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Mandala of Health : A Scientific Journal
Published by Universitas Jenderal Soedirman
ISSN : -     EISSN : 26156954     DOI : https://doi.org/10.20884/1.mandala
Core Subject : Health,
Dentistry Health Professions Public Health
Mandala of Health : A Scientific Journal is a medical scientific journal with open access published by the Faculty of Medicine, Jenderal Soedirman University, containing research articles, systematic reviews, and case reports in all areas of basic medical science, clinical medicine, biomedical science, medical biotechnology, and public health.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 131 Documents
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GAMBARAN KLINIS OTOMIKOSIS DI RS MARGONO SOEKARJO Kinanthi, Rusy; Kusdaryanto, Wahyu Dwi; Darmawan, Anton Budhi; Krisniawati, Nia; Nur Hestiyanti, Rani Afifah
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.11498

Abstract

Otomycosis is a disease of the outer ear canal caused by fungal microorganisms. Signs found in patients with otomycosis may also vary, such as edema, redness of the outer ear canal, tragus pain, discharge, or fungal mass through the clinical examination. This study aimed to determine the clinical features of patients diagnosed with otomycosis at Margono Soekarjo Hospital. This research was a descriptive study with a cross-sectional approach using primary data from July-November 2022 at the ENT clinic, Margono Soekarjo Hospital. An ENT specialist took data through the stages of anamnesis and physical examination. After otomycosis is clinically diagnosed, further documentation is carried out on the patient’s examination sheet regarding the characteristics of the subject and the clinical features in the form of symptoms and signs experienced by the subject. The data analysis performed was a univariate analysis to demonstrate the frequency distribution of clinical features in the study subjects. The total samples obtained are 46 samples from 42 subjects diagnosed with otomycosis with an age range of 17-73 years, and the susceptible age to undergo otomycosis is 26-35 years. The most common symptom is itching (80,43%). Other commonly found symptoms are hearing loss (78,26%) and a sensation of blockage in the ears (73,91%). At the same time, the sign commonly found in the physical examination is a fungal mass (100%). The most typical form of fungal group is white mass. In addition, signs are frequently found in discharge (64,04%) and perforation (60,87%). Otomycosis is a common disease in young adults. Symptoms and signs of otomycosis vary, but the common symptoms are itching, hearing loss, and the sensation of blockage in the ears. At the same time, the common signs are fungal mass in the ear, discharge, and perforation of the ear.
PENGARUH EFEK EKSTRAK ETANOL DAUN BAYAM HIJAU (Amaranthus hybridus L.) TERHADAP MOTILITAS SPERMATOZOA: Studi Pada Tikus Wistar Jantan Dengan Paparan Asap Rokok Mulyani, Diah Nauvalia; Hediningsih, Yekti; Tursinawati, Yanuarita
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.11828

Abstract

Cigarette smoke contains free radicals that trigger oxidative stress causing decreased sperm motility. A decrease in antioxidants causes reduced motility. Antioxidants found in vegetables in green spinach leaf extract function as antioxidants to prevent oxidant stress and increase levels of Reactive Oxygen Species (ROS). The aim of this study was to determine the effect of ethanol extract of green spinach leaves (Amaranthus hybridus L.) on spermatozoa motility. This quasi-experimental research used 25 male Rattus norvegicus mice using a post-test only control group design strategy and a simple random sampling approach. The initial stage in data analysis is the normality test. The Levene One Way ANOVA test was then performed, and the Post Hoc LSD test was used to compare the results. Based on the research results, the ethanol extract group of green spinach leaves had maximum motility at a dose of 588 mg/KgBW (82%) and the lowest at a dose of 147 mg/KgBW (64%). The groups Kn- and Kn+ (0.000), Kn- and P1 (0.000), Kn+ and P2 (0.009), Kn+ and P3 (0.005), P1 and P2 (0.009), and P1 and P3 (0.005) are significantly different from each other. Ethanol extract of green spinach leaves (Amaranthus hybridus L.) affected spermatozoa motility, and significant differences were seen among the five groups studied.
ISOLAT PROTEIN WHEY MENINGKATKAN SATIETY DAN MENGURANGI ASUPAN KALORI MELALUI INDUKSI SINYAL ANOREKSIGENIK Wisesa, Sindhu; Soraya, Aristi Intan; Wahyudin, Wahyudin
Mandala Of Health Vol 17 No 1 (2024): Mandala of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.1.11838

Abstract

Restriksi kalori merupakan strategi yang efektif dalam menurunkan berat badan, tetapi sulit diimplementasikan pada individu overweight atau obesitas dengan masalah overeating. Kurangnya asupan kalori dan penurunan lemak tubuh meningkatkan sinyal lapar (hunger) pada hipotalamus, sehingga dapat memicu konsumsi makan yang berlebih. Asupan protein menunjukkan peningkatan satiety lebih baik daripada karbohidrat atau lemak, sehingga diet tinggi protein dapat menurunkan total asupan kalori. Isolat protein whey merupakan olahan susu dengan jumlah protein yang tinggi dengan harga yang relatif murah, berpotensi digunakan dalam manajemen penurunan berat badan karena dapat meningkatkan satiety. Review ini bertujuan untuk menelaah efektivitas dan mekanisme protein whey dalam meningkatkan satiety pada orang dewasa. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) digunakan dalam review. Kata kunci “whey”, “protein”, “isolate”, “satiety”, dan “adult” digunakan untuk mencari artikel pada database Pubmed dan ScienceDirect. Sebanyak tujuh studi hasil uji klinik ditemukan setelah skrining. Isolat protein whey meningkatkan satiety, menurunkan rasa lapar, dan mengurangi jumlah asupan makan lebih baik daripada karbohidrat atau placebo, terutama jika dikonsumsi bersamaan dengan makanan. Kadar serum adiponectin dan plasma glucagon-like peptide-1 (GLP-1) meningkat setelah konsumsi isolat protein whey. Tidak terdapat perbedaan satiety antara asupan isolat protein whey dengan asupan isolat protein kedelai, kacang polong, kentang, beras, β-lactoglobulin, α-lactalbumin, atau campuran asam amino. Isolat protein whey meningkatkan satiety dan menurunkan rasa lapar pada orang dewasa melalui peningkatan sinyal adiponectin dan GLP-1, sehingga menurunkan total asupan kalori dan berpotensi digunakan dalam manajemen penurunan berat badan.
PEMANFAATAN DAN INOVASI DAUN KATUK (Sauropus androgynus) SEBAGAI SUPLEMENTASI ASI DI INDONESIA: MINI REVIEW Yudhawan, Indra; Cahyaningrum, Putri Khaerani; Suhartomo, Dalri Muhammad; Fadlillah, Synta Haqqul; Haresmita, Perdana Priya; Hamzah, Hasyrul; Sari, Mely Anita; Wicaksari, Sifa Aulia
Mandala Of Health Vol 17 No 1 (2024): Mandala of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.1.12017

Abstract

Zat gizi paling penting dalam masa emas pertumbuhan dan perkembangan bayi dalam 6 bulan pertama kehidupan adalah Air Susu Ibu (ASI). ASI mengandung zat gizi lengkap dan memiliki komponen imunitas yang penting bagi untuk pertumbuhan, perkembangan, dan sistem imun bayi. Akan tetapi, tidak semua ibu dapat menghasilkan ASI secara optimal dikarenakan berbagai faktor. Sehingga, sebagian ibu menyusui membutuhkan tambahan asupan berupa suplemen pelancar ASI. Salah satu tanaman yang banyak digunakan adalah daun katuk (Sauropus androgynus). Penelitian ini merupakan studi literatur terkait pemanfaatan daun katuk di Indonesia, sebagian besar pencarian adalah penelitian 5 tahun terakhir untuk mengetahui pemanfaatan dan pengembangan daun katuk di Indonesia. Hasil penelusuran menunjukkan bahwa terdapat efektivitas daun katuk dalam meningkatkan produksi ASI. Inovasi daun katuk sebagai suplementasi ASI banyak dilakukan, baik dalam bentuk makanan, cemilan, maupun minuman instan. Edukasi dan sosialisasi terkait pemanfaatan daun katuk juga telah banyak dilakukan oleh tenaga kesehatan. Namun, penelitian lebih dalam terkait mekanisme aksi daun katuk, serta pengembangannya dalam bentuk sediaan farmasi masih belum banyak dilakukan. Mengingat potensi yang besar dari daun katuk, perlu dilakukan penelitian lanjutan untuk mengeksplorasi mekanisme aksi dan mengembangkan produk daun katuk secara saintifik dalam bentuk nutrasetikal, obat herbal terstandar maupun fitofarmaka.
TINGKAT POSITIVITAS PEMERIKSAAN KALIUM HIDROKSIDA PADA PASIEN OTOMIKOSIS Widhi, Anriani Puspita Karunia Ning; Krisniawati, Nia; Darmawan, Anton Budhi; Nur Hestiyani, Rani Afifah
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.12096

Abstract

Otomycosis is an opportunistic fungal infection of the external ear canal and is widespread worldwide. The clinical manifestations of otomycosis are non-specific symptoms such as earache, discharge, itching, hearing loss, feeling of fullness in the ear, and tinnitus. The most common etiology found is Aspergillus sp. and Candida sp. The purpose of this study was to assess the positivity level of KOH examination in patients with a clinical diagnosis of otomycosis. The method used in this research uses a descriptive quantitative approach. The research subjects were otomycosis patients at the ENT-KL clinic at Margono Soekarjo Hospital from April to August 2022. Samples were taken using Flexible minitip flocked sterile swabs (Copan, Italy) on white to black ear secretions. Swabs were isolated on Saboraud Dextrose Agar (SDA) mushroom culture media (Himedia, India) and for KOH examination. The results obtained in this study were 48(85.7%) positive KOH, positive culture and 8(14.3%) negative KOH, positive culture. In a sample of 56 patients with a clinical diagnosis of otomycosis the most common isolates were Aspergillus sp 32 (57.1%) and Candida sp (42.9%). KOH sensitivity and specificity test results for Aspergillus sp were 37.7% and 100%, while for Candida sp were 97.7% and 50%. The conclusion of this study is that the KOH examination has a positivity rate of 85.7%. This examination needs to be routinely carried out as an initial screening to support the clinical diagnosis of otomycosis.
SYSTEMATIC REVIEW: POTENSI ANTI-INFLAMASI PADA TANAMAN PETAI (Parkia speciosa) Ati, Viva Ratih Bening; Zahra, Rafika; Pristika, Alya; Hevatio, Dufvan; Widodo, Azzahra Wuri; Kinanti, Luhung Sekar; Munawir, Azzah Azizah; Widyasari, Ailsya Inaayah Putri
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.12209

Abstract

Anti-inflammatory is defined as a compound or class of drugs that has the activity of suppressing or reducing the inflammatory response. Inflammation is a dynamic body defense mechanism and can be acute or chronic. There are still many Indonesian people who self-medicate (self-medication) using modern and herbal medicine. One of the native Indonesian plants used as a herbal medicinal plant is petai (Parkia speciosa). One of the known benefits of petai is as an anti-inflammatory because of the flavonoid content in it. The aim of this research is to examine the potential anti-inflammatory activity of the petai plant (Parkia speciosa). This research method was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The articles used in this research came from databases such as Google Scholar, Pubmed, Semantic Scholar, Researchgate, Ebsco with the keywords used namely (Parkia speciosa) AND (stink bean) AND (anti-inflammatory). There were 8 articles taken for review. The conclusion is that petai (Parkia speciosa) seed, skin and leaf extracts have anti-inflammatory potential based on in vitro and in vivo tests.
INFEKSI SOIL TRANSMITTED HELMINTHS PADA ANAK USIA SEKOLAH DASAR: PERILAKU JAJAN DAN PERILAKU HIGIENE Sari, Octavia Permata; Susiawan, Lieza Dwianasari; Wisesa, Sindhu; Harini, Ika Murti; Setiawati, Setiawati
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.12213

Abstract

Soil Transmitted Helminths (STH) are a group of parasitic nematodes that pass through the soil in their life cycle. STH can infect the digestive system and cause harm to humans. One of the risk factors for STH is snacking behavior and poor hygiene behavior in school-aged children. This study aims to determine the relationship between snacking behavior and hygiene behavior with the incidence of STH infection in students at SDN Ciberem, Sumbang District, Banyumas Regency. This research is an analytical observational study with a cross-sectional design and was carried out using purposive sampling. The population of this study were students in grades 1-5 at SDN Ciberem with a sample size of 96 students. Data collection was carried out using questionnaires and fecal examination at the FK Unsoed Parasitology Laboratory using qualitative methods. The data obtained were analyzed using Fisher's Exact Test. In this study, it was found that 5 students (5.2%) were infected with Trichuris trichiura type STH. The Fisher's Exact test showed a significant relationship between STH infection with hand washing habits (p = 0.037), the condition of the snacks being served open (p = 0.026), and lots of flies around the snacks (p = 0.031), but there was no significant relationship with the habit of using footwear (p = 1.000), the habit of cutting nails (p = 0.256), and the frequency of snacks (p = 0.333). There is a significant relationship between the habit of washing hands, buying open snacks and snacks with lots of flies around them and the incidence of STH infection. Key words: STH, SD, snacking behavior, hygiene behavior, washing hands
KONSENTRASI EKSTRAK ETANOLIK DAUN PEPAYA (Carica papaya L.) TERHADAP PERUBAHAN WARNA BASIS GIGI TIRUAN RESIN AKRILIK POLIMERISASI PANAS Purnama, Ryana Budi; Laksitasari, Anindita; Handayani, Fani Tuti; Widyaningsih, Pratiwi Nur; Rahmawati, Dewi; Milla, Dzhofirotul; Artanti, Evania Bellinda; Nahya, Bintan
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.12218

Abstract

Heat-cured acrylic resin is one of the materials used in making denture bases which has the disadvantage that it easily absorbs water and can make discoloration. Papaya leaves (C. papaya L) contain phenolic compounds (C6H6OH-) which can affect the color change of heat-cured acrylic resin. The purpose of this study is to determine the effect of various concentrations of papaya extract on discoloration of the heat-cured acrylic resin denture base. This experimental research is done in vitro at a laboratory using papaya leaf extract (C. papaya L) concentrations of 5%, 10%, and 20%. Thirty two samples of acrylic resin plates were divided into 4 groups, namely the immersion treatment group in papaya leaf extract concentrations of 5%, 10%, and 20%, and the negative control group in the form of aquadest soaking. The color change test was carried out using a UV-visible spectrophotometer. Data was analyzed using the One-Way ANOVA followed by Post-Hoc LSD test. The results of the study showed that there was a very significant difference in the mean value of color change between the treatment groups soaking in papaya leaf extract at concentrations of 10% and 20% and the control group, while at 5% concentration there was no significant difference from the control group. The lowest mean absorbance value was in the distilled water immersion group of 3.341350 ± 0.0942091 and the highest mean absorbance value was in the 20% immersion group of 3.553638 ± 0.0227829. This study concluded that there is an effect of various concentrations of papaya leaf extract on discoloration of the heat-cured acrylic resin denture base. Keywords: Carica papaya L, discoloration, acrylic resin, denture base.
ETIOLOGI DIAGNOSIS DAN MANAJEMEN SUMBATAN JALAN NAPAS Suryantarini, Ni Wayan Puspa Wijaya; Ansary, M Fathir Rahadian; Sultan Firdaus, Nadine Aisyah; Artha Jaya Kusuma, I Gusti Ketut
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.12443

Abstract

Airway obstruction is an emergency condition characterized by occlusion of the lumen of the airway caused by various etiologies, ranging from benign to malignant. Cases of airway obstruction require immediate management starting from an immediate evaluation of the patient’s condition, establishing a diagnosis of etiology and severity, and planning the most appropriate management. Awake intubation, tracheostomy incision, also balloon and stent placement are still quite effective and recommended in various guidelines. Trained medical personnel are essential for the success of the management process of patients with airway obstruction. The high mortality rate makes this condition require attention and treatment as early as possible. The literature review aims to discuss the etiology of airway obstruction that is often encountered in health facilities, as well as the diagnostic modalities and selection of appropriate managements.
DETEKSI DINI ATRIAL FIBRILASI UNTUK MENURUNKAN RISIKO STROKE Suryantarini, Ni Wayan Puspa Wijaya
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.12529

Abstract

Stroke is one of the major causes of death and contributes to loss of productivity in daily activities throughout the world. Every year it is estimated that there are 13,7 million new cases of stroke with a possibility of 1 in 4 people over 25 years will developing stroke. Stroke has various pathogenesis depending on the age at which the onset of stroke and the type of stroke. The increase in prevalence and mortality due to stroke has prompted many studies to examine stroke risk factors as well as early detection and management, including prevention. One common form of cardiac arrhythmia, is atrial fibrillation or AF, is one of the triggering factors for stroke with a five-fold risk. AF often does not manifest the symptoms in patients. Early detection of AF in all individuals, especially those at high risk of AF and stroke, is crucial to initiating early intervention and reducing the possibility of complications. Various devices have been developed to detect the occurrence of AF in asymptomatic and at-risk patients. This literature aims to explain how to detect early atrial fibrillation, including screening for AF symptoms, physical examination, ECG examination, use of technological devices, stratifying the risk of stroke in AF patients, and finally the prevention strategies for both AF and stroke.

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