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All Journal PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) TRANSPUBLIKA INTERNATIONAL RESEARCH IN EXACT SCIENCES (TIRES) Jurnal Pengabdian Masyarakat Bangsa Heca Journal of Applied Sciences Malacca Pharmaceutics Leuser Journal of Environmental Studies Ekonomikalia Journal of Economics Journal of Educational Management and Learning Infolitika Journal of Data Science Grimsa Journal of Science Engineering and Technology Grimsa Journal of Business and Economics Studies
Ghazi Mauer Idroes
Department Of Occupational Health And Safety, Faculty Of Health Sciences, Universitas Abulyatama, Aceh Besar 23372, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Heca Journal of Applied Sciences

 1 
QSAR Classification of Beta-Secretase 1 Inhibitor Activity in Alzheimer's Disease Using Ensemble Machine Learning Algorithms Noviandy, Teuku Rizky; Maulana, Aga; Emran, Talha Bin; Idroes, Ghazi Mauer; Idroes, Rinaldi
Heca Journal of Applied Sciences Vol. 1 No. 1 (2023): June 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v1i1.12

Abstract

This study focuses on the development of a machine learning ensemble approach for the classification of Beta-Secretase 1 (BACE1) inhibitors in Quantitative Structure-Activity Relationship (QSAR) analysis. BACE1 is an enzyme linked to the production of amyloid beta peptide, a significant component of Alzheimer's disease plaques. The discovery of effective BACE1 inhibitors is difficult, but QSAR modeling offers a cost-effective alternative by predicting the activity of compounds based on their chemical structures. This study evaluates the performance of four machine learning models (Random Forest, AdaBoost, Gradient Boosting, and Extra Trees) in predicting BACE1 inhibitor activity. Random Forest achieved the highest performance, with a training accuracy of 98.65% and a testing accuracy of 82.53%. In addition, it exhibited superior precision, recall, and F1-score. Random Forest's superior performance was a result of its ability to capture a wide variety of patterns and its randomized ensemble approach. Overall, this study demonstrates the efficacy of ensemble machine learning models, specifically Random Forest, in predicting the activity of BACE1 inhibitors. The findings contribute to ongoing efforts in Alzheimer's disease drug discovery research by providing a cost-effective and efficient strategy for screening and prioritizing potential BACE1 inhibitors.
Characterizing the Size Distribution of Silver Nanoparticles Biofabricated Using Calotropis gigantea from Geothermal Zone Kemala, Pati; Khairan, Khairan; Ramli, Muliadi; Mauer Idroes, Ghazi; Mirda, Erisna; Setya Ningsih, Diana; Tallei, Trina Ekawati; Idroes, Rinaldi
Heca Journal of Applied Sciences Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v1i2.21

Abstract

This research aims to synthesize silver nanoparticles (AgNPs) using an aqueous leaf extract of Calotropis gigantea obtained from the geothermal manifestation Ie Seu-Um, Aceh Besar, Aceh Province, Indonesia. The C. gigantea leaf extract was mixed with AgNO3 solutions at concentrations of 2, 5, and 9 mM, respectively. The mixture was stirred at 80 rpm by a magnetic stirrer for 48 hours in the dark. The change in solution color indicated the reduction of Ag+ to Ag0. The resulting AgNPs synthesized using C. gigantea leaf extract (AgNPs-LCg) exhibited cloudy grey, reddish dark brown, and light brown colors when synthesized with AgNO3 concentrations of 2, 5, and 9 mM, respectively. The particle sizes of AgNPs-LCg had maximum frequencies at 246.98 nm (synthesized using AgNO3 2 mM), 93.02 nm (synthesized using AgNO3 5 mM), and 171.25 nm (synthesized using AgNO3 9 mM). The zeta potential values of AgNPs-LCg using 2, 5, and 9 mM AgNO3 were -41.9, -40.1, and -31.4 mV, respectively. Based on the solution color, nanoparticle size, and stability value of AgNPs, it can be concluded that the use of AgNO3 at 5 mM is optimal for the green synthesis process of AgNPs-LCg.
Evaluating Geothermal Power Plant Sites with Additive Ratio Assessment: Case Study of Mount Seulawah Agam, Indonesia Azhar, Fauzul; Misbullah, Alim; Lala, Andi; Idroes, Ghazi Mauer; Kusumo, Fitranto; Noviandy, Teuku Rizky; Irvanizam, Irvanizam; Idroes, Rinaldi
Heca Journal of Applied Sciences Vol. 2 No. 1 (2024): March 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v2i1.158

Abstract

Indonesia, a country rich in geothermal resources, has yet to fully exploit its potential, particularly in volcanic regions like Mount Seulawah Agam. This study investigates the application of the Additive Ratio Assessment (ARAS) method for the site selection of Geothermal Power Plants (GPP) in Indonesia. The ARAS method provides a systematic approach to evaluating and prioritizing geothermal development sites by integrating multiple criteria, including geological, environmental, and socio-economic factors. The study collects data from various sources and weights criteria using the Ordinal Priority Approach (OPA), incorporating expert opinions. The findings demonstrate the effectiveness of the ARAS method in identifying optimal locations for GPP development, ensuring sustainability and feasibility. The study also tests the ARAS method in existing GPP locations in Jaboi, Sabang, Indonesia, to investigate alignment with the results and validate the approach. Furthermore, the study presents recommendations for GPP site selection. This research emphasizes the significance of multi-criteria decision-making techniques in facilitating renewable energy projects. It promotes a more systematic and informed approach to geothermal energy development in Indonesia and other geothermal-rich regions.
Explainable Deep Learning Approach for Mpox Skin Lesion Detection with Grad-CAM Idroes, Ghazi Mauer; Noviandy, Teuku Rizky; Emran, Talha Bin; Idroes, Rinaldi
Heca Journal of Applied Sciences Vol. 2 No. 2 (2024): September 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v2i2.216

Abstract

Mpox is a viral zoonotic disease that presents with skin lesions similar to other conditions like chickenpox, measles, and hand-foot-mouth disease, making accurate diagnosis challenging. Early and precise detection of mpox is critical for effective treatment and outbreak control, particularly in resource-limited settings where traditional diagnostic methods are often unavailable. While deep learning models have been applied successfully in medical imaging, their use in mpox detection remains underexplored. To address this gap, we developed a deep learning-based approach using the ResNet50v2 model to classify mpox lesions alongside five other skin conditions. We also incorporated Grad-CAM (Gradient-weighted Class Activation Mapping) to enhance model interpretability. The results show that the ResNet50v2 model achieved an accuracy of 99.33%, precision of 99.34%, sensitivity of 99.33%, and an F1-score of 99.32% on a dataset of 1,594 images. Grad-CAM visualizations confirmed that the model focused on relevant lesion areas for its predictions. While the model performed exceptionally well overall, it struggled with misclassifications between visually similar diseases, such as chickenpox and mpox. These results demonstrate that AI-based diagnostic tools can provide reliable, interpretable support for clinicians, particularly in settings with limited access to specialized diagnostics. However, future work should focus on expanding datasets and improving the model's capacity to distinguish between similar conditions.
Co-Authors Abas, Abdul Hawil Abd Rahman, Sunarti Ahmad, Noor Atinah Akmal Muhni Alfizar Alfizar Ali Bakri Anggi, Tiara Aprianto . Arkadinata, Teguh Asep Rusyana Azhar, Fauzul Bachtiar, Boy Muhclis Bahri, Ridzky Aulia Bako, Winanda Celik, Ismail Delya, Mussa Issack Diah, Muhammad Diana Setya Ningsih, Diana Diana Setya Ningsih, Diana Setya Diki, Diki Eko Suhartono El-Shazly, Mohamed Emran, Talha Bin Erkata Yandri Faisal, Farassa Rani Fajar Fakri Fauziah, Niken Fazli, Qalbin Salim Hafni Zahara Harahap, Saima Putri Harera, Cheariva Firsa Hewindati, Yuni Tri Hizir Sofyan Idroes, Ghalieb Mutig Ifandi, Ilham Imelda, Eva Irvanizam, Irvanizam Irwana, Salman Jainury, Aldi Jauna, Jauna Kemala, Pati Khairan Khairan Khalijah Awang Kihwili, Erick Hironimus Kurniadinur, Kurniadinur Kusumo, Fitranto Lala, Andi Lukman Hakim Maria Paristiowati Marwan Marwan Maulana, Aga Maulydia, Nur Balqis Maysarah, Hilda Medyan Riza Mirda, Erisna Mirja, Mirja Misbullah, Alim Muhammad Adam, Muhammad Muhammad Ichsan Muhammad Ichsan Muhammad Sabri Muhammad Subianto Muhammad Yanis Muhammad Yusuf Mukhlisuddin Ilyas Muliadi Ramli Muslem Muslem, Muslem Musvira, Intan Natasya Natasya Nizamuddin Nizamuddin Nova Yanti Pasyamei Rembune Kala Patwekar, Mohsina Prasetio, Rasi Purnama, M. Risky Putri Raisah Raisah, Putri Raudhatul Jannah Razief Perucha Fauzie Afidh Rinaldi Idroes Rizkia, Tatsa Sasmita, Novi Reandy Shofi, Shofi Siti Maulina Rukmana Souvia Rahimah Suhendra , Rivansyah Suhendra, Rivansyah Suhendrayatna Suhendrayatna Surna, Muhammad Ipan Susanna Susanna Syamsiar, Syamsiar Taufiq Karma Teuku Rizky Noviandy Teuku Zulfikar Tjut Chamzurni TRINA EKAWATI TALLEI Wahyuni, Srie Wangi, Putri Ayu Sekar Wildan Seni, Wildan Wiranatakusuma, Dimas Bagus Wiwik Handayani Yustiana Yustiana, Yustiana Zahriah, Zahriah Zuchra Helwani, Zuchra Zulkarnain Jalil