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Bagas Ardiyantoro
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Pengaruh Pemberian Fraksi Etil Asetat Daun Kelor (Moringa Oleifera Lamk.) terhadap Daya Ingat Mencit Jantan dengan Menggunakan Metode Labirin Y-Maze Bagas Ardiyantoro; Muhamad Farid Nurohman Krisnadi; Danang Raharjo
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 3 (2025): November : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i3.8021

Abstract

Memory decline is an early symptom of neurodegenerative disorders such as dementia, often caused by oxidative stress due to an imbalance between the production of Reactive Oxygen Species (ROS) and the body’s antioxidant defense system. Moringa leaves (Moringa oleifera Lamk.) are known to contain flavonoids, particularly quercetin, which exhibit antioxidant activity and are potentially beneficial for cognitive function. This study aimed to evaluate the effect of the ethyl acetate fraction of Moringa leaves on memory improvement in male mice induced with 10% ethanol. The ethyl acetate fraction was obtained through maceration using 70% ethanol, followed by fractionation with ethyl acetate. A total of 25 male mice were divided into five groups: negative control (1% CMC Na), positive control (Ginkgo biloba 60 mg/kgBW), and three treatment groups receiving the ethyl acetate fraction of Moringa leaves at doses of 50, 100, and 150 mg/kgBW. Memory performance was assessed using the Y-Maze method, consisting of three phases: acclimatization (T0), induction (T1), and treatment (T2). Data were analyzed using one-way ANOVA followed by Duncan’s post hoc test.The results showed that the ethyl acetate fraction of Moringa leaves significantly (p value < 0.05) reduced error counts and latency time, with the most optimal effect observed at a dose of 150 mg/kgBW. This dose led to a significant improvement in memory performance compared to the control groups, including the positive control. These findings suggest that the ethyl acetate fraction of Moringa leaves has a more effective potential to enhance memory compared to the positive control, with a time difference of 40 seconds and an error rate difference of 11.67%.
Uji Stabilitas dan Uji Hedonik Sediaan Gel Ekstrak Daun Rambusa (Passiflora Foetida L) dengan Variasi Na-Cmc Sebagai Basis Sari, Silvia Mega Kusuma; Rohmana, Vivin Marwiyati; Ardiyantoro, Bagas
Indonesian Research Journal on Education Vol. 5 No. 2 (2025): Irje 2025
Publisher : Fakultas Keguruan dan Ilmu Pendidikan, Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/irje.v5i2.2319

Abstract

Daun rambusa (Passiflora foetida L) dikenal memiliki berbagai khasiat herbal yang dapat dimanfaatkan sebagai bahan aktif dalam sediaan gel. Sediaan gel dipilih karena memiliki penetrasi obat ke dalam kulit lebih baik serta waktu kontak lebih lama dibandingkan sediaan topikal lainnya. Tujuan penelitian ini untuk mengetahui pengaruh variasi konsentrasi Na-CMC terhadap uji stabilitas dan hedonik sediaan gel ekstrak daun rambusa. Metode yang digunakan dalam penelitian ini meliputi formulasi sediaan gel dengan tiga variasi konsentrasi Na-CMC (2%, 2,5%, dan 3%), pengujian stabilitas dengan cycling test selama 6 siklus pada suhu 4⁰C dan 40⁰C, serta uji hedonik. Uji stabilitas mencakup pengamatan perubahan organoleptik, homogenitas, nilai pH, daya sebar, daya lekat, dan viskositas. Sedangkan uji hedonik melibatkan penilaian responden terhadap warna, aroma, dan tekstur gel. Analisis data dilakukan dengan One Way ANOVA untuk melihat perbedaan antara formula dan T-Test Dependent untuk mengetahui stabilitas sediaan gel ekstrak daun rambusa. Hasil penelitian menunjukkan variasi konsentrasi Na-CMC pada ketiga formula sesuai dengan standar terhadap uji organoleptik, homogenitas, pH, daya sebar, daya lekat, dan viskositas. Hasil statistik menunjukkan nilai <0,05 yang berarti terdapat perbedaan signifikan pada uji stabilitas dan hedonik terhadap variasi konsentrasi Na-CMC. Gel ekstrak daun rambusa menunjukkan sifat yang stabil, kecuali FI yang kurang stabil pada viskositas. FIII mendapatkan penilaian tertinggi terhadap parameter warna dan aroma, sedangkan pada tekstur lebih disukai FI.
Teratogenic Test of Brotowali Stem Extract (Tinospora Crispa) And Temulawak Rhizome Extract (Curcuma Xanthorrhiza) On Fetus Mencit Putih (Mus musculus) Ardiyantoro, Bagas; Merari P, Ason; Mardiyono, Mardiyono
Eduvest - Journal of Universal Studies Vol. 4 No. 1 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i1.999

Abstract

The stem of Brotowali and the rhizome of Temulawak are among the ingredients used in the production of traditional herbal medicine, specifically Brotowali and Temulawak herbal concoctions. These herbal mixtures are also consumed by pregnant women. The extracts from Brotowali stem and Temulawak rhizome contain bioactive antioxidants of the flavonoid group. Flavonoid compounds can inhibit the activities of phosphodiesterase enzymes that hydrolyze cAMP, and an elevated concentration of cAMP can impede growth acceleration. The aim of this research is to determine the teratogenic effects on white mouse fetuses after the administration of Brotowali stem and Temulawak rhizome extracts. The study involved 49 white mice (Mus musculus) divided into 5 groups. The first test group was given 0.5% Na CMC and used as the negative control, the second test group was injected with intravenous Cyclophosphamide at 50 mg/kg BW for the positive control. The groups included EB Dose 1120, ET Dose 1120, Dose 1 EBT 2:1, Dose 2 EBT 1:2, and Dose 3 EBT 1:1. Brotowali stem and Temulawak rhizome extracts were administered during the organogenesis period, and on the 18th day, the mice were subjected to laparotomy to collect the fetuses. Biometric, gross morphological, and skeletal abnormality observations were conducted to assess the effects of Brotowali stem and Temulawak rhizome extract administration. The research results indicate that Brotowali stem and Temulawak rhizome extracts have the potential to cause teratogenic effects, particularly at Dose 3 EBT 1:1.
Optimasi Metode Microwave-Assisted Extraction (MAE) untuk Menentukan Kadar Flavonoid Total Ekstrak Etanol Kulit Pisang Kepok (Musa Paradisiaca.L) Salsabila Khoerunniyssa; Danang Raharjo; Bagas Ardiyantoro
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 6 (2024): November : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i6.814

Abstract

Indonesia is a country that has a lot of banana diversity. One of the banana plants that is widely found in Indonesia is the Kepok banana (Musa Paradisiaca.L). Kepok banana skin has a very high content of flavonoids and phenols. Flavonoids are known as good antioxidants because they can find reactive oxygen species with the phenolic hydroxyl group that flavonoids have. The aim of this research was to determine the results of the optimization of the Microwave-Assisted Extraction (MAE) method on the total flavonoid content of kapok banana peel ethanol extract. Microwave-Assisted Extraction (MAE) was done to extraction flavonoid from ethanol extract of kepok banana peel (Musa Paradisiaca.L). The sample collected from Widoro village, Karangsambung sub-district, Kebumen regency. Optimum extraction condition was determined by the Response Surface Methodology (RSM). The Box- Behnken design (BBD) was used to evaluate the influence of 3 factors with 3 levels extraction that is power level (10%, 30%, 50%), ethanol concentration (50, 70, 96%), and extraction time (3, 5 and 7 minutes) with 15 different runs. The research showed that optimum extraction condition was at 24,14 % of power level, 66,26% ethanol concentration, and time extraction of 3,52 minutes with calculations from the Design Expert program, the total flavonoid content response was 8.491 Mg QE/g. The total flavonoid content value obtained experimentally was 8,246 Mg QE/g under condition of 30 % power level, 70% ethanol concentration, and time extraction of 5 minutes. Based on the result, total flavonoid content can be significantly increased by optimizing the MAE process use RSM.
Formulasi dan Uji Aktivitas Antibakteri Sabun Cair Ekstrak Daun Jeruk Purut (Citus hystrix) terhadap Bakteri Staphylococcus aureus ATCC 25923 dan Escherichia coli ATCC 25922 Iqbal Sirajudin Maulidinawan; Tatiana Siska Wardani; Bagas Ardiyantoro
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 3 (2025): Desember : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i3.6647

Abstract

Skin that is prone to bacterial infections requires proper care using products containing antibacterial agents. One potential alternative is kaffir lime leaves (Citrus hystrix), which are known to contain antibacterial compounds. This study aimed to evaluate the formulation of liquid soap containing kaffir lime leaf extract and to determine the optimal concentration for inhibiting bacterial growth. An experimental laboratory design was applied, and the antibacterial effectiveness was tested using the disk diffusion method against two test bacteria, namely Staphylococcus aureus and Escherichia coli. Statistical analysis was performed using One-Way ANOVA, followed by Scheffe’s post-hoc test to identify significant differences among treatment groups. The results indicated that the liquid soap containing kaffir lime leaf extract exhibited good physical quality and met standard parameters, including organoleptic evaluation, pH, viscosity, and foam height tests. Antibacterial testing showed that the highest inhibition zone against Staphylococcus aureus was observed at a 15% concentration with a zone diameter of 18.28 mm (strong category), while the highest inhibition zone against Escherichia coli was also at a 15% concentration with a diameter of 19.03 mm (strong category). The One-Way ANOVA results showed a significance value (p < 0.05), indicating a statistically significant difference among treatments for both bacterial species. These findings suggest that liquid soap formulated with kaffir lime leaf extract, particularly at a 15% concentration, has strong antibacterial activity and potential as an effective skin care product. Further studies are recommended to evaluate safety, stability, and long-term effectiveness.
Pengaruh Pemberian Ekstrak Daun Alpukat (Persea Americana Mill.) terhadap Daya Ingat Mencit Jantan dengan Metode Labirin Y-Maze Meyliawati, Ika; Ardiyantoro, Bagas; Jayak Pratama, Kharisma
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 3 (2025): Desember : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i3.6694

Abstract

Memory is a vital biological system in the body that plays a role in storing, processing, and recalling information. Over time, due to aging or external factors, memory function may decline. One possible effort to maintain and improve cognitive performance is through the use of bioactive compounds with antioxidant properties. Avocado (Persea americana Mill.) leaves contain flavonoids, which act as antioxidants and possess neuroprotective effects that may enhance cognitive function, including memory. This study aimed to determine the effect of avocado leaf extract on the memory of male mice and to identify the most effective dose in improving cognitive performance. The extract was obtained using the maceration method with 70% ethanol as the solvent. Memory activity was tested on male mice, which were divided into five groups: negative control, positive control, and three treatment groups given avocado leaf extract at doses of 50, 100, and 200 mg/kgBW. The Y-Maze method was employed to assess memory through two parameters: latency time and error numbers. The results demonstrated that avocado leaf extract significantly improved memory in the test animals. Mice induced with 10% ethanol showed an increase in latency time and error numbers, while the groups treated with avocado leaf extract experienced reductions in both parameters. The most effective dose was 200 mg/kgBW, which produced a latency time difference of 19.5 seconds and an error number difference of 3.57. Therefore, avocado leaf extract shows potential as a natural agent to support and enhance cognitive function.
Growth Inhibiting Activity Of Staphylococcus Aureus ATCC 25923 Kirinyuh Leaves (Chromolaena Odorata L.) Using The Soxhletation Method Fitriawati, Anna; Rahmad Adji, Alenda; Ardiyantoro, Bagas; Abdul Wahab Sabrina, Azimah; Karim, Karim
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2024: Proceeding of the 5th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v5i1.4227

Abstract

Kirinyuh leaves (Chromolaena odorata L.) have the potential as a medicinal plant because of the active compounds contained in kirinyuh leaves (Chromolaena odorata L.). The purpose of this study was to determine the antibacterial activity of ethanol extract of kirinyuh leaves (Chromolaena odorata L.) against the growth of Staphylococcus aureus ATCC 25923 bacteria. Kirinyuh leaf extract (Chromolaena odorata L.) was carried out using the soxhletation method and the solvent used was 96% ethanol. The concentrations used for each treatment were 30%, 40% and 50%. Each concentration was tested for antibacterial activity against Staphylococcus aureus bacteria using the disc diffusion method. The results showed that the extract of kirinyuh leaves (Chromolaena odorata L.) with a concentration of 30% had an average diameter of the inhibition zone of 9.2 mm, a concentration of 40% had an average diameter of the inhibition zone of 12.36 mm, and a concentration of 50% had an average diameter of the inhibition zone of 13.71 mm. The research conducted can be concluded that the extract of kirinyuh leaves can provide the best effect of inhibiting bacterial growth at a concentration of 50% with the results of the anova test p <0.05 which means there is a significant difference compared to other concentrations
Teratogenic Tinospora Cordifolia And Carica Papaya On White Mouse Fetuses (Mus Musculus) ardiyantoro, Bagas; arniwati mat daud, Noor
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2024: Proceeding of the 5th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v5i1.4241

Abstract

Tinospora cordifolia and Carica papaya in the production of traditional herbal medicines, specifically in formulations known as tinospora cordifolia and Carica papaya herbal mixtures. Extracts from Tinospora cordifolia stems and Carica papaya contain bioactive flavonoid antioxidants, which can inhibit phosphodiesterase enzymes that hydrolyze cAMP. Elevated cAMP concentrations can impede growth acceleration. This research aims to assess the teratogenic effects on the fetuses of white mice after administering tinospora cordifolia and carica papaya extracts. The study involved 25 Mus musculus divided into five groups. The first group, serving as the negative control, received 0.5% Na CMC, while the second group, serving as the positive control, was injected with intravenous Cyclophosphamide at 50 mg/kg. The other groups were administered various doses: ET Dose 1120, ECP Dose 1120, Dose 1 ETCP 2:1, Dose 2 ETCP 1:2, and Dose 3 ETCP 1:1. The extracts were given during the organogenesis period, and on the 18th day, the mice underwent laparotomy to collect the fetuses. The research findings indicate that tinospora cordifolia and carica papaya extracts can cause teratogenic effects, particularly at Dose 3 ETCP 1:1.
UJI AKTIVITAS STIMULANSIA INFUSA DAUN COKELAT (Theobroma cacao L) PADA MENCIT PUTIH (Mus musculus) DENGAN METODE ROTAROD Fadila, Vera Nurhidayatul; Ardiyantoro, Bagas; Listyani, Tiara Ajeng
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 1 (2025): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i1.1971

Abstract

Fatigue due to excessive activity can be overcome with stimulants, but the use of synthetic stimulants carries the risk of side effects. This study aims to determine the stimulant activity of cocoa leaf infusion (Theobroma cacao L) and to determine the best dose that can increase central nervous system stimulation in white mice (Mus musculus). Synthetic stimulants often cause side effects, so natural alternatives are needed. This study tested the stimulant effect of cocoa leaf infusion (Theobroma cacao L.) on white mice (Mus musculus) using a rotarod test. Mice were divided into five groups: negative control (distilled water), positive control (caffeine 100 mg/kgBW), and infusion with doses of 50, 100, and 150 mg/kgBW. The results showed that all infusion doses significantly increased the survival time of mice compared to the negative control (p < 0.05). The dose of 150 mg/kgBW gave the effect closest to caffeine. Phytochemical tests showed the presence of alkaloids and flavonoids that are suspected to play a role in stimulant activity. Cocoa leaf infusion has the potential as a natural stimulant.
UJI AKTIVITAS DAYA INGAT EKSTRAK DAUN CENGKEH (Syzygium aromaticum) TERHADAP MENCIT PUTIH (MUS MUSCULUS) DENGAN METODE RADIAL ARM MAZE Putri, Fera Adila; Ardiyantoro, Bagas; Lutfiyanti, Niken
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 1 (2025): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i1.1973

Abstract

Memory loss is often associated with dementia, which can be caused by oxidative stress and increased free radicals. Therefore, this study aims to determine the activity of clove leaf extract (Syzygium aromaticum) in improving memory in white mice (Mus musculus) and to determine the most effective dose. In the practice that has been carried out, it has been proven that clove leaves containing flavonoid compounds are extracted using the maserai method with 70% ethanol solvent. The test used was the Radial Arm Maze in five groups, namely negative control, positive control, and test group with a dose of clove leaf extract of 50 mg/kgBW, 100 mg/kgBW, and 200 mh/kgBW. This study involved three stages, namely, acclimatization, 10% alcohol induction, and treatment according to group. It can be concluded that the results of the statistical test showed a significant increase in the memory of mice in all dose treatments compared to the negative control. The most effective dose was 200 mg/kgBW, with a decrease in latency time of 92.4 seconds and an error rate of 2.63%.
Co-Authors Abdul Wahab Sabrina, Azimah Alya Atla Lidya Anita Dwi Septiarini Anita dwi setiarini Anna Fitriawati apriliyanti, laela intan arniwati mat daud, Noor Danang Raharjo Dwi Nurul Khotimah Dwi S, Anita Fachry Abda El Rahman Fadila, Vera Nurhidayatul Fika Riyanti Fitriana, Mona Haikal Zanki Hery Widijanto Intan Oktaviani Iqbal Sirajudin Maulidinawan Jayak Pratama, Kharisma Karim Karim, Karim Listyani, Tiara Ajeng Lutfiyanti, Niken Luthfiyanti, Niken Merari P, Ason Meyliawati, Ika Muhamad Farid Nurohman Krisnadi Nadia Nafiah, Azidatun Netty Dea Sosiantini Ningrum, Della Puspita Permata, Bangkit Riska Putri, Anisa Fadilah Kumala Putri, Fera Adila Rahmad Adji, Alenda Rahmat Hidayat Rahmat Hidayat Rahmatillah, Annie Retno Kurnia Dewi Rohmana, Vivin Marwiyati Salsabila Khoerunniyssa Sari, Silvia Mega Kusuma Septian Maulid Wicahyo Siwi Hastuti Sugeng Santoso Suharjaya, Feby Nuranawati Tasya Aurelia Thoha Irfan Darojat Triana Triana uswatun hasanah, alfiana Wali Jati, Ilham Wardani, Tatiana Siska Wiwin Novitasari