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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 20 Documents
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Search results for , issue "Vol 23 No 2 (2025): JIFI" : 20 Documents clear
The utilization of red dragon fruit peel extract (Hylocereus polyrhizus) in nanoemulsion as an antioxidant Agustin, Eriska; Zahara, Ega
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1614

Abstract

The red dragon fruit plant (Hylocereus polyrhizus) contains bioactive substances, one of which functions as an antioxidant from anthocyanin and betacyanin. The Dragon Fruit Peel (DFP) has not been widely used by the community in the health sector, and it is only becomes waste. The preparation of nanoemulsion aims to increase the low antioxidant activity of dragon fruit peels. The preparation of DFP nanoemulsion using 8% Tween 80 as emulsifier, 1% oleic acid, and 2% transcutol, with variations in extract concentrations of 1% and 2%. The globule size is reduced to nanoemulsion using a sonicator bath for 60 minutes. The testing of antioxidant activity using the DPPH method. The results of the organoleptic test showed that the DFP extract nanoemulsion had a transparent yellow color with a globule size and Polidispersity Index (PI) of 165±5.54 nm (PI=0.2±0.03) and 115±3.46 nm (PI=0.3±0.02) at an extract concentration of 1 % and 2%. The globule morphology using TEM shows a spherical shape. The results of the pH test showed a range of 4.5-5.3. In testing the antioxidant activity, the DFP extract nanoemulsion showed an increase in IC50 values at 1% and 2% extract concentrations, namely 85.39±4.69 and 64.46±3.45, compared to the extract without formula (pure extract), namely 167.34±8.98. The DFP nanoemulsion preparations produced globule sizes in the nano range, and antioxidant activity testing showed an increase in the IC50 value of 2 concentrations compared to conventional extracts (p<0.05).
Ethanolic extract of Parkia speciosa Hassk leaves innovation of gastroretentive tablet: standardization and optimization Nurfitriyana, Nurfitriyana; Fitriya, Fitriya; Fithri, Najma Annuria; Putri, Dwi Kurnia; Lestari, Siti Marwah; Waluyo, Dyah Ayuwati; Syarif, Hardiyanti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1461

Abstract

Parkia speciosa ethanol leaves extract contains flavonoid, tannin, and terpen as ulcus peptic remedy. These compounds exhibit limited activity in the stomach due to the short gastric residence time following oral administration. The formulation of gastroretentive tablets can overcome this limitation. This research aims to control the prolonged release of drugs in the stomach to increase bioavailability and characterize the ethanol leaves extract. Extraction was carried out by maceration using ethanol, followed by standardization based on specific and non-specific parameters extract. Gastroretentive tablet was formulated with combination of HPMC-K4M and chitosan using factorial design 22. Effects of compositional factors and their interactions on gastroretentive tablet was observed on hardness, friability, floating lag/duration time, swelling index, and mucoadhesive time. Results standardization extract showed that extract met the required criteria for both specific parameters (organoleptic properties and phytochemical screening) and non-specific parameters (moisture content, loss on drying, water/ethanol-soluble extract content). Based on with DX®10 analysis, the optimum formulation was achieved with 20.25% of HPMC-K4M and 10.26% of chitosan. The analysis of the optimum formulation characteristics was as follows: friability (0.22%), hardness (29.53 N), mucoadhesive time (22.86 hours), floating lag/duration time (27.54 minutes; 12 hours), and swelling index (312.82%). Result revealed that gastroretentive tablets formulated with ethanol extract of Parkia speciosa leaves improve gastric residence duration and promote better bioavailability.
Optimizing plant exosome isolation: a systematic review of PEG-based precipitation, ultracentrifugation, and hybrid methodologies for biomedical applications Dewi, Rika Sari; Sandhiutami, Ni Made Dwi; Louisa, Melva; Pratomo, Irandi Putra
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1582

Abstract

Plant-derived exosome-like nanoparticles (PDELNs) represent a promising frontier in nanomedicine, offering natural alternatives to synthetic drug delivery systems. These membrane-bound vesicles, typically 30-150 nm in size, contain bioactive compounds and demonstrate potential for cross-kingdom communication with mammalian cells. This objective study is to evaluate PEG-based and ultracentrifugation methods, benchmark hybrid approaches, compare emerging alternatives, and assess their impact on biomedical applications. A systematic analysis of diverse studies employing comparative yield, purity, bioactivity, scalability, and complexity metrics was conducted. A systematic search of 3 databases SciSpace Deep Search; Google Scholar; MEDLINE (2016-2024) following PRISMA guidelines, 52 studies met the inclusion criteria with combined terms : ``plant exosome'' AND (``PEG precipitation'' OR ``polyethylene glycol'' OR ``ultracentrifugation'' OR ``hybrid methods'') AND ``biomedical applications''. Findings indicate that PEG-based precipitation offers higher or comparable yields with greater scalability and cost-effectiveness but lower purity due to protein co-precipitation; ultracentrifugation yields purer exosomes with preserved bioactivity yet is resource-intensive and less scalable; hybrid methods combining PEG precipitation with ultracentrifugation or size-exclusion chromatography balance yield and purity while increasing procedural complexity. Emerging techniques, such as immunoaffinity capture, enhance specificity but face limitations in plant systems. Overall, optimized hybrid protocols improve isolation quality and bioactivity retention, supporting translational potential. These insights underscore the need for standardized, scalable isolation strategies tailored to plant exosomes to advance their clinical and biomedical applications.
Comparison of unfractionated heparin and fondaparinux in relation to the incidence of recurrent myocardial infarction Suryoputri, Masita Wulandari; Astuti, Dwi Aprilia; Endriastuti, Nialiana Endah; Ilma, Dewi Latifatul
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1680

Abstract

Acute Myocardial Infarction (AMI) is a cardiovascular condition that involves necrosis of the heart muscle because of a decrease in blood supply to the heart caused by an obstruction of the coronary arteries. The prevalence of cardiac disease is 1.5% including AMI, and ranked 4th above all provinces in Indonesia. Anticoagulants are administered for the management of AMI treatment. Anticoagulants are treatments utilized to prevent thrombosis and reduce ischemic injury, preventing hemorrhage from developing in the heart's arteries and veins. Unfractionated heparin (UFH) and fondaparinux are both anticoagulants, that are utilized frequently in the treatment of AMI-EST patients. In decreasing the production of thrombin and preventing coagulation, unfractionated heparin, and fondaparinux can avoid death and recurrent myocardial infarction. The research was conducted as an observational study with retrospective data collection from medical records of inpatients diagnosed with acute transmural myocardial infarction of the anterior wall at Prof. Dr. Margono Soekarjo Purwokerto from January 2019 to December 2021. The chi-square test was used to examine the association between the type of anticoagulant therapy (unfractionated heparin or fondaparinux) and the incidence of recurrent myocardial infarction. The statistical analysis showed a significant association between the type of anticoagulant therapy and the incidence of recurrent myocardial infarction (p < 0.05). A higher proportion of patients treated with fondaparinux did not experience recurrent myocardial infarction compared to those treated with unfractionated heparin, suggesting that fondaparinux may be more effective in preventing recurrence.
Gastroprotective effect test of ekor naga leaves extract (Rhaphidophora pinnata (L.f) Schott) on male white rats Sani K, Fathnur; Putri, Kresentia; Elisma, Elisma; Lestari, Uce; Maharini, Indri; Yuliawati, Yuliawati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1698

Abstract

Rhaphidophora pinnata leaves are one of the herbal plants that have pharmacological effects. Previous research has shown that ekor naga leaves contain secondary metabolites with tonic pharmacological effects, including the ability to heal cut wounds, as well as antihyperglycemic and antidiabetic properties. This research aims to demonstrate the potential of ekor naga leaf extract as a gastroprotective agent. The extract was evaluated using standard methods, including determination of water content, ash content, phytochemical screening, and compound identification by LC-MS. Gastroprotective testing was carried out by dividing the treatment group into six groups, including the Group 1: normal group, Group 2: negative control (Sodium CMC 0.5%), Group 3: positive control (Sucralfate), Group 4: 125mg/KgBW extract, Group 5: 250 mg/KgBW extract, and Group 6: 500mg/KgBW extract. The results of the observations were in the form of gastric ulcer severity scores and histological images of the gastric organs. Gastroprotective testing revealed significant differences between the treatment groups and the negative control group (p<0.05). The 500 mg/kgBW extract exhibited the most effective gastroprotective effect, with a 42.5% inhibition rate and minimal inflammation observed both macroscopically and microscopically. These results suggest that ethanol extract from ekor naga leaves may serve as an alternative or complementary therapy for gastritis.
Anti-inflammatory effectiveness of Cymbopogon citratus DC. Staff in Na CMC gel preparation Indrawati, Teti; Hakim, Zainur Rahman; Rahayu, Renu; Djuhariah, Yayah St
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1668

Abstract

Cymbopogon citratus DC. Stapf contains saponins, tannins, and flavonoids. Traditionally, tea from lemongrass leaves is useful as an anti-inflammatory, anti-malarial, anti-mutagenic, anti-mycobacterial, antioxidant, hypoglycemic, and neurobehavioral. A study has been conducted to formulate an anti-inflammatory gel preparation from C. citratus extract. The study was conducted by macerated a C. citratus leafs using 70% ethanol, then evaporated in a rotary evaporator at a temperature of 40 ºC until viscouse extract obtained and evaluated. The anti-inflammatory gel was prepared using Na CMC 6%, with the concentration of C. citratus extract 6%, 8%, and 10%. The resulting gel preparation was evaluated for its physical and chemical properties and then tested for its anti-inflammatory effects using male mice (Mus musculus L.). Flavonoids, alkaloids, tannins, and saponins are found in this C. citratus extract. The characteristics of the C. citratus extract gel made were, brown and dark brown, had a distinctive C. citratus odor, semi-solid, and homogeneous, had a pH of 5.54–5.62, a viscosity value between 57000-73000 cP, had pseudoplastic flow properties, a specific gravity between 1.055-1.078 g/cm3, had an adhesiveness of 231-252 seconds, and a spreadability of 3490.11-3021.20 mm2. The gel contained 10% of C. citratus extract, indicating the highest anti-inflammatory effect, with a decrease in edema diameter of 67.79% in the legs of male mice.
Optimizing carrot extract serum (Daucus carota L.) for anti-aging: efficacy in moisturizing and pore size reduction using Box-Behnken design method Iskandar, Benni; Antasya, Vaylia; Nasution, Musyirna Rahmah; Frimayanti, Neni; Peng-Wei, Ching; Khairani, Sondang
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1566

Abstract

Carrot extract (Daucus carota L.) contains various bioactive compounds, including vitamins A, B, and C, alkaloids, flavonoids, tannins, anthraquinones, saponins, diterpenes, steroids, beta-carotene, phenols, terpenoids, and minerals, all of which possess antioxidant properties. These compounds are known to help slow down the aging process. The aim of this study was to determine the optimal concentrations of gelling and alkalizing agents, assess their interactions, and evaluate the anti-aging effects of the most effective serum formulation. The formulation was optimized using the Box–Behnken design with two key factors: Carbopol 940 concentration (0.5–1%) and triethanolamine (0.5–1%). The effects on pH, adhesion, and spreadability were evaluated. The best formulation was achieved with 0.837% Carbopol 940 and 0.855% triethanolamine, showing a pH error of 2.45%, adhesion error of 0.76%, and spreadability error of 1.01%, all within acceptable limits (errors < 10%). After four weeks of stability testing, the formulation remained stable, well-mixed, with a pH of 5.16, an adhesion time of 1.60 seconds, and spreadability of 6.73 cm, with no discomfort. The combination of Carbopol 940 and triethanolamine improved the physical properties, enhancing anti-aging effects compared to the base formula. The optimized serum increased skin moisture by 84.62%, reduced pore size by 64.71%, lightened spots by 62.79%, and reduced wrinkles by 67.50%. This indicates the optimized carrot extract serum is stable, safe, and effective as an anti-aging agent, making it a promising natural skincare product.
Molecular docking and pharmacokinetic prediction of isoniazid and curcumin compounds against N-acetyltransferase 2 (NAT2) protein Simanullang, Gayatri; Rahayyu, Annisa Maulidia; Nabila, Novrilia Atika; Hammami, Akmal; Wardani, Intan Kusuma
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1699

Abstract

NAT2 serves as the key enzyme responsible for metabolizing the INH compound, with its expression and functional activity significantly contributing to the risk of hepatotoxicity. Due to the possible inhibitory role of curcumin on NAT2, it is important to assess its effect on the metabolic processing of INH and to examine the enzyme-related interactions that may occur between drugs. Molecular docking studies demonstrated that curcumin can localize in the hydrophobic pocket and form a strong bond with NAT2. The aim of this study was to predict the potential interaction of the isoniazid and curcumin compounds against NAT2 protein. In this study, NAT2 protein (PDB ID: 2PFR) was used as a receptor. The results obtained showed the binding energies of native ligand, isoniazid, and curcumin were -5.78, -4.47, -8.35 kcal/mol, respectively. The findings of this research suggest that curcumin is capable of suppressing NAT2 activity, thereby affecting the pharmacokinetics of INH. These results may offer insights into minimizing INH-related liver toxicity and enhancing its effectiveness through co-administration with curcumin.
Cost-effectiveness analysis of the use of antibiotics for typhoid fever inpatients in RSUD Bayu Asih Purwakarta Purkon, Dicki Bakhtiar; Agustin, Himeliya; Widyastiwi, Widyastiwi; Kusmiyati, Mimin; Fadhlillah, Faizah Min
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1679

Abstract

Typhoid fever is an infectious disease caused by Salmonella typhi, commonly treated with antibiotics to promote recovery and prevent complications. This study aimed to evaluate both the therapeutic effectiveness (clinical outcomes such as fever resolution and hospital stay duration) and the cost-effectiveness (economic efficiency of antibiotic use) in inpatients with typhoid fever at RSUD Bayu Asih Purwakarta (Bayu Asih District Hospital, Purwakarta) in 2023. A retrospective descriptive design was applied using 75 medical records from January to December 2023. Results showed that levofloxacin had the highest therapeutic effectiveness, reflected by the shortest hospitalization (3.5 days), whereas ceftriaxone was the most cost-effective, with an Average Cost-Effectiveness Ratio (ACER) of Rp. 194,858.78 per treatment. The Incremental Cost-Effectiveness Ratio (ICER) analysis indicated that the additional cost required for levofloxacin compared to ceftriaxone was disproportionate to the clinical benefit gained. In conclusion, while levofloxacin provides faster recovery, ceftriaxone remains the preferred option considering its superior cost-effectiveness. These findings emphasize the need to balance clinical outcomes and economic efficiency when determining antibiotic policies for typhoid management.
Optimization of oil-based liquid lipstick formula from sesame seed oil (Sesamum indicum L.) and antibacterial activity test against Staphylococcus aureus Miksusanti, Miksusanti; Wijaya, Dina Permata; Kovalina, Yosi; Wardana, Mutia Sari; Herlina, Herlina
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1712

Abstract

Liquid lipstick is a type of lip color cosmetic that consumers highly favor. However, repeated use of liquid lipstick can promote the growth of Staphylococcus aureus (S. aureus) bacteria. The formulation of liquid lipstick involves several components, including a mixture of wax, oil, and other additives. Sesame seed oil (Sesamum indicum L.), incorporated into the formulation, serves as both a base and preservative due to its fatty acid content, which is expected to inhibit the growth of S. aureus bacteria. Microcrystalline wax is added to achieve a good texture and enhance the adhesion properties of the formulation. This study aimed to determine the optimum formula and evaluate the antibacterial activity of the liquid lipstick formulation. The formula was developed using a 2² factorial design method, with sesame seed oil and microcrystalline wax as variables. The optimum formula was analyzed using Design Expert® 13 software based on parameters such as viscosity, spreadability, and adhesion. The final optimum formula consisted of 70% sesame seed oil and 5% microcrystalline wax. The formulation demonstrated good stability during the cycling test, maintaining red color, vanilla and sesame-like aroma, liquid texture, and pH 5. The viscosity was 11797.51 cP, the spreadability was 6.06 cm, and the adhesion time was 64 seconds. Antibacterial activity, assessed using the disk diffusion method, yielded an inhibition zone diameter of 15±1.322 mm, indicating a strong inhibition zone. Based on the research findings, it was concluded that the optimum sesame seed oil-based liquid lipstick formula exhibited good product characteristics, stability, and strong antibacterial activity.

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