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All Journal SAINSMAT Nusantara Medical Science Journal Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Mandala Pharmacon Indonesia Jurnal Biomedika Jurnal Kesehatan Celebes Health Journal Sasambo Journal of Pharmacy JUMANTIK (Scientific Journal of Health research) Eduvest - Journal of Universal Studies Jurnal Kedokteran Hewan SAINSMAT: Jurnal Ilmiah Ilmu Pengetahuan Alam
Yulia Yusrini Djabir
Fakultas Farmasi Universitas Hasanuddin
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Insulin Therapy Increases the Risk of Hypokalemia and Arrhythmia in Diabetic Patients with Coronary Heart Disease: A Retrospective Study in Wahidin Sudirohusodo General Hospital: Terapi Insulin Meningkatkan Risiko Hipokalemia dan Aritmia pada Penderita Diabetes dengan Penyakit Jantung Koroner: Studi Retrospektif di RSU Wahidin Sudirohusodo Hastuti Tajuddin; Elly Wahyudin; Yulia Yusrini Djabir; Firzan Nainu; Latifah Rahman
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 8 No. 2 (2022): (October 2022)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2022.v8.i2.15930

Abstract

Background: Cardiovascular disease is the most common cause of morbidity and mortality in diabetic patients. Patients with Diabetes Mellitus (DM) often require insulin therapy to control hyperglycemia, yet, it is associated with the risk of hypokalemia and dysrhythmia. Objectives: To evaluate the prevalence and the risk of hypokalemia and arrhythmia due to insulin therapy in DM patients with Coronary Heart Disease (CHD) comorbidity. Material and Methods: The study was conducted retrospectively based on medical record data from January 2021 to December 2021 in Wahidin Sudirohusodo general hospital. The inclusion criteria include the out-hospital patients diagnosed with DM with CHD comorbidity. The patients were divided into 2 groups, those who received insulin and those who received oral antidiabetic drugs (OAD). Hypokalemia was defined if an electrolyte characterized by a low serum potassium concentration with a normal range of 3.5 – 5.0 mEq/L. Arrhythmia was defined if abnormal changes in a regular heartbeat, including an irregular heartbeat, a skipped heartbeat, a fast heart rate (tachycardia), or a slow heart rate (bradycardia). Results: The data were obtained from 322 patients’ medical record, 161 was treated with insulin, and 161 received OAD. The insulin-treated patients had a significantly lower blood potassium level compared to the OAD group. The insulin group had 63,40% incidents of hypokalemia, while in the OAD group only 16,80% experienced hypokalemia (p<0.05). The presence of arrhythmia was detected in 63,40 % of insulin-treated patients, while only 29,80% had arrhythmia in the OAD group (p<0,05). Conclusions: Insulin Therapy in DM patients with coronary heart disease can increase the incidence of hypokalemia, which may result in arrhythmia in patients with coronary heart disease.
PENERAPAN PELAYANAN INFORMASI OBAT DI BEBERAPA PUSKESMAS KOTA MAKASSAR A. Anggriani; Yulia Yusrini Djabir; Nurhaeni; Nabila Hakim; Rahyunita; St. Atifah Ananda Usman
Majalah Farmasi dan Farmakologi Vol. 26 No. 3 (2022): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v26i3.23846

Abstract

Pelayanan informasi obat (PIO) merupakan salah satu bentuk pelayanan farmasi klinik yang esensial untuk dilakukan di Puskesmas. Hal ini juga diatur pada Permenkes Nomor 74 Tahun 2016 Tentang Standar Pelayanan Kefarmasian di Puskesmas. Penelitian ini bertujuan untuk mengetahui bagaimana penerapan PIO pada sarana pelayanan kesehatan yaitu empat Puskesmas di Kota Makassar yang dipilih sebagai tempat penelitian yang dapat menggambarkan pelaksanaan PIO dikarenakan telah memiliki Apoteker aktif dan representatif dalam pelaksanaan PIO. Kegiatan pengumpulan data dilakukan selama dua bulan, sejak bulan Agustus hingga Oktober 2022 dengan total pasien sebagai subjek penelitian sebanyak 277 orang, yang diambil berdasarkan kriteria yaitu pasien rutin berobat dengan penyakit kronis pada periode pengambilan data tersebut agar dapat dievaluasi dan dikonfirmasi terkait dengan pelaksanaan PIO di Puskesmas. Kuesioner survei tertutup dan terstruktur digunakan dalam penelitian ini untuk menilai parameter layanan PIO, kuesioner ini diadaptasi berdasarkan literatur berupa regulasi pada petunjuk teknis pelayanan kefarmasian di Puskesmas yang dikeluarkan oleh Kementerian Kesehatan Republik Indonesia Tahun 2019 sebagai penjelasan lebih lanjut dan melengkapi Standar Pelayanan Kefarmasian di Puskesmas dalam Permenkes Nomor 74 Tahun 2016. Kuesioner survei berisi total 7 pertanyaan terkait pemberian PIO pada pasien dan kuesioner pengumpulan data untuk mengetahui proses pemberian PIO berupa dokumentasi, sumber informasi, kualifikasi pemberi PIO, serta hal lainnya yang terkait dengan kebijakan pelaksanaan PIO di Puskesmas. Hasil penelitian ini menunjukkan bahwa PIO yang diberikan kepada pasien di Puskesmas, pada tiga aspek informasi yaitu terkait waktu, lama atau durasi, dan cara penggunaan obat telah (100%) disampaikan, namun empat dari tujuh aspek masih belum optimal meliputi efek samping obat dan cara penyimpanan obat, bahkan untuk informasi interaksi obat dan cara pembuangan obat masih belum diberikan. Hal ini perlu menjadi perhatian oleh Apoteker dan staf farmasi yang ada di Puskesmas untuk mendukung keamanan penggunaan obat dan keberhasilan pengobatan.
Vitamin C elicits protection against cylophosphamide-induced nephrotoxicity in rat animal model: Vitamin C Memproteksi Terhadap Nefrotoksisitas Yang Diinduksi Siklofosfamid Pada Hewan Model Tikus Alifah Dwi Yulianti; Yulia Yusrini Djabir; Prihantono Prihantono
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 1 (2023): (March 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i1.15992

Abstract

Background: Cyclophosphamide (CPD) causes renal cell toxicity due to its toxic metabolites. Objectives: This study aimed to evaluate the nephroprotective effect of vitamin C at 125 mg/kgBW, 250 mg/kgBW, and 500 mg/kgBW doses based on the biomarker level of urea, creatinine, parameter of urinalysis and renal histopathology. Material and Methods: The experimental animals consisted of 25 rats (Rattus norvegicus) that were divided into 5 treatment groups: healthy control, placebo (water for injection + CPD 250mg/kgBB), and 3 vitamin C treatment groups (125, 250, or 500 mg/kgBW + CPD 250mg/kgBB). Results: The results of blood biomarker, urine analysis, and histopathological analysis showed that CPD induced nephrotoxicity characterized by an increase in urea levels from 21.79 mg/l to 156.65 mg/l, creatinine from 0.375 to 0.717 mg/l, urine protein from 0 to 2.7, with histopathological damage scores from mild to severe (scores 1-3). In the treatment groups, the average damage score was 1-2 (mild score). However, of the three doses used, only the 500 mg/kg dose had significantly improved biomarkers compared to the placebo group, including the urea, creatinine, and urine protein levels, as well as histopathological scores (p<0.05). Conclusions: Vitamin C at a dose of 250 mg/kgBW was able to prevent the increase of urea, creatinine, and urine protein levels, however, a higher dose (500 mg/kg) was required to provide optimal protection against renal structural damage caused by cyclophosphamide.
A Hepatoprotective Effect of Extract Ethanol Gynura procumbens on Liver Injury Induced by Toxic Dose of Paracetamol Sri Almarahma; Peter Kabo; Yulia Yusrini Djabir
Biomedika Vol 15 No 1 (2022): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/biomedika.v15i1.1289

Abstract

Gynura procumbens is a plant that contains flavonoid compounds as antioxidants and has a hepatoprotective effect. A hepatoprotector is a compound that can protect the liver from liver damage. One way to determine liver function is to measure the enzyme activity of Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT). This study aimed to determine the hepatoprotective effect of the extract ethanol of Gynura procumbens on the liver induced by paracetamol toxic dose. This study used 20 white male rats divided into five groups: positive control group, negative control (NaCMC 1%), and paracetamol dose of 2.400mg/kg bw). EDSNY 100 mg/kg bw, 200 mg/kg bw, 300 mg/kg bw + 2.400 mg/kg paracetamolThe rat blood samples were taken through the lateral vein, and then the SGOT and SGPT were measured before, after 4 days, and on the 6th day after paracetamol induction. The results showed that the ethanol extract of Gynura procumbens significantly reduced the levels of SGPT in mice at a dose of 300 mg/kg bw. However, the ethanol extract of Gynura procumbens leaves could not reduce SGOT levels in rats. From the histopathological results, it was evident that both low, medium, and high doses had not been able to significantly improve liver damage induced by toxic doses of paracetamol. However, the ethanol extract of Gynura procumbens leaves appeared to reduce the number of areas of necrosis and degeneration of hepatocytes compared to the negative control group. Based on the study's results, the ethanol extract of Gynura procumbens leaves at a dose of 300 mg/kg bw was able to protect against an increase in SGPT. Still, it hadn't shown that it was the best way to protect the liver from damage caused by too much paracetamol.
SUBACUTE TOXICITY TEST OF BEACH CABBAGE [Scaevola taccada (Gaertn.) Roxb.] LEAF EXTRACT ON HISTOPATHOLOGICAL CHANGES IN THE LIVER AND KIDNEYS OF WHITE RATS Aritzah Dwi Widati; Tenri Ayu Adri; Peter Kabo; Yulia Yusrini Djabir
Jurnal Kedokteran Hewan Vol 16, No 2 (2022): June
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (466.496 KB) | DOI: 10.21157/j.ked.hewan.v16i2.19310

Abstract

The purpose of this study was to evaluate the toxic effects of beach cabbage leaves [Scaevola taccada (Gaertn.) Roxb.]by observing the histopathological changes in the livers and kidneys of male white rats. This study used 20 white rats which were divided into 4 groups: 1 control group and 3 groups receiving treatments in the form of Scaevola taccada leaf ethanolic extract (STLEE) in graded doses (200 mg/kg BW, 400 mg/kg BW, and 600 mg/kg BW). Toxicity test was performed by administering STLEE for 14 days. The results of daily observations showed that the experimental animals experienced diarrhea. Meanwhile, histopathological observations showed the occurrences of hydropic degeneration, fat degeneration, necrotic liver cells, and dilatation of Bowman's capsule in the animals’ kidney cells. It was concluded that STLEE at a dose of 200 mg/kg BW is safe to use, but is toxic at a dose of 600 mg/kg BW, both to the livers and kidneys.
EFEK PEMBERIAN DANGKE TERHADAP KADAR KOLESTEROL DAN TRIGLISERIDA DARAH TIKUS PEMODELAN HIPERKOLESTEROLEMIA DAN HIPERTRIGLISERIDEMIA Sasmita Sasmita; Yulia Yusrini Djabir; Ika Yustisia
Majalah Farmasi dan Farmakologi Vol. 27 No. 2 (2023): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i2.25302

Abstract

Dangke adalah makanan tradisional Enrekang, Sulawesi Selatan terbuat dari susu dan getah pepaya. Dangke mengandung bakteri asam laktat, yang bermanfaat bagi kesehatan. Penelitian ini bertujuan untuk mngevaluasi pengaruh dangke terhadap hiperkolesterolemia dan hipertrigliseridemia pada hewan model tikus yang diinduksi dengan propiltiourasil (PTU) dan diet tinggi lemak. Dangke dibuat dengan memanaskan susu sapi, ditambahkan getah pepaya hingga menggumpal, dicetak dan difermentasi hingga 3 hari. Induksi hiperkolesterolemia dan hipertrigliseridemia dilakukan pada 30 ekor tikus menggunakan PTU dan kuning telur bebek lalu diberi pakan tinggi lemak selama 28 hari dan dibagi menjadi 5 kelompok yaitu kelompok kontrol tanpa intervensi, kelompok intervensi dangke (0,5, 1 dan 1,5 g per 200 g bobot tikus), serta kontrol intervensi simvastatin (0,2 mg). Pemberian intervensi dangke maupun simvastatin diberikan 14 hari post induksi hiperlipidemia. Nilai kadar kolesterol total dan trigliserida serum setiap kelompok dibandingkan dengan kontrol normal (n=6). Pada kelompok yang diberi terapi dangke menunjukkan penurunan kadar kolesterol total yang signifikan pada dosis 1 g dan 1,5 g, setara dengan pemberian simvastatin. Kadar trigliserida pada kelompok terapi dangke pada dosis 0,5 g dan 1 g menurun signifikan seperti halnya kelompok terapi simvastatin, tetapi tidak pada kelompok dosis 1,5 g. Dapat disimpulkan bahwa terapi dangke dengan dosis 1 gram per 200 gram bobot badan paling efektif menurunkan kadar kolesterol dan trigliserida secara signifikan pada tikus yang diinduksi PTU dan diet tinggi lemak.
Effect of administration of ajwa date extract on renal histopathological changes in meloxicam induced in rats Abdul Halim, Musdalifah; Arsyad, M Aryadi; Dwi Kesuma Sari; Sartini Natsir; Muhammad Husni Cangara; Yulia Yusrini Djabir
Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) VOLUME 7, No 2, JULY 2023
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jrvi.v7i2.21785

Abstract

Objective: This study aimed to examine the nephroprotector effect of ajwa date extract on the kidneys of white rats induced by meloxicam. Methods: 25 male (Rattus norvegicus) rats weighing 200-300 g were divided into 5 groups (n = 5), namely group 1 healthy control without meloxicam and ajwa date extract, group 2 negative control with meloxicam 30mg/kgBB without ajwa dates, group 4 with ajwa date extract 150mg/kgBW and meloxicam 30mg/kgBW, and group 5 with ajwa date extract 300mg/kgBW and meloxicam 30mg/kgBW. The treatment was given for 14 days, on the 15th day a necropsy was performed to take kidney organs for microscopic evaluation or histipathological examination. Results: Meloxicam at a dose of 30mg/kgBW caused damage to the kidneys with observations of glomerular hemorrhage, tubular necrosis, hydropic degeneration and narrowing of the tubular lumen as well as narrowing of the capsular space with an average degree of damage reaching 75% while ajwa date extract doses of 150 and 300mg/kgBW has a nephroprotector effect against meloxicam induction. Conclusion: Ajwa date extract doses of 150 and 300mg/kgBW had a nephroprotector effect on meloxicam induction.
Formulation and Evaluation of Papaya Seed Extract Hydrogel (Carica Papaya L.) As Well as its Effectiveness in Repairing Incision Wounds in Mice (Mus Musculus) Fathoanah Qiran Sakinah; Aliyah Aliyah; Yulia Yusrini Djabir
Eduvest - Journal of Universal Studies Vol. 6 No. 6 (2026): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v6i6.53233

Abstract

Papaya seeds (Carica papaya L.) contain flavonoids, saponins, alkaloids, steroids, and tannins that have been proven effective in accelerating the wound healing process. This research aims to formulate hydrogel preparations from papaya seed extract and test their effectiveness in healing incision wounds in mice. This research is experimental in nature, involving the preparation of a papaya seed extract hydrogel with chitosan as a polymer and PEG 400 as a crosslinker. The papaya seed extract hydrogel was tested on mice (Mus musculus) across five treatment groups. Wound healing data were statistically analyzed using a repeated measures ANOVA test, and the physical evaluation of the hydrogel preparations was conducted descriptively. The results of the study showed that the papaya seed extract hydrogel met the requirements of the hydrogel preparation evaluation tests. The statistical test results indicated a significant effect on wound healing in male mice (p < 0.05). Based on the results obtained, the papaya seed extract hydrogel (Carica papaya L.) demonstrated the best incision wound healing effectiveness. In conclusion, papaya seed extract hydrogel, particularly at a 15% concentration, effectively accelerates incision wound healing in mice and meets the physical quality standards for topical hydrogel preparations, making it a promising natural-based wound dressing.
Pengaruh Pemberian Dehydroepiandrosterone (DHEA) terhadap Aktivitas Peroksidasi Lipid dan Kadar Nitrit Oksida pada Aorta Tikus Wistar Jantan yang Terpapar Asap Rokok Nila Ridayani; Aryadi Arsyad; Yulia Yusrini Djabir
Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam Vol. 11 No. 2 (2022): Volume 11 Nomor 2 (September 2022)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The research aimed to investigate the effect of dehydroepiandrosterone (DHEA) on lipid peroxidation activity and nitric oxide concentration in the aorta of male Wistar rats due to exposure to cigarette smoke. This study was a laboratory experiment using 21 rats that were divided into 3 groups: KN-14 (negative control that is given smoke exposure within 14 days), DHEA-1 (15 mg/kgBW + smoke exposure for 14 days), and DHEA-2 (30 mg/kgBW + smoke exposure for 14 days). The exposure was carried out in 25-45 minutes with 4 cigarettes/day within 14 days. Surgery was performed in the 15th days to remove the aorta to examine malondialdehyde (MDA) as a biomarker of lipid peroxidation and nitric oxide (NO) concentration using Enzyme-linked Immunosorbent Assay (ELISA). The results showed that a significant increase in MDA concentrations was found in the group administered with DHEA, particularly at a dose of 30 mg/kgBW (p<0.05). Meanwhile, the administration of DHEA at doses of 15 and 30 mg/kgBW did not have a significant effect (p>0,05) on aortic NO concentrations compared to the group KN-14. Therefore, it can be concluded that the administration of DHEA could increase lipid peroxidation activity, as indicated by a significant increase in aortic MDA concentrations, without affecting aortic NO concentrations in rats exposed to cigarette smoke for 14 days.
Pengaruh Pemberian Dehydrepiandrosterone (DHEA) Terhadap Paru-Paru Tikus Wistar Jantan Yang Terpapar Asap Rokok Sri Hardiyanti Asad; Aryadi Arsyad; Yulia Yusrini Djabir
Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam Vol. 11 No. 2 (2022): Volume 11 Nomor 2 (September 2022)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study investigated the effect of dehydroepiandrosterone on the lungs of male Wistar rats exposed to cigarette smoke. A total of 21 male Wistar rats were divided into 3 groups, namely the first group (negative control exposed to cigarette smoke for 14 days), the second group (given DHEA at a dose of 15 mg/kgBW and exposure to cigarette smoke), the third group (given DHEA at a dose of 30 mg/kgBW and exposure to cigarette smoke). DHEA was administered orally through a cannula 30 minutes before exposure to cigarette smoke with an exposure duration of about 25-40 minutes, equivalent to 4 cigarettes/day. After 14 days of experimentation, the rats were euthanized. Right lungs were harvested for malondialdehyde level measurement using the thiobarbituric acid reactive substance method measured by UV-Visible spectrophotometer at a wavelength of 532 nm. The left lungs were also harvested for histopathological examination. This study showed that pulmonary malondialdehyde levels in second and third group tended to be higher than in first group. Meanwhile, histopathological examination showed that the percentage of lung tissue damage in second and third group tended to be lower than in first group. Thus, it can be concluded that DHEA at doses of 15 and 30 mg/kgBW tended to act as a pro-oxidant but might potentially improve lung histology due to cigarette smoke exposure.
Co-Authors Abdul Halim, Musdalifah Adnan, Jumasni Ainun Amalia Sultang Alifah Dwi Yulianti Aliyah Aliyah Aliyah Aliyah Aliyah Aliyah Andi Anggriani Andi Nurpati Panaungi Arif Santoso Arif Santoso Aritzah Dwi Widati Aritzah Dwi Widati Arsyad, M Aryadi Arsyad, Muhammad Aryadi Cangara, Husni Devi Yulianti Yusra Dila Pramitha S. Putri Dwi Kesuma Sari Elly Wahyudin Elly Wahyudin Elly Wahyudin Fathoanah Qiran Sakinah Firzan Nainu Firzan Nainu Fityatun Usman Gemini Alam Gemini Alam Hastuti Tajuddin Herlina Rante Ika Reskia N Hamka Ika Yustisia Ika Yustisia Imelda Dhea Meylin Irma Amalia Kasim, Hasyim Latifah Rahman Latifah Rahman Latifah Rahman M Natsir Djide Marianti A Manggau Masrika, Nur Upik En Mirnawati Salampe Misriyani Misriyani Mufidah Mufidah Muh. Akbar Bahar Munawarah Munawarah Nabila Hakim Nasrawati Basir Nila Ridayani Nila Ridhayani Nurhaeni Peter Kabo Peter Kabo Peter Kabo Peter Kabo Peter Kabo Prihantono Prihantono Putri Nur Hafifah Rafly Suwandhi Wahid Rahyunita Restuyani Paranoan Risfah Yulianty Rosany Tayeb Sartini Natsir Sartini Sartini Sasmita Sasmita Sitti Hadijah Sri Almarahma Sri Hardiyanti Asad Sriyanty Sadsyam St. Atifah Ananda Usman Subehan Lallo Subehan Lallo Sukamto Salang Mamada Tenri Ayu Adri Usmar Usmar Yani Pratiwi Yusril Dwimeddy Tunggeleng