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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 429 Documents
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FORMULASI DAN UJI AKTIVITAS GEL ANTIJERAWAT FRAKSI N-HEKSAN DAUN KERSEN (Muntingia calaburaL.) TERHADAP BAKTERI Propionibacterium acnes Saparuddin Latu; Musnur, Aldha Irjayanti; Jangga, Jangga; Mansur, Mansur
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1352

Abstract

ABSTRACT Cherry leaves contain many compounds, namely flavonoids, tannins, saponins, phenolics, steroids, and alkaloids. One of the compounds that act as an antibacterial is the flavonoid compound. One of the uses of cherry leaves is anti-acne. Acne is a chronic inflammatory disease of the pilosebaceous glands. One of the bacteria that causes acne is Propionibacterium acnes bacteria. Preparations that can be made for anti-acne are gel preparations. This study aims to determine whether the n-hexane fraction of cherry leaf (Muntingia calabura L.) can be made into anti-acne gel preparations and to find out at what concentration the n-hexane fraction of cherry leaf (Muntingia calabura L.) in anti-acne gel preparations can provide antioxidant activity. inhibiting the growth of Propionibacterium acnes bacteria. This research method is true experimental by making an anti-acne gel preparation of the n-hexane fraction of cherry leaves (Muntingia calabura L.) with various concentrations of 2.5%, 5%, 7.5% and testing the activity of the preparation against Propionibacterium acnes using the well method. so that. The results of the gel preparation formula showed that there were significant differences before and after the cycling test in both organoleptic, homogeneity, pH, viscosity, spreadability and adhesion tests. The activity test results obtained were that the largest inhibition zone was the concentration of 2.5%, namely 11.7 mm, which was in the strong category, while the 5% concentration, which was 13.4 mm, was in the strong category, and the concentration of 7.5%, which was 15.0 mm, was included in the category strong.
PROFIL DISOLUSI TABLET LEPAS LAMBAT KALIUM DIKLOFENAK MENGGUNAKAN PATI PREGELATINASI TALAS PRATAMA (Colocasia esculenta (L). Schott var. Pratama) Desy Nawangsari; Rani Prabandari; Ammanu Kurniadi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1493

Abstract

Starch is one of the commonly used excipients in tablet preparations. Natural starch has limitations in the form of poor flow rate and compressibility, so it is not suitable for use in the manufacture of tablets by direct compression. One source of plants that produce starch and has not been widely developed is (Colocasia esculenta (L). Schott var. Pratama). The purpose of this study was to modify (Colocasia esculenta (L). Schott var. Pratama) starch by gelatinization used in diclofenac potassium slow-release tablets. This research is a type of laboratory experimental research that begins with the isolation of starch from taro tubers, modification of starch by pregelatinization, manufacture of diclofenac potassium slow release tablet press mass, evaluation of physical properties and finished tablet dissolution tests. The results of the printing mass test showed that the use of (Colocasia esculenta (L). Schott var. Pratama) pregelatinated starch matrix had good flowability. The results of the tablet test showed that the average tablet weight was 209 ± 3.40 mg, the diameter and thickness were 7.69 ± 0.02 and 2.82 ± 0.01 mm respectively, the hardness was 7.00 ± 0.35 kg, the friability was 0. 73 ± 0.27 % and disintegration time 65.33 ± 2.52 minutes and the dissolution results showed that within 8 hours the potassium diclofenac sustained release tablet dissolved 60.20%. Based on the physical properties and dissolution tests performed, it can be concluded that the use of pregelatinated modified starch as a matrix in diclofenac potassium slow-release tablets fulfills the specified test parameters.
EVALUASI PENGELOLAAN SEDIAAN FARMASI DI GUDANG INSTALASI FARMASI RSUD DR. DRAJAT PRAWIRANEGARA SERANG-BANTEN TAHUN 2022 Yusransyah, Yusransyah; Herawati, Fera; Noviyanto, Fajrin; Udin, Baha; Stiani, Sofi Nurmay
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1531

Abstract

Pharmaceutical supply management is a series of sequential actions that begin with the procurement of drugs, the act of receiving drugs, and the process of storing drugs. This study aims to evaluate the suitability of pharmaceutical preparation management process at the Pharmacy Installation, Regional General Hospital dr. Drajat Prawiranegara in 2022 according to the provisions of the Regulation of the Minister of Health of the Republic of Indonesia Number 72 of 2016. The research method is explained quantitatively through selecting information, carried out in observation as an assessment and analysis of suitability. After the evaluation, aspects of the procurement process were identified that met the standards, including the high frequency of procurement per drug item (48 times per year), complete orders or invoices, and no late payments from the hospital. The aspect of the receiving process has also met the standards. That is, all drug orders are by the goods received. The storage process has met the standards, namely all goods according to the stock card, while the Turn Over Ratio (TOR) aspect has not met the standards with a value of 3.91 times. The warehouse management system uses First In First Out (FIFO) and First Expired First Out (FEFO). The percentage of damaged or expired drugs and the percentage of non-spinning stock is 0%. The conclusion of this research is the process of procuring and receiving drugs at IFRS dr. Dradjat Prawiranegara Serang has followed the guidelines, but in the TOR aspect it has not met the standards.
FORMULASI DAN UJI IN VITRO NILAI SPF KRIM TABIR SURYA EKSTRAK KULIT BUAH NANAS MADU (Anana comosus L. Merr) Wimzy Rizqy Prabhata; Alfa Salsabila, Pradini; Wulandari, Fitri
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1572

Abstract

Excessive UV exposure from sun causes negative impacts on the skin. Honey pineapple peel (Anana comosus L. Merr) is known to contain flavonoid and tannin that absorb UV light. This study reports the activity of sunscreen in cream preparations of 96% ethanolic extract of honey pineapple peel along with its physical characteristics and stability test results. Honey pineapple peel was soxhleted using 96% ethanol. The extract was then formulated into a cream using various concentrations of cream base: stearic acid (8-12%) and triethanolamine (2-4%) generating three formulas. The cream was then tested for its physical characteristics, physical stability, and sunscreen activity. The SPF value of extract at concentrations of 10%, 20%, and 30% respectively were 28.38; 31.05; and 35.12. The physical characteristics of the cream were brown in color, semisolid in shape, have a distinctive smell, homogeneous; with pH value, adhesion capability and spreadability that meet the cream requirements. Of the three formulas, formula I has the best pH stability, adhesion capability and spreadability. The results of SPF value of each cream formula: F1 (34.54); F2 (34.35) and F3 (34.27). This study demonstrated that the 96% ethanolic extract of honey pineapple peel can be formulated into cream dosage form and has a good sunscreen activity.
ASESMEN RISIKO PERDARAHAN SEKELOMPOK PASIEN FIBRILASI ATRIUM PENERIMA WARFARIN BERDASARKAN NILAI HAS-BLED DI RS ABC GIANYAR Putu Dian Marani Kurnianta; Ni Komang Putri Pradnyani; Kadek Dwi Oktariadi; Anak Agung Ngurah Putra Riana Prasetya
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1590

Abstract

In the management of atrial fibrillation (AF) preventing risk of stroke, warfarin may be prescribed. Warfarin’s narrow therapeutic index encourages the importance of regular monitoring during therapy to avoid the risk of bleeding. This study aimed to describe the risk of bleeding in a group of patients with AF receiving warfarin based on HAS-BLED score assessment at ABC Hospital Gianyar, Bali. A descriptive-observational study was conducted under retrospective case study approach involving outpatient’s data at mentioned hospital. This study included all patients with AF receiving warfarin based on visit history during January 2022-May 2023. Risk of bleeding documentation addressed the HAS-BLED assessment which then were illustrated into tables and diagram according to patients’ profile. From a total of eight eligible patients, five patients (62.5%) had moderate-risk of bleeding (score 1-2) and the rest were in the low-risk category (score 0). Advanced age >65 y.o. (50.00%), use of specified drugs (25.00%), and high INR values had contributed to the findings of moderate-risk based on stratification category. Despite the absence of high-risk category, therapeutic monitoring is necessary focusing on modifiable risk factors. The limited number of samples and several laboratory parameters may suggest for the advancement of clinical practice and further research.
SENYAWA FITOKIMIA DAN AKTIVITAS ANTI COVID STUDI IN SILICO EKSTRAK CABE JAWA (Piper retrofractum Vahl) Umarudin, Umarudin; Syafitri, Meyke Herina; Aristyawan, Andhika Dwi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1591

Abstract

Javanese chili has the potential to develop, one of which is that it contains phytochemical compounds and essential oils, which can act as antioxidants in preventing COVID-19, so it is necessary to utilize the natural potential in Indonesia, namely Javanese chili. This research aims to determine the phytochemical screening and anti-covid activity of an in silico study of Javanese chili extract. This research method carried out phytochemical screening of ethanol extracts, tested for alkaloids, flavonoids, tannins, saponins, and terpenoids, tests for determining levels of piperine, essential oils, and cavitsin, as well as in silico studies with piperine ligands with RdRP and ACE2 receptors docked with Hex.8.0.0 and visualized with discovery studio. This research shows that the phytochemical screening results of Javanese chili fruit extract are positive for containing alkaloids, flavonoids, tannins, saponins, terpenoids, piperine 3.36%. This research concludes that in silico, the Javanese chili piperine compound can bind to the active site of ACE Sarcov 2 through RdRP inhibition.
UJI AKTIVITAS ANTI TUBERKULOSIS H37RV EKSTRAK DAN FRAKSI TANAMAN MERBAU (Intsia bijuga) Ayik Rosita Puspaningtyas; Dian Agung Pangaribowo; Tasya Salsabila Multazam
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1619

Abstract

Tuberculosis (TB) is recognized as one of the top ten potentially fatal diseases. TB is caused by the bacterium Mycobacterium tuberculosis, which attacks the lungs. Indonesia has a variety of plants that can potentially serve as a treatment, one of which is the merbau plant (Intsia bijuga). The purpose of this study was to determine the anti-tuberculosis activity of extracts and fractions of merbau stem bark against Mycobacterium tuberculosis H27Rv bacteria based on IC50 values. Merbau bark was extracted using maceration method using methanol solvent. Then fractionated using n-hexane, dichloromethane (DCM) and ethyl acetate solvents. Next was phytochemical screening test using KLT method. In vitro anti-tuberculosis activity test using resazurin colorimetric method with concentrations of 25, 100, 500, and 1000 µg/mL. The results of the in vitro anti-tuberculosis test showed that the n-hexane fraction had the smallest IC50 of the extracts and other fractions with a result of 2,920 µg/mL, which indicates that it has the best activity as an anti-tuberculosis agent. Screening results from the n-hexane fraction showed positive for alkaloid and flavonoid compounds.
UJI AKTIVITAS TABIR SURYA EKSTRAK DAN LOTION KUNYIT (Curcuma domestica Val.) SECARA INVITRO MENGGUNAKAN SPEKTROFOTOMETER UV-VIS Alfian, Muhammad; Hasanudin, Muhammad Nurul; Maulana, Mochamad Luqni; Mustainin, Muhammad
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1623

Abstract

Excessive UV B radiation can lead to premature skin aging, but research suggests that turmeric (Curcuma domestica Val.) may have antioxidant compounds that could serve as a sunscreen. To investigate, the researchers tested turmeric extracts and lotions in vitro using a UV-Vis spectrophotometer. They extracted turmeric by maceration with 70% ethanol to obtain a thick extract, then evaluated the physical characteristics of turmeric lotion preparations including organoleptics, spreadability, adhesion, pH, SPF values (using the Mansur method), and Erythema Transmission Percentage (%T) in vitro using a UV-Vis spectrophotometer with absorbance wavelengths of 290-320 nm. The results showed that F1 to F5 turmeric lotion preparations were semi-solid, brownish yellow, fragrant, with spreadability above 7 cm, adhesion less than 1 second, and pH below 8. The highest SPF value of turmeric extract was at a concentration of 500 mg with SPF 46, while the highest SPF of turmeric lotion was F5 with SPF 15. All turmeric extracts are categorized as sunblock, while F5 lotion is also sunblock and F1 to F4 lotions are fast-tanning. Although the SPF value decreases when turmeric extract is made into a lotion, it still has sunscreen potential.
PENGARUH METODE MICROWAVE-ASSISTED EXTRACTION (MAE) DENGAN PELARUT NATURAL DEEP EUTECTIC SOLVENT (NADES) EKSTRAK DAUN MANGGA GEDONG TERHADAP KADAR TOTAL FLAVONOID DAN AKTIVITAS ANTIOKSIDAN Latifah, Fadzil; Nuh, Muhammad
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1628

Abstract

Antioxidant activity with flavonoids has a strong relationship because it is influenced by the functional groups attached to the main structure. This study aims to determine the effect of solvents and extraction methods used on total flavonoid levels and antioxidant activity of gedong mango leaf extract. Gedong manggo was extracted using teh MAE-NADES combination method (sodium acetate and lactic acid solvents 1:3 in distilled water until temperature reached 70 ). Gedong mango were extracted in terms of temperature and time (80 :20', 80 :10', 60 :20', 60 :10'). Next, the value of total flavonoid content and antioxidant activity was determined for the extract. The results showed that gedong mango leaf extract had high total flavonoid content values, with respective values of 80 :20' 6.5994%, 80 :10' 5.5504%, 60 :20' 5.0890%, and 60 :10' 3.8902%. In addition, gedong mango leaf extract has antioxidant activity, with IC50  value of 80 :20 ' 21.666 ppm, 80 :10' 39.734 ppm , 60 :20' 61.687 ppm, and 60 :10' 135.487 ppm. From the results of the study it can be concluded that the MAE method using NADES solvent has values for total flavonoid levels and antioxidant activity. The best gedong mango leaf extract was at temperature and time of 80:20 '. Where the total value of flavonoids is directly proportional to the antioxidant activity, the higher the value of the flavonoid compounds produced, the higher the antioxidant activity.
POTENSI SALEP EKSTRAK ETIL ASETAT Jatropha multifida L. SEBAGAI AGEN PENYEMBUHAN LUKA Syam, Akhirul Kahfi; Lahagu, Helga Nitulo Berliana; Ramdhani, Amalia Kusuma; Azhar, Farah Salsabilla Saidah; Mardiana, Grace Selly; Dewilestari, Meyra Pratami; Windyaswari, Ari Sri
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1630

Abstract

Jarak tintir (Jatropha multifida L.) umumnya terkenal sebagai tanaman hias yang berasal dari suku Euphorbiaceae. Masyarakat secara empiris memanfaatkan bagian getahnya sebagai obat luka. Telah dilakukan penelitian mengenai suku Euphorbiaceae memiliki aktivitas sebagai antioksidan pada ekstrak etil asetat dengan nilai IC50 < 50 ug/mL. Tujuan penelitian  ini untuk melihat  potensi metabolit sekunder pada ekstrak etil asetat yang berpotensi sebagai antioksidan untuk dikembangkan sebagai kosmedika penyembuhan luka.  Ekstraksi simplisia batang jarak tintir dilakukan menggunakan Refluks dengan pelarut etil asetat. Aktivitas antioksidan yang dinyatakan dalam nilai IC50 diuji menggunakan metode peredaman radikal bebas DPPH. Formulasi sediaan salep menggunakan basis vaselin album dan ekstrak etil asetat dengan konsentrasi 5,5% dan 11%. Potensi aktivitas penyembuhan luka dari ekstrak etil asetat dilakukan dengan metode telaah jurnal. Hasil uji aktivitas antioksidan ekstrak etil asetat memberikan nilai IC50 110,4 µg/mL. Formulasi sediaan salep ekstrak etil asetat batang Jarak tintir dengan konsentrasi 5,5% dan 11% memenuhi persyaratan uji evaluasi sediaan salep yang baik. Hasil telaah pustaka, metabolit sekunder yang memiliki potensi aktivitas antioksidan juga memiliki potensi sebagai agen penyembuhan luka dengan berbagai mekanisme penyembuhan dan metabolit sekunder yang bertanggung jawab sebagai agen penyembuhan luka antara lain alkaloid, flavonoid, tanin dan saponin.

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