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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Biology, Medicine, & Natural Product Chemistry Mutiara Medika: Jurnal Kedokteran dan Kesehatan Biomedika The Indonesian Biomedical Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Herb-Medicine Journal Journals of Ners Community Health Information : Jurnal Penelitian PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Pengabdian kepada Masyarakat Nusantara Epidemiology and Society Health Review (ESHR) Jurnal Sehat Indonesia (JUSINDO) Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara
Erika Diana Risanti
Universitas Muhammadiyah Surakarta
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Journal : The Indonesian Biomedical Journal

 1 
WIF1 Qualitative-Methylation from Peripheral Blood Could Not Be Used as Biomarker for The Risk of Nasopharyngeal Carcinoma or Smoking Behavior in Yogyakarta Panel Aditya Kurniawan; Erika Diana Risanti; Saihas Suhda; Hanggoro Tri Rinonce; Ery Kus Dwianingsih; Jajah Fachiroh
The Indonesian Biomedical Journal Vol 11, No 3 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i3.810

Abstract

BACKGROUND: Tobacco smoking plays an important role in nasopharyngeal carcinoma (NPC) risk. The Wingless-related integration site (WNT) Inhibitory Factor 1 (WIF1) as one of the tumor suppressor gene (TSG), functions to control cell proliferation through suppression of WNT signaling pathway. WIF1 methylation is one of epigenetic mechanisms which causes overactivated of WNT pathway in NPC development. WIF1 methylation from buffy coat related to smoking status and NPC risk is not known yet.METHODS: This was a nested case-control study involving 39 newly diagnosed NPC patients and 40 healthy controls. All subjects were enrolled at Dr. Sardjito Hospital, Yogyakarta. Subjects were male, with known smoking status, duration, and quantity of cigarette consumed. Parallel DNA isolated from buffy coat was used for WIF1 DNA methylation analysis, by using methylation-specific PCR (MSP) method. Chi-square analysis was used to determine distribution of differences among groups. Two tailed p-value≤0.05 was considered as statistically significant.RESULTS: No significant difference between WIF1 methylation of cases and controls (p=0.30), nor smoking habit among smokers (p=0.51) and non-smokers (p=0.43).CONCLUSION: WIF1 methylation from buffy coat could not be used as an NPC marker nor as a smoking behavior marker.KEYWORDS: buffy coat, cigarette smoking, methylation, nasopharyngeal carcinoma, WIF1
Association of Peripheral Blood RASSF1A and CDKN2A Methylation Status with Smoking Behaviour in Nasopharyngeal Carcinoma Erika Diana Risanti; Aditya Kurniawan; Laila Wahyuningsih; Ery Kus Dwianingsih; Hanggoro Tri Rinonce; Jajah Fachiroh
The Indonesian Biomedical Journal Vol 10, No 2 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i2.381

Abstract

BACKGROUND: Hypermethylation of RASSF1A and CDKN2A is one of epigenetic factor underlies nasopharyngeal carcinoma (NPC) development. Smoking behavior as an NPC’s risk factor causes aberrant DNA methylation. RASSF1A and CDKN2A promoter hypermethylation from peripheral blood cells correlates with smoking behavior. The use of body fluids including peripheral blood as a specimen for DNA methylation analyzes are widely developed, as less invasive method compared to the use of tissue biopsy. This study aims to observe the association between RASSF1A and CDKN2A methylation in peripheral blood and smoking behavioramong NPC patients.METHODS: Newly diagnosed NPC subjects were recruited from ear-nose-throat (ENT) outpatient clinic of Dr. Sardjito Hospital, Yogyakarta. DNA from buffycoat of 19 smokers and 20 non-smokers NPC’s patients were isolated. Bisulphite modification was applied to 500 ng of the isolated DNA. The methylation status was detected by MSP (methylation-specific polymerase chain reaction (PCR)). The association between smoking status and promoter hypermethylation was analysis using Chi-Square test.RESULTS: MSP analysis of RASSF1A showed that 68.42% smoker and 75% non-smoker NPC’s patients were methylated. MSP analysis of CDKN2A showed that 21.05% smoker and 25% non-smoker NPC’s patients were methylated. There was no association between smoking behavior with RASSF1A and CDKN2A methylation (p>0.05).CONCLUSION: Statistical analysis showed that smoking behavior is not associated with methylation of RASSF1A and CDKN2A among NPC’s patients.KEYWORDS: DNA methylation, CDKN2A, RASSF1A, Nasopharyngeal carcinoma, Smoking
Co-Authors Aditya Kurniawan Aditya Kurniawan Anak Agung Istri Sri Wiadnyani Anggraeny, Anisa Aqmarina, Nadia Wdihi Asfarina, Fatin Balqis, Aida Bima Tirta Pradana Ajie Gewab Binuko, Raafika Studiviani Dwi Budi Hernawan Busyra Busyra, B Devi Usdiana Rosyidah Dhiastika Nanda Sari Dyah Mustikaturrokhmah El Mubaraq, Syahrun Erna Herawati Erna Herawati Erna Herawati, Erna Ery Kus Dwianingsih Fitka Romanda Flora Ramona Sigit Prakoeswa Gewab, Bima Tirta Pradana Ajie Gusti Reka Kusuma Hanggoro Tri Rinonce Harun Joko Prayitno Hernawan, Budi Iin Novita Nurhidayati Mahmuda Jajah Fachiroh, Jajah Khairunnisa, Kana Laila Wahyuningsih Lestari, Nining Listiana Masyita Dewi Maharani, Faradiba Nadia Wdihi Aqmarina Naufal Yusuf Narindra Novita, Iin Nur Mahmudah Nur Mahmudah Nurhayani Nurhayani Nurhayani nurhayani Pramesti, Neva Galih Priyambodo Priyambodo Putri Nabilla Mitha Talita Qonita Rahmadiena Rahmadiena, Qonita Ratih Pramuningtyas Ratnasari Bondan Wijayanti Riandini Aisyah Rochmadina Suci Bestari Rohmaniar, Delianti Romanda, Fitka Safari Wahyu Jatmiko Sahilah Ermawati Saiful Hidayat Saihas Suhda Sari, Dhiastika Nanda Sari, Winda Atika Shinta Riana Setiawati Shinta Riana Setiawati, Shinta Riana Sri Wahyu Basuki Suci Bestari, Rochmadina Sulistyani, S Syahrun El Mubaraq Syifa Ramadhani Susilo Talita, Putri Nabilla Mitha Tri Agustina Tri Agustina, Tri Wijayanti, Ratnasari Bondan Zelindrah, Virgil