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JFL : Jurnal Farmasi Lampung
Published by Universitas Tulang Bawang
ISSN : 23552506     EISSN : 25984896     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
The focus of JFL is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences, natural medicine and clinic community. The scope of the journal is Pharmaceutical sciences, its research and its application.
Arjuna Subject : -
Articles 157 Documents
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suburwidodo Formulasi Krim Anti Acne Ekstrak Etanol Kulit Kentang (Solanum Tuberosum L.) Dan Aktivitas Antibakteri Terhadap Staphylococcus epidermidis Dan Propionibacterium acnes.: Anti Acne Cream Formulation Of Potato Ethanol Extracts (Solanum Tuberosum L.) And Antibacterial Activities On Staphylococcus epidermidis And Propionibacterium acnes. Widodo, Subur; Susanti, Laila; Samsuar; Hartono, Adityo; Safitri, Andika
JFL : Jurnal Farmasi Lampung Vol. 13 No. 1 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i1.1646

Abstract

Pengobatan jerawat di klinik kulit biasanya menggunakan antibiotik yang dapat menghambat inflamasi dan membunuh bakteri. Penggunaan antibiotik jangka panjang dapat menimbulkan resistensi antibiotik. Efek samping penggunaan antibiotik dapat dikurangi dengan mengganti bahan aktif obat yang diperoleh dari alam seperti kulit kentang yang mampu menghambat pertumbuhan bakteri penyebab jerawat. Penelitian ini bertujuan untuk membuktikan bahwa ekstrak kulit kentang dapat di formulasikan menjadi sediaan krim dan memiliki aktivitas antibakteri terhadap S.epidermidis dan P.acnes. Ekstrak diformulasikan dalam sediaan krim dengan konsentrasi ekstrak berbeda yaitu F1 (15%), F2 (30%) dan F3 (45%) dengan menggunakan asam stearat, paraffin liquidum, adeps lanae sebagai fase minyak dan TEA, aquadest sebagai fase air, dan metil paraben sebagai pengawet. Kemudian diuji sifat fisik sediaan meliputi ,homogenitas, pemeriksaan organoleptis, pengukuran pH, viskositas, daya sebar, daya lekat, uji stabilitas dan uji antibakteri. Hasil evaluasi sediaan memiliki nilai pH berkisar  antara 6,2 - 8,1, viskositas berkisar antara  3120  - 4920 cps, daya sebar antara 5,3 - 6,7 cm, dan daya lekat 4,2 - 5,3 detik. Setiap formula stabil dalam penyimpanan cycling test serta penyimpanan suhu 40ºC ± 2ºC, 28ºC ± 2ºC, 4ºC ± 2ºC dan ketiga formula memiliki sifat antibakteri terhadap S.epidermidis dan P.acnes. Luas zona hambat F1 (7,61 mm), F2 (8,47 mm) dan F3 (9,92 mm) terhadap S.epidermidis dan Luas zona hambat F1 (7,58 mm), F2 (7,86 mm) dan F3 (9,65 mm) terhadap P.acnes. Kesimpulan penelitian ini yaitu ekstrak kulit kentang dapat diformulasikan dalam sediaan krim dan memiliki zona hambat terhadap S.epidermidis dan P.acnes.
PENGARUH METODE EKSTRAKSI DAN PELARUT TERHADAP KANDUNGAN METABOLIT SEKUNDER DAN AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN INSULIN (Smallanthus sonchifolius): SOLVENTS EFFECT AND EXTRACTION METHODS ON SECONDARY METABOLITE CONTENT AND ANTIOXIDANT ACTIVITY OF INSULIN LEAF EXTRACT (Smallanthus sonchifolius) Saputri, Alip Desi Suyono; Sa'ad, Muhammad; Maharani, Putri; Prahesti, Maya Tesa
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1629

Abstract

Insulin leaves (Smallanthus sonchifolius) are reported to have strong antioxidant activity. This activity comes from the content of secondary metabolite compounds such as phenolics, flavonoids, tannins, as well as anthocyanin and betacyanin pigments. To obtain the phytochemical content of a plant, an extraction process is carried out. The extraction method and solvent are factors that influence the amount of phytochemical content in the extract. There has been no research analyzing effective methods and solvents for extracting insulin leaves to obtain the highest antioxidant effect. This research was conducted to determine the effect of extraction methods and solvents on the antioxidant activity of insulin leaf extract. Maceration and digestion methods with distilled water, 50% ethanol and 96% ethanol were used in the extraction of insulin leaf simplicia in this study. Samples obtained were Aquadest Macerated Extract (EMA), 50% Ethanol Macerated Extract (EME50), 96% Ethanol Macerated Extract (EME96), Aquadest Digested Extract (EDA), 50% Ethanol Digested Extract (EDE50), and 96% Ethanol Digested Extract (EDE96). Testing the antioxidant activity of each sample used the DPPH method by calculating the IC50 value and using Quercetin as a positive control. Data analysis was carried out using one way anova analysis. The results show that the choice of solvent and extraction method influences the antioxidant activity of the extract. The IC50 values ​​for each extract from low to high are: EDA, EDE50, EMA, EDE96, EME50, and EME96, with values: 20.06ppm; 22.44ppm; 23.77ppm; 23.84ppm; 24.55ppm; and 27.71ppm. It can be concluded that the method and solvent to obtain the best antioxidant activity from insulin leaves (Smallanthus sonchifolius) is extraction using the digestion method with distilled water as a solvent (p<0,05). Keywords:  antioxidant, digestion, insulin leaf, maceration, solvent  
ANALISIS KEJADIAN STROKE BERULANG PADA PASIEN YANG MENGGUNAKAN ANTIPLATELET DI RUMAH SAKIT X CIAMIS: ANALYSIS OF RECURRENT STROKE INCIDENTS IN PATIENTS USING ANTIPLATELETTS AT X CIAMIS HOSPITAL Wisastry, Seisa; Alifiar, Ilham; Salasanti, Citra Dewi; Ilham Alifiar; Citra Dewi Salasanti
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1632

Abstract

Stroke is an acute and focal neurological deficit syndrome, which is clinically defined as the result of blood vessel injury in the central nervous system caused by rupture and blockage of blood vessels to the brain which results in reduced energy and the brain lacking nutrition. The aim of the study was to analyze the incidence of recurrent stroke in patients using antiplatelet drugs single aspirin, single clopidogrel and the combination at Hospital primary data obtained from the patient's medical record. Data and frequencies collected through patient medical records were analyzed using the chi-square test to determine the relationship between antiplatelet use and recurrent stroke. The results of this study showed that the number of stroke patients was 368 and recurrent stroke was 32 patients with an average duration of stroke recurrence, namely single aspirin 127.86 days, single clopidogrel 77 days, and the combination 237.39 days. From the data obtained, it can be concluded that Antiplatelet administration can affect the time to recurrent stroke. Keywords:  Stroke, Antiplatelet, Aspirin, Clopidogrel, Combination
IDENTIFIKASI POTENTIALY INAPPROPRIATE MEDICATIONS PADA GERIATRI DENGAN PENYAKIT KRONIS DI UPTD PUSKESMAS X KABUPATEN KUNINGAN: IDENTIFICATION OF POTENTIALLY INAPPROPRIATE MEDICATIONS IN GERIATRIC WITH CHRONIC DISEASES AT UPTD PUSKESMAS X KUNINGAN Salasanti, Citra Dewi; Iskandar, Rossa Deliana Putri; Alifiar, Ilham
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1718

Abstract

The administration of medication and use of drugs in elderly patients must be carefully considered, as elderly patients are highly susceptible to adverse drug reactions. Beer’s and STOPP/START criteria are screening tools employed to prevent inappropriate drug use in geriatrics. This study aimed to determine the incidence of potentially inappropriate medications (PIMs) in geriatric with a history of chronic diseases at UPTD Puskesmas X. The research method was a cross-sectional observational study with prospective data collection from January to April 2024. The data was analyzed descriptively using the Beer’s 2023 criteria and STOPP/START version 3. The results of this study show that among the total sample, there were 185 geriatrics, with 132 (71.35%) females and 53 (28.65%) males. The most common chronic diseases observed were hypertension, diabetes mellitus, and osteoarthritis. According to the Beer’s criteria, there were 142 incidents of PIMs, while the STOPP criteria identified 16 incidents. Most of the drugs identified as PIMs based on both Beer’s and STOPP criteria were nonsteroid anti-inflammatory drugs (NSAIDs). Based on the results, PIMs occurred in geriatric who sought treatment from January to April 2024 at UPTD Puskesmas X. Therefore, it is necessary to enhance services and closely monitor therapy for geriatric.  Keywords:  Beer’s, Geriatric, STOPP START
KAJIAN PENINGKATAN PENGETAHUAN FITOFARMAKA UNTUK SWAMEDIKASI PADA TIM PENGGERAK PKK DI SURAKARTA: A STUDY ON IMPROVING PHYTOPHARMACA KNOWLEDGE FOR SELF-MEDICATION IN THE PKK MOBILIZATION TEAM IN SURAKARTA Pambudi, Risma Sakti; Khusna, Khotimatul; Safitri, Desti Anggi; Windiasari, Farah Puteri
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1755

Abstract

Public knowledge related to the use of traditional medicine is still low and does not know other traditional medicine classes such as OHT (Standardized Herbal Medicine) and phytopharmaca groups. The purpose of this study was to determine the level of knowledge of the use of phytopharmaca for self-medication in the PKK team of Surakarta city. The method in this study used quantitative research with a quasi experimental design with one group pre and post test design. The pre-test was used at the time of the delivery of the material with the aim of knowing the extent to which the material was understood by the respondents. While the post-test is carried out at the end of the material treatment process with the aim of knowing the extent of understanding of the material provided.  Analyze respondents' knowledge by looking at the formula to measure the percentage of answers obtained from the questionnaire. The results showed the level of knowledge of respondents during the pre-test, namely having good knowledge (39.22%), sufficient knowledge (48.04%) and less (12.75%). After being given treatment, respondents filled out a questionnaire and obtained a value for the post-test knowledge level, namely good (63.73%), sufficient (30.39%), and less (12.75%). The results showed that there was a difference in the pre and post test scores of respondents after being treated with a sig value (2-tailed) of 0.000, which is <0.05. The conclusion of this study is that there is an average difference between pre and post and there is an effect with a sig value of 0.000, which is <0.05. Keywords:  Medicine, Phytopharmaca, Knowledge, Self-medication, Surakarta
POTENSI INTERAKSI OBAT PADA PASIEN HIPERTENSI DENGAN PENYAKIT PENYERTA DI RSUD PREMBUN: POTENTIAL DRUG INTERACTIONS IN HYPERTENSION PATIENTS WITH COMORBID DISEASES AT PREMBUN HOSPITAL Kurniawati, Desi; Widiastuti, Tri Cahyani; Khuluq, Khusnul
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1762

Abstract

In the treatment of hypertension accompanied by comorbidities, there are many occurrences, so the potential for polypharmacy is very large, which causes the possibility of drug interactions. Drug interactions cause various problems such as decreased therapeutic effects, increased toxicity, or altered pharmacological effects of a drug.This study aims to describe the potential interaction of hypertension drugs in inpatients at Prembun Hospital for the 2023 period. This research is descriptive research by collecting data retrospectively. Data on the use of antihypertensive drugs and data on inpatient visits were obtained from the Inpatient Institution of Prembun Hospital for the 2023 Period. Out of a total of 100 patients, there were 93 interactions (93%). There were 3 interactions, namely the most severe level, namely moderate interactions as many as 150 interactions (58.3%) occurred in drugs between Aspirin and Amlodipine, the severity of minor interactions as many as 71 interactions (27.6%) occurred between Amlodipine drugs and Furosemide, and the least severe level of drug interactions was major interactions as many as 36 interactions (14%) occurred between Spironolactone and Candesartan. From the results of the study, it can be concluded that there is 93% interaction in the use of hypertension drugs, and 7% there is no interaction in the use of hypertension drugs. Keywords:  Hypertension, Comorbidities, Interaction
UJI AKTIVITAS ANTIBAKTERI DAUN JUKUT PENDUL (Kyllinga nemoralis) YANG DIPEROLEH DARI KOTABARU, KALIMANTAN SELATAN, INDONESIA Soemarie, Yulistia Budianti; Niasti, Ignalia; Hasniah
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1763

Abstract

The use of antibiotics as acne treatment is often used as the main treatment by the community. Natural acne treatments that are easily available should be developed to replace chemical products, such as the jukut pendul plant (Kyllinga nemoralis). The purpose of this study was to determine the antibacterial activity of jukut pendul leaves against Propionibacterium acnes. The sample was determined, extracted by maceration method using 70% ethanol, then fractionated with water, ethyl acetate, and n-hexane solvents. Phytochemical screening on ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction. Antibacterial activity tests were conducted on extracts and fractions of jukut pendul leaves with concentrations of 5%, 10%, and 15%. Antibacterial activity testing of 5% concentration ethanol extract produced inhibition of 9.5 mm (medium), 10% 9.6 mm (medium), 15% 10.16 mm (strong). The n-hexane fraction of 5%, 10% and 15% concentration was 6 mm (medium). Ethyl acetate fraction of 5% concentration was 9 mm (medium), 10% 9.6 mm (medium), 15% 11.2 mm (strong). Water fraction of 5% and 10% concentration was 6 mm (medium), 15% concentration was 8.3 mm (medium). Keywords: Antibacterial, Jukut Pendul (Kyllinga nemoralis), Propionibacterium acnes
Analisis Kuersetin dan Rutin pada Ekstrak Krokot (Portulaca oleraceae L.) dan Ekstrak Pare (Momordica charantia L.) secara KCKT: Analysis of Quercetin and Rutin in Krokot (Portulaca oleraceae L.) Extract and Pare (Momordica charantia L.) Extract by HPLC Sari, Anggya Shinta Etika; Syaira, Dear; Susilowati; Dhurhania, Crescentiana Emy
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1766

Abstract

Krokot (Portulaca oleraceae L.) and Pare (Momordica charantia L.) are plants containing flavonoid compounds of quercetin and rutin. The purpose of this study is to know quercetin levels and rutin in the krokot and pare established by high performance liquid chromatography (HPLC) and to know the acceptance of linearity test requirements. Krokot extraction uses soxhletation techniques with ethanol 96% while pare uses maseration techniques with ethanol 70%. The viscous extract is used for the quercetin and rutin compound concentrations by HPLC using stationary phase is C18, mobile phase is methanol : phospat acid 0,1% (70:30), flow rate of 1 ml/min and the length of the detection at 371 nm wavelength. The result of quercetin compound of krokot gets 0.019 % and the rutin compound 0.042 % while its quercetin compound of pare extract is 0.028 % and the rutin compound 0.037 %. The results of the linearity test of quercetin and rutin compounds obtained a correlation coefficient value of 0.99 so that it meets the requirements for a good linearity test. Keywords:  Quercetin, Rutin, Krokot, Pare, HPLC
PERBANDINGAN PROFIL KANDUNGAN KIMIA EKSTRAK AIR, EKSTRAK HIDROTROPI, DAN EKSTRAK ETANOL RAMUAN JAMU SAINTIFIK PENURUN KADAR GULA DARAH SERTA UJI STABILITASNYA: CHEMICAL CONTENT PROFILE COMPARISON OF WATER EXTRACT, HYDROTROPIC EXTRACT, AND ETHANOLIC EXTRACT OF SCIENTIFIC JAMU FOR LOWERING BLOOD SUGAR LEVEL AND ITS STABILITY TEST Sasmita, Sasmita; Retno Wahyuningrum; Ika Yuni Astuti
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1801

Abstract

Scientific jamu for lowering blood sugar are used in the form of decoction preparations, so it is less practical. The method of using scientific herbal medicine which is still traditional has several disadvantages, namely it is impractical and reduces the level of patient compliance which can result in a decrease in the effectiveness of scientific jamu. Based on this, the development of scientific herbal medicine into a more modern dosage form is very important to do. The selection of the right extraction method and solvent will produce an extract with the most optimal active constituent in producing pharmacological effects, so that it can increase the effectiveness of research in the context of drug discovery and development. In this study, the chemical content profiles of 3 (three) different types of extracts were compared, namely water extract, hydrotropic extract, and ethanol extract. The three types of extracts were then compared for their yield values, total flavonoid levels, andrographolide, cinnamaldehyde, and curcumin. The total flavonoid levels were determined by the UV-Vis spectrophotometry method, the andrographolide, cinnamaldehyde, and curcumin levels were determined by the densitometry thin layer chromatography (TLC) method. The extract with the best chemical content profile was subjected to forced degradation tests. The results showed that the ethanol extract produced the highest yield compared to the water extract and hydrotrope extract, which was 4.48%. The ethanol extract also provided the best chemical content profile, namely the total flavonoid content of 16.15 ± 0.96 mg QE / g, andrographolide content of 2.14 ± 0.12%, cinnamaldehyde content of 8.22 ± 0.31%, and curcumin of 6.46 ± 0.80%. In the forced degradation test, the total flavonoid content in the ethanol extract decreased due to several conditions, such as hydrolysis, oxidation, thermal, and photolytic.   Keywords:  Extraction, Forced degradation, Hydrotropic, Scientific jamu
UJI VALIDASI METODE DAN PENETAPAN KADAR RANITIDIN DALAM SEDIAAN TABLET SECARA SPEKTROFOTOMETRI UV: METHOD VALIDATION TEST AND DETERMINATION OF RANITIDINE CONTENT IN TABLET PREPARATIONS BY UV SPECTROPHOTOMETRY Dona, Rahma; Ningrum, Tilar Eka Widia; Nasution, Musyirna Rahmah; Fernando, Armon; Syahbandi, Ilham; Milianty, Jesy
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1805

Abstract

This study aims to determine the levels of ranitidine in generic and trade name tablet preparations by UV spectrophotometry. Based on the results obtained linearity value of r = 0.9999 with limit of detection (LOD) 0.1667 ppm and limit of quantitation (LOQ) 0.5558 ppm. Precision obtained RSD results of 0.641% and in accuracy obtained % recovery at 3 concentrations of 9, 12 and 15 ppm respectively 101.05; 100.63; and 100.33%. The results of the determination of levels in ranitidine tablet preparations with five generic tablets and five trade name tablets have met the requirements for levels in medicinal preparations for ranitidine tablet preparations according to the Indonesian Pharmacopoeia VI Edition, which contains ranitidine not less than 90.0% and not more than 110.0%. It can be concluded that the UV spectrophotometric method used in the study has met the parameters set in the validation test so that this method can be applied to the analysis of determining ranitidine levels in a laboratory. Keywords:  Ranitidine, UV Spectrophotometry, Method validation

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