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Mandala of Health : A Scientific Journal
Published by Universitas Jenderal Soedirman
ISSN : -     EISSN : 26156954     DOI : https://doi.org/10.20884/1.mandala
Core Subject : Health,
Dentistry Health Professions Public Health
Mandala of Health : A Scientific Journal is a medical scientific journal with open access published by the Faculty of Medicine, Jenderal Soedirman University, containing research articles, systematic reviews, and case reports in all areas of basic medical science, clinical medicine, biomedical science, medical biotechnology, and public health.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 131 Documents
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AKTIVITAS ANTIBIOFILM PROPOLIS LEBAH MADU TERHADAP BAKTERI Pseudomonas aeruginosa Purnama, Fadila Milenia; Nur Hestiyani, Rani Afifah; Ning Widhi, Anriani Puspita Karunia; Wahyudin, Wahyudin
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.9585

Abstract

Background: The number deaths of the infection effect from the bacterium Pseudomonas aeruginosa reaches 50% depending on the type of infection. The P.aeruginosa can be found in various environments, one of which is the hospital, with an incidence around 10-15%. P.aeruginosa is one of the bacteria that is difficult to treat because of its ability to form biofilm. Propolis is a natural resin containing flavonoid, fenol and terpenoid which used as antibiofilm. This study aims to examine the antibiofilm activity of propolis in inhibiting the formation of P. aeruginosa biofilm. Methods: This study is an in vitro laboratory experimental with a post-test only control group design. The number of samples was determined by the federer formula, where the samples in this study were 4 per groups. The propolis dissolved using aquades with the result the concentration became 12.5%, 6.25%, 3.125%, 1.56%, 0.78%. The proces of of inhibition of biofilm formation was measured using a microtiter plate assay with a wavelength of 620 nm. Results: Propolis can inhibit biofilm formation by 19.67% at a concentration of 0.78%. However, the proces cannot inhibit biofilm formation at other high concentrations because of the high viscosity of propolis, and the presence of other propolis ingredients which may be able to initiate biofilm formation. Conclusion: Propolis has antibiofilm activity against P.aeruginosa bacteria at a concentration of 0.78%.
EFEK PROPOLIS SEBAGAI RENOPROTEKTOR TERHADAP GAMBARAN HISTOPATOLOGI GINJAL MENCIT YANG DIINDUKSI PARASETAMOL Baihaqi, Achmad Alfan; AD, Noor Yazid; Marfu’ati, Nanik
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.9607

Abstract

The use of paracetamol with a toxic dose of 15 grams/day can cause damage, one of which is the kidney in the form of acute tubular necrosis. Propolis has a renoprotector effect through an antioxidant mechanism. The purpose of this study is to identify the renoprotector effect of propolis on the histopathological appearance of paracetamol-induced mouse kidneys. This research was an experimental research using the Post Test Only Control Group Design method. The sample of this study were 28 Swiss Webster mice divided into 4 groups: group (K-) was not given propolis and paracetamol, group (K+) was given paracetamol at a dose of 250 mg/kg BW; group (P1) was given propolis at a dose of 0.100 ml and group (P2) 0.125 ml was then induced by paracetamol at a dose of 250 mg/kgBW. The research was conducted for 10 days. Data were analyzed using the One Way Anova and Post Hoc LSD tests to determine whether there were significant differences in the histopathological appearance of the kidneys between treatment groups. The One Way Anova test showed significant differences in all treatment groups with p<0.05. The results of the LSD Post Hoc test showed that there was a significant difference between the K- group and the K + group, between the K + group and the P1 and P2 groups there was a significant difference. There was no significant difference between group P1 and group P2. There was an effect of propolis renoprotector on the histopathological appearance of paracetamol-induced mouse kidneys. Giving propolis at a dose of 0.100 ml was more optimal in preventing kidney damage in mice than a dose of 0.125 ml.
HUBUNGAN PENGGUNAAN TABIR SURYA DENGAN KEJADIAN MELASMA PADA PEGAWAI WANITA DI DINAS PERHUBUNGAN KOTA SEMARANG Adhi Pramudya, Dimas Sigit; Krisnarto, Eko; Setiawan, M Riza
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.9670

Abstract

Melasma is hyperpigmentation disorder in form of dark brown irregular macules which thought to caused excessive sun exposure. Regular and correct use of sunscreen is recommended as prevention from UVA and UVB rays, especially for people who have high risk of long-term sun exposure. The purpose of this study was determine the relationship between history of using sunscreen and the incidence of melasma and differences between respondents who used sunscreen compared to respondents who did not use sunscreen on the incidence of melasma. This research is observational analytic study with cross-sectional quantitative approach to female employees at the Semarang City Transportation Office. Obtained 45 samples through total sampling method. Data collection obtained from the anamnesis and respondents' answers through personal data sheets, questionnaires that been distributed and the results of physical examination using wood lamp as well as results of taking photos on the respondent's face which been consulted with dermatologist and genital specialist who met the inclusion and exclusion criteria which then analyzed with SPSS. The results showed that there was significant relationship between history of using sunscreen and incidence of melasma (P<0.05) and there was significant relationship between duration of sun exposure and incidence of melasma (P<0.05). There is significant relationship between history of using sunscreen and incidence of melasma and there is significant difference between respondents who have history of using sunscreen and those who do not have history of using sunscreen with incidence of melasma.
POTENSI CINNAMOMUM CASSIA (KAYU MANIS) SEBAGAI TERAPI KOMPLEMENTER DIABETES MELITUS Norinkha, Eksava Khalda’ Putri; Norinkha, Putri; Ramadhanti, Nadia Zahra Nursetya; Denastyo, M. Ravindra Patria; Azani, Arafiudin; Omnia, Omnia; Hasyim, Naila Nururridha; Muntafiah, Alfi
Mandala Of Health Vol 17 No 1 (2024): Mandala of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.1.10899

Abstract

Pendahuluan: Diabetes melitus (DM) merupakan suatu penyakit kronis multi etiologi yang ditandai dengan peningkatan kadar glukosa darah. Di samping terapi medis, saat ini telah berkembang banyak pilihan terapi komplementer untuk membantu mengatasi permasalahan DM. Kayu manis merupakan salah satu pilihan terapi komplementer dari penyakit diabetes. Terdapat berbagai bioaktif dalam kayu manis yang berperan dalam diabetes yang dapat menurunkan kadar glukosa darah pada DM. Oleh karena itu, fokus utama dalam literature review ini adalah untuk mengetahui efektivitas dari berbagai kandungan kayu manis (Cinnamomum cassia) sebagai terapi komplementer penurun glukosa darah pada penderita DM. Metode: Desain yang digunakan adalah literature review didasarkan pada Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline yang meliputi population, intervention, comparators, dan outcome (PICO). Artikel dikumpulkan dengan menggunakan database online yang valid, yaitu Pubmed dan Google Scholar. Kriteria artikel yang digunakan adalah diterbitkan tahun 2019-2023, fulltext, dan experimental study. Pencarian dilakukan dengan keywords (Cinnamomum cassia OR Kayu Manis) AND (Diabetes Mellitus OR Anti Diabetik OR Anti Diabetic). Hasil: Data dianalisis dari 15 jurnal ilmiah yang memenuhi kriteria inklusi dan eksklusi. Kesimpulan: Keberhasilan kayu manis dalam menurunkan kadar glukosa darah dipengaruhi oleh beberapa faktor seperti kondisi lingkungan pertumbuhan, cara pengolahan, penyimpanan, spesies, bentuk ekstrak atau suplemen, dosis, serta cara konsumsi. Oleh karena itu, masih diperlukan lebih banyak studi praklinis dan klinis mengenai kayu manis sebagai terapi komplementer DM.
STUDI EFEKTIVITAS HERBA TEMPUYUNG (Sonchus arvensis), KAYU SECANG (Caesalpinia sappan L.), DAN DAUN KEPEL (Stelechocarpus burahol), SEBAGAI ANTIHIPERURISEMIA: SYSTEMATIC REVIEW Putri, Natalie Wiguna; Ramadani, Jasmine Athaya; Maulana, Hamzah; Adawiyah, Nurul Robiah Al; Putri, Dwi Nuranggia Apriliani; Wibowo, Rafif Dzaky; Deviriandra, Yoana Rizki; Pribadi, Fajar Wahyu
Mandala Of Health Vol 17 No 1 (2024): Mandala of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.1.10940

Abstract

Hiperurisemia adalah kadar asam urat yang melebihi batas normal. Terapi konvensional yang terutama mengandalkan obat-obatan penghambat xantin oksidase yang tidak lepas dari adanya efek samping. Sebagai alternatif pengobatan, digunakanlah obat tradisional yang memiliki efek yang mirip dalam kemampuan menurunkan kadar asam urat seperti Cesalpinia sappan L. (daun tempuyung), Sonchus arvensis (kayu secang), dan Stelechocarpus burahol (daun kepel) yang memerlukan pengkajian lebih lanjut. Penelitian ini dilakukan untuk mengkaji efektivitas tiga tanaman herbal untuk menangani hiperurisemia. Pengkajian didasarkan pada metode preferred reporting items for systematic reviews and meta-analyses guideline. Daun tempuyung memiliki potensi penurunan kadar asam urat 52-64,267% dan konsentrasi penghambatan 50 terhadap xantin oksida pada 119.02 ppm, kayu secang dapat menghambat xantin oksida sebesar 58,922% dan konsentrasi penghambatan 50 pada 9.236 μg/ml, serta daun kepel memiliki konsentrasi penghambatan 50 terhadap xantin oksida pada 28,39±20,21 μg/ml. Berdasarkan hasil yang didapatkan, diketahui bahwa daun kepel tempuyung dan kayu secang memiliki kemampuan menghambat enzim xantin oksidase yang signifikan sehingga dapat digunakan sebagai jamu antihiperurisemia.
POTENSI EKSTRAK JINTAN HITAM (Nigella sativa) SEBAGAI KANDIDAT TERAPI KOMPLEMENTER DIABETES MELITUS Fary, Kevin Zufaris; Simanjuntak, Evi Christina Madalena; Marhadhani, Syifa Fatimatuzzahra; Azzahra, Aurora; Oktaviana, Husnul Afifah Rizky; Putri, Iqfani Amalia; Daffa, Mochamad Zidqi; Setiawati, Setiawati
Mandala Of Health Vol 17 No 1 (2024): Mandala of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.1.10958

Abstract

Diabetes melitus merupakan penyakit metabolik dengan peningkatan glukosa dalam darah dengan ketidakmampuan sel β pankreas menghasilkan insulin maupun penurunan efektivitas penggunaan insulin. Perawatan utama Diabetes Melitus (DM) adalah terapi konvensional dengan menggunakan obat hipoglikemik oral dan terapi injeksi insulin. Masyarakat juga menggunakan pengobatan tradisional karena dianggap memiliki efek samping minimal. Jintan hitam (Nigella sativa) merupakan salah satu tanaman herbal yang dapat digunakan untuk menurunkan kadar gula darah. Penelitian ini bertujuan untuk mengetahui potensi manfaat dan dosis yang digunakan pada pengobatan diabetes melitus. Literature review ini diperoleh dengan hasil pencarian literatur melalui Pubmed dan Sciencedirect didapatkan 7(tujuh) jurnal penelitian eksperimental. Pemberian ekstrak jintan hitam (Nigella sativa) pada pasien diabetes melitus dapat menurunkan gula darah dengan efek hipoglikemik yang dimiliki dan sebanding dengan penggunaan metformin. Kata kunci: diabetes melitus, metformin, Nigella sativa
HUBUNGAN ANTARA DUKUNGAN KELUARGA DAN PENGENDALIAN HIPERTENSI PADA PESERTA PROLANIS JAMINAN KESEHATAN NASIONAL DI KABUPATEN BANYUMAS Ramadani, Jasmine Athaya; Krisnansari, Diah; Wicaksono, Madya Ardi
Mandala Of Health Vol 17 No 1 (2024): Mandala of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.1.11245

Abstract

Latar belakang: Hipertensi merupakan penyakit kronis yang dapat menimbulkan terjadinya komplikasi dan meningkatkan mortalitas di Indonesia. Salah satu upaya pengendalian hipertensi yang dilakukan oleh pemerintah melalui Program Pengelolaan Penyakit Kronis (Prolanis). Dukungan keluarga diperlukan dalam pengendalian hipertensi karena pengobatannya yang lama. Belum ada penelitian mengenai hubungan antara dukungan keluarga dan pengendalian hipertensi peserta Prolanis di Kabupaten Banyumas. Tujuan: Mengetahui hubungan antara dukungan keluarga dan pengendalian hipertensi peserta Prolanis JKN hipertensi di Kabupaten Banyumas. Metode: Penelitian observasional analitik kuantitatif cross sectional pada 172 peserta Prolanis hipertensi di 9 fasilitas kesehatan tingkat pertama (FKTP) di Kabupaten Banyumas yang terpilih berdasar proportional cluster sampling bertingkat. Pengendalian hipertensi diukur berdasarkan tingkat dukungan keluarga, usia, jenis kelamin, pendidikan, lokasi tinggal peserta, pekerjaan, rutinitas kunjungan, dan rutinitas minum obat. Signifikansi yang digunakan dalam penelitian ini 95%. Analisis bivariat menggunakan uji Chi-Square dan analisis multivariat menggunakan analisis regresi logistik berganda. Hasil: Terdapat 175 peserta, (102) 58,3% memiliki hipertensi yang terkendali. Variabel dukungan keluarga (OR=1.44 (95% CI)) tidak berhubungan signifikan terhadap pengendalian hipertensi. Variabel usia (OR=0.93(95% CI)), jenis kelamin (OR=1.15 (95% CI)), pendidikan (OR=0.68 (95 CI)), lokasi tinggal peserta (OR=0.92(95% CI)), rutinitas kunjungan (OR=0.0.75(95% CI)), dan rutinitas minum obat (OR=0.96(95% CI)) tidak berhubungan signifikan terhadap pengendalian hipertensi. Variabel pekerjaan (OR=0.45(95% CI)) berhubungan signifikan terhadap pengendalian hipertensi. Kesimpulan: Dukungan keluarga tidak memiliki hubungan dengan pengendalian hipertensi pada peserta Prolanis hipertensi di Kabupaten Banyumas.
EFEK EKSTRAK DAUN KEMANGI (Ocimum basilicum L.) TERHADAP KADAR HIGH-DENSITY LIPOPROTEIN TIKUS (Rattus norvegicus) MODEL ATEROSKLEROSIS Mazara, Fitria; Mahata, Liganda Endo; Kadri, Husnil; Putri, Biomechy Oktomalio; Ali, Hirowati; Khaira, Fathiyyatul; Rusjdi, Dina Arfiani
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.11432

Abstract

Atherosclerosis is the cardiovascular disease’s main pathological mechanism. Basil leaves are food companion that s widely consumed by Indonesians and contains phenolic and flavonoid bioactive compounds that can increase HDL levels. The purpose of this study was to see the effect of basil leaves extract (Ocimum basilicum L.) on HDL levels in atherosclerosis model rat. This study was conducted using the post test only control group design method on 29 rats. The rats were divided into 5 groups, K-, K+, P1, P2, and P3. K- is group of rats without treatment. K+ was treated with partial carotid ligation (PCL) and high fat diet (HFD), P1 was treated with PCL, HFD and given a dose of 100 mg/kgB basil leaves extract, P2 was treated with PCL, HFD and given a dose of 200 mg/kgBB basil leaves extract, P3 was treated with PCL, HFD and given simvastatin 1.5 mg/rat/day. HFD was given for 7 days, basil leaves extract and simvastatin given for 14 days using oral feeding tube. HDL levels tested with CHOD-PAP method using a microlab 300 spectrophotometer. The result from this study were analyzed by Saphiro-Wilk test, and Kruskal-Wallis test. The mean HDL levels obtained in the K- group were 52,65(49,70‒68.10) mg/dL, K+ 49,67±8,77 mg/dL, P1 52.70±1.58 mg/dL, P2 54.40±9.94 mg/dL, P3 58,05 ±5,34 mg/dL. The results showed there was a non-significant increase in HDL levels (p=0.377) in atherosclerosis model rat by giving basil leaves extract on both dose, and simvastatin.
HUBUNGAN KADAR TIMBAL, ARSEN, DAN AIR RAKSA DENGAN STATUS GIZI ANAK CEREBRAL PALSY DI KABUPATEN BANYUMAS Widodo, Azzahra Wuri; Laksana, Agung Saprasetya Dwi; Kuncoro, Prasetyo Tri
Mandala Of Health Vol 17 No 1 (2024): Mandala of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.1.11453

Abstract

Latar Belakang Salah satu faktor risiko penyebab cerebral palsy adalah paparan logam berat. Timbal (Pb), arsen (As), dan air raksa (Hg) merupakan logam berat yang neurotoksik. Pb, Hg, dan As juga dapat mempengaruhi status gizi anak normal maupun anak cerebral palsy. Tujuan penelitian ini adalah untuk mengetahui hubungan kadar Pb, As, dan Hg dengan status gizi anak cerebral palsy di Kabupaten Banyumas. Metode Rancangan penelitian ini adalah cross-sectional. Sampel ditetapkan dengan non probability sampling menggunakan metode consecutive sampling. Pengumpulan data dilakukan dengan mengisi kuesioner data diri, mengukur tinggi dan berat badan, serta memotong rambut anak untuk dilakukan pemeriksaan kadar Pb, As dan Hg dengan spektrofotometer serapan atom (SSA). Data yang diperoleh dianalisis menggunakan uji Spearman. Hasil didapatkan sebanyak 24 anak cerebral palsy usia 1-12 tahun. Karakteristik data yang diperoleh berdasarkan jenis kelamin didapatkan mayoritas laki-laki (54,2%) dan berdasarkan usia paling banyak berusia 6-12 tahun (70,8%). Uji statistik menunjukkan kadar Pb (p = 0,716) tidak berhubungan dengan status gizi anak cerebral palsy di Kabupaten Banyumas. Hasil uji statistik kadar arsen (p = 0,681) tidak berhubungan dengan status gizi anak cerebral palsy di Kabupaten Banyumas. Uji statistik kadar air raksa (p = 0,453) menunjukkan tidak ada hubungan dengan status gizi anak cerebral palsy di Kabupaten Banyumas.
HUBUNGAN KADAR NATRIUM DAN KALIUM SERUM DENGAN TEKANAN DARAH DAN DENYUT NADI PADA PASIEN GAGAL JANTUNG Asworo, Fadhillah Noor Izza; Hediningsih, Yekti; Marfuati, Nanik
Mandala Of Health Vol 17 No 1 (2024): Mandala of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.1.11470

Abstract

Heart failure is the inability of the heart to carry out its function, namely pumping blood at a normal frequency for tissue needs, which causes compensatory mechanisms, namely activation of the renin-angiotensin system, narrowing of the arteries and release of adrenergic. The renin-angiotensin system will increase renin which will then increase aldosterone, causing changes in serum sodium levels and serum potassium levels. Meanwhile, narrowing of the arteries due to decreased contractility will affect blood pressure, while adrenergic release will increase the pulse rate. This study aims to prove the relationship between serum sodium and potassium levels with blood pressure and pulse rate in heart failure patients. This research is a cross sectional study, with 23 patients as respondents. Samples were collected using the sequential sampling method. The data used are medical records that check serum sodium and potassium levels at one time with blood pressure and pulse. The results obtained showed that the average serum sodium level was 135.7 ± 6.643 mEq/L, the average serum potassium level was 4,087 ± 0.7485 mEq/L, the average systolic blood pressure was 123.35 ± 29.518 mmHg, the average mean diastolic blood pressure 70.43 ± 31,334 mmHg, mean pulse 99 ± 31,010 times per minute. The significance value of the Spearman Rank test on serum sodium levels with blood pressure was 0.910 (p>0.05), on sodium levels with pulse rate was 0.713 (p>0.05), on serum potassium levels with blood pressure was 0.076 (p> 0.05), and serum potassium level with pulse was 0.344 (p>0.05). It can be concluded that there is no significant relationship between serum sodium and potassium levels and blood pressure and pulse rate.

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