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Formulation And Activity Tests Of Anti Dandruff Shampoo Ethanol Extract Of Peperomia Pellucida (L.) Kunth Leaves On The Growth Of Pityrosporum Ovale Fungus Abadi, Hafizhatul; Eulis, Vivi
International Archives of Medical Sciences and Public Health Vol. 4 No. 1 (2023)
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v4i1.593

Shampoo is a cosmetic preparation used to clean hair. The leaves of Peperomia pellucida (L.) Kunth are one of the plants that can be used to get rid of dandruff. The plants contain alkaloids, saponins, tannins, hydroxylated sesquiterpenes, especially carotol and peppermint which have antifungal activity. Purpose; formulating anti-dandruff shampoo preparations containing suruh leaves, as well as evaluating shampoo preparations which include homogeneity, pH, organoleptic tests, foam height, viscosity, and irritation. Method; The research method used was an experimental method, namely Peperomia pellucida (L.) Kunth leaf extract obtained by maceration method, then formulated as an anti-dandruff shampoo preparation starting with making a base consisting of sodium lauryl sulfate, cocamydopropyl betaine, polyquaternium 7, methyl paraben, sodium chloride, citric acid, menthol, rose perfume, and distilled water. Then added the extract of the leaves of the order each with a concentration of 1%, 3%, and 5%. The results obtained were then tested statistically with one way type ANOVA. Results:. The ethanol extract of suruh leaves can be formulated as an anti-dandruff shampoo preparation, and the ethanol extract of suruh leaf anti-dandruff shampoo preparations with a concentration of 5% has provided an effective inhibition against the growth of the fungus Pityrosporum ovale. Conclusion; The concentration of the ethanol extract of suruh leaves anti-dandruff shampoo which has an effective inhibitory activity against the growth of the fungus Pityrosporum ovale is in formula III with an inhibition zone of 14.2 mm.

Formulation of Mouth Mouth From Ethanol Extract of Carrot (Daucus Carota L.) Tubes as an Antifungal Against The Growth of Candida Albicans Diana, Vivi Eulis; Abadi, Hafizhatul
International Archives of Medical Sciences and Public Health Vol. 4 No. 2 (2023)
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v4i2.633

One of the causes of canker sores and bad breath is the presence of fungus in the oral cavity. This can be overcome by gargling using mouthwash. Research has been carried out on the formulation of mouthwash preparations from ethanol extract of carrot (Daucus carota L.) tubers as an antifungal against the growth of Candida albicans. Objectives: The aim of this study was to see the antifungal activity of carrot tuber extract mouthwash preparations. Methods: This research is a type of laboratory experimental research using the paper disc diffusion method on agar media to see the antifungal activity of carrot root extract mouthwash preparations. Carrot tuber extract mouthwash was made into four formulas, namely F0 (preparation without extract), F1 (5% carrot extract), F2 (15% carrot extract) and F3 (30% carrot extract). Evaluation of mouthwash preparations includes examination of organoleptic, pH, viscosity and stability. Results: indicate that mouthwash preparations can provide antifungal activity against the growth of Candida albicans. The diameter of the inhibition zone obtained at concentrations of 5% (2.9 mm), 15% (3.9 mm) and 30% (5.3 mm). All mouthwash formulations have a weak category of inhibitory power. The results of organoleptic evaluation, pH, viscosity and stability of mouthwash preparations gave good results, were stable and fulfilled the requirements for mouthwash preparations. Conclusion is that the ethanol extract of carrot root can be formulated into mouthwash and has weak antifungal activity.

FORMULASI DAN UJI ANTIDIARE SEDIAAN PATCH TRANSDERMAL EKSTRAK DAUN SENGGANI (Melastoma malabathricum L.) TERHADAP KELINCI Winata, Hanafis Sastra; Abadi, Hafizhatul; Leny, Leny; Andry, Muhammad; Ngete, Ani Florida; Yudianto, Tri; Nurjanah, Ayu; Pamungkas, Barolym Tri; Gumilar, Roni
AGRIBIOS Vol 22 No 2 (2024): November
Publisher : Program Studi Agribisnis Fakultas Pertanian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36841/agribios.v22i2.5494

One plant that has been used for traditional medicine with good results is Melastoma (Melastoma malabatricum L.). The plant known as Melastoma has three active compounds: tannins, saponins, and flavonoids. Melastoma leaves work well to cure diarrhoea. Adhesive patches with medication applied topically are called transdermal patches. Melastoma leaf extract transdermal patch formulations were utilised in this study, which employed laboratory experimental techniques. The potential of Melastoma leaf extract transdermal patch preparation formula as an antidiarrheal for rabbits was the subject of the study. Concentrations of extract: 10%, 20%, and 30%. Organoleptic testing, pH tests, weight uniformity tests, moisture tests, thickness tests, and fold resistance tests were the preparatory assessment parameters that were conducted. The characteristics of the antidiarrheal test were timing of diarrhoea occurrences, consistency of the stool, frequency of diarrhoea, and length of diarrhoea, all of which were monitored for six hours. The evaluation of the Melastoma leaf extract transdermal patch formulation demonstrated a significant difference, namely <0.05, according to the results of the ANOVA data analysis. The antidiarrheal test parameters had a significant difference between each concentration, namely <0.05, according to the findings of the ANOVA data analysis. The conclusions was possible to use a transdermal patch formulation of Melastoma leaf extract (Melastoma malabathricum L.) at a 30% concentration to prevent diarrhoea by making stools softer.

Formulation of Mouth Mouth From Ethanol Extract of Carrot (Daucus Carota L.) Tubes as an Antifungal Against The Growth of Candida Albicans Diana, Vivi Eulis; Abadi, Hafizhatul
International Archives of Medical Sciences and Public Health Vol. 4 No. 2 (2023)
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v4i2.633

One of the causes of canker sores and bad breath is the presence of fungus in the oral cavity. This can be overcome by gargling using mouthwash. Research has been carried out on the formulation of mouthwash preparations from ethanol extract of carrot (Daucus carota L.) tubers as an antifungal against the growth of Candida albicans. Objectives: The aim of this study was to see the antifungal activity of carrot tuber extract mouthwash preparations. Methods: This research is a type of laboratory experimental research using the paper disc diffusion method on agar media to see the antifungal activity of carrot root extract mouthwash preparations. Carrot tuber extract mouthwash was made into four formulas, namely F0 (preparation without extract), F1 (5% carrot extract), F2 (15% carrot extract) and F3 (30% carrot extract). Evaluation of mouthwash preparations includes examination of organoleptic, pH, viscosity and stability. Results: indicate that mouthwash preparations can provide antifungal activity against the growth of Candida albicans. The diameter of the inhibition zone obtained at concentrations of 5% (2.9 mm), 15% (3.9 mm) and 30% (5.3 mm). All mouthwash formulations have a weak category of inhibitory power. The results of organoleptic evaluation, pH, viscosity and stability of mouthwash preparations gave good results, were stable and fulfilled the requirements for mouthwash preparations. Conclusion is that the ethanol extract of carrot root can be formulated into mouthwash and has weak antifungal activity.

Formulasi sediaan body butter ekstrak etanol bunga rosella (Hibiscus sabdariffa L.) sebagai pelembab kulit Diana, Vivi Eulis; Abadi, Hafizhatul; Andry, Muhammad
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.321

Background: Body butter is a semi-solid preparation with the highest fat content, so it is very thick and has a consistency very similar to butter, and has a better ability to nourish the skin than body lotion. In addition, body butter itself is perfect for eliminating reddish lines that usually appear on the skin or commonly called strechmarks. Objective: To test the physical quality stability of the concentration of rosella flower ethanol extract formula (Hibiscus sabdariffa L.) in body butter preparations that have been made. Method: The method used is laboratory experimental. Research includes plant extraction, plant identification, making simplisia, phytochemical screening, making ethanol extract, body butter preparation formulation, and quality stability testing of preparations. The sample used in this study was Rosella Flower (Hibiscus sabdariffa L). The research data was analyzed using the SPSS program, namely the Anova test. Result: Rosella flower ethanol extract (Hibiscus sabdariffa L.) has a semisolid form, homogeneous no coarse particles, with a pH value of the preparation ranging from 6.3-6.4, non-irritating, and can moisturize the skin. But it is not stable with cycling test method storage and stable at room temperature for 4 weeks. The best formula of body butter preparation from ethanol extract of rosella flower (Hibiscus sabdariffa L.) to moisturize the skin is a concentration of 3%. Conclusion: Rosella flower ethanol extract (Hibiscus sabdariffa L.) can be formulated in body butter preparations. It is recommended that future researchers formulate it into other preparations in the same concentration using the same plant from rosella flowers (Hibiscus sabdariffa L.).

Isolasi senyawa flavonoid dari daun bakung (Crinum asiaticum L.) Abadi, Hafizhatul; Rumanti, Ruth Mayana; Andry, Muhammad; Nasution, Muhammad Amin
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.322

Introduction Sprains and fractured bones are treated with spider lily leaves (Crinum asiaticum L.). Alkaloids, flavonoids, tannins, steroids, and triterpenoids are among the chemical components found in spider lily leaves. The most significant phytochemicals in plants with wide biological advantages for humans are bioactive flavonoids. The purpose of: The study aimed to isolate flavonoid components from spider lily leaves. Methods: This study was descriptive, using the following steps: plant material collection and preparation, sample processing, simplicia characterization, extract preparation, phytochemical screening, hydrolysis, fractionation, analysis using paper chromatography (KKt), and compound isolation using preparative paper chromatography. The isolates were tested for purity using one-way and two-way KKt, and they were identified using UV-Vis spectrophotometry with a shear reagent. The results: The results of the characterization showed that the water content was 7.21%, the water-soluble extract was 11.21%, the ethanol-soluble extract was 9.23%, the total ash content was 1.99%, and the acid-insoluble ash content was 0.81%. The screening findings indicated the presence of flavonoid chemicals. The KKt analysis results revealed that the best mobile phase was 5% acetic acid with ammonia vapor specks, and the preparative KKt isolation results yielded a single blue isolate, which was then identified by UV-Vis spectrophotometry using a shear reagent, resulting in maximum wavelength absorption (max) at band II of 253nm, presumably identifying the isoflavone group of flavonoids. Conclusion: The conclusion showed the ethyl acetate fraction of spider lily leaves could be separated using paper chromatography and that identification by spectrophotometry UV-Vis using a shear reagent wasolate, which was assumed to be an isoflavone group component.

EFEKTIVITAS ANTI JERAWAT SEDIAAN KRIM EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lam.) TERHADAP Propionibacterium acnes Abadi, Hafizhatul; Diana, Vivi Eulis; Tarigan, Jacub; Khairani, Tetty Noverita; Sundari, Tri
Jurnal Ilmiah Manuntung Vol 7 No 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.419

Jackfruit (Artocarpus heterophyllus Lam.) leaves have medicine potential, such as an antibacterial in anti-acne treatment contain flavonoids, tannins and saponins. The study aims to determine whether the ethanol extract of jackfruit leaves 96% can be formulated and determined the effectiveness of concentration preparation in inhibiting the Propionibacterium acnes bacteria. The preparation of cream preparations used a concentration of 20%, 30% and 40% jackfruit leaf ethanol extract. Then carried out the evaluation test of the preparation including the organoleptic test, homogeneity test, spreadability test, and pH test. Furthermore, the antibacterial effectiveness test was carried out by using the diffusion method. The results of evaluation test for cream preparations which included organoleptic tests with the results of three concentrations meeting the requirements, the homogeneity test and the dispersion test of the preparations, the results meet the specified conditions and the results of the pH test with the three concentrations of preparations that met the specified pH requirements. And it can inhibit the growth of Propionibacterium acnes bacteria with an inhibition zone of 7.5 mm at a concentration of 20%, 11 mm at a concentration of 30%, and 11.7 mm at a concentration of 40%. Antibacterial effectiveness test using positive control had an inhibition zone of 25.9 mm. The conclusion of this study is that the ethanol extract of jackfruit leaves can be formulated into anti-acne cream preparations.

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