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JFL : Jurnal Farmasi Lampung
Published by Universitas Tulang Bawang
ISSN : 23552506     EISSN : 25984896     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
The focus of JFL is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences, natural medicine and clinic community. The scope of the journal is Pharmaceutical sciences, its research and its application.
Arjuna Subject : -
Articles 145 Documents
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The ANALYSIS OF PHARMACEUTICAL SERVICES IN COMMUNITY PHARMACIES IN DKI DURING COVID-19 PANDEMIC: ANALYSIS OF PHARMACEUTICAL SERVICES IN COMMUNITY PHARMACIES IN DKI DURING COVID-19 PANDEMIC Karlina, Lina; Sumiyati, Yati; Utami Ramadaniati, Hesty; S. Mardiko, Etty
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2307

Abstract

The COVID-19 pandemic has caused changes to pharmaceutical services activities in community pharmacies, due to various adjustments that must be made. To analyze the impact of COVID-19 pandemic on pharmaceutical service activities in community pharmacies. Cross-sectional approach involving community pharmacist in DKI Jakarta. The quantitative data were collected through distributing online questionnaires in November 2022, while qualitative data were obtained through online in-depth interviews. The quantitative data was analyzed descriptively whereas qualitative data was analyzed using content analysis. Research revealed an increase of 29.4% of pharmacies experiencing out of stock in pharmaceutical supplies compared to before the pandemic. There was a 42.1% decrease indirect Drug Information Services (DIS) compared to before the pandemic. Meanwhile, during the pandmeic a 42.1% increase in online DIS. There were various innovations and strategies done by pharmacies including maximizing the use of digitalization both in the implementation of pharmaceutical services, as well as in promotional activities and online sales of pharmacy productsand. It can be concluded that there are considerable differences in managerial activities and clinical pharmacy services before and during the COVID-19 pandemic, with more digital-based technology involvement in managerial activities and clinical pharmacy services during the pandemic. Keywords: Pharmaceutical services, Pharmacy, COVID-19, Innovations, Strategic
A COMPARATIVE STUDY OF ANTIBIOTIC KNOWLEDGE BETWEEN PHARMACY STUDENTS AT INSTITUT TEKNOLOGI SUMATERA: A COMPARATIVE STUDY OF ANTIBIOTIC KNOWLEDGE BETWEEN PHARMACY STUDENTS AT INSTITUT TEKNOLOGI SUMATERA Oktariza, Yasinda; Hasanah, Uswatun; Yusuf, Mubarika Sekarsari
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2389

Abstract

Abstract Knowledge about antibiotics is one of the key factors that can increase awareness for the appropriate use of antibiotics. Pharmacy students, as part of health-related academic programs, are expected to take on a role in educating the public about appropriate use of antibiotics. This study aims to assess the level of antibiotic knowledge among second-semester and sixth-semester pharmacy students. The research used an observational design with a cross-sectional approach. The study subjects were pharmacy students from the Faculty of Science at Institut Teknologi Sumatera. The research instrument was a questionnaire that had been tested for validity and reliability, and it was distributed online via Google Forms. A total of 219 respondents participated in this study. Data analysis was conducted by comparing the mean total knowledge scores between the two groups using the Mann-Whitney test. The results showed that sixth-semester students had higher knowledge scores compared to second-semester students. Statistically, a significant difference was found (p < 0.001) between the two groups. These findings indicate that the academic level influences knowledge improvement, as senior students have undergone a longer educational and academic process. Overall, pharmacy students have acquired adequate knowledge regarding the proper use of antibiotics. Keywords:  antibiotic, knowledge, pharmacy, student
STUDI IN SILICO QUININ SEBAGAI KANDIDAT AGEN ANTI AGING: IN SILICO STUDY OF QUININE AS A CANDIDATE ANTI-AGING AGENT Yuli Aliviyanti, Risa Umari; Aji, Tri Maruto
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2399

Abstract

Aging is a complex natural process and an inherent part of the life cycle. The continuous aging and accumulation of cells contribute to the degradation of the extracellular matrix, which further accelerates the aging process. Various topical agents have been utilized to combat aging, primarily through anti-aging treatments. Examples include the use of topical agents such as retinoids (retinol), vitamin C, hyaluronic acid, alpha hydroxy acids (AHA), and beta hydroxy acids (BHA). This study aims to explore the potential anti-aging properties of compounds found in the quinine-producing plants Cinchona ledgeriana (Ledger) and Cinchona succirubra (Succi) through a molecular approach using the molecular docking method to assess their activity against aging-related proteins. The tested ligands in this study include quinine, cinchonine, quinidine, and cinchonidine, with retinol as the antagonist ligand. In silico analysis suggests that quinine, cinchonine, quinidine, and cinchonidine from Cinchona ledgeriana (Ledger) and Cinchona succirubra (Succi) exhibit strong potential as anti-aging agents by targeting the proteins hyaluronidase receptor (1FCV), elastase (1Y93), collagenase (2D1N), tyrosinase (2Y9X), and HSP90 (5XRB). Molecular docking simulations using MOE 2015.10 revealed quinine's superior binding affinity, with free energy values ranging from -4.9 to -6.8 kcal/mol across target proteins. Critical interactions with His263 (tyrosinase) and Asp206 (elastase)were identified through LigPlot analysis. The docking analysis confirmed the reliability of the methodology, demonstrating that quinine, quinidine, cinchonine, and cinchonidine strongly bind to key skin-ageing enzymes. This study demonstrates the potential of Cinchona bark-derived phytochemicals as anti-aging agents, with quinine exhibiting superior inhibitory activity against tyrosinase. Quinine demonstrated the strongest inhibition against tyrosinase (ΔG = -6.84 kcal/mol), outperforming reference ligands and other Cinchona alkaloids. These findings provide a scientific basis for further exploration of these compounds in mitigating skin aging and enhancing dermatological health. Keywords: Antiaging, in silico, molecular docking, quinine
ANALISIS KUANTITATIF KANDUNGAN MERKURI (Hg) PADA PRODUK BEDAK PEMUTIH YANG BEREDAR DI KOTA BATAM: QUANTITATIVE DETERMINATION OF MERCURY (Hg) LEVELS IN WHITENING POWDERS DISTRIBUTED IN BATAM CITY Mayefis, Delladari; Marliza, Hesti; Maharani, Refina
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2404

Abstract

Cosmetics are ingredients or mixtures of ingredients to be used on parts of the human body with the intention of cleansing, protecting to keep it in good condition and can play a role in healing and skin care. Facial cosmetic products that are currently often used are powder. There are various forms of powder, one of which is whitening powder which is widely discussed not only the product that floods the market, but also because of the impact of using the product which is able to whiten and brighten the face in a very short time. The content contained in these products also varies, some are formulated safe to use and dangerous when used. One of them is that mercury (Hg) is usually added intentionally or not very unjustified because it will be in direct contact with the skin and can be toxic. This study aims to identify the content of Mercury (Hg) in whitening surgery circulating in Batam City using the FIMS (Flow Injection Mercury System) test method. The results of research conducted on 10 whitening powder samples obtained mercury (Hg) levels with the largest average value, namely in the Px sample code with a value of 0.924 mg/kg, while the smallest average value was in the Lv sample code with a value of 0.021 mg/kg. In the test, there is a mercury content, but no one exceeds the maximum limit for cosmetics set by BPOM, which in BPOM regulations regarding metal contamination requirements in cosmetics containing mercury (Hg) is no more than 1 mg/kg, so it is safe to use. Keywords:  Cosmetics, whitening powder, mercury, FIMS (Flow Injection Mercury     System), Hg
PREDIKSI TOKSISITAS, ANALISIS ADME DAN DOCKING MOLEKULER ASIATICOSIDE TERHADAP PENGHAMBATAN ANGIOTENSIN CONVERTING ENZYME: TOXICITY PREDICTION, ADME ANALYSIS AND MOLECULAR DOCKING OF ASIATICOSIDE AGAINST ANGIOTENSIN CONVERTING ENZYME INHIBITION Capritasari, Rafiastiana; Akrom, Akrom; Setianto, Arif Budi; Putri, Meilisa; Hasna, Elly Rosita; Astuti, Febriana
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2411

Abstract

The presence of risk factors related to the severity of cardiovascular disease is a key consideration in adjunct therapy as an immunostimulant.One of the plants with potential as a cardioprotective immunostimulant is pegagan.Asiaticoside in pegagan leaves can inhibit AT1R and reduce NF-κβ activity.This study aims to predict the interaction of ligands with the receptor of cardioprotective immunostimulant agents.This study uses Molecular Docking simulations with molecular docking using Autodock Tools 1.5.6 and visualization using BIOVIA Discovery Studio Visualizer 24.1.The target macromolecule used is AT1R (PDB 4ZUD) which was downloaded from the PDB.The molecular docking parameters were analyzed based on binding energy.Pharmacokinetic characteristics were evaluated using the SwissADME tool.The binding result of the test ligand molecule to AT1R is -4.50 ±0.595 kcal/mol. The reference ligand has an AT1R binding value of -7.74±0.036 kcal/mol. Validation of the molecular docking method has an RMSD value of 1.857±0.356 Å. The toxicity prediction of the compound Asiatikoside at LD50 4000mg/kg and pharmacokinetic analysis were conducted using the boiled-egg method, which indicates that  Asiatikoside is predicted cannot cross the blood-brain barrier. The ADME prediction results show that the Asiatikoside has 3 parameters that do not meet the bioavailability parameters, namely a molecular weight of 959.12g/mol, TPSA polarity of 315.21A, and flexibility of 10. Conclusion Asiaticosides is predicted to have limitations in terms of oral bioavailability, so special formulations such as nanoencapsulation techniques are needed to help improve its bioavailability Keywords:  Asiaticosides; ACE Inhibition; Molecular Docking
Penilaian Pengetahuan Masyarakat tentang Swamedikasi Gastritis: Studi Cross-Sectional Nasional di Indonesia: Assessing Community Knowledge on Gastritis Self-Medication: A Nationwide Cross-Sectional Study in Indonesia Hikmah, Nurul; Utami, Pinasti; Octavia, Mega; Rahajeng, Bangunawati; Ramadhani, Firda Ratnasari; Prameswara, Annisaa Bella; Charismawati, Erlinda Mimbar; Diastri, Hanna
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2412

Abstract

Gastritis is a common gastrointestinal disorder that affects global population, including Indonesia. Many individuals choose self-medication as a primary approach to manage gastritis symptoms. Inappropriate self-medication practices can lead to worsening symptoms and complications. Understanding the knowledge level is essential to improve self-medication safety. This study aims to assess the level of community knowledge regarding gastritis self-medication in Indonesia. An observational study with cross-sectional design conducted among Indonesia community. Data were collected through an e-questionnaire, which was distributed across 34 provinces. The instrument in this study has been tested for validity and reliability using Content Validity, Face Validity, and Cronbach's Alpha tests. Descriptive statistical analysis was performed using SPSS to summarize the characteristics of the respondents and to categorize knowledge levels into low, moderate, and high. The results of this study indicated that 921 respondents (78.1%) had a high knowledge level, 247 respondents (21%) had a moderate knowledge level, and 11 respondents (0.9%) had a low knowledge level of gastritis self-medication. In conclusion, knowledge level of Indonesian community regarding gastritis self-medication is categorized as high. Limited number of respondents still have low to moderate knowledge level, indicating the necessity for further roles and strategies from healthcare professionals in gastritis self-medication education. Keywords: Gastritis, Knowledge, Self-medication, Indonesia
USING PARE FRUIT (Momordica charantia L) AS AN ANTIDEPRESSANT AGENT USING THE FORCED SWIM TEST (FST) METHOD: PARE FRUIT (Momordica charantia L) AS AN ANTIDEPRESSANT AGENT USING THE FORCED SWIM TEST (FST) METHOD Suzana, Dona; Kencana, Ghista Kurnia
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2419

Abstract

Depression is a serious psychological disorder that requires long-term therapy. The use of synthetic antidepressants such as fluoxetine often causes side effects and complex drug interactions, thus encouraging the search for herbal alternatives. This study evaluated the antidepressant activity of ethanol extract of bitter melon fruit (Momordica charantia L.) through the Forced Swim Test (FST) method in male Balb/c mice. Four treatment groups were used: negative control (aquadest), positive control (fluoxetine 120 mg/kgBB), comparative control (stelazine), and bitter melon extract (270 mg/kgBB). The results of the FST test showed that bitter melon extract significantly reduced the immobility time of mice (p = 0.005), equivalent to fluoxetine and stelazine. Phytochemical tests identified the presence of flavonoids, triterpenoids, alkaloids, saponins, and polyphenols, which are thought to contribute to antidepressant activity through increased monoamine levels and neuroprotective effects. The conclusion is that ethanol extract of bitter melon shows strong potential as an herbal antidepressant agent comparable to fluoxetine, as well as being feasible to be developed as a phytopharmaceutical for depression therapy. Keywords: bitter melon, antidepressant, Momordica charantia, Forced Swim Test, triterpenoids
FORMULATION AND ANTIBACTERIAL ACTIVITY OF MOUTHWASH COMBINATION OF GUAVA LEAF (Psidium guajava L.) AND BASIL LEAF (Ocinum basilicum L.) EXTRACT AGAINST Streptococcus mutans : FORMULASI SEDIAAN MOUTHWASH KOMBINASI EKSTRAK DAUN JAMBU BIJI (Psidium guajava L.) DAN DAUN KEMANGI (Ocinum basilicum L.) TERHADAP AKTIVITAS BAKTERI Streptococcus mutans Samsuar, Samsuar; Ariawan, M Wahyu; Pratiwi, Inda; Widodo, Subur; Susanti, Laila; Luthfiyah, Yosi
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2427

Abstract

Dental caries is basically caused by cariogenic bacteria, including Streptococcus mutans, which are found in the oral cavity, especially dental plaque. To treat dental caries, antiseptics packaged in the form of mouthwash use unnatural active ingredients which often cause side effects. Therefore, it is necessary to carry out preventive measures to reduce side effects by using waste from guava leaves and basil leaves. This research purpose were to making mouthwash formulation with the active ingredients guava leaf extract and basil leaf extract and determine the antibacterial activity of mouthwash formulation. The method used is the diffusion method, a combination of concentrations of guava leaf extract and basil leaves, namely F1(0%+20%), F2(5%+15%), F3(10%+10%), F4( 15%+ 5.0%), F5(20%+0%), F6(15%+15%). In this study, the variable measured in this study was the diameter of the inhibition zone formed by the combination of extracts. Data analysis was tested using One Way Anova. The significant value obtained was 0.00 ≤ 0.05, indicating a significant difference from the formulation containing a combination of extracts. The results of this research showed that the largest inhibitory zone was at F5 with the largest average value of 15.07mm which had a strong inhibitory response. This research can be concluded that the mouthwash formulation of extracts meets the physical requirements and can inhibit S. mutans. Keywords :  Guava, basil, mouthwash, S. mutans
STUDI ANALISIS EFEK SAMPING KEMOTERAPI PADA PASIEN KANKER PAYUDARA DI RSUD DR. H. ABDUL MOELOEK PROVINSI LAMPUNG TAHUN 2023: STUDY ANALYSIS OF SIDE EFFECTS OF CHEMOTHERAPY IN BREAST CANCER PATIENTS AT DR. H. ABDUL MOELOEK LAMPUNG PROVINCE YEAR 2023 Widiyastuti, Asih; Handayani, Kartika; Harissa, Nola; Wahidah, Lilik Koernia; Nopiyansyah
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2446

Abstract

The high mortality rate in breast cancer and with the most malignancy attacking women, therapy is needed in the treatment of breast cancer by chemotherapy. Chemotherapy works by killing rapidly dividing cancer cells. However, due to its non-selective nature, chemotherapy also affects healthy cells and causes side effects that affect the patient's quality of life. This study aims to determine the side effects of chemotherapy in breast cancer patients at Dr. H. Abdul Moeloek Hospital, Lampung Province in 2023. This type of research is a qualitative descriptive observational study with a cross-sectional design and accidental sampling data collection techniques. Data analysis was done descriptively in the form of a percentage. The sample in this study was 41 patients. The results of the study based on the characteristics of female gender were 41 patients (100%) and male patients were 0 patients (0%), the age of the diagnosed patients was in the age range of 36-45 years as many as 13 patients (31.7%), 46-55 years as many as 13 patients (31.7%), and 56-65 years as many as 13 patients (13.7%), based on the patient's occupation with the occupation of a housewife (IRT) as many as 24 patients (58.5%), treatment with the TdCar regimen (Taxane (docetaxel), Carboplatin) as many as 13 patients (26.9%) and the AC regimen (Doxorubicin, Cyclophosphamide) as many as 11 patients (21.2%). The conclusion of this study is the side effects using the Naranjo algorithm, the score obtained is between 1-4 (possible) which means that there may be an ADR. The most common side effects suffered by breast cancer chemotherapy patients at Dr. Soetomo Hospital. H. Abdul Moeloek Lampung Province in 2023 was hair loss (87.8%). Keywords: Side Effects, Breast Cancer, Chemotherapy, Cross-sectional
UJI EFEKTIVITAS INFUSA DAUN BINAHONG (ANREDERA CORDIFOLIA) TERHADAP PROFIL LIPID TIKUS HIPERLIPIDEMIA: EFFECTIVENESS TEST OF BINAHONG LEAF INFUSION (ANREDERA CORDIFOLIA) ON LIPID PROFILE OF HYPERLIPIDEMIA RATS Sari, Novita; Anasis, Annisa Mulia; Nurjanah, Siti; Mulyani, Yuli Wahyu Tri; Hidayasari, Nur Wafa; Romadhani, Sucitra Anugerah; Kristiana, Mita
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2455

Abstract

Hyperlipidemia is a lipid disorder characterized by increased levels of total cholesterol, triglycerides, LDL or decreased HDL in the blood. A High lipid level is a strong marker of the risk factors for cardiovascular diseases. The research aims to identifity Effect of Binahong leaf infusion (Anredera cordifolia) on Lipid Profile in Hyperlipidemia Rats. Experimental study of pretest-posttest control group design. Rats were given a high-fat diet (HFD) and Propylthiouracil (PTU) 1% for 21 days. After hyperlipidemia archieved, rats were divided randomly into five groups: negative control, positive control, treatment groups with Binahong leaf infusion (Anredera cordifolia) 100, 200 and 300 mg/200BW/day. Blood was taken for lipid profile measurements in hyperlipidemia conditions and after treatment with Binahong leaf infusion (Anredera cordifolia) for 14 days. The statistical analysis that had been done used ANOVA with an LSD test. The result showed that giving of Binahong leaf infusion (Anredera cordifolia) 100, 200 and 300 mg/200BW/day in hyperlipidemia rats reducted of total cholesterol, triglycerides, LDL and increased HDL levels significantly (p<0,05) than negative control but less effective compared to positive control. Binahong leaf infusion (Anredera cordifolia) has been shown to effectively reducted of total cholesterol, triglycerides, LDL and increased HDL levels in hyperlipidemia rats. Keywords: Anredera cordifolia, binahong, cholesterol, infuse, lipid profile

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