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All Journal Medical Journal of Indonesia MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Jurnal Biomedika dan Kesehatan Majalah Kedokteran Neurosains Bioscientia Medicina : Journal of Biomedicine and Translational Research eJournal Kedokteran Indonesia Journal of General Procedural Dermatology and Venereology Indonesia Neurona Acta Neurologica Indonesia Journal of Neurointervention and Stroke (JNeViS) Jurnal Akta Trimedika
Fitri Octaviana
Department Of Neurology, Faculty Of Medicine, Universitas Indonesia; Dr. Cipto Mangunkusumo Hospital, Jakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Optimal time point for evaluation in a chronic peripheral nerve injury rat model: a preclinical study Widodo, Wahyu; Dilogo, Ismail Hadisoebroto; Kamal, Achmad Fauzi; Antarianto, Radiana Dhewayani; Wuyung, Puspita Eka; Siregar, Nurjati Chairani; Octaviana, Fitri; Kekalih, Aria; Suroto, Heri; Aprilya, Dina; Canintika, Anissa Feby
Medical Journal of Indonesia Vol. 35 No. 1 (2026): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257778

Abstract

BACKGROUND Peripheral nerve injury (PNI) can cause severe functional disabilities and progresses dynamically over time. Since evaluations held at different time points will yield different results, finding an optimal model for PNI comparison is needed. This study aimed to create an animal model of chronic denervation that simulates the progress of nerve injury. METHODS 6 male Sprague-Dawley rats underwent complete sciatic nerve transection in their right hind limbs, with severed nerve ends secured to a nearby muscle to prevent nerve regrowth. The rats were sacrificed at 2, 3, and 4 weeks. The assessment included walking analysis (pre- and post-injury), wet muscle weight measurement, and histological examination. RESULTS Progressive gastrocnemius muscle degeneration was observed at 3 different time points. Minimal degenerative changes were noted at 2 weeks, while extensive fibrosis (83.25 [12.19]% collagen area) appeared in the 4th week. The 3rd-week samples showed lymphocyte infiltrations, muscular atrophy, and progressive fibrosis, making it the best model for chronic PNI. CONCLUSIONS A 3-week chronic denervation model is proposed as a long-term PNI for further regenerative research.
Indonesian Stroke Management Neurointerventional Services Challenges Fritz Sumantri Usman; Achmad Firdaus Sani; Fitri Octaviana; Merlin Prisilia Kastilong; Leny Kurnia; Theodorus K Hendartono; Andika S Atmadja; Yan Leo Tambunan; Syahrul Syahrul; Dodik Tugasworo Pramukarso
Journal of Neurointervention and Stroke Vol. 1 No. 1: MAY 2025
Publisher : Neurointervention Working Group of Indonesian Neurological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63937/jnevis-2025.11.3

Abstract

Highlight: Stroke burden in Indonesia Challenges for Indonesian neurointerventionst ABSTRACT Introduction: Stroke is a leading cause of death and disability in Indonesia. Currently, stroke management has become more aggressive, and neurointerventionists are required to optimize acute stroke management. Objective: To determine the distribution of neurointerventionists in Indonesia and identify the obstacles faced in neurointervention services. Method: This cross-sectional study used an online questionnaire distributed to neurointerventionists in Indonesia between October and November 2024. Result: A total of 105 neurointerventionists completed the questionnaires. The distribution of neurointerventionists remains concentrated in Java, especially in Jakarta. The highest ratio of neurointerventionists to stroke cases was observed in Jakarta, while the lowest was in Lampung. West Java identified the largest gap in the number of neurointerventionists compared to Jakarta. Notably, 20.9% of neurointerventionists had not performed any neurointerventional procedures, and 46.8% reported challenges related to the funding of neurointerventional procedures through government insurance. Conclusion: Despite the increasing number of neurointerventionists in Indonesia, their distribution remains concentrated in Java. The main barrier was the funding of neurointerventional procedures through government insurance.
Serial Kasus: Pola EEG dan Hubungannya dengan Luaran Pasien Pasca-Kembalinya Sirkulasi Spontan (ROSC) Rima Anindita Primandari; Winda Arista Haeriyoko; Fitri Octaviana; Astri Budikayanti
Jurnal Biomedika dan Kesehatan Vol 9 No 2 (2026)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2026.v9.179-193

Abstract

Return of spontaneous circulation after cardiopulmonary resuscitation is often followed by hypoxic-ischemic brain injury, which may affect neurological recovery. Electroencephalography (EEG) is commonly used to evaluate brain function and prognosis in these patients. EEG patterns can be classified into benign, malignant, and highly malignant categories, which reflect the severity of brain injury. Objective of this study was to evaluate the relationship between EEG patterns and clinical outcomes in patients after return of spontaneous circulation. This case series included six patients who underwent EEG examination more than 24 hours after cardiac arrest. EEG findings were classified according to the Westhall classification and compared with clinical outcomes using the Cerebral Performance Category (CPC) scaler The Results were Four patients showed highly malignant EEG patterns, including electrocerebral inactivity or continuous suppression, and all had poor outcomes (CPC 4–5). Two patients with benign EEG patterns had relatively better outcomes (CPC 3–4). No patient achieved good neurological recovery (CPC 1–2). Low EEG reactivity was observed in all cases, and amplitudes below 10 µV were mostly found in patients with CPC 5. Highly malignant EEG patterns were strongly associated with poor neurological outcomes after return of spontaneous circulation. EEG may be useful as part of a multimodal approach for prognostic evaluation in post-cardiac arrest patients.
POLA EEG SEBAGAI CERMINAN PATOFISIOLOGI ENSEFALOPATI HIPOKSIK-ISKEMIK AKUT Rima Anindita Primandari; Winda Arista Haeriyoko; Fitri Octaviana; Astri Budikayanti
Jurnal Akta Trimedika Vol. 2 No. 3 (2025): Juli 2025
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/aktatrimedika.v2i3.22816

Abstract

Ensefalopati hipoksik-iskemik (EHI) merupakan komplikasi neurologis berat yang umumnya terjadi pasca-henti jantung akibat berkurangnya aliran darah dan suplai oksigen ke otak. Patofisiologi EHI terdiri dari fase primer dan sekunder yang melibatkan depolarisasi iskemik, cedera reperfusi, disregulasi metabolik, dan fase pemulihan. Adanya cedera jaringan otak pada EHI ditandai dengan adanya disfungsi mitokondria, eksitotoksisitas, stres oksidatif, dan inflamasi yang memperberat kerusakan neuron. Elektroensefalografi (EEG) dapat digunakan untuk menilai tingkat keparahan dan prognosis EHI. Pola EEG seperti burst-suppression, irama isoelektrik, dan aktivitas epileptiform pada latar yang datar dikaitkan dengan prognosis buruk, terutama bila ditemukan setelah 24 jam pasca-return of spontaneous circulation (ROSC). Sebaliknya, pola EEG kontinu dengan amplitudo normal dalam 12–24 jam pasca-ROSC menunjukkan kemungkinan pemulihan neurologis yang lebih baik. Kesimpulan. Pemahaman terhadap karakteristik pola EEG pada EHI dapat membantu dokter dalam pengambilan keputusan klinis dan penyusunan rencana tatalaksana yang lebih tepat bagi pasien kritis dengan akut EHI.
Co-Authors Achmad Fauzi Kamal Achmad Firdaus Sani, Achmad Firdaus Ahmad Sulaiman Alwahdy Ahmad Yanuar Ahmad Yanuar Amelia, Ria Andika S Atmadja Angelita, Michelle Cancera Aprilya, Dina Ardiansyah, Irfani Ryan Aria Kekalih Astri Budikayanti Astri Budikayanti Astri Budikayanti Bazzar Ari Mighra Canintika, Anissa Feby Citra Ananta Avis Dewi Wulandari Dodik Tugasworo Pramukarso Donny Hamid Erial Bahar, Erial Fachniadin, Ande Fadli, Nurul Fika Tiara Fikry Syahrial Fritz Sumantri Usman Hadiweijaya, Antonia Hakim, Manfaluthy Handayani, Sri Harsono, Adrian Ridski Harun, Yusril Heri Suroto Imran, Darma Indrawati, Luh Ari Ismail Hadisoebroto Dilogo Leny Kurnia Luh A. Indrawati Luh Ari Indrawati Luh Ari Indrawati Luh Ari Indrawati Luh Ari Indrawati Luh Ari Indriawati Maharani, Kartika Manfaluthy Hakim Marissa, Melani Merlin Prisilia Kastilong Mustika, Alyssa Putri Nadia Ayu Mulansari, Nadia Ayu Nova Lestari Nurjati Chairani Siregar Nurwahyuni, Atik Olivia, Taruli Pangeran, David Parindra, Cakra Pasmanasari, Elta Diah Pramudya, Hermawan Pratiwi, Astri Dewina Purba, Jan Sudir Puspita Eka Wuyung Putri Auliya Putri Widya Andini Radiana Dhewayani Antarianto Radiyati Umi Partan, Radiyati Umi Retnaningsih Retnaningsih Ricky Rusydi Satriawan Rima Anindita Primandari Rini Nindela Riwanti Estiasari Safri, Ahmad Yanuar Santoso, Fabianto Sari, Waode Satriana Savitri, Irma selly marisdina Sjamsoe-Daili, Emmy Soedarmi Sri Handayani Sri L. Menaldi Syahrul Syahrul Taufik Mesiano Theodorus K Hendartono Tiara Aninditha Triana Ayuningtyas Triana Ayuningtyas Triana Ayuningtyas Wahyu Widodo Widi Nugroho, Setyo Widiawaty, Alida Wiguna, Fikry Ichsan Winda Arista Haeriyoko Winda Arista Haeriyoko Winnugroho Wiratman Yan Leo Tambunan Yoga Putra Zen Hafy