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Abadi, Hafizhatul
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Evaluasi Peresepan Antibiotik Pada Pasien Rawat Jalan di Puskesmas Dabun Gelang Kabupaten Gayo Lues Jamiati Jamiati; Hafizhatul Abadi; Mayang Sari
Jurnal Dunia Farmasi Vol 3, No 3 (2019): Edisi Agustus
Publisher : Program Studi Farmasi, Fakultas Farmasi dan Kesehatan, Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jdf.v3i3.4482

Abstract

Pendahuluan; Peresepanan antibiotik bertujuan mengatasi penyakit infeksi (terapi) dan mencegah infeksi pada pasien yang berisiko tinggi untuk mengalami infeksi bakteri pada tindakan pembedahan (profilaksis bedah) dan beberapa kondisi medis tertentu  profilaksis medik). Antibiotik tidak di berikan pada penyakit non-infeksi dan penyaki tinfeksi yang dapat sembuh sendiri (self-limited) seperti infeksi virus. Tujuan; Penelitian ini adalah mengetahui pola peresepan antibiotik pada pasien rawat jalan di puskesmas Dabun Gelang  Kabupaten Gayo Lues. Metode; Penelitian deskriptif kualitatif dengan pengambilan data secara retrospektif. populasi adalah pasien yang datanya tertulis dalam data resep dengan jumlah populasi 1.244 pasien. Pasien yang menggunakan antibiotik berjumlah 86 pasien. Hasil; Penelitian menunjukan antibiotik yang sering diresepkan adalah antibiotik generik golongan beta lactam yaitu amoksisilin ( 32,6% ). Bentuk sediaan yang banyak digunakan adalah tablet ( 54,7 % ) . Gambaran kesesuaian pemberian antibiotik di Puskesmas Dabun Gelang Kabupaten Gayo Lues dengan pedoman pengobatan dasar puskesmas adalah tepat indikasi 54,6 %, tepat dosis 60,5 % , tepat frekwensi 87,7 % dan tepat durasi 26,7 %. Kesimpulan; Dari penelitian ini Sesuai peresepan antibiotik belum sepenuhnya sesuai dengan pedoman pengobatan dasar di puskesmas dan diharapkan kepada dokter untuk memperhatikan pesesepan antibiotik sehingga di dapatkan terapi antibiotik yang rasional. 
TINGKAT PENGETAHUAN DAN SIKAP MASYARAKAT TENTANG ANTIBIOTIK DI KELURAHAN MANDAILING KECAMATAN TEBING TINGGI KOTA Septiana, Lilik; Hafizhatul Abadi; Sipahutar, Rizki Anjani; Zulmai Rani
FARMASAINKES: JURNAL FARMASI, SAINS, dan KESEHATAN Vol. 4 No. 2 (2025): FARMASAINKES: JURNAL FARMASI, SAINS dan KESEHATAN
Publisher : Fakultas Farmasi Universitas Muslim Nusantara Al Washliyah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/farmasainkes.v4i2.4006

Abstract

Antibiotics are a group of compounds, both natural and synthetic, that have the effect of suppressing or stopping a biochemical process in an organism, especially in the process of infection by bacteria. This study only describes the object of the study by collecting questionnaire data from the community to determine the knowledge and attitudes of the community about antibiotics in Mandailing Village, Tebing Tinggi District, City. The results of the study obtained from univariate analysis found that the level of knowledge of respondents in the high category was 34 people (35.79%), in the moderate category was 47 people (49.47%), and in the low category was 14 people (14.74%). The total score was 680. At the level of attitude, respondents in the good category were 21 people (22.10%), in the sufficient category were 22 people (23.16%), and in the less category were 52 people (54.74%); the total score was 529. At the level of community knowledge, it was in the moderate category (71.57%), community attitudes were in the less category (55.68%), and there was a relationship between age, education, and occupation with the level of knowledge; there was a relationship between education and occupation with community attitudes about antibiotics; there was a relationship between the level of knowledge and community attitudes about antibiotics in the use of antibiotics in Mandailing Village, Tebing Tinggi District, City.
Formulation And Activity Tests Of Anti Dandruff Shampoo Ethanol Extract Of Peperomia Pellucida (L.) Kunth Leaves On The Growth Of Pityrosporum Ovale Fungus Abadi, Hafizhatul; Eulis, Vivi
International Archives of Medical Sciences and Public Health Vol. 4 No. 1 (2023)
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v4i1.593

Abstract

Shampoo is a cosmetic preparation used to clean hair. The leaves of Peperomia pellucida (L.) Kunth are one of the plants that can be used to get rid of dandruff. The plants contain alkaloids, saponins, tannins, hydroxylated sesquiterpenes, especially carotol and peppermint which have antifungal activity. Purpose; formulating anti-dandruff shampoo preparations containing suruh leaves, as well as evaluating shampoo preparations which include homogeneity, pH, organoleptic tests, foam height, viscosity, and irritation. Method; The research method used was an experimental method, namely Peperomia pellucida (L.) Kunth leaf extract obtained by maceration method, then formulated as an anti-dandruff shampoo preparation starting with making a base consisting of sodium lauryl sulfate, cocamydopropyl betaine, polyquaternium 7, methyl paraben, sodium chloride, citric acid, menthol, rose perfume, and distilled water. Then added the extract of the leaves of the order each with a concentration of 1%, 3%, and 5%. The results obtained were then tested statistically with one way type ANOVA. Results:. The ethanol extract of suruh leaves can be formulated as an anti-dandruff shampoo preparation, and the ethanol extract of suruh leaf anti-dandruff shampoo preparations with a concentration of 5% has provided an effective inhibition against the growth of the fungus Pityrosporum ovale. Conclusion; The concentration of the ethanol extract of suruh leaves anti-dandruff shampoo which has an effective inhibitory activity against the growth of the fungus Pityrosporum ovale is in formula III with an inhibition zone of 14.2 mm.
Formulation of Mouth Mouth From Ethanol Extract of Carrot (Daucus Carota L.) Tubes as an Antifungal Against The Growth of Candida Albicans Diana, Vivi Eulis; Abadi, Hafizhatul
International Archives of Medical Sciences and Public Health Vol. 4 No. 2 (2023)
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v4i2.633

Abstract

One of the causes of canker sores and bad breath is the presence of fungus in the oral cavity. This can be overcome by gargling using mouthwash. Research has been carried out on the formulation of mouthwash preparations from ethanol extract of carrot (Daucus carota L.) tubers as an antifungal against the growth of Candida albicans. Objectives: The aim of this study was to see the antifungal activity of carrot tuber extract mouthwash preparations. Methods: This research is a type of laboratory experimental research using the paper disc diffusion method on agar media to see the antifungal activity of carrot root extract mouthwash preparations. Carrot tuber extract mouthwash was made into four formulas, namely F0 (preparation without extract), F1 (5% carrot extract), F2 (15% carrot extract) and F3 (30% carrot extract). Evaluation of mouthwash preparations includes examination of organoleptic, pH, viscosity and stability. Results: indicate that mouthwash preparations can provide antifungal activity against the growth of Candida albicans. The diameter of the inhibition zone obtained at concentrations of 5% (2.9 mm), 15% (3.9 mm) and 30% (5.3 mm). All mouthwash formulations have a weak category of inhibitory power. The results of organoleptic evaluation, pH, viscosity and stability of mouthwash preparations gave good results, were stable and fulfilled the requirements for mouthwash preparations. Conclusion is that the ethanol extract of carrot root can be formulated into mouthwash and has weak antifungal activity.
Difference in Effectiveness Gel Dosage form Green Papaya (Carica papaya L.) Skin Ethanol Extract and Gel Dosage form Green Papaya Seed Against Cutibacterium acnes Bacteria Diana, Vivi Eulis; Abadi, Hafizhatul; Rumanti, Ruth Mayana; Andry, Muhammad
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.9330

Abstract

Many things can cause acne, including stress, fatty foods, inappropriate or unsuitable makeup, and pollution. Cosmetics made from plants are safer to use. Papaya skin and seeds (Carica papaya L.) have antibacterial properties in the form of alkaloids, tannins, steroids, saponins, and flavonoids. This study aims to determine the comparison of the antibacterial power of young papaya skin ethanol extract gel and young papaya seed ethanol extract gel against Cutibacterium acnes bacteria. The research method is experimental with various formulas consisting of F0 (0%), F1 (11%), F2 (12%), and F3 (13%). The results of the study obtained antibacterial gel preparations from the three concentrations showed that the organoleptic test of the young papaya fruit skin ethanol extract gel preparation was light brown, blackish brown, dark blackish brown. The homogeneity test was homogeneous. The pH test was 5.9, 6.5, 7.0, and the seed ethanol extract gel preparation was light brown, dark brown, thick dark brown. The homogeneity test was homogeneous. Test pH 5.0, 5.6, 5.5, 5.1. The conclusion of this study is that the antibacterial effectiveness of young papaya fruit skin ethanol extract gel is greater than young papaya fruit seed ethanol extract gel at a concentration of 13% against Cutibacterium acnes bacteria.
Formulation and Effectiveness Test of Liquid Soap from Siam Weed (Chromolaena odorata (L.) Leaves Ethanol Extract Against Staphylococcus aureus Diana, Vivi Eulis; Abadi, Hafizhatul; Andry, Muhammad
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7981

Abstract

Chromolaena odorata (L.) is one of the plants known as weeds. Alkaloids, flavonoids, saponins, tannins, and glycosides are active chemicals found in Siam weed leaves. The study aimed to see if an ethanol extract of Siam weed leaves can be made into liquid soap and has antibacterial action against Staphylococcus aureus germs. The liquid soap of Siam weed (Chromolaena odorata L.) leaf ethanol extract at concentrations of 3%, 6%, and 9% was carried out experimentally in the laboratory, along with physical liquid soap evaluation tests such as organoleptic test, homogeneity test, pH test, foam height test, specific gravity test, test irritation, and hedonic test. Staphylococcus aureus bacteria were then tested. The assessment test criteria were met by making liquid soap preparations of ethanol extract of Siam weed leaves  at concentrations of 3%, 6%, and 9%. The color of the solid soap was brown - dark brown, and the texture was liquid with a lemon scent; the homogeneity test showed that all preparations were homogeneous; the pH test of the soap was 9.1 -9.7; the foam height test was 53-66 mm; the specific gravity test was 1-1.01 g/ml; and the irritation test revealed that all preparations had no reaction to redness, itching, and swelling on the skin. The hedonic test on skin revealed that all preparations obtained favorable evaluations from the panelists. The antibacterial activity of liquid soap against Staphylococcus aureus germs was F1 3.65 mm, F2 5.75mm, and F3 6.5mm. Based on the results of the Staphylococcus aureus test, it could be concluded that in the formula F1 (3% concentration), F2 (6% concentration) and F3 (9% concentration) had an inhibition zone.
FORMULASI DAN UJI ANTIDIARE SEDIAAN PATCH TRANSDERMAL EKSTRAK DAUN SENGGANI (Melastoma malabathricum L.) TERHADAP KELINCI Winata, Hanafis Sastra; Abadi, Hafizhatul; Leny, Leny; Andry, Muhammad; Ngete, Ani Florida; Yudianto, Tri; Nurjanah, Ayu; Pamungkas, Barolym Tri; Gumilar, Roni
AGRIBIOS Vol 22 No 2 (2024): November
Publisher : Program Studi Agribisnis Fakultas Pertanian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36841/agribios.v22i2.5494

Abstract

One plant that has been used for traditional medicine with good results is Melastoma (Melastoma malabatricum L.). The plant known as Melastoma has three active compounds: tannins, saponins, and flavonoids. Melastoma leaves work well to cure diarrhoea. Adhesive patches with medication applied topically are called transdermal patches. Melastoma leaf extract transdermal patch formulations were utilised in this study, which employed laboratory experimental techniques. The potential of Melastoma leaf extract transdermal patch preparation formula as an antidiarrheal for rabbits was the subject of the study. Concentrations of extract: 10%, 20%, and 30%. Organoleptic testing, pH tests, weight uniformity tests, moisture tests, thickness tests, and fold resistance tests were the preparatory assessment parameters that were conducted. The characteristics of the antidiarrheal test were timing of diarrhoea occurrences, consistency of the stool, frequency of diarrhoea, and length of diarrhoea, all of which were monitored for six hours. The evaluation of the Melastoma leaf extract transdermal patch formulation demonstrated a significant difference, namely <0.05, according to the results of the ANOVA data analysis. The antidiarrheal test parameters had a significant difference between each concentration, namely <0.05, according to the findings of the ANOVA data analysis. The conclusions was possible to use a transdermal patch formulation of Melastoma leaf extract (Melastoma malabathricum L.) at a 30% concentration to prevent diarrhoea by making stools softer.
Formulasi sediaan body butter ekstrak etanol bunga rosella (Hibiscus sabdariffa L.) sebagai pelembab kulit Diana, Vivi Eulis; Abadi, Hafizhatul; Andry, Muhammad
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.321

Abstract

Background: Body butter is a semi-solid preparation with the highest fat content, so it is very thick and has a consistency very similar to butter, and has a better ability to nourish the skin than body lotion. In addition, body butter itself is perfect for eliminating reddish lines that usually appear on the skin or commonly called strechmarks. Objective: To test the physical quality stability of the concentration of rosella flower ethanol extract formula (Hibiscus sabdariffa L.) in body butter preparations that have been made. Method: The method used is laboratory experimental. Research includes plant extraction, plant identification, making simplisia, phytochemical screening, making ethanol extract, body butter preparation formulation, and quality stability testing of preparations. The sample used in this study was Rosella Flower (Hibiscus sabdariffa L). The research data was analyzed using the SPSS program, namely the Anova test. Result: Rosella flower ethanol extract (Hibiscus sabdariffa L.) has a semisolid form, homogeneous no coarse particles, with a pH value of the preparation ranging from 6.3-6.4, non-irritating, and can moisturize the skin. But it is not stable with cycling test method storage and stable at room temperature for 4 weeks. The best formula of body butter preparation from ethanol extract of rosella flower (Hibiscus sabdariffa L.) to moisturize the skin is a concentration of 3%. Conclusion: Rosella flower ethanol extract (Hibiscus sabdariffa L.) can be formulated in body butter preparations. It is recommended that future researchers formulate it into other preparations in the same concentration using the same plant from rosella flowers (Hibiscus sabdariffa L.).
Isolasi senyawa flavonoid dari daun bakung (Crinum asiaticum L.) Abadi, Hafizhatul; Rumanti, Ruth Mayana; Andry, Muhammad; Nasution, Muhammad Amin
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.322

Abstract

Introduction Sprains and fractured bones are treated with spider lily leaves (Crinum asiaticum L.). Alkaloids, flavonoids, tannins, steroids, and triterpenoids are among the chemical components found in spider lily leaves. The most significant phytochemicals in plants with wide biological advantages for humans are bioactive flavonoids. The purpose of: The study aimed to isolate flavonoid components from spider lily leaves. Methods: This study was descriptive, using the following steps: plant material collection and preparation, sample processing, simplicia characterization, extract preparation, phytochemical screening, hydrolysis, fractionation, analysis using paper chromatography (KKt), and compound isolation using preparative paper chromatography. The isolates were tested for purity using one-way and two-way KKt, and they were identified using UV-Vis spectrophotometry with a shear reagent. The results: The results of the characterization showed that the water content was 7.21%, the water-soluble extract was 11.21%, the ethanol-soluble extract was 9.23%, the total ash content was 1.99%, and the acid-insoluble ash content was 0.81%. The screening findings indicated the presence of flavonoid chemicals. The KKt analysis results revealed that the best mobile phase was 5% acetic acid with ammonia vapor specks, and the preparative KKt isolation results yielded a single blue isolate, which was then identified by UV-Vis spectrophotometry using a shear reagent, resulting in maximum wavelength absorption (max) at band II of 253nm, presumably identifying the isoflavone group of flavonoids. Conclusion: The conclusion showed the ethyl acetate fraction of spider lily leaves could be separated using paper chromatography and that identification by spectrophotometry UV-Vis using a shear reagent wasolate, which was assumed to be an isoflavone group component.
EFEKTIVITAS ANTI JERAWAT SEDIAAN KRIM EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lam.) TERHADAP Propionibacterium acnes Hafizhatul Abadi; Vivi Eulis Diana; Jacub Tarigan; Tetty Noverita Khairani; Tri Sundari
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.419

Abstract

Jackfruit (Artocarpus heterophyllus Lam.) leaves have medicine potential, such as an antibacterial in anti-acne treatment contain flavonoids, tannins and saponins. The study aims to determine whether the ethanol extract of jackfruit leaves 96% can be formulated and determined the effectiveness of concentration preparation in inhibiting the Propionibacterium acnes bacteria. The preparation of cream preparations used a concentration of 20%, 30% and 40% jackfruit leaf ethanol extract. Then carried out the evaluation test of the preparation including the organoleptic test, homogeneity test, spreadability test, and pH test. Furthermore, the antibacterial effectiveness test was carried out by using the diffusion method. The results of evaluation test for cream preparations which included organoleptic tests with the results of three concentrations meeting the requirements, the homogeneity test and the dispersion test of the preparations, the results meet the specified conditions and the results of the pH test with the three concentrations of preparations that met the specified pH requirements. And it can inhibit the growth of Propionibacterium acnes bacteria with an inhibition zone of 7.5 mm at a concentration of 20%, 11 mm at a concentration of 30%, and 11.7 mm at a concentration of 40%. Antibacterial effectiveness test using positive control had an inhibition zone of 25.9 mm. The conclusion of this study is that the ethanol extract of jackfruit leaves can be formulated into anti-acne cream preparations.
Co-Authors Adek Chan Amalia Juliani Hasibuan Anjani Sipahutar Diana, Vivi Eulis Eulis, Vivi Faadhilah Yusa Simbolon Fitria Mahira Mumtaz Sitorus Gumilar, Roni Hafizah Cintya Putri Hanafis Sastra Winata Ignasia Amaerita Buulolo Jacub Tarigan Jamiati Jamiati Khairani Fitri Khairani Fitri Lathi Furrahmi Leny Leny, Leny Leny, Leny Lilik Septiana Linda Hernike Napitupulu Mayang Sari Muhammad Amin Nasution Muhammad Andry Ngete, Ani Florida Nidawah Nidawah Nurjanah, Ayu Pamungkas, Barolym Tri Parhan Parhan Pricella Aqwilla Br Ginting Rani Monalisa Hutagaol Riva Rainiza Zuddin Riva Rainiza Zuddin Rumanti, Ruth Mayana Ruth Mayana Rumanti Silvia Loren Siti Fatimah Hanum Siti Netti Ritonga Surbakti, Chemayanti Tetty Noverita Khairani Tetty Noverita Khairani Tri Sundari Vivi Eulis Diana Vivi Eulis Diana William Wijaya Winata, Hanafis Sastra Yoksan Duha Yudianto, Tri Yusta Suriani Ndruru Zulmai Rani