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All Journal Jurnal Analis Farmasi Jurnal Kesehatan Tambusai Jurnal Buana Farma JAF (Jurnal Analis Farmasi) JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Duta Pharma Journal Jurnal Kesehatan Amanah Proceeding of International Conference Health, Science And Technology (ICOHETECH) Indonesian Research Journal on Education Eduvest - Journal of Universal Studies Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Jurnal Pengabdian Bersama Masyarakat Indonesia Jurnal Akademik Pengabdian Masyarakat Journal of Innovative and Creativity Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Padamu Negeri Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Bagas Ardiyantoro
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AKTIVITAS STIMULANSIA EKSTRAK DAUN WORTEL (Daucus carota L.) PADA MENCIT PUTIH (Mus musculus) JANTAN DENGAN METODE ROTAROOD apriliyanti, laela intan; Ardiyantoro, Bagas; Raharjo, Danang
Jurnal Kesehatan Tambusai Vol. 6 No. 3 (2025): SEPTEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i3.48932

Abstract

Pendahuluan: Penelitian ini bertujuan untuk mengetahui efek stimulansia dari ekstrak daun wortel (Daucus carota L.) pada mencit putih jantan (Mus musculus) menggunakan metode rotarood. Daun wortel diketahui mengandung senyawa metabolit sekunder seperti flavonoid, alkaloid, saponin, tanin, dan steroid/terpenoid yang dapat memengaruhi sistem saraf pusat. Metode: Ekstraksi dilakukan secara maserasi menggunakan etanol 96%, dan 25 ekor mencit dibagi menjadi lima kelompok perlakuan: kontrol negatif (CMC-Na 0,5%), kontrol positif (kafein 100 mg/kgBB), serta tiga kelompok ekstrak dengan dosis 100, 150, dan 200 mg/kgBB. Hasil: Uji rotarood menunjukkan adanya peningkatan waktu bertahan mencit secara signifikan pada kelompok dosis 150 dan 200 mg/kgBB. Analisis statistik dengan ANOVA menghasilkan nilai p<0,05 yang menunjukkan perbedaan signifikan antar kelompok. Simpulan: Dengan demikian, ekstrak daun wortel terbukti memiliki efek stimulansia dan berpotensi dikembangkan sebagai bahan baku alami produk farmasi.
STUDI IN VITRO ANTIKOLESTEROL DAN FLAVONOID TOTAL DARI EKSTRAK BAWANG PUTIH TUNGGAL (Allium sativum L) Nafiah, Azidatun; Raharjo, Danang; Ardiyantoro, Bagas
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1504

Abstract

Hypercholesterolemia is one of the main factors that increase the risk of heart and blood vessel disease, which can cause atherosclerosis and disorders in fat metabolism. Single garlic is known to contain bioactive compounds such as flavonoids that play a role in reducing cholesterol. This study aims to assess the total flavonoids and anticholesterol activity in vitro of ethanol extract of single garlic (Allium sativum L.). The extraction process was carried out using the maceration method with 96% ethanol as the solvent. Total flavonoids were measured using UV-Vis spectrophotometry with quercetin as the standard, while anticholesterol activity was tested using the Lieberman-Burchard method in vitro. The findings of this study indicate that the sample extract contains secondary metabolites such as flavonoids, alkaloids, saponins, and tannins. Single garlic shows effective flavonoid content in lowering lipid levels. The anticholesterol test shows that this extract can reduce cholesterol levels with a significant IC₅₀ value. The conclusion of this study is that single garlic has the potential as an alternative way to lower cholesterol.
Effectiveness Of Cucumber Extract (Cucumis Sativus) In Reducing Cholesterol Levels In Mice (Mus Musculus) Induced By Hypercholesterolemia Haikal Zanki; Bagas Ardiyantoro; Tatiana Siska Wardani
International Journal of Health Engineering and Technology Vol. 4 No. 3 (2025): IJHET SEPTEMBER 2025
Publisher : CV. AFDIFAL MAJU BERKAH

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Abstract

Hypercholesterolemia is a global health problem and a major cause of cardiovascular disease. This study aims to explore the potential, determine the optimal dose, and identify the active compounds of cucumber (Cucumis sativus) ethanol extract as a cholesterol-lowering agent. Using a quantitative approach with a pure experimental method, a pre-test and post-test control group research design was applied in vivo to 25 mice (Mus musculus) divided into five treatment groups. The main instruments used included the Easy Touch cholesterol checker, and the data were analyzed using the One-Way ANOVA test. The results showed that cucumber extract had a significant effect in lowering cholesterol levels, with the effect increasing with dose. A dose of 700 mg/kgBW resulted in an average reduction of 49.51%, which was close to the effectiveness of simvastatin (54.05%). In conclusion, cucumber ethanol extract is a potential natural cholesterol-lowering agent, with a dose of 700 mg/kgBW being the most optimal dose that provides an effect almost comparable to that of standard drugs.
Comparison Of Flavonoid Content And Α-Amylase Inhibition Activity Of Ethanol Extracts From Compound Garlic (Allium Sativum L), Black Garlic, And Single Garlic Dwi Nurul Khotimah; Danang Raharjo; Bagas Ardiyantoro
International Journal of Health Engineering and Technology Vol. 4 No. 3 (2025): IJHET SEPTEMBER 2025
Publisher : CV. AFDIFAL MAJU BERKAH

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Abstract

Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose levels due to impaired insulin metabolism, and it remains one of the leading global health problems. One promising therapeutic strategy for diabetes management is the inhibition of digestive enzymes such as α-amylase, which plays a role in carbohydrate breakdown. Flavonoids, as natural bioactive compounds found in plants, have been reported to act as effective enzyme inhibitors. This study aims to compare the flavonoid content and α-amylase enzyme inhibitory activity of ethanol extracts from compound garlic (Allium sativum L.), black garlic, and single garlic. The extraction process was carried out using maceration with 96% ethanol solvent, followed by flavonoid content determination using UV-Vis spectrophotometry, while α-amylase inhibitory activity was tested using the Fuwa method. The results demonstrated that black garlic extract contained the highest flavonoid concentration, reaching 48.874 mg QE/g, compared to single garlic (40.561 mg QE/g) and compound garlic (35.943 mg QE/g). In addition, black garlic exhibited the strongest α-amylase inhibitory activity with the lowest IC₅₀ value of 32.390 ppm, indicating a higher potency compared to the other garlic extracts. These findings suggest that the fermentation process in black garlic enhances its flavonoid profile and bioactivity. Therefore, black garlic has significant potential as a natural antidiabetic agent and could be further explored as a functional food ingredient or herbal therapy for diabetes prevention and management.
Testing the Tonic Effect of Gotu Kola (Centella asiatica) Extract on Male White Mice (Mus musculus) Using the Rotarod Method Wiwin Novitasari; Anita Dwi Septiarini; Bagas Ardiyantoro
International Journal of Health Engineering and Technology Vol. 4 No. 3 (2025): IJHET SEPTEMBER 2025
Publisher : CV. AFDIFAL MAJU BERKAH

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Abstract

A tonic is a substance or mixture of substances that can strengthen the body or increase a person's energy. The tonic effect is caused by stimulation of the central nervous system (CNS). The herb gotu kola (Centella Asiatica) is a natural substance that contains bioactive compounds such as terpenoids, which play a role in producing the tonic effect. This study aims to analyze the ability of gotu kola herb extract (Centella asiatica) to provide a tonic effect on male white mice (Mus Musculus) and to determine the optimal dose of gotu kola herb extract (Centella Asiatica) to provide an optimal tonic effect. This study used the Rotarod test with treatment groups, each consisting of 5 test animals given Na-CMC 0.5% as a negative control, caffeine 100mg/kgBW as a positive control, and Centella asiatica herb extract suspension at varying doses, namely 50mg/kgBW as a low dose treatment, 100 mg/kgBW as a medium dose treatment, and 150 mg/kgBW as a high dose treatment. Statistical test results showed a significant increase in the time mice remained on the rotarod in all dose treatments compared to the negative control and no treatment. The 150 mg/kgBW dose provided a tonic effect closest to that of caffeine. Phytochemical testing showed that gotu kola herb contains terpenoids, which are thought to play a role in its tonic activity. Thus, gotu kola herb extract has the potential to be developed as a natural tonic alternative.
Comparison of Antioxidant Activity Tests Using the DPPH, ABTS, and FRAP Methods on Ethanol Extracts of Cherry Leaves (Muntingia calabura L.) and Total Flavonoids Alya Atla Lidya; Anna Fitriawati; Bagas Ardiyantoro
International Journal of Health Engineering and Technology Vol. 4 No. 3 (2025): IJHET SEPTEMBER 2025
Publisher : CV. AFDIFAL MAJU BERKAH

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Abstract

This study investigates the antioxidant activity of ethanol extracts of Muntingia calabura L. leaves using DPPH, ABTS, and FRAP methods. The background emphasizes increasing environmental pollution and free radical-induced oxidative stress, which contribute to degenerative diseases and aging. The research aims to compare the sensitivity and effectiveness of these three assays in evaluating the antioxidant potential of cherry leaves and to quantify their total flavonoid content. The study employs a comparative descriptive design with samples collected from Sukoharjo, Indonesia. Instruments used include spectrophotometers, rotary evaporators, and standard reagents. Data analysis involves IC50 calculation and statistical comparison of the methods. Results show that the ethanol extract exhibited high antioxidant activity with IC50 values below 50 μg/mL across all methods, with the highest sensitivity observed in the FRAP assay. The total flavonoid content was approximately 47.2 mgQE/g. The conclusion indicates that Muntingia calabura leaves possess potent antioxidant activity and high phenolic compounds, supporting their potential as natural antioxidant sources. Future research should explore different extraction techniques and in vivo assessments.
KADAR KALSIUM KARBONAT LIMBAH CANGKANG AYAM RAS DALAM PEMANFAATAN MENJADI SEDIAAN GEL TABIR SURYA Hidayat, Rahmat; Ardiyantoro, Bagas; Permata, Bangkit Riska; Khasanah, Uswatun
Duta Pharma Journal Vol. 5 No. 1 (2025): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/djp.v5i1.4815

Abstract

Potensi pemanfaatan limbah cangkang telur ayam sebagai sumber kalsium karbonat (CaCO3) untuk formulasi sediaan gel tabir surya. Cangkang telur ayam, yang sering dibuang sebagai limbah, mengandung sekitar 90,5% kalsium karbonat, yang memiliki sifat pemblokiran UV. Tujuan dari penelitian ini adalah untuk membuat formulasi gel tabir surya menggunakan tepung cangkang telur dan mengevaluasi sifat fisik serta nilai Sun Protection Factor (SPF) sediaan tersebut. Cangkang telur diproses menjadi tepung, dan kadar kalsium ditentukan menggunakan titrasi kompleksometri dengan EDTA. Tepung yang dihasilkan kemudian dimasukkan ke dalam basis gel yang mengandung karbopol 940, propilen glikol, gliserin, dan stabilisator lainnya untuk membuat empat formulasi dengan konsentrasi tepung cangkang telur yang berbeda (0%, 10%, 15%, dan 20%). Formulasi gel tabir surya diuji untuk sifat fisiknya, termasuk uji organoleptik, pH, homogenitas, daya sebar, daya lekat, dan viskositas. Nilai SPF ditentukan menggunakan spektrofotometer UV-Vis, dengan hasil yang menunjukkan peningkatan signifikan pada SPF seiring dengan peningkatan konsentrasi tepung cangkang telur. Formulasi dengan 20% tepung cangkang telur menunjukkan nilai SPF tertinggi sebesar 15,1, yang dikategorikan sebagai perlindungan maksimal. Secara keseluruhan, penelitian ini membuktikan bahwa limbah cangkang telur dapat dimanfaatkan secara efektif sebagai bahan aktif dalam formulasi tabir surya, memberikan solusi ramah lingkungan untuk pengelolaan limbah sekaligus aplikasi kosmetik.
UJI TERATOGENIK JAMU BROTOWALI (Tinospora Crispa) DAN DAUN PEPAYA (Carica Papaya) TERHADAP FETUS MENCIT PUTIH (Mus Musculus) : UJI TERATOGENIK JAMU BROTOWALI (Tinospora Crispa) DAN DAUN PEPAYA (Carica Papaya) TERHADAP FETUS MENCIT PUTIH (Mus Musculus) bagas ardiyantoro; Fitriana, Mona
Duta Pharma Journal Vol. 4 No. 1 (2024): DUTA PHARMA JOURNAL
Publisher : Universitas Duta Bangsa Surakarta

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Abstract

Jamu brotowali dan daun pepaya merupakan ramuan tradisional yang umum dikonsumsi oleh masyarakat Indonesia. Namun, informasi terkait potensi efek teratogenik dari konsumsi jamu ini masih terbatas. Penelitian ini bertujuan untuk mengkaji dampak teratogenik dari pemberian jamu brotowali dan daun pepaya pada mencit hamil (Mus musculus). Sebanyak 35 ekor mencit putih dibagi ke dalam lima kelompok perlakuan. Kelompok pertama diberi aquadest sebagai kontrol normal, sedangkan kelompok kedua diberi injeksi intravena cyclophosphamide dengan dosis 50 mg/kg berat badan. Kelompok ketiga, keempat, dan kelima menerima jamu brotowali dan daun pepaya dengan dosis masing-masing 0,26; 0,52; dan 1,04 ml/kg berat badan. Pemberian jamu dilakukan selama periode organogenesis, dan pada hari ke-18 kehamilan, mencit dibedah secara laparotomi untuk mengambil janin. Pengamatan meliputi analisis biometrik, morfologi makroskopis, dan kelainan kerangka untuk menilai efek teratogenik. Hasil menunjukkan bahwa jamu brotowali dan daun pepaya memiliki potensi teratogenik, terutama pada dosis lebih dari 1,04 ml/kg berat badan.
Pengaruh Pemberian Fraksi Etil Asetat Daun Kelor (Moringa Oleifera Lamk.) terhadap Daya Ingat Mencit Jantan dengan Menggunakan Metode Labirin Y-Maze Bagas Ardiyantoro; Muhamad Farid Nurohman Krisnadi; Danang Raharjo
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 3 (2025): November : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i3.8021

Abstract

Memory decline is an early symptom of neurodegenerative disorders such as dementia, often caused by oxidative stress due to an imbalance between the production of Reactive Oxygen Species (ROS) and the body’s antioxidant defense system. Moringa leaves (Moringa oleifera Lamk.) are known to contain flavonoids, particularly quercetin, which exhibit antioxidant activity and are potentially beneficial for cognitive function. This study aimed to evaluate the effect of the ethyl acetate fraction of Moringa leaves on memory improvement in male mice induced with 10% ethanol. The ethyl acetate fraction was obtained through maceration using 70% ethanol, followed by fractionation with ethyl acetate. A total of 25 male mice were divided into five groups: negative control (1% CMC Na), positive control (Ginkgo biloba 60 mg/kgBW), and three treatment groups receiving the ethyl acetate fraction of Moringa leaves at doses of 50, 100, and 150 mg/kgBW. Memory performance was assessed using the Y-Maze method, consisting of three phases: acclimatization (T0), induction (T1), and treatment (T2). Data were analyzed using one-way ANOVA followed by Duncan’s post hoc test.The results showed that the ethyl acetate fraction of Moringa leaves significantly (p value < 0.05) reduced error counts and latency time, with the most optimal effect observed at a dose of 150 mg/kgBW. This dose led to a significant improvement in memory performance compared to the control groups, including the positive control. These findings suggest that the ethyl acetate fraction of Moringa leaves has a more effective potential to enhance memory compared to the positive control, with a time difference of 40 seconds and an error rate difference of 11.67%.
Uji Stabilitas dan Uji Hedonik Sediaan Gel Ekstrak Daun Rambusa (Passiflora Foetida L) dengan Variasi Na-Cmc Sebagai Basis Sari, Silvia Mega Kusuma; Rohmana, Vivin Marwiyati; Ardiyantoro, Bagas
Indonesian Research Journal on Education Vol. 5 No. 2 (2025): Irje 2025
Publisher : Fakultas Keguruan dan Ilmu Pendidikan, Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/irje.v5i2.2319

Abstract

Daun rambusa (Passiflora foetida L) dikenal memiliki berbagai khasiat herbal yang dapat dimanfaatkan sebagai bahan aktif dalam sediaan gel. Sediaan gel dipilih karena memiliki penetrasi obat ke dalam kulit lebih baik serta waktu kontak lebih lama dibandingkan sediaan topikal lainnya. Tujuan penelitian ini untuk mengetahui pengaruh variasi konsentrasi Na-CMC terhadap uji stabilitas dan hedonik sediaan gel ekstrak daun rambusa. Metode yang digunakan dalam penelitian ini meliputi formulasi sediaan gel dengan tiga variasi konsentrasi Na-CMC (2%, 2,5%, dan 3%), pengujian stabilitas dengan cycling test selama 6 siklus pada suhu 4⁰C dan 40⁰C, serta uji hedonik. Uji stabilitas mencakup pengamatan perubahan organoleptik, homogenitas, nilai pH, daya sebar, daya lekat, dan viskositas. Sedangkan uji hedonik melibatkan penilaian responden terhadap warna, aroma, dan tekstur gel. Analisis data dilakukan dengan One Way ANOVA untuk melihat perbedaan antara formula dan T-Test Dependent untuk mengetahui stabilitas sediaan gel ekstrak daun rambusa. Hasil penelitian menunjukkan variasi konsentrasi Na-CMC pada ketiga formula sesuai dengan standar terhadap uji organoleptik, homogenitas, pH, daya sebar, daya lekat, dan viskositas. Hasil statistik menunjukkan nilai <0,05 yang berarti terdapat perbedaan signifikan pada uji stabilitas dan hedonik terhadap variasi konsentrasi Na-CMC. Gel ekstrak daun rambusa menunjukkan sifat yang stabil, kecuali FI yang kurang stabil pada viskositas. FIII mendapatkan penilaian tertinggi terhadap parameter warna dan aroma, sedangkan pada tekstur lebih disukai FI.
Co-Authors Abdul Wahab Sabrina, Azimah Alya Atla Lidya Anita Dwi Septiarini Anita dwi setiarini Anna Fitriawati apriliyanti, laela intan arniwati mat daud, Noor Ason Merari P Danang Raharjo Della Puspita Ningrum Dwi Nurul Khotimah Dwi S, Anita Fadila, Vera Nurhidayatul Fika Riyanti Fitriana, Mona Haikal Zanki Hery Widijanto Intan Oktaviani Iqbal Sirajudin Maulidinawan Jayak Pratama, Kharisma Karim Karim, Karim Listyani, Tiara Ajeng Lutfiyanti, Niken Luthfiyanti, Niken Mardiyono Mardiyono Meyliawati, Ika Muhamad Farid Nurohman Krisnadi Nafiah, Azidatun Netty Dea Sosiantini Permata, Bangkit Riska Putri, Anisa Fadilah Kumala Putri, Fera Adila Rahmad Adji, Alenda Rahmat Hidayat Rahmat Hidayat Rahmatillah, Annie Retno Kurnia Dewi Rohmana, Vivin Marwiyati Salsabila Khoerunniyssa Sari, Silvia Mega Kusuma Septian Maulid Wicahyo Siwi Hastuti Sugeng Santoso Suharjaya, Feby Nuranawati Tasya Aurelia Thoha Irfan Darojat Triana Triana uswatun hasanah, alfiana Wali Jati, Ilham Wardani, Tatiana Siska Wiwin Novitasari