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All Journal Jurnal Delima Harapan JURNAL FARMASIMED (JFM) Jurnal Review Pendidikan dan Pengajaran (JRPP) Jurnal Analis Farmasi PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Peduli Masyarakat Jurnal Kesehatan Tambusai Jurnal Buana Farma JAF (Jurnal Analis Farmasi) JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Sains dan Teknologi GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Inovasi Jurnal Pengabdian Masyarakat (IJPM) Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Jurnal Pengabdian Masyarakat dan Riset Pendidikan EduInovasi: Journal of Basic Educational Studies Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Anna Fitriawati
Universitas Duta Bangsa Surakarta
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : JURNAL FARMASIMED (JFM)

 1 
Synergistic Impact of The Combination of Moringa Leaves and Butterfly Pea Flowers Infusion on Cognitive Enhancement Annie Rahmatillah; Anna Fitriawati; Anisa Fadilah Kumala Putri
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/n9214f64

Abstract

Oxidative stress can induce memory loss, which may be mitigated by antioxidants. Moringa leaves (Moringa oleifera) and butterfly pea flowers (Clitoria ternatea) possess flavonoid chemicals that function as natural antioxidants. This study seeks to evaluate the impact of combined Moringa leaf and butterfly pea flower infusions on enhancing the memory of mice and to identify the optimal dosage. The research utilized male white mice (Mus musculus), categorized into six groups: a normal group, a negative control (aquadest), a positive control (Ginkgo biloba), and three treatment groups receiving various infusion doses. The procedure had three phases: acclimatization (T0), intraperitoneal administration of hyoscine butylbromide (T1), and therapy (T2). The manufacture of INDUK BUNTEL (an infusion of moringa leaves and butterfly pea flowers) was conducted using an infusion extraction method. Testing on test subjects was conducted utilizing the Radial Arm Maze methodology. The findings indicated that the infusion combination at dose III (100 mg/KgBW: 100 mg/KgBW) was the most efficacious in enhancing the memory of mice. The mean mistake rate in mice was 16.44%, representing the lowest score among the treatment groups. The one-way ANOVA test indicated no significant difference across treatment groups with three distinct dose combinations (p > 0.05).
Optimization of Tomato Fruit Extract Gel (Solanum lycopersicum L.) Using the Simplex Lattice Design Method and Antioxidant Activity Evaluation Salma uswatun khasanah; Anna Fitriawati; Bangkit Riska Permata
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/7tr8t086

Abstract

Background: Exposure to ultraviolet radiation and free radicals can induce oxidative stress, leading to skin damage and premature aging. Therefore, topical formulations containing effective and safe antioxidants are required. Tomato fruit (Solanum lycopersicum  L.) is known to contain flavonoids and lycopene, which act as natural antioxidants and possess potential photoprotective properties. Gel formulations were selected due to their good spreadability, cooling sensation, non-comedogenic nature, and ease of application. To achieve optimal physical quality of gel preparations, optimization of the gel base composition is necessary. Objective: This study aimed to determine the optimum formulation of tomato fruit extract (Solanum lycopersicum  L.) gel with varying concentrations of HPMC and propylene glycol using the Simplex Lattice Design (SLD) method, as well as to evaluate the physical characteristics and antioxidant activity of the resulting optimum formulation. Tomato fruit extract was obtained by maceration using 96% ethanol as the solvent. Methods: Gel formulation optimization was performed using the Simplex Lattice Design method with Design- Expert® software, involving combinations of HPMC as a gelling agent and propylene glycol as a humectant. The evaluated physical quality parameters included organoleptic properties, homogeneity, pH, spreadability, adhesiveness, and viscosity. The optimum formulation was subsequently tested for antioxidant activity using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method by UV–Vis spectrophotometry and expressed as the IC₅₀ value. Results: The results indicated that variations in HPMC and propylene glycol concentrations significantly affected the physical characteristics of the gel formulation. The obtained optimum formulation met all the requirements for good and stable gel physical quality. Conclusion: Antioxidant activity testing demonstrated that the optimum formulation exhibited strong antioxidant activity, with an IC₅₀ value of 74.12 ppm, indicating its potential for development as a natural antioxidant topical gel.
Co-Authors Abdul Wahab Sabrina, Azimah Adhe Wibawa Mahardika Putra Agustiningrum, Nurul Alifia, Neha Azziza Cherrysha Alya Atla Lidya Aminnulloh, Muhammad Aminnulloh, Muhhamad Aminulloh, Muhammad Anisa Fadilah Kumala Putri Bagas Ardiyantoro Bangkit Riska P Bangkit Riska Permata Bryan Dwi Multi Danang Raharjo Diyah Nurayuni Dwi S, Anita Emin Karoba Endang Suciati Evania Yudya Prameswari, Ninda Fitrohrezky Akbar Maulana Hasna Afifah, Diyana Hendra, Naufal Dhuha Indi yatno, Aurora Shalfa Alkhariza Karim Karim, Karim Kharisma Jayak P Krisnantari, Ni Luh Novelia Kusumaningrum, Indah Mega Lestari, Vera Fuji Listyani, Tiara Ajeng Luthfiyanti, Niken Mei Vita Rachma Pertiwi Muhammad Abdul Azis Nia Kurniati Ningrum, Della Puspita ningsih, endang wahyu Nursalim, Effendi Nurul Agustiningrum Nurul Fatimah Olga Nordeka, Marcela Ones Kotouki P, Kharisma Jayak Peni Indrayudha Permata, Bangkit Riska Pradina Arifah Nurcahyani Pratama, Kharisma Jayak Prity, Intan Qurrota'Ain, Rusyda Raden Rara Anteng Pujowati Rahmad Adji, Alenda Rahmat Hidayat Rahmatillah, Annie Riska P, Bangkit Riska Permata, Bangkit Riztiandi Ardiansyah Rochayati, Popiy Eko Salma uswatun khasanah Sari, Cantyka Eka Viemala Sari, Sindy Avita Septian Maulid W Septian Maulid Wicahyo siska, Tatiana Tanoyo, William Toyang, Gresilia Wahana Ayu Saputri Wahyu, Rizka Wardani, Lydia Puspita Wardani, Tatiana Siska Wulandari, Diana