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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Majalah Kedokteran Bandung Research Journal of Life Science Jurnal Kebidanan Dan Kesehatan Tradisional MNJ (Malang Neurology Journal) Majalah Obstetri dan Ginekologi Biomedical Journal of Indonesia Medical Laboratory Technology Journal AcTion: Aceh Nutrition Journal Jurnal Ilmu Kedokteran dan Kesehatan Journal of Issues in Midwifery Asian Journal of Health Research
Wiyasa, I Wayan Arsana
Department Of Obstetrics And Gynaecology, Faculty Of Medicine, Universitas Brawijaya/ Saiful Anwar General Hospital, Malang, East Java, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Association between Vitamin D 1,25 (OH)2 D3 Serum with Endometriosis-Related Pelvic Pain and Infertility Condition in Endometriosis Wiyasa, I Wayan Arsana; Suseno, Daniel Alexander; Suwana, Febie Putra
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.253

Abstract

Introduction: Endometriosis is an estrogen-dependent chronic inflammatory disease characterized by the growth of endometrial tissues outside the endometrium or in the pelvic area. This condition is usually found in reproductive women, 15 – 49 years old. Chronic pelvic pain related to endometriosis is one of the major symptoms that makes women come to the clinic, besides dysmenorrhea and dyspareunia. This condition also affects the fertility of women, which, in some reports, shows that 30 – 50% women with endometriosis are also infertile. Vitamin D is a type of vitamin that is popular for treating reproductive problems. Vitamin D (1,25 (OH)2 D3) serum is important in inflammation and implantation, which supports overcoming endometriosis symptoms. Material and Methods: The Present study performed a cross-sectional study. A total of ninety-one women were included in this study, which was divided into three groups: normal group, the pelvic pain group, and the infertility pain. In this study, from ANOVA and confirmed with LSD 95% test. Results: There is a difference in Vitamin D (1,25 (OH)2 D3) serum level in the chronic pelvic pain group and/or infertility group. This significantly shows that there is a correlation between those variables. Conclusion: Sexual health is an important concern for patients with coronary artery disease. Some patients are symptomatic and have difficulty having sex. This study identifies specific issues that need to be addressed, especially convenient time, medication safety, and effective communication when providing sexual education.
Enhancing Adolescent Girls’ Knowledge of Premenstrual Syndrome through Flipbook and Video-Based Health Education Zahrani, Safira Astri Atika; Wiyasa, I Wayan Arsana; Kusumaningtyas, Dian
Jurnal Kebidanan dan Kesehatan Tradisional Jurnal Kebidanan dan Kesehatan Tradisional Volume 10 Number 2 Year 2025
Publisher : Poltekkes Kemenkes Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37341/jkkt.v10i2.624

Abstract

Background: Premenstrual syndrome (PMS) is symptom occur in luteal phase. The manifestation of PMS varies in each individual, may affect the quality of life in physical and physiological. Knowledge about PMS possibly improved through health education especially in adolescent girls as high-risk group. Flipbook and video are the media usually used for education; both are digital innovations that potentially facilitate the provision of health education. Methods: This quasi-experimental study was conducted by pre-posttest design without control group. A total population of 254 adolescent girls were selected for random sampling, resulting in 80 participants divided into two groups. The data was taken before and after education by questionnaires, analyzed with Wilcoxon test, and compared with Mann-Whitney test. Results: The result indicated there were increase to high level knowledge in flipbook group (50%) with mean score 77.83 and video group (72,5%) with mean score 85.33. The p-value using Wilcoxon test was p=<0.001 (p<0.01) respectively for both flipbook and video group. Mann-Whitney test resulted in higher effectiveness of video p=0.003 (p<0,05). Conclusion: There is increase in knowledge level after education both in flipbook and video groups. Meanwhile, video is highly suggested that the result shows higher effectiveness than flipbook.
Effect of Curcumin Nanoemulsion on Insulin Levels and Malondialdehyde Concentration in Zebrafish Embryos Model of Gestational Diabetes Mellitus Subandi, Subandi; Paramita, Galuh Anggarda; Khoir, Safa’atul; Nurdiana, Nurdiana; Wiyasa, I Wayan Arsana
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 11 (2025): Volume 12 Nomor 11
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i11.21464

Abstract

Gestational Diabetes (GD) is a condition characterized by increased blood sugar levels (hyperglycemia) in pregnant women who were previously undiagnosed with diabetes. Hyperglycemia disrupts the performance of pancreatic β cells that are responsible for producing the hormone insulin. Curcumin functions as an anti-inflammatory, allowing the insulin reaction to occur more quickly and insulin production to increase. Methods. Post Test Only Control Group Design was used in this experimental study which was tested on each research variable consisting of 1000 zebrafish embryos divided into 5 treatment groups with each sample containing 40 embryos, consisting of a negative control, a positive control exposed to 3% glucose, and a diabetic group given curcumin nanoemulsion with three different doses (0.3125 μg/ml, 0.625 μg/ml, 1.25 μg/ml). The exposure was carried out at 2-50 hpf and then measured using INS ELISA Kit and MDA ELISA Kit. The results were analyzed using a one-way ANOVA test. Results. NOVA showed p = 0.254 for insulin levels (not significant) and p = 0.029 for MDA concentrations. Post-hoc analysis revealed that the significant difference occurred only between the negative (K−) and positive (K+) control groups (p = 0.012), while the curcumin-treated groups (K1, K2, K3) showed no statistically significant differences compared with either control group (p > 0.05). Conclusion. Curcumin nanoemulsion tended to increase insulin levels and reduce MDA concentrations, but these effects were not statistically significant (p > 0.05). The induction of hyperglycemia with 3% glucose successfully established oxidative stress in zebrafish embryos, validating the model. Further studies with larger sample sizes and molecular analyses are needed to confirm the biological trends observed.
Co-Authors Achmad Hidayat Adriana, Kusuma Agus Hendra Al Rahmad Akhmalia, Qorry' Afyu Annissa Febriani Arianto, Onni Dwi Arifiandi, Maya Devi Asih, Aliyah Tresna Azahra, Mutiara Syifa Baihaqi, Irfani Bambang Rahardjo DAMAYANTI, ZUHRIA PUSPITA Darwitri, Darwitri Dewi Santosaningsih Dewi, Ratih Frastika Dian Kusumaningtyas, Dian Diani, Yuli Ayu Donny Wisnu Wardhana Dwi Yuni Nur Hidayati Edy Mustofa Een Nuraenah Effendi, Madina Paramitha Elisa Danik Kurniawati Evi Zahara Eviana Norahmawati Fahimma Fahimma Fajar Dwi Prastiwi Fikhy Rizky Hapsari Gandhari, Anak Agung Sagung Agung Ayuska Hariyati, Suheni Ninik Heni Pujiastuti Husnul Khotimah Husnul Khotimah Husnul Khotimah I Wayan Agung Indrawan I Wayang Agung Indrawan Irfani Baihaqi Kalsumy, Umi Kartika Agustina Khoir, Safa’atul Kusuma Adriana Lamadi, Sutini Machlusil Husna Maharani Maharani Maria Antonia Barbara Batu Mali Mohammad Muljohadi Ali Nany Nita Noviana Ni Putu Sri Haryati Nina Rini Suprobo Nirwan Nugraha Noryanto, Mukhamad Nugrahanti Prasetyorini Nurdiana Nurdiana Nurlaili Ramli Ovinery, Amarsya Paramita, Galuh Anggarda Prastiwi, Fajar Dwi Puspita Handayani Qonita Prasta Agustia Raras, Tri Yudani M. Siskanita Nur Fitriana Sri Andarini Sri Winarsih Subandi Subandi Suheni Ninik Hariyati Sulistomo, Hikmawan Wahyu Sumarno Reto Prawiro Suseno, Daniel Alexander Sutini Lamadi Sutrisno Sutrisno Sutrisno Sutrisno Suwana, Febie Putra Syah Sembung Wasiso Tanti Tri Lestary Tatit Nurseta Teguh Wiyono Tri Yudani Mardining Raras Tri Yuliyani Wibisono, Hermawan Wino Vrieda Vierlia Yahya Irwanto Zahrani, Safira Astri Atika