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All Journal Jurnal Biologi Tropis Jurnal Kesehatan Global Jurnal Farmasi Indonesia Jurnal Dunia Farmasi Majalah Farmasetika Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Ilmiah Agribios International Archives of Medical Sciences and Public Health FARMASAINKES Journal of Pharmaceutical and Sciences. Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Journal of Nursing Update
Abadi, Hafizhatul
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Formulasi dan Uji Efektivitas Sabun Padat dari Ekstrak Etanol Daun Kopasanda (Chromolaena odorata L.) terhadap Bakteri Staphylococcus epidermidis Hafizhatul Abadi; Hanafis Sastra Winata; Adek Chan; Faadhilah Yusa Simbolon
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 4 (2024): Oktober: Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i4.444

Abstract

Siam Weed leaf plants contain high levels of flavonoids and tannins. These compounds provide antibacterial potential. This study aims to formulate solid soap dosage form of ethanol extract of Siam weed leaves and test the antibacterial activity of it against the growth of Staphylococcus epidermidis bacteria. This is experimental research. Making the extract phytochemical screening test. Evaluation of the dosage form was done by organoleptic tests, homogeneity, pH, foam height, moisture content, irritation, stability, and antibacterial activity tests using the well method. The results showed that solid bath soap dosage form from the ethanol extract of siam weed leaves could be formulated into soap dosage form which had a pH in the range of 9.2 – 9.8, high foam that was stable and did not cause irritation to the skin of volunteers and tested for antibacterial activity on bacteria. Staphylococcus epidermidis with a concentration of 10% 8.84 mm, 15% concentration 10.56 mm and 20% concentration 12.11 mm. The conclusion showed that solid soap dosage form of ethanol extract of Siam weed leaves (Chromolaena odorata L.) could be formulated and fulfilled the requirements after being evaluated and the antibacterial effectiveness of Staphylococcus epidermidis was the best at a concentration of 20% (strong).
Pengaruh Ekstrak Daun Nanas Terhadap Pertumbuhann Candida albicans Dan Malassezia furfur Dalam Bentuk Sediaan Shampo Herbal Hafizhatul Abadi; Tetty Noverita Khairani; Khairani Fitri; Vivi Eulis Diana; Leny Leny; Amalia Juliani Hasibuan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1181

Abstract

Background: Dandruff is a common scalp problem often caused by the overgrowth of fungi such as Candida albicans and Malassezia furfur. Pineapple leaves (Ananas comosus (L.) Merr.) are known to contain active antifungal compounds, such as alkaloids, flavonoids, saponins, and tannins, making them a potential active ingredient for anti-dandruff preparations. Objective: This study aimed to formulate an herbal anti-dandruff shampoo using pineapple leaf ethanol extract and to evaluate its effectiveness in inhibiting the growth of Candida albicans and Malassezia furfur. Methods: This experimental research used the disc diffusion method with PDA and SDA media to test antifungal inhibition. The shampoo preparations were formulated with varying extract concentrations (10%, 20%, 30%). The evaluation of the preparations included organoleptic tests, homogeneity, pH, foam height, viscosity, stability (cycling test), skin irritation, and hedonic tests. Results: The resulting shampoo preparation had a blackish-brown color, liquid form, and a menthol odor. Evaluation results showed the preparation was homogeneous, with pH values (5.0-5.8), foam height, and viscosity meeting the requirements. The preparation was also stable during the cycling test and did not cause irritation. The antifungal activity test showed that increasing the extract concentration increased the inhibitory power. The formula with a 30% concentration (F3) provided the greatest inhibition against Candida albicans (average 15.76 mm) and Malassezia furfur (average 15.9 mm), which is categorized as strong. Conclusion: Pineapple leaf ethanol extract was successfully formulated into an effective herbal anti-dandruff shampoo preparation, with the 30% concentration being the most optimal. It is recommended that further research investigate the antifungal activity of this extract against other types of fungi and in different dosage forms.
Formulasi Sediaan Obat Kumur Dari Ekstrak Etanol Umbi Wortel (Daucus Carota L) Sebagai Antifungsi Terhadap Pertumbuhan Candida Albicans William Wijaya; Hafizhatul Abadi; Silvia Loren; Fitria Mahira Mumtaz Sitorus; Hafizah Cintya Putri
Journal of Nursing Update Vol 7, No 1 (2025): EDISI JUNI
Publisher : LPPM Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jnu.v7i2.7151

Abstract

Salah satu penyebab sariawan dan bau mulut adalah adanya pertumbuhan jamur pada rongga mulut, salah satunya Candida albicans, yang dapat diatasi dengan berkumur menggunakan obat kumur. Umbi wortel (Daucus carota L.) diketahui mengandung senyawa aktif yang berpotensi sebagai antifungi. Penelitian ini bertujuan untuk memformulasikan sediaan obat kumur dari ekstrak etanol umbi wortel dan menguji aktivitas antifunginya terhadap pertumbuhan Candida albicans. Metode penelitian yang digunakan adalah eksperimental laboratorium dengan metode difusi kertas cakram pada media agar. Sediaan obat kumur dibuat dalam empat formula, yaitu F0 (tanpa ekstrak), F1 (ekstrak wortel 5%), F2 (ekstrak wortel 15%), dan F3 (ekstrak wortel 30%). Evaluasi sediaan meliputi pemeriksaan organoleptis, pH, viskositas, dan stabilitas. Hasil penelitian menunjukkan bahwa sediaan obat kumur ekstrak umbi wortel memiliki aktivitas antifungi terhadap Candida albicans, dengan diameter zona hambat sebesar 2,9 mm pada konsentrasi 5%, 3,9 mm pada konsentrasi 15%, dan 5,3 mm pada konsentrasi 30%, yang seluruhnya tergolong kategori lemah. Hasil evaluasi organoleptis, pH, viskositas, dan stabilitas sediaan menunjukkan hasil yang baik dan memenuhi syarat sediaan obat kumur. Dapat disimpulkan bahwa ekstrak etanol umbi wortel dapat diformulasikan menjadi sediaan obat kumur yang stabil dan memiliki aktivitas antifungi meskipun tergolong lemah terhadap Candida albicans.
Formulation And Activity Tests Of Anti Dandruff Shampoo Ethanol Extract Of Peperomia Pellucida (L.) Kunth Leaves On The Growth Of Pityrosporum Ovale Fungus Abadi, Hafizhatul; Eulis, Vivi
International Archives of Medical Sciences and Public Health Vol. 4 No. 1 (2023)
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v4i1.593

Abstract

Shampoo is a cosmetic preparation used to clean hair. The leaves of Peperomia pellucida (L.) Kunth are one of the plants that can be used to get rid of dandruff. The plants contain alkaloids, saponins, tannins, hydroxylated sesquiterpenes, especially carotol and peppermint which have antifungal activity. Purpose; formulating anti-dandruff shampoo preparations containing suruh leaves, as well as evaluating shampoo preparations which include homogeneity, pH, organoleptic tests, foam height, viscosity, and irritation. Method; The research method used was an experimental method, namely Peperomia pellucida (L.) Kunth leaf extract obtained by maceration method, then formulated as an anti-dandruff shampoo preparation starting with making a base consisting of sodium lauryl sulfate, cocamydopropyl betaine, polyquaternium 7, methyl paraben, sodium chloride, citric acid, menthol, rose perfume, and distilled water. Then added the extract of the leaves of the order each with a concentration of 1%, 3%, and 5%. The results obtained were then tested statistically with one way type ANOVA. Results:. The ethanol extract of suruh leaves can be formulated as an anti-dandruff shampoo preparation, and the ethanol extract of suruh leaf anti-dandruff shampoo preparations with a concentration of 5% has provided an effective inhibition against the growth of the fungus Pityrosporum ovale. Conclusion; The concentration of the ethanol extract of suruh leaves anti-dandruff shampoo which has an effective inhibitory activity against the growth of the fungus Pityrosporum ovale is in formula III with an inhibition zone of 14.2 mm.
Formulation of Mouth Mouth From Ethanol Extract of Carrot (Daucus Carota L.) Tubes as an Antifungal Against The Growth of Candida Albicans Diana, Vivi Eulis; Abadi, Hafizhatul
International Archives of Medical Sciences and Public Health Vol. 4 No. 2 (2023): International Archives of Medical Sciences and Public Health
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v4i2.633

Abstract

One of the causes of canker sores and bad breath is the presence of fungus in the oral cavity. This can be overcome by gargling using mouthwash. Research has been carried out on the formulation of mouthwash preparations from ethanol extract of carrot (Daucus carota L.) tubers as an antifungal against the growth of Candida albicans. Objectives: The aim of this study was to see the antifungal activity of carrot tuber extract mouthwash preparations. Methods: This research is a type of laboratory experimental research using the paper disc diffusion method on agar media to see the antifungal activity of carrot root extract mouthwash preparations. Carrot tuber extract mouthwash was made into four formulas, namely F0 (preparation without extract), F1 (5% carrot extract), F2 (15% carrot extract) and F3 (30% carrot extract). Evaluation of mouthwash preparations includes examination of organoleptic, pH, viscosity and stability. Results: indicate that mouthwash preparations can provide antifungal activity against the growth of Candida albicans. The diameter of the inhibition zone obtained at concentrations of 5% (2.9 mm), 15% (3.9 mm) and 30% (5.3 mm). All mouthwash formulations have a weak category of inhibitory power. The results of organoleptic evaluation, pH, viscosity and stability of mouthwash preparations gave good results, were stable and fulfilled the requirements for mouthwash preparations. Conclusion is that the ethanol extract of carrot root can be formulated into mouthwash and has weak antifungal activity.
Co-Authors Adek Chan Amalia Juliani Hasibuan Anjani Sipahutar Diana, Vivi Eulis Eulis, Vivi Faadhilah Yusa Simbolon Fitria Mahira Mumtaz Sitorus Gumilar, Roni Hafizah Cintya Putri Hanafis Sastra Winata Ignasia Amaerita Buulolo Jacub Tarigan Jamiati Jamiati Khairani Fitri Khairani Fitri Lathi Furrahmi Leny Leny, Leny Leny, Leny Lilik Septiana Linda Hernike Napitupulu Mayang Sari Muhammad Amin Nasution Muhammad Andry Ngete, Ani Florida Nidawah Nidawah Nurjanah, Ayu Pamungkas, Barolym Tri Parhan Parhan Pricella Aqwilla Br Ginting Rani Monalisa Hutagaol Riva Rainiza Zuddin Riva Rainiza Zuddin Rumanti, Ruth Mayana Ruth Mayana Rumanti Silvia Loren Siti Fatimah Hanum Siti Netti Ritonga Surbakti, Chemayanti Tetty Noverita Khairani Tetty Noverita Khairani Tri Sundari Vivi Eulis Diana Vivi Eulis Diana William Wijaya Winata, Hanafis Sastra Yoksan Duha Yudianto, Tri Yusta Suriani Ndruru Zulmai Rani