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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 680 Documents
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Hubungan Tingkat Pengetahuan Penggunaan Obat dengan Kepatuhan Minum Obat pada Pasien Hipertensi di Puskesmas Niken Dyahariesti; Richa Yuswantina; Eflina Devita Sablon; Yola Nasinta
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1152

Abstract

Hypertension is a silent killer disease because the symptoms are often without complaints and the treatment requires a long period of time, so the outcomes are greatly affected by patient compliance. Hypertension is one of the main factors causing heart problems, kidney failure and cerebrovascular disease. Compliance with taking medication in patients with hypertension is very important because it can control blood pressure to prevent complications. This study was conducted to determine the relationship between knowledge and drug compliance in hypertensive patients. The measurement of knowledge was done using the Hypertension Knowledge-Level Scale (HK-LS) questionnaire and the measurement of compliance using the Morisky Medication Adherence Scale (MMAS-8) questionnaire. The samples used were patients at Pasir Panjang community health center and Buntok community health center with a total sample of 95 people. The results obtained, the level of good knowledge was 39%, 33% sufficient knowledge and 28% less knowledge. Meanwhile, the high level of compliance is 41% and the level of compliance is 31% and the level of knowledge is at 28%. Data analysis using the chi-square test showed p-values of <0.05 which means that there was a relationship between the level of knowledge and drug compliance in hypertensive patients.
Penyembuhan Luka Diabetes dan Aktivitas Antimikroba dari Gel Ekstrak Melastoma malabathricum L. dan Psidium guajava L. pada Tikus Sprague Dawley Refdanita Refdanita; Tonny Cortis Maigoda; Firdaus Firdaus; Barakatun Nisak; Teodhora Teodhora
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1390

Abstract

Diabetes mellitus (DM) is a degenerative disease characterized by abnormalities in carbohydrate, lipid, and protein metabolisms. This research was aimed at the gel’s pharmacological activity, the extract’s potential in treating diabetic wounds in male rats of Melastoma malabathricum L leaves (ML) and Psidium guajava L leaves (PL), as well as microbiological activity. Viscous extracts of ML and PL were prepared in gel dosage form with concentrations of 4% and 6%. Clindamycin was used as a positive control. This study was conducted using an experimental laboratory method, and the study population included white male rats. The pharmacological activity was tested in the form of a gel dosage formula, and the rats were made diabetic using alloxan. The potential of the extract was observed in healing diabetic wounds in male rats. ML and PL leaf extract gels affect wound healing in diabetic patients. This can be seen from the change in diameter. Wound swab examination revealed the presence of bacteria Klebsiella pneumoniae and Staphylococcus aureus. Secondary metabolites of flavonoids, tannins, steroids, and saponins help stimulate the regeneration of epithelial cells and tissues. The results for wound healing of 4% and 6% gel formulations were derived from maturation data on day 10.
Formulasi dan Uji Aktivitas Antioksidan Kombinasi Bunga Rosella Ungu (Hibiscus sabdariffa L.) sebagai Nutrasetikal Intan Permata Sari; Yuslia Noviani; Ridwan Rachmadi; Esti Mumpuni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1395

Abstract

A nutraceutical is a functional food containing natural components that have the potential for health, especially from medicinal plants. The purple rosela (Hibiscus sabdariffa L.), one of many therapeutic plants that have been effectively transformed into herbal products, is one such example. High quantities of anthocyanin are found in bioactive substances found in rosela flowers. This study aims to formulate and determine the antioxidant activity of purple rosela flower in combination with red ginger and cinnamon bark. Following the liking test, which includes the organoleptic test, and the calculation of shelf life with the Accelerated Shelf-Life Testing (ASLT) method, the brewed tea formulation was kept to determine the total content of phenolate. Antioxidant activity was measured by the DPPH (1,1-diphenyl-2-picrylhidrazyl) method. This study obtained an average result of 0,38±0,05% for the total phenol content of the three formulas. Formula I, II, and III showed antioxidant activity with IC50 values of 21.59 g/mL, 27.13 g/mL, and 20.05 g/mL, respectively. Organoleptic observations that have been observed for 20 days at three different temperatures (4°C, 25°C, and 37°C) in the three formulas indicate no change in color, aroma, or taste, indicating the product remains stable. Based on the score results, the most preferred by panelists was Formula I, with its composition of purple, rose and red ginger.
Penghambatan Aktivitas Enzim α-Glukosidase oleh Ekstrak Etanol Terstandar Daun Abelmoschus manihot (L.) Medik Prasetiyo, Andri; Winarti, Wiwi; Agustia, Rini
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1387

Abstract

People have long utilised the leaves of the red gedi, Abelmoschus manihot (L.) Medik is an anti-diabetic medication. The study’s objectives were to classify chemical constituent groups, assess extract quality, and evaluate the activity of α-glucosidase enzyme inhibitors. The extraction method employed kinetic maceration with a 70% ethanol solvent, identification was accomplished through phytochemical screening, a quality determination was based on both specific and non-specific parameters, and α-glucosidase inhibition was used in an in vitro antidiabetic activity test. Flavonoids, alkaloids, saponins, steroids, and triterpenoids were found in the phytochemical screening test results. The results of the quality parameter test obtained viscous extract, blackish green color, 70.58% water soluble extract, 49.46% ethanol soluble extract, 7.82% loss on drying, 4.19% water content, total ash content 6.97%, acid insoluble ash content 0.60%, water-soluble ash content 5.64%, residual solvent 0.76%, heavy metal content Pb 1.35 mg/kg, Cd 0.06 mg/kg, plate number total ≤10 colonies/g, yeast plate number 20.1995 colonies/g and total flavonoid content 1.20%. The α-glucosidase enzyme inhibitory activity test from the extract and acarbose (positive controls) obtained IC50 values of 81.84 μg/mL and 42.6 μg/mL, respectively. In conclusion, the α-glucosidase enzyme may be inhibited by the ethanolic extract of A. manihot (L.) Medik leaves.
Analisis Keberhasilan Pengobatan Pasien TB Paru dan TB HIV di Rumah Sakit Penyakit Infeksi Sulianti Saroso Andayani, Nurita; Maninda, Raise; Marlina, Rosa; Noviantani, Qoina; Qalalwa, Khaled
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1282

Abstract

Mycobacterium tuberculosis causes Tuberculosis (TB), an infectious disease. The study aims to evaluate DOTS therapy's impact on pulmonary TB and TB-HIV patients. This research used a descriptive qualitative study design with a retrospective descriptive research approach using secondary data for the period June 2017 to July 2020. The analysis uses the Miles and Huberman model. A study of 305 people found that 83% of pulmonary TB cases completed treatment within the initial phase, 64% completed the continuation phase. TB-HIV cases 93% completed treatment within the initial phase, 71% the continuation phase. The combination of OAT and ARV doses was successful in reducing initial smear conversion in pulmonary TB cases. The treatment was evaluated as cure in pulmonary TB cases, complete in pulmonary TB-HIV cases, and had no treatment failure status in both groups. Treatment success in pulmonary TB patients was not significantly related (p-value≥5%) with the type of OAT, type of PMO, gender, and age. Whereas in HIV co-infected pulmonary TB patients, treatment success was significantly related (p-value <5%) with the type of PMO, and not related (p-value≥5%) with the type of OAT, gender, and age.
Optimasi Fast Disintegrating Tablet Difenhidramin HCl Menggunakan Modifikasi Pati Pisang Kepok Kuning, Crospovidone, dan Microcrystalline Cellulose Rahmawati, Tias Eka; Siswanto, Agus; Djalil, Asmiyenti Djaliasrin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1406

Abstract

Diphenhydramine HCl is an antihistamine drug that is available in conventional tablet form. This study aimed to produce the optimum formula for a diphenhydramine fast disintegrating tablet (FDT) using a modification of starch, crospovidone, and microcrystalline cellulose (MCC) to produce quality tablets that meet the tablet's physical requirements and tablet dissolution. Starch modification was made using a two-step method of starch cross-link, then continued with silica coprecipitation. FDT was prepared by the direct compression method. Optimisation with the simplex lattice design (SLD) model uses three components: co-process starch crosslink-silica, crospovidone, and MCC, which obtained 14 formula designs. The hardness, wetting time, disintegration time, and percent dissolution are optimisation parameters. Equations, contour plots, and desirability values were determined as the optimum formula. Based on the research results, an optimum formula was obtained with the proportion of co-process cross-link starch-silica was 56.185 mg, crospovidone at 6 mg, and MCC at 45.815 mg. The result of hardness was 5 kg, wetting time 51.061 seconds, disintegration time 63.129 seconds, and dissolution was 100.972%. The interaction of the three components reduces hardness and increases disintegration time, wetting time, and percent dissolution.
Penggunaan Obat Herbal untuk Meningkatkan Libido Mencit Jantan (Mus musculus): Tribulus terrestris dan Panax ginseng Kirtishanti, Aguslina; Wulansari, Devyani Diah; Kesuma, Dini; Dwi Putri, I Gusti Ayu Laksmi; Rahmadinar, Amirah Nabila
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1485

Abstract

Tribulus terrestris and Panax ginseng are two therapeutic plants that might increase libido. The aim of the study was to see the effects of herbal medicine containing Tribulus terrestris and Panax ginseng on increasing male mice libido. This study used mice divided into two sets of 7 and 14 days. Each group was divided into four parts: control (solvent), comparator (Vitan), and test 1 (herbal medicine). Parameters measured were mice sexual behaviour (introduction, climbing, coitus), sperm concentration, sperm motility, and testicular weight. Except for coitus behaviour, there were no significant changes between groups in the 7 days of treatment. There were significant differences in introduction and climbing behaviour between the control group and test 2 after 14 days of treatment, but not in other parameters. There were no significant variations in any parameters of the mice’s libido between 7 and 14 days of treatment with 1x dose of herbal medicine; however, with 2x doses, only introduction behaviour showed a significant difference. Based on the research results, it can be concluded that administering two doses of herbal medicine can increase the frequency of treatment for 14 days.
Penelitian Terbaru terhadap 3 (Tiga) Jenis Ekstrak Teripang di Pulau Tegal Mas, Lampung Hutapea, Manuel; Swandiny, Greesty Finotory; Syafawi, M. Irfan; Putra, Fahreza Pratama; Kokadir, Sucipto; Basilianus, Edward; Putri, Vinessa Gracia; Abdillah, Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1447

Abstract

Sea cucumbers are deep-sea-dwelling invertebrate animals that are rich in nutrients and have been empirically used to prevent various degenerative diseases, especially due to their ability to dampen free radicals. The purpose of this study was to identify, and determine antioxidant activity, total phenolic content, and toxic properties in extracts of several sea cucumber species originating from Tegal Mas Island, Lampung. The identification results of the three sea cucumber species were Stichopus vastus Sluiter (SV), Stichopus monotuberculatus Quay & Gaimard (SM), and Stichopus quadrifasciatus Massin. (SQ). The extraction was performed by kinetic maceration against all parts of the sea cucumber using a 70% ethanol solvent. Antioxidant activity test using the DPPH (2,2-diphenylpicrilhydrazyl) free radical suppression method and determination of the total phenolic content using the Folin-Ciocalteu method. The results showed that SV had the highest total phenolics and antioxidants with the lowest toxicity. However, optimisation of extraction between wet and dry sea cucumbers is still required. Extraction optimisation with various solvents can also be done to gain secondary metabolites more effectively.
Analisis Efektifitas Biaya dalam Terapi Jamu Saintifik dan Konvensional untuk Terapi Dispepsia Nurhaliza, Inta; Prasuma, Galar Sigit; Sugiantoro, Ergia Andang; Lianawati, Lianawati; Sutheeraprasert, Praewthip; Setiawan, Didik
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1470

Abstract

Dyspepsia is a common digestive disorder among global health problems. This study aimed to examine the cost-effectiveness of scientific herbs in the treatment of dyspepsia. This study has used a societal perspective, but the indirect costs are considered equal because the patient is undergoing outpatient care. The analysis was used to determine the cost-effectiveness using the Incremental Cost-Effectiveness Ratio (ICER) method. The results were reported in rupiah currency, which includes categories of direct medical costs and direct non-medical costs. Sensitivity analysis reported changes in results, taking into account various possible influencing variables. A total of 62 patients who were respondents in this study were included in scientific herbal therapy (48.38%) and conventional dyspepsia therapy (51.62%). The cost of scientific herbal therapy was higher than conventional dyspepsia therapy (45.558±4.351 vs. 39.202±4.500). However, this difference was not statistically significant on the effectiveness of therapy (96.67% vs. 90.62%; p-value 0.600), the utility index of scientific herbal medicine was greater than conventional dyspepsia therapy (0.85±0.11 vs. 0.74±0.14). The ICER value for 1 additional unit of effectiveness was IDR 105,933; while for the addition of 1 unit of quality of life was IDR 57,781. The effectiveness of scientific herbal medicine therapy for dyspepsia was greater than the effectiveness of conventional dyspepsia therapy, where the cost was higher but the effectiveness was better.
Tren Penggunaan Antikoagulan Oral Direk dan Warfarin pada Pasien Fibrilasi Atrium Musnelina, Lili; Handayani, Fitri; Hoa Vo, Thanh -; Pontoan, Jenny
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1475

Abstract

Treatments used in atrial fibrillation therapy, such as those of anticoagulants, consist of vitamin K antagonists (warfarin) and direct oral anticoagulants (dabigatran, apixaban, rivaroxaban, and edoxaban). The use of warfarin requires regular monitoring of prothrombin time (PT) and international normalised ratio (INR). The therapeutic dose range is narrow, but the price is cheaper. Oral anticoagulants are directed, the incidence of major bleeding is lower, ease of use, food and drug interactions are minor, the half-life is shorter, and there is a lack of laboratory monitoring needs. Based on this problem, researchers conducted a study to determine the trend of using warfarin and oral anticoagulants in patients with atrial fibrillation at a public hospital in Jakarta. This study uses a qualitative approach, with longitudinal methods and retrospective data using outpatient medical records for the period 2014 to 2018. The trend of using warfarin anticoagulants decreased from 82.3% in 2014 to 62% in 2016, while oral anticoagulants were reduced. Direct oral anticoagulants are rivaroxaban and dabigatran, which are more widely used than apixaban, and edoxaban; no data on their use has been obtained. The opposite was true from 2017 to 2018, when the use of warfarin increased and caused a decrease in the use of direct oral anticoagulants. This research is expected to contribute to various parties, both health practitioners and academics, in terms of selecting therapies for atrial fibrillation.

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