Article Per Year (5 Year)
p-Index From 2020 - 2025
2.978
P-Index
This Author published in this journals
All Journal Lumbung Farmasi : Jurnal Ilmu Kefarmasian PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Jurnal Lentera Innovative: Journal Of Social Science Research Business and Economic Publication Journal of Social Science and Multidisciplinary Analysis Gotong Royong Interaksi : Jurnal Pengabdian Kepada Masyarakat International Journal of Contemporary Sciences (IJCS) Journal of Community Service for Health Multicore International Journal of Multidisciplinary (MIJM) Mitra Jurnal Pengabdian Masyarakat Multidisiplin (MJPMM) JES-TM Social and Community Service
Mildawati, Ratna
Unknown Affiliation
Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

Published : 20 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 20 Documents
Search

 1   2 
Prediction of Sinensetin from Kumis Kucing (Orthosiphon aristatus) as Aspulvinone Dimethylallyltransferase Inhibitor for Anticancer Agent Prasetyawan, Fendy; Arifin, Chandra; Astutik, Widhi; Rohmah, Eka Hayati; Kadir, Mujtahid Bin Abd; Ariawan, M Wahyu; Marhenta, Yogi Bhakti; Mildawati, Ratna; Saristiana, Yuneka; Rofiq, Abd
Multicore International Journal of Multidisciplinary (MIJM) Vol. 1 No. 1 (2025): May
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mijm.v1.i1.3

Abstract

Sinensetin, a polymethoxylated flavone found in Orthosiphon aristatus (commonly known as Kumis Kucing), was evaluated in silico for its potential inhibitory activity against Aspulvinone Dimethylallyltransferase, an enzyme implicated in cancer-related biosynthetic pathways. The SMILES structure of sinensetin was retrieved from PubChem and analyzed using the PASS online prediction tool (www.way2drug.com). The results showed a high probability of activity (Pa = 0.865) and a very low probability of inactivity (Pi = 0.016), indicating that sinensetin is likely to act as a potent inhibitor of the enzyme. These findings suggest that sinensetin could be a promising anticancer agent candidate by targeting Aspulvinone Dimethylallyltransferase. Further studies are recommended to validate this prediction through molecular docking and biological assays.
Pharmacokinetics and Druglikeness of Amoxicillin Drug using SwissADME Prasetyawan, Fendy; Saristiana, Yuneka; Mildawati, Ratna; Rhomah, Eka Hayati; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Multicore International Journal of Multidisciplinary (MIJM) Vol. 1 No. 2 (2025): November
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mijm.v1.i2.3

Abstract

Amoxicillin, a widely utilized semi-synthetic penicillin derivative, remains a cornerstone in treating various bacterial infections. Despite its extensive clinical application, a comprehensive in silico assessment of its pharmacokinetic and "druglikeness" properties using modern computational tools can provide valuable complementary insights. This study employed the SwissADME web platform to meticulously analyze the computed descriptors, physicochemical characteristics, ADME profile, druglikeness, and medicinal chemistry aspects of amoxicillin. The chemical structure of amoxicillin, represented by its SMILES string, was retrieved from the PubChem database and subsequently input into SwissADME for analysis. The results indicate that amoxicillin possesses a molecular weight of 365.40 g/mol and a hydrophilic nature, as evidenced by its consensus LogP value of -0.39 and high water solubility predictions. Its Topological Polar Surface Area (TPSA) is 158.26 Ų, and it contains 4 hydrogen bond donors and 6 hydrogen bond acceptors. While the in silico prediction for gastrointestinal (GI) absorption was "Low" (likely due to the high TPSA and hydrophilicity, suggesting reliance on active transport mechanisms in vivo), amoxicillin fully complies with Lipinski's Rule of Five, indicating good oral bioavailability potential. Furthermore, it is predicted not to permeate the Blood-Brain Barrier (BBB) and shows no inhibitory activity against major CYP450 enzymes (CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4) or P-glycoprotein, minimizing potential drug-drug interactions. The absence of PAINS and Brenk alerts signifies a clean chemical profile regarding assay interference and toxicity flags. Although some stricter druglikeness filters were violated due to its polar nature, amoxicillin's overall in silico profile, combined with its established clinical efficacy, highlights the complex interplay of physicochemical properties and biological transport mechanisms. This study reaffirms amoxicillin's favorable attributes from a computational perspective, serving as a valuable reference for understanding established antibiotics and guiding future antimicrobial design.
SOSIALISASI DAN DEMONSTRASI TENTANG KESEHATAN DIRI PADA ANAK-ANAK MELALUI VIDEO Mildawati, Ratna; Prasetyo Nugroho, Bandhi; Prasetyawan, Fendy
Jurnal LENTERA Vol. 4 No. 1 (2024): Jurnal LENTERA
Publisher : Stikes Yarsi Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57267/lentera.v4i1.341

Abstract

Health is the most important part of human life, physically and spiritually healthy. However, not all children have sufficient knowledge about personal health. Elementary school age is an ideal time to train children's motor skills, including personal health. The aim is to provide education about personal health, including washing hands with soap, cleaning body parts, food and drink restrictions that can keep teeth and mouth clean. The methods used are demonstrations, counseling, using animated video media to create two-way communication and make students active in participating in activities. In this service, an instrument is used in the form of a questionnaire to measure students' knowledge and skills. The results of the socialization and demonstration that have been carried out are an increase of 40% to 90% in the knowledge indicator and an increase in skills of 35% to 80% in the skills indicator, so that this activity can be concluded to be able to increase the knowledge and skills of grade 3 students at Dawuhan Kidul I Elementary School. Explain about your own health.
EDUKASI SWAMEDIKASI PENGGUNAAN OBAT ASAM URAT PADA PEMERIKSAAN KESEHATAN BERKALA Mildawati, Ratna; Prasetyo Nugroho, Bandhi; Prasetyawan, Fendy; Kristjono, Ary; Saristiana, Yuneka
Jurnal LENTERA Vol. 4 No. 2 (2024): Jurnal LENTERA
Publisher : Stikes Yarsi Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57267/lentera.v4i2.369

Abstract

Self-medication or self-medication is the use of drugs or self-soothing forms of behavior to treat a perceived or real illness. Most Indonesians practice self-medication or use drugs to cure diseases, including gout and cholesterol. Aim: To increase understanding of how to self-medicate using gout and cholesterol medication. The method used is lectures related to education through leaflets and PPTs, discussions and questions and answers. The results of the Self-Medication Education after the pretest and posttest were that of the 32 participants, 5 were in the good category, 10 were adequate and 17 were poor, to 28 were good and 4 were sufficient, so that in this activity it can be concluded that there is an understanding of the community to carry out self-medication for gout and the importance of carrying out regular examinations so that they can detect early if there is an increase in uric acid
Utilization of Antiviral Medications in COVID-19 Patients with Chronic Kidney Disease in Hospital Saristiana, Yuneka; Prasetyawan, Fendy; Muslikh, Faisal Akhmal; Dhafin, Anis Akhwan; Mildawati, Ratna; Putri, Elsa Mahardika; Raharjo, Susilo Margining
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 1 (2023): November 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i1.7284

Abstract

The COVID-19 pandemic has presented a substantial global health challenge, affecting diverse patient populations, particularly those with chronic kidney disease. Hospitals are presently dependent on two antiviral medications, favipiravir and remdesivir, to mitigate the impact of this disease on patients with chronic kidney disease. This study aims to evaluate the utilization of favipiravir and remdesivir in COVID-19 patients with chronic kidney disease in a hospital setting. This research will employ a retrospective approach to gather data from the medical records of COVID-19 patients with chronic kidney disease who received treatment with favipiravir or remdesivir in the hospital. Considering the prevalence of favipiravir usage at 64% and remdesivir at 36%, this research aims to provide a comprehensive understanding of the effectiveness and associated risks of toxicity linked to these two medications in COVID-19 patients with chronic kidney disease
The Evaluation of the use of Antihypertensive Drugs with ATC&DDD Method in Cardiac Poly Geriatric Patient at Ajibarang Hospitas Inpatient Instalation Khumaeni, Eko Hidayaturrohman; Mildawati, Ratna; Prasetyawan, Fendy
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 1 (2023): November 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i1.7292

Abstract

Hypertension is one of the leading causes of mortality and morbidity in Indonesia. This research aims to determine the quantity of antihypertensive drugs used with Anatomical Therapeutic Chemical & Defined Daily Dose methods and determine antihypertensive drugs which include in Drug Utilization 90% segment. This research used secondary data which were taken from the patient's Medical Record. This research was quantitative descriptive research, the data were collected retrospectively. Data of antihypertensive drugs utilization and inpatient visit obtained from Medical Record Installation. Entire data then were processed to determine the quantity of antihypertensive drugs utilization in DDD/100 unit of inpatient day and Drug Utilization profile (DU90%).The results showed that the antihypertensive drugs utilization in hypertensive patients in RSUD Ajibarang were furosemid 28,07%, candesartan 17,42%, amlodipin 17,15%, spironolactone 11,52%, captopril 8,81%, valsaran 6,36%, irbesartan 3,60%, bisoprolol 3,38%, ramipril 3,31%, propranolol 0,34%. And from the DU90% table, drugs which include in the DU90% segment were furosemid, candesaran, amlodipin, spironolactone and captopril..
Farmakoantartika Literature Study: Bioactivity of Pagodroma nivea on Fossil Deposits from Mujito Saristiana, Yuneka; Prasetyawan, Fendy; Mildawati, Ratna; Muslikh, Faisal Akhmal; Dhafin, Anis Akhwan; Raharjo, Susilo Margining; Arifin, Candra; Rofiq, Abd
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 2 (2023): December 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i2.7593

Abstract

This report investigates the biodiversity of marine animals, focusing on extinct sponge species near Lesbos Island based on Aristotle's descriptions. Mujito, introduced in the literature review, is from the GeoMaud expedition in Antarctica. Various instrumental analysis methods, such as ESI mass spectrometry and NMR, contribute to a comprehensive understanding of the compounds, particularly in the context of Alzheimer's research. The pharmacantarctic literature study concludes that Antarctic Mumijo, particularly from Mujito fossil deposits, holds significant biomedical potential. It exhibits organic components like wax esters with notable biomedical activities, particularly in treating bone diseases. Additionally, Mumijo's composition resembles non-fossil samples, with wax esters dominating and unique components like α-glyceryl fatty alcohol ethers indicating neuroprotective potential. The research suggests promising applications in Oriental medicine, addressing wounds, skin diseases, tuberculosis, respiratory diseases, and neurological conditions like Parkinson's and Alzheimer's. Overall, Antarctic Mumijo showcases diverse biomedical prospects, emphasizing its organic components' therapeutic value
Forensic Pharmacy Case Study: Identification of Hazardous Mercury Content as a Whitening Agent in Beauty Cream Products Ardianto, Nanda; Prasetyawan, Fendy; Saristiana, Yuneka; Muslikh, Faisal Akhmal; Mildawati, Ratna; Dhafin, Anis Akhwan; Arifin, Candra; Rofiq, Abd
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 2 (2023): December 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i2.7594

Abstract

Forensic pharmacy is crucial in identifying hazardous substances like mercury in beauty products. Counterfeit items with mercury pose health risks, emphasizing the need for accurate identification methods. The research, employing content analysis, focuses on illegal cosmetics containing mercury, aiming to understand distribution patterns and assess associated health risks. This systematic approach provides valuable insights into public health issues, contributing to safer regulatory practices. The utilization of these products may pose serious health risks to consumers. The implicated products include Temulawak New Day & Night, CAC Glow, Natural 99, HN (Day & Night), SP Special UV Whitening, Dr Original Pemutih, Super DR Quality Gold SPF 30, Diamond Cream, Herbal Plus New Day & Night, Ling Zhi Day & Night, Sj Sin Jung, Tabita, and Krim Labella. In Indonesia, the use of mercury in cosmetic products is prohibited by legislation, such as Law Number 32 of 2009 on Environmental Protection and Government Regulation of the Republic of Indonesia Number 81 of 2016 on the Security of Industrial Chemicals. Additionally, BPOM, responsible for overseeing drugs, food, and cosmetics, has issued relevant regulations
Pharmacy Philosophy in the Law of Power: The Morality of Pharmaceutical Ethics towards Rhetoric of Logic Hakim, Adiyansyah Lukman; Prasetyawan, Fendy; Saristiana, Yuneka; Muslikh, Faisal Akhmal; Dhafin, Anis Akhwan; Mildawati, Ratna; Arifin, Candra; Rofiq, Abd
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 2 (2023): December 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i2.7595

Abstract

Pharmacy's evolution relies on technical and philosophical aspects. Research delves into the intricate link between pharmaceutical philosophy and legal power, emphasizing moral values in daily practice. The study aims to enhance policies, regulatory frameworks, and awareness, optimizing pharmacy's pivotal role in healthcare services. The results of this study depict an investigation and comprehension of the close interconnection between the philosophy of pharmacy, the law of power, the morality of pharmaceutical ethics, and rhetorical logic. A profound integration of these four aspects can provide a solid foundation for the development of ethical policies, maintaining the integrity of the pharmacy profession, and maximizing benefits for society. A deeper understanding of the complexity of these relationships can help shape a more sustainable and ethical future in the field of pharmacy. The findings of this research depict the complexity of these relationships, highlighting that deep integration can provide a solid foundation for ethical policies and the sustainable future of pharmacy
Empowering the Elderly to Create Gardens for Aromatherapy; Enhancing Healthy Life Expectancy Wulandari, Ning Arti; Romadhon, Wimar Anugrah; Mildawati, Ratna
Journal of Community Service for Health Vol. 5 No. 2 (2024)
Publisher : STIKes Patria Husada Blitar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26699/jcsh.v5i2.1149

Abstract

Life expectancy is one of the indicators of the success of health development, especially in the elderly population. One way to improve Healthy Life Expectancy is through Active Aging, which aims to transform previously inactive seniors into active individuals, with the goal of extending life expectancy in a healthy and quality manner. The partner in this community's dedication was Blitar PSTW in Tulungagung who had an old age problem, lack of physical activity, poor quality of sleep and lack of use of empty land. The aim of the beginner community service program was to empower potential elderly individuals to produce aromatic materials in the form of essential oils and scented candles, starting from planting the plants that provide the raw materials, all the way to the production of aromatic materials to enhance their physical activity. The results of the data analysis used the Wilcoxon signed-rank test showed P=0.000, thus it can be concluded that the used of aromatherapy at night and increased physical activity through gardening and the activities of making aromatherapy materials conducted by the elderly can improved sleep quality. This service has produced an innovative technology product in the form of Standard Operating Procedures (SOP) for the production of essential oils and aromatherapy candles, aromatherapy candles, essential oils, and therapy gardens. The outcomes achieved in healthy living skills include utilizing free time by engaging in activities for the elderly (16%) and improving the quality of sleep for the elderly (86%).
Co-Authors Anis Akhwan Dhafin Ardianto, Nanda Astutik, Widhi Awilda, Pertiwi Bawaihi Bawaihi Besan, Emma Jayanti Candra Arifin, Candra Chandra Arifin Faisal Akhmal Muslikh Febriana, Laela Fendy Prasetyawan Hakim, Adiyansyah Lukman Hamida Oktavia , Laura Jiddan, Muhammad Jayyid Kadir, Mujtahid Bin Abd Karingga, Devangga Darma Khumaeni, Eko Hidayaturrohman Kristjono, Ary Lailaturohmah, Lailaturohmah M. Wahyu Ariawan Marhenta, Yogi Bhakti Muhammad Nurul Fadel Ning Arti Wulandari, Ning Arti Oktadiana, Isma Prasetyo Nugroho , Bandhi Prasetyo Nugroho, Bandhi Putri, Elsa Mahardika Raharjo, Susilo Margining Rhomah, Eka Hayati Rofiq, Abd Rohmah, Eka Hayati Romadhon, Wimar Anugrah Salmasfattah, Novyananda Samsul Hadi Shinta Mayasari Titik Juwariyah Winarni, Jajuk Yuneka Saristiana