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All Journal Jurnal Analis Farmasi Jurnal Kesehatan Tambusai Jurnal Buana Farma JAF (Jurnal Analis Farmasi) JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Duta Pharma Journal Jurnal Kesehatan Amanah Proceeding of International Conference Health, Science And Technology (ICOHETECH) Indonesian Research Journal on Education Eduvest - Journal of Universal Studies Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Jurnal Pengabdian Bersama Masyarakat Indonesia Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Akademik Pengabdian Masyarakat Journal of Innovative and Creativity Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Padamu Negeri Green Health: Journal of Health Sciences, Nursing and Nutrition Galen: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Bagas Ardiyantoro
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Formulasi dan Uji Aktivitas Antibakteri Sabun Cair Ekstrak Daun Jeruk Purut (Citus hystrix) terhadap Bakteri Staphylococcus aureus ATCC 25923 dan Escherichia coli ATCC 25922 Iqbal Sirajudin Maulidinawan; Tatiana Siska Wardani; Bagas Ardiyantoro
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 3 (2025): Desember : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i3.6647

Abstract

Skin that is prone to bacterial infections requires proper care using products containing antibacterial agents. One potential alternative is kaffir lime leaves (Citrus hystrix), which are known to contain antibacterial compounds. This study aimed to evaluate the formulation of liquid soap containing kaffir lime leaf extract and to determine the optimal concentration for inhibiting bacterial growth. An experimental laboratory design was applied, and the antibacterial effectiveness was tested using the disk diffusion method against two test bacteria, namely Staphylococcus aureus and Escherichia coli. Statistical analysis was performed using One-Way ANOVA, followed by Scheffe’s post-hoc test to identify significant differences among treatment groups. The results indicated that the liquid soap containing kaffir lime leaf extract exhibited good physical quality and met standard parameters, including organoleptic evaluation, pH, viscosity, and foam height tests. Antibacterial testing showed that the highest inhibition zone against Staphylococcus aureus was observed at a 15% concentration with a zone diameter of 18.28 mm (strong category), while the highest inhibition zone against Escherichia coli was also at a 15% concentration with a diameter of 19.03 mm (strong category). The One-Way ANOVA results showed a significance value (p < 0.05), indicating a statistically significant difference among treatments for both bacterial species. These findings suggest that liquid soap formulated with kaffir lime leaf extract, particularly at a 15% concentration, has strong antibacterial activity and potential as an effective skin care product. Further studies are recommended to evaluate safety, stability, and long-term effectiveness.
Pengaruh Pemberian Ekstrak Daun Alpukat (Persea Americana Mill.) terhadap Daya Ingat Mencit Jantan dengan Metode Labirin Y-Maze Meyliawati, Ika; Ardiyantoro, Bagas; Jayak Pratama, Kharisma
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 3 (2025): Desember : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i3.6694

Abstract

Memory is a vital biological system in the body that plays a role in storing, processing, and recalling information. Over time, due to aging or external factors, memory function may decline. One possible effort to maintain and improve cognitive performance is through the use of bioactive compounds with antioxidant properties. Avocado (Persea americana Mill.) leaves contain flavonoids, which act as antioxidants and possess neuroprotective effects that may enhance cognitive function, including memory. This study aimed to determine the effect of avocado leaf extract on the memory of male mice and to identify the most effective dose in improving cognitive performance. The extract was obtained using the maceration method with 70% ethanol as the solvent. Memory activity was tested on male mice, which were divided into five groups: negative control, positive control, and three treatment groups given avocado leaf extract at doses of 50, 100, and 200 mg/kgBW. The Y-Maze method was employed to assess memory through two parameters: latency time and error numbers. The results demonstrated that avocado leaf extract significantly improved memory in the test animals. Mice induced with 10% ethanol showed an increase in latency time and error numbers, while the groups treated with avocado leaf extract experienced reductions in both parameters. The most effective dose was 200 mg/kgBW, which produced a latency time difference of 19.5 seconds and an error number difference of 3.57. Therefore, avocado leaf extract shows potential as a natural agent to support and enhance cognitive function.
Growth Inhibiting Activity Of Staphylococcus Aureus ATCC 25923 Kirinyuh Leaves (Chromolaena Odorata L.) Using The Soxhletation Method Fitriawati, Anna; Rahmad Adji, Alenda; Ardiyantoro, Bagas; Abdul Wahab Sabrina, Azimah; Karim, Karim
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2024: Proceeding of the 5th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v5i1.4227

Abstract

Kirinyuh leaves (Chromolaena odorata L.) have the potential as a medicinal plant because of the active compounds contained in kirinyuh leaves (Chromolaena odorata L.). The purpose of this study was to determine the antibacterial activity of ethanol extract of kirinyuh leaves (Chromolaena odorata L.) against the growth of Staphylococcus aureus ATCC 25923 bacteria. Kirinyuh leaf extract (Chromolaena odorata L.) was carried out using the soxhletation method and the solvent used was 96% ethanol. The concentrations used for each treatment were 30%, 40% and 50%. Each concentration was tested for antibacterial activity against Staphylococcus aureus bacteria using the disc diffusion method. The results showed that the extract of kirinyuh leaves (Chromolaena odorata L.) with a concentration of 30% had an average diameter of the inhibition zone of 9.2 mm, a concentration of 40% had an average diameter of the inhibition zone of 12.36 mm, and a concentration of 50% had an average diameter of the inhibition zone of 13.71 mm. The research conducted can be concluded that the extract of kirinyuh leaves can provide the best effect of inhibiting bacterial growth at a concentration of 50% with the results of the anova test p <0.05 which means there is a significant difference compared to other concentrations
Teratogenic Tinospora Cordifolia And Carica Papaya On White Mouse Fetuses (Mus Musculus) ardiyantoro, Bagas; arniwati mat daud, Noor
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2024: Proceeding of the 5th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v5i1.4241

Abstract

Tinospora cordifolia and Carica papaya in the production of traditional herbal medicines, specifically in formulations known as tinospora cordifolia and Carica papaya herbal mixtures. Extracts from Tinospora cordifolia stems and Carica papaya contain bioactive flavonoid antioxidants, which can inhibit phosphodiesterase enzymes that hydrolyze cAMP. Elevated cAMP concentrations can impede growth acceleration. This research aims to assess the teratogenic effects on the fetuses of white mice after administering tinospora cordifolia and carica papaya extracts. The study involved 25 Mus musculus divided into five groups. The first group, serving as the negative control, received 0.5% Na CMC, while the second group, serving as the positive control, was injected with intravenous Cyclophosphamide at 50 mg/kg. The other groups were administered various doses: ET Dose 1120, ECP Dose 1120, Dose 1 ETCP 2:1, Dose 2 ETCP 1:2, and Dose 3 ETCP 1:1. The extracts were given during the organogenesis period, and on the 18th day, the mice underwent laparotomy to collect the fetuses. The research findings indicate that tinospora cordifolia and carica papaya extracts can cause teratogenic effects, particularly at Dose 3 ETCP 1:1.
UJI AKTIVITAS STIMULANSIA INFUSA DAUN COKELAT (Theobroma cacao L) PADA MENCIT PUTIH (Mus musculus) DENGAN METODE ROTAROD Fadila, Vera Nurhidayatul; Ardiyantoro, Bagas; Listyani, Tiara Ajeng
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 1 (2025): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i1.1971

Abstract

Fatigue due to excessive activity can be overcome with stimulants, but the use of synthetic stimulants carries the risk of side effects. This study aims to determine the stimulant activity of cocoa leaf infusion (Theobroma cacao L) and to determine the best dose that can increase central nervous system stimulation in white mice (Mus musculus). Synthetic stimulants often cause side effects, so natural alternatives are needed. This study tested the stimulant effect of cocoa leaf infusion (Theobroma cacao L.) on white mice (Mus musculus) using a rotarod test. Mice were divided into five groups: negative control (distilled water), positive control (caffeine 100 mg/kgBW), and infusion with doses of 50, 100, and 150 mg/kgBW. The results showed that all infusion doses significantly increased the survival time of mice compared to the negative control (p < 0.05). The dose of 150 mg/kgBW gave the effect closest to caffeine. Phytochemical tests showed the presence of alkaloids and flavonoids that are suspected to play a role in stimulant activity. Cocoa leaf infusion has the potential as a natural stimulant.
UJI AKTIVITAS DAYA INGAT EKSTRAK DAUN CENGKEH (Syzygium aromaticum) TERHADAP MENCIT PUTIH (MUS MUSCULUS) DENGAN METODE RADIAL ARM MAZE Putri, Fera Adila; Ardiyantoro, Bagas; Lutfiyanti, Niken
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 1 (2025): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i1.1973

Abstract

Memory loss is often associated with dementia, which can be caused by oxidative stress and increased free radicals. Therefore, this study aims to determine the activity of clove leaf extract (Syzygium aromaticum) in improving memory in white mice (Mus musculus) and to determine the most effective dose. In the practice that has been carried out, it has been proven that clove leaves containing flavonoid compounds are extracted using the maserai method with 70% ethanol solvent. The test used was the Radial Arm Maze in five groups, namely negative control, positive control, and test group with a dose of clove leaf extract of 50 mg/kgBW, 100 mg/kgBW, and 200 mh/kgBW. This study involved three stages, namely, acclimatization, 10% alcohol induction, and treatment according to group. It can be concluded that the results of the statistical test showed a significant increase in the memory of mice in all dose treatments compared to the negative control. The most effective dose was 200 mg/kgBW, with a decrease in latency time of 92.4 seconds and an error rate of 2.63%.
INDUKSI DIGITAL MARKETING PADA UKM HEWAN MENCIT DALAM MENINGKATAN PENJUALAN Triana Triana; Bagas Ardiyantoro; Intan Oktaviani
Jurnal Padamu Negeri Vol. 2 No. 4 (2025): Oktober : Jurnal Padamu Negeri (JPN)
Publisher : CV. Denasya Smart Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69714/zkrh9q73

Abstract

The development of digital technology provides great opportunities for Small and Medium Enterprises (SMEs) to improve efficiency and expand their marketing reach. The SME providing laboratory test mice in Surakarta still faces limitations in marketing processes, customer data management, and product distribution, which are mostly carried out manually. This Student Creativity Program (PKM) activity aims to implement digital marketing transformation through the development and application of the Digital Laboratory Test Mice Application of Surakarta as an integrated platform for promotion, ordering, and customer data management. The implementation methods include partner needs analysis, web and mobile-based system design, user training, and effectiveness evaluation. The results show significant improvements in transaction efficiency, ease of product information access, and market reach expansion for the SME. Through the application’s implementation, the partner SME is able to adapt to digital trends, strengthen competitiveness, and enhance service professionalism in providing laboratory test mice.
Formulasi dan Uji Aktivitas Antioksidan Face Toner Ekstrak Etanol Daun Yakon (Smallanthus sonchifolius) Menggunakan Metode DPPH Fika Riyanti; Bagas Ardiyantoro; Siwi Hastuti
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Excessive exposure to sunlight can cause the formation of free radicals that can damage skin tissue, thus requiring natural antioxidants. The use of natural ingredients as a source of antioxidants in the form of topical preparations is a potential alternative. This study aims to formulate ethanol extract of yakon leaves (Smallanthus sonchifolius) into a face toner formulation and evaluate its physical quality, antioxidant activity, and to determine the optimal concentration of the face toner formulation that can inhibit free radicals. Extraction was carried out using the maceration method with 70% ethanol, then formulated into face toner with different concentrations, namely 1%, 2%, and 3%. After that, physical quality evaluation was carried out in the form of organoleptic tests, pH tests, homogeneity tests, and viscosity tests. Antioxidant activity was tested using the DPPH method and measured using UV-Vis spectroscopy at a wavelength of 520 nm. The results showed that all formulas met the physical quality test standards and had antioxidant activity at concentrations of 1%, 2%, and 3% with IC50 values of 95.91, 93.58, and 91.70, respectively, all of which were classified as strong. while the negative control formula without extract had a value of 167 (weak category), and the positive control quercetin had a value of 9.95 (very strong category).
Optimasi Nilai Sun Protection Factor (SPF) Ekstrak Daun Bayam Hijau (Amaranthus hybridus L.) Berdasarkan Variasi Pelarut Etanol 70% dan Aseton dengan Metode Spektrofotometri UV-Vis Tasya Aurelia; Rahmat Hidayat; Bagas Ardiyantoro
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.8293

Abstract

ABSTRACT Indonesia has high levels of ultraviolet (UV) exposure, which poses a risk of skin health problems. The use of sunscreen is necessary as a protective measure, but synthetic sunscreens can cause side effects, so natural alternatives are needed. Green amaranth leaves (Amaranthus hybridus L.) contain flavonoids that have the potential to absorb UV rays. This study aims to evaluate the sunscreen activity of green amaranth leaf extract using 70% ethanol and acetone solvents, determine the optimum Sun Protection Factor (SPF) value, and identify the most effective and efficient solvent. Extraction was performed using the maceration method, then the sunscreen activity was tested using UV-Vis spectrophotometry at a wavelength of 290–320 nm with concentration variations of 40, 60, 80, 100, and 120 ppm. The results showed that both extracts had sunscreen activity. The optimum SPF value was obtained at a concentration of 120 ppm, namely 70% ethanol extract 11,45 (maximum protection) and acetone extract 19,11 (ultra protection). Acetone was the most effective and efficient solvent in extracting UV-absorbing compounds. Keywords: 70% Ethanol, Acetone, Green Spinach Leaves (Amaranthus hybridus L.), SPF, Sunscreen
Deteksi dan Kuantifikasi Hidrokuinon pada Sampel Night Cream di Kecamatan X Sukoharjo Retno Kurnia Dewi; Danang Raharjo; Bagas Ardiyantoro
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.8503

Abstract

Hydroquinone is a skin lightening agent that effectively inhibits melanogenesis, but its use in cosmetics is restricted due to the potential for serious side effects. Although banned in over-the-counter cosmetics, hydroquinone is still found in unregistered night cream products. This study aims to detect the presence, determine the levels of hydroquinone, and evaluate its safety risks in night cream products sold in District X, Sukoharjo Regency. The study was conducted experimentally in a laboratory using a purposive sampling technique on 15 night cream samples consisting of 8 BPOM-registered products and 7 non-BPOM products. Qualitative analysis was carried out using FeCl₃, Benedict's, and o-phenanthroline color reaction tests, while quantitative analysis used the HPLC method with a C18 column and a UV-Vis detector at a wavelength of 280 nm. The results showed that all BPOM-registered samples did not contain hydroquinone, while several non-BPOM samples were detected to contain hydroquinone at levels ranging from 0.0688%–0.2043%. These findings indicate a higher safety risk in non-BPOM products. The implications of this research emphasize the importance of strengthening regulatory oversight and increasing public literacy in choosing safe and legal cosmetic products.
Co-Authors Abdul Wahab Sabrina, Azimah Adliah Suci Rahmadani Alya Atla Lidya Anita Dwi Septiarini Anita dwi setiarini Anna Fitriawati apriliyanti, laela intan arniwati mat daud, Noor Ason Merari P Chofifatun Mubarokah Danang Raharjo Della Puspita Ningrum Dwi Nurul Khotimah Dwi S, Anita Fadila, Vera Nurhidayatul Fika Riyanti Fitriana, Mona Haikal Zanki Hery Widijanto Intan Oktaviani Iqbal Sirajudin Maulidinawan Jayak Pratama, Kharisma Karim Karim, Karim Listyani, Tiara Ajeng Lutfiyanti, Niken Luthfiyanti, Niken Mardiyono Mardiyono Meyliawati, Ika Muhamad Farid Nurohman Krisnadi Nabila Melyi Aryani Nafiah, Azidatun Netty Dea Sosiantini Niken Luthfiyanti Nissa Syahraningtyas Putri Permata, Bangkit Riska Putri, Anisa Fadilah Kumala Putri, Fera Adila Rahmad Adji, Alenda Rahmat Hidayat Rahmat Hidayat Rahmatillah, Annie Rahmawati Retno Kurnia Dewi Rohmana, Vivin Marwiyati Salsabila Khoerunniyssa Sari, Silvia Mega Kusuma Septian Maulid Wicahyo Septian Maulid Wicahyo Siwi Hastuti Sugeng Santoso Suharjaya, Feby Nuranawati Tasya Aurelia Thoha Irfan Darojat Triana Triana Trianita Septiana uswatun hasanah, alfiana Wali Jati, Ilham Wardani, Tatiana Siska Wiwin Novitasari Zainul ‘Arifah