol extract of tali kuning stem at 19.25 mg/kgBW, 38.5 mg/kgBW, and 77 mg/kgBW. The results indicated that the ethanol extract of tali kuning stem at all three doses produced sedative activity, as validated by a paired sample t‑test that revealed significant differences condition between pre‑ and post‑treatment measurements. The ethanol extract of tali kuning stem at doses of 19.25 mg/kgBW, 38.5 mg/kgBW, and 77 mg/kgBW demonstrated sedative activity, although statistical comparison with the positive control showed variable results depending on dose and observation time.
Studi In Vivo Efek Nefroprotektif Ekstrak Etanol Batang Tali Kuning (Anamirta cocculus (L.) Wight & Arn.) terhadap Profil Kreatinin Serum Mencit Dian Nur Khofifah; A. M. Muslihin; Lukman Hardia
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1522

Abstract

Background: Nephrotoxicity due to the use of drugs such as gentamicin can cause kidney damage characterized by increased creatinine levels. The use of medicinal plants as nephroprotective agents is a potential alternative; one such plant is yellow rope stem (Anamirta cocculus (L.) Wight & Arn.), known to contain antioxidant compounds. Objective: This study aims to assess the nephroprotective activity of yellow rope stem ethanol extract and determine the optimal dose for reducing gentamicin-induced increases in creatinine levels in mice. Method: The study was conducted experimentally with a pre-test and post-test design using the maceration method with 70% ethanol solvent. Mice were divided into six groups, namely negative control, positive control (vitamin E), healthy control, and three treatment groups with varying extract doses. Creatinine levels were measured using the Jaffe method with a UV-Vis spectrophotometer. Results: The results showed that the yellow rope stem ethanol extract at a dose of 77 mg/kgBW was able to reduce creatinine levels significantly (p<0.05), while lower doses did not show a significant difference. Conclusion: Ethanol extract of yellow rope stems has nephroprotective activity at an optimal dose of 77 mg/kgBW, thus having the potential to be developed as a herbal agent to protect kidney function.
Evaluasi Mutu Fisikokimia dan Aktivitas Antioksidan Minuman Isotonik Ekstrak Batang Tali Kuning (Anamirta cocculus (L.) Wight & Arn.) Nadziatul Khasanah; A.M. Muslihin; Marzella Dea Rossardy; Justitia Cahyani Fadli
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1529

Abstract

as having potential as a natural antioxidant agent. One potential way to utilize this plant is by innovating it into an isotonic drink product. Objective: This study aimed to evaluate the physicochemical properties and antioxidant activity of an isotonic drink formulated with yellow rope stem extract. Methods: he extraction process was conducted using the maceration method with 70% ethanol as the solvent. The isotonic drink was developed into three formulas, which were then tested for their physicochemical properties and antioxidant activity using the DPPH method. Results: The results indicated that the best formula was FII, with an overall hedonic score of 4,6 (neutral). All three formulas showed identical pH values (4,0) and Total Soluble Solids (TSS) of 7%, while the total acidity decreased progressively: FI (1,024%), FII (0,896%), and FIII (0,704%). The isotonic drinks from yellow rope stem extract for formulas FI, FII, and FIII produced IC50 values of 35,61, 46,56, and 57,69 μg/mL, respectively. Based on these data, FI and FII were identified as having very strong antioxidant intensity, while the FIII showed activity classified in the strong category. Conclusion:.The test results demonstrate that the isotonic drink made from yellow rope stem extract exhibits antioxidant potential with intensity levels ranging from strong to very strong.
Research Trends of Stunting Related to Insulin-Like Growth Factor-1: Bibliometric Analysis Lukman Hardia; Agus Sangka Pratama; A. M. Muslihin
Jurnal Penelitian Pendidikan IPA Vol 9 No SpecialIssue (2023): UNRAM journals and research based on science education, science applic
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9iSpecialIssue.6903

Abstract

Stunting is a condition in which a person's height is less than normal based on age and gender. The prevalence of stunting in Indonesia in 2021 is 24.4%. This illustrates that stunting is still a problem that cannot be resolved in Indonesia. Research on the incidence of stunting was carried out to determine its relationship with insulin-like growth factor-1 (IGF-1) levels. Search results on the Pubmed database obtained 446 English-language articles published from 1993 – April 12, 2023. The results of bibliometric analysis and VOSViewer show that new research trends began to be seen in 2018 to 2023 even though there had been publications previously in 1993 and 2000, but very minimal amount. The most dominating document types were journal articles with 310 publications (69.51%) and reviews with 89 publications (19.96%). The most trending keywords are humans (268), female (176), male (145), animals (142), insulin-like growth factor i/metabolism (94), child (74), adult (60), mice (56), pregnancy (47) and child preschool (43). The publishing journals that published the most articles were Frontiers in Endochronolgy (22 publications), International Journal of Molecular Sciences (19 publications), Scientific Reports (13 publications). The highest number of author collaborations is from the USA with 78 articles being the country with the most collaboration on both SCP and MCP with an MCP to SCP ratio of 0.244. China ranks second with the number of articles of 63 with an MCP ratio of 0.190.
Phytochemical Screening and Antioxidant Activity Test of Ethanol Extract of Nelambosuon (Rubiaceae) Leaves Using the DPPH Method Natalia Aksamina Sagisolo; Ratih Arum Astuti; Wahyuni Watora; A.M. Muslihin
Jurnal EduHealth Vol. 17 No. 02 (2026): Jurnal EduHealt
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia is recognized as one of the world’s megabiodiversity countries, possessing a vast diversity of medicinal plants that have long been utilized in traditional medicine. Nelambo suon (Rubiaceae) is an indigenous plant traditionally used by the Tehit Imian tribe in South Sorong, Southwest Papua, for treating wounds, skin infections, and inflammatory conditions. However, scientific information regarding its phytochemical profile and antioxidant activity remains limited. This study aimed to evaluate the phytochemical constituents and antioxidant activity of the ethanol extract of Nelambo suon leaves using the DPPH method. Fresh, undamaged green leaves were dried at room temperature without direct sunlight and extracted by maceration using 96% ethanol. Phytochemical screening was performed to identify major secondary metabolites, while antioxidant activity was assessed using the DPPH free radical scavenging assay and expressed as IC₅₀ values. The phytochemical screening revealed the presence of flavonoids and tannins in the ethanol extract, whereas alkaloids, saponins, steroids, and terpenoids were not detected. The antioxidant assay demonstrated a concentration-dependent increase in radical scavenging activity. The ethanol extract of Nelambo suon leaves exhibited an IC₅₀ value of 83.7 µg/mL, indicating strong antioxidant activity. These findings suggest that Nelambo suon leaves are a promising source of natural antioxidants, likely attributed to their flavonoid and tannin contents. This study provides preliminary scientific evidence supporting the traditional use of Nelambo suon and highlights its potential for further development as a natural antioxidant agent in pharmaceutical and herbal product applications.
Co-Authors Agus sangka pratama Aisyah, Heti Angga Bayu Budianto Angga Bayu Budiyanto Aponno, Alyssa Mileta Astuti, Ratih Arum Darmayanti Tumpu Dian Nur Khofifah Dieta Andaristi Erawati, Rika Fabanyo, Syahrul H Fabanyo, Syahrul H. Fadhilah, Windi Nur Fahira, Ifana Nur Hardiansyah, La Ode Heti Aisyah Irwandi , Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Justitia Cahyani Fadli Khusnul Fitriana Liwen Vinesia Bilat Werluka Lukman Hardia Maria Gloria Yeuyanan Marzella Dea Rossardy Maulana, Fajar Muhammad Andy Irfan Mustopa Mustopa Nadziatul Khasanah Natalia Aksamina Sagisolo Ni'ma, Eka Savira Nur Hasana Lamarunga Nur ‘Azah nurjanah, sartika wahyu Pratama, Agus Sangka Ratih Arum Astuti Rossardy, Marzella Dea Selfiana Iek Serlin Marsela Sintya Sari Dwi Kusumaningrum Siti Mun Muhliza Ahmad Tunazzila, Nurhikmah Utami, Hikmahtul Putri Wa Ode Nurwahida Wahyuni Watora Wasaraka, Fadila Alfiah Watora, Wahyuni Wiwit Ayu Fitrianti Yapsenang, Amar Jansen