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Dian Nurmansyah
Universitas Borneo Lestari
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Jumlah Leukosit berkorelasi dengan Jumlah Trombosit pada Demam Tifoid Anak Nurmansyah, Dian; Gunasari, Lala Foresta Valentine; Puspawati, Puspawati; Sasmitha, Maya Herliana
Media Ilmiah Kesehatan Indonesia Vol. 4 No. 2 (2026): MAY
Publisher : Pakis Journal Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58184/miki.v4i2.938

Abstract

Typhoid fever in children remains a health problem in developing countries, with hematological changes such as leukocyte and platelet abnormalities being frequently observed. This study aimed to analyze the relationship between leukocyte and platelet counts in pediatric patients with typhoid fever. A cross-sectional design was employed using secondary data from the Clinical Pathology Laboratory of RSDI Banjarbaru City. A total of 72 children aged 5–13 years who met the inclusion criteria (diagnosis of typhoid fever by Tubex TF, no prior antibiotic therapy) were analyzed. Leukocyte and platelet measurements were performed using a hematology analyzer, and data were analyzed using simple linear regression (SPSS version 24). Results showed a mean age of 8.2 years, with a higher proportion of males (59.7%). Leukocyte distribution was highly variable, ranging from severe leukopenia (1200–1248/mm³) to extremely high values. Platelet distribution was also wide, with very low values of 51,000/mm³ and high outliers up to 460,000/mm³. Regression analysis yielded the equation y = 13.74x + 118195 with a coefficient of determination (R²) of 0.4998, indicating that approximately 50% of the variability in platelet count could be explained by leukocyte count. Pathophysiologically, this relationship is mediated by proinflammatory cytokines (TNF-α, IL-1, IL-6) and leukocyte-platelet aggregation induced by Salmonella typhi endotoxin. In conclusion, there is a moderate positive correlation between leukocyte and platelet counts in children with typhoid fever. These hematological parameters have the potential to serve as adjunctive diagnostic tools and for risk stratification, particularly in settings with limited blood culture facilities.
Co-Authors Afra, Fairuz Yaumil Aldiana Astuti Ansari, Muhammad Hafiz Becker, Sören L. Buehler, Nina Dessy Triana Fauzana, Erwin Fayumi, Syihab Firda Zalianty Gunasari, Lala Gunasari, Lala Foresta Valentine Hayatush Shalihah Humairah, Salsabila Ifan Anom Bintoro Aji Jayanto, Imam Julpadli, Muhammad Khairunnisa Khairunnisa Khasanah, Maulisa Kristi, Priska PP. Kusuma Dewi, Ratih Puspita Kusumasari, Peni Kusumasari, Rizqiani A. Lala Foresta Valentine Gunasari Liana Fitriani Hasymi Lystirini, Eka Maya Herliana Sasmitha Maya Sasmitha Mudzakkir, Musyirah Mudzakkir, Musyirrah Muhammad Arsyad Muhammad Arsyad Muhammad Fahmi Murhandarwati, Elsa H. Muslim, Abdul Aziz Nafila nafila Nisa, Shalehatun Normilawati, Santi Nurmaidah Nurmaidah Nurul Mardiati Puspawati Puspawati Puspawati Puspawati Puspawati Puspawati, Puspawati Putri Ayanti, Bio Putri Kartika Sari Rahmi Muthia Rifqoh Rifqoh Rizal Rizal Rufi'i Sasmitha, Maya Sasmitha, Maya Herliana Schneitler, Sophie Shabrina Dewi Ramadhani Sholikhah, Eti N. Sy, Issa Syairaji, Muhammad Tanzil, Yurniah Wahyuni, Rizka Ayu Yoga Yuniadi Zalianty, Firda