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Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 10 Documents
 1 
Search results for , issue "Vol. 34 No. 1 (2026)" : 10 Documents clear
Clinical Characteristics and Outcomes of Neonatal Sepsis due to Pseudomonas putida in South Kalimantan Andayani, Pudji; Hartoyo, Edi; Pasaribu, Munawaroh; Marhaeni, Wulandewi; Yunanto, Ari; Putra, Nataniel Hadi; Himawan, Gratianus Billy; Salim, Monica Anggriana; Halim, Pricilia Gunawan
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.01.4

Abstract

Pseudomonas putida is a Gram-negative bacterium that can cause nosocomial infections, particularly in neonates. This study aimed to identify the characteristics of neonates with P. putida infection, the antibiotics administered, and the treatment outcomes during a P. putida outbreak. This descriptive study collected data from the medical records of neonates diagnosed with neonatal sepsis admitted to Ulin Hospital, Banjarmasin, between August and October 2022. Data collected included patient characteristics, clinical profiles, laboratory results, antibiotic therapy, P. putida antibiotic sensitivity results, and bacterial culture results from samples taken in the NICU during the outbreak period. Fourteen neonates (6.5%) had positive P. putida during the outbreak of blood cultures, including 13 neonates born at Ulin Hospital and one referred from another health facility. Neonates with P. putida infection exhibited leukopenia, thrombocytopenia, and elevated CRP levels. After obtaining the culture results and antibiotic sensitivity tests, the choice of antibiotics was adjusted based on the bacteria's sensitivity. The antibiotics found compelling during treatment included ciprofloxacin, cefepime, tazobactam, gentamicin, a combination of ciprofloxacin and amikacin, and a combination of piperacillin. Most of the clinical and laboratory characteristics improved following treatment, but three neonates unfortunately died during hospitalization. Overall, there were clinical and laboratory improvements after administering antibiotics according to the culture-based antibiotic resistance results.
Glutathione Sulfhydryl (GSH) and Malondialdehyde (MDA) Levels Comparison in Senile Cataract Lenses of Coastal and Mountain Populations Hidayat, Muhammad; Primasakti, Pattih
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.01.3

Abstract

Cataracts are a leading cause of global blindness, affecting over 20 million individuals, according to the WHO are primarily age-related but are influenced by UV radiation-induced oxidative stress on lens proteins and cells. Geographic UV intensity variations prompted further comparative studies Glutathione Sulfhydryl (GSH) and Malondialdehyde (MDA) in senile cataracts. This was a cross-sectional study. utilized all senile cataract patients who underwent extracapsular cataract extraction (ECCE) surgery. Lens nucleus specimens were examined for GSH and MDA levels at the Biomedical Laboratory of the Faculty of Medicine and Andalas University. The examination results were processed and analyzed using Pearson’s correlation test. The study included 32 participants, with the majority (68.8%) being men, primarily working as farmers (56.3%), and 81.3% having mature cataracts. No significant differences were found in GSH and MDA levels between residents living in coastal areas and those living in mountainous areas, with p-values of 0.087 and 0.484, respectively (p>0.05). There was no correlation between GSH and MDA levels in patients with senile cataracts living in coastal and mountainous areas or in those living solely in coastal or mountainous areas (p>0.05). There was no correlation between GSH and MDA levels in patients with senile cataracts living in coastal and mountainous areas. The decrease in GSH levels was due to aging and was not influenced by UV exposure. The average MDA levels in mountain residents were higher than those in coastal residents. UV radiation in mountainous areas induced more ROS, resulting in slightly higher MDA levels than in coastal areas.
Effectivity of Artery Ligation for Bleeding Control in Placenta Accreta Spectrum: A Systematic Review Daniati, Lidya; Rahardjo, Bambang
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.01.9

Abstract

Placenta accreta spectrum (PAS) is a potentially life-threatening obstetric condition that causes severe postpartum hemorrhage. This study aimed to evaluate these techniques and their effectiveness in controlling postpartum hemorrhage. This systematic review used four databases: ScienceDirect, PubMed, Embase, and Scopus. We included studies on arterial ligation or occlusion, particularly of the internal iliac, uterine, hypogastric, or abdominal arteries, that compared arterial occlusion with conservative therapy or other interventions in women with PAS. We included eighteen studies with 1,338 patients. A total of 884 patients underwent the arterial ligation technique, whereas 454 underwent the balloon technique. Several studies have shown that arterial ligation or ballooning may be beneficial in controlling bleeding and reducing the need for hysterectomy. In contrast, other studies found that arterial ligation and occlusion did not result in significant differences in terms of intraoperative blood loss, required hysterectomy, and blood transfusion. All studies consistently found that arterial ligation and occlusion led to an increase in overall operative time compared to the control group. In addition, arterial ligation and occlusion are considered safe techniques with few complications. Arterial ligation and occlusion are effective techniques for managing PAS, particularly for controlling blood loss. Arterial ligation and occlusion are safe procedures with minimal complications.
How Far Has the Development of Endometriosis Murine Models Progressed? A Systematic Review Hermawan, Wibisono; Ayu Rizky, Widowati; Leny Silviana , Farida
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.01.10

Abstract

Up to 15% of women of reproductive age suffer with endometriosis, an inflammatory condition that is dependent on estrogen. Its complex nature and nonspecific symptoms often delay diagnosis and treatment. Due to limited human studies and rare spontaneous cases in primates, murine models are essential for exploring disease mechanisms and therapies. This systematic review evaluated seven experimental studies conducted between 2005 and 2025 using murine models, selected from PubMed, Cochrane, SCOPUS, and Taylor & Francis databases. Most studies employed syngeneic models, which facilitate compatibility with transgenic tools. Advanced visualization techniques, such as GFP fluorescence and luciferase-based bioluminescence, allowed non-invasive and real-time tracking of lesion development. Although these models offer significant advantages, inconsistencies in hormonal protocols, tissue sources, and imaging depth remain challenges. Despite these limitations, murine models have progressed notably, particularly with innovative imaging technologies. However, further standardization and improvements in physiological relevance are needed to enhance translational potential.
Comparisons of Karnofsky Score, Quality of Life, and Glomerular Filtration Rate in Cervical Cancer Patients with Bilateral Obstructive Uropathy before and after DJ Stent Insertion Daryanto, Besut; Wijaya, Mangkubumi Putra; Seputra, Kurnia Penta
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.01.2

Abstract

Cervical cancer is the second most common cancer in Indonesia, and it can lead to urinary tract obstruction. Obstructive uropathy can progress to hydronephrosis and kidney failure with a poor prognosis and can lead to several complications such as sepsis and uremia.  This study aims to compare outcomes of advanced-stage cervical cancer patients with obstructive uropathy who underwent DJ stent insertion versus those who did not at Saiful Anwar Malang General Hospital in Indonesia. An observational study conducted with a prospective cohort approach. Data collection was done through purposive sampling. Inclusion criteria include cervical cancer patients with bilateral obstructive uropathy who undergo DJ stent insertion and who failed or refused DJ stent insertion at the Saiful Anwar General Hospital. Paired T-tests were conducted to compare patients before and after DJ stent insertion, and unpaired T-tests were performed to compare patients who underwent DJ stent insertion and who did not. Glomerular Filtration Rate (GFR), Karnofsky Score (KS), and Quality of Life (QoL) Values before DJ stent insertion were 0.382, 0.454, and 0.246, respectively. After 3 months, these values were found to be 0.002, 0.000, and 0.002, respectively. DJ stent insertion has been proven to improve the quality of life, performance status, and kidney function in patients with cervical cancer and obstructive uropathy.
Corneal Epithelial Damage Following Bacillus thuringiensis Bioinsecticide Exposure in Wistar Rats Komariah, Cicih; Astuti Setyawardani; Al Kamal, Ahmad Asrori; Nurul Amin, Aldi Nawaf; Hurriyyah, Hashinatul; Ulil Albab, Fathiah; Daeng Ndiko, Siti Aminah
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.01.7

Abstract

Approximately 2% of bioinsecticides for pest control are biopesticides; 90% are Bt bioinsecticides, typically in spray form. Bt solution is acidic and may cause ocular surface damage. This study is conducted to determine the Bt exposure method and concentration that might cause corneal ocular surface damage. This study was performed on Wistar rats anesthetized with 75mg/kg BW ketamine intraperitoneally, with these four treatments: 1. Bt Dipel WG solution exposure by filter paper with 0.5g/L, 1g/L, 2g/L, and 4g/L concentrations for 1 minute; 2. Bt Dipel WG solution exposure by filter paper with 6g/L, 8g/L, and 10g/L concentrations for 1 minute; 3. 3mL Bt Dipel WG solution exposure by drops for 2 minutes with 6g/L, 8g/L, and 10g/L concentrations; and 4. 3mL Bt Dipel WG solution exposure by drops for 2 minutes with 6g/L, 8g/L, and 10g/L concentrations and eyelid closure for 30 minutes. Treatments 1, 2, and 3 were performed for 3 days; treatment 4 was performed for 7 days. Exposures were made on different rats. Corneal defects were identified using fluorescent liquid and blue penlight. Corneal ocular surface damage was evident in two Wistar rats exposed to 10g/L Bt Dipel WG solution drops in the cornea with 30 minutes of eyelid closure for seven consecutive days. Bt bioinsecticide may cause corneal defects with exposures of 10 g/L and 30 minutes of eyelid closure for seven days.
The Effect of Centella asiatica Cream on Transforming Growth Factor Beta 1 in Acute Wounds Ulfa, Maria; Iskandar, Elza; Erna, Riani; Saleh, M Irsan
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.01.6

Abstract

Centella asiatica contains triterpenoids with anti-inflammatory, antioxidant, and antifibrotic properties and has long been used in wound healing. Previous studies suggest that Centella asiatica may reduce TGF-β1 expression, which is implicated in scar and keloid formation. Given the pleiotropic role of TGF-β in wound healing being required in the inflammatory phase and downregulated during proliferation this study employed an acute wound model to represent normal healing and to evaluate the effect of Centella asiatica extract on TGF-β1 expression. This study aimed to evaluate the effects of topical Centella asiatica cream application at concentrations of 0.5%, 1%, and 2% on TGF-β1 levels in acute wound healing in Wistar rats. An experimental posttest-only control group design was conducted at the Pharmacology Laboratory, Animal House, and Biotechnology Laboratory, Faculty of Medicine, Universitas Sriwijaya. Five groups were studied, consisting of one untreated group, three groups treated with Centella asiatica cream at concentrations of 0.5%, 1%, and 2%, respectively, and one group treated with placebo, with five rats in each group. Data were analyzed using  One-way ANOVA, and Post Hoc LSD tests. Results showed the highest TGF-β1 levels in the placebo group and the lowest in the 1% Centella asiatica cream group. Significant differences were found between the 1% Centella asiatica cream group and the untreated  (p=0.026), placebo, and 2% Centella asiatica cream groups (p=0.008).  In conclusion, the Centella asiatica cream concentration of 1% was the most effective in reducing TGF-β1 levels in acute eyelid wound healing in Wistar rats.
Sexual Function Disorders after Hormonal Therapy or Surgery for Endometriosis in Moewardi General Hospital, Surakarta Anggraeni, Asih; Budihastuti, Uki Retno; Darto, Darto; Laqif, Abdurrahman; Melinawati, Eriana; Ksatriya, Yudhistya Ngudi Insan; Wijayanti, Agung Sari; Nuur, Aliffudin
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.01.1

Abstract

Endometriosis significantly affects women’s sexual health, manifesting as pain and dyspareunia, which reduces quality of life. In Indonesia, hormonal and surgical interventions are both used to manage endometriosis. However, the study of their effect on sexual function among Indonesia’s population is still unclear. This quasi-experimental study included 60 women, divided into two groups based on the type of therapy. This study was conducted from June to September 2024 at the Department of Obstetrics and Gynecology, Dr. Moewardi General Hospital. Outcomes were assessed with the Female Sexual Function Index (FSFI) questionnaire, before and after treatment. The analysis showed the mean rank of the surgical intervention (44.97) is higher than the hormonal intervention (16.03). The Mann-Whitney U test revealed a significant difference between the two groups of intervention (p=0.000). These findings indicate that surgical intervention is superior to hormonal therapy in improving the FSFI score that reflects sexual function among women.  
Potential Vitamin D3 in Reducing Hyperglicemia on Wistar Diabetic Mellitus Maulidi, Ahmad; Parmasari, Wahyuni Dyah; Ari Tania, Putu Oky; Setiawan, Heru; Sunaryati, Titiek
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.01.8

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia due to impaired insulin secretion or insulin resistance. Potential alternative to DM management is vitamin D supplementation, which is known to play a role in glucose homeostasis by enhancing insulin sensitivity and protecting pancreatic beta cells. This study aimed to evaluate the effect of vitamin D3 administration on blood glucose levels in Wistar rats induced diabetes mellitus using alloxan. Alloxan causes diabetes by damaging pancreatic β-cells in the islets of Langerhans. This substance enters the cells via the glucose transporter (GLUT2), producing free radicals (ROS), promote oxidative stress and β-cell necrosis, resulting in decreased insulin secretion and increased blood glucose levels. This study uses an experimental design with pre-test and post-test control group. The results showed a significant difference in blood glucose levels between groups (p=0.002) with Kruskal-Wallis Test. The treatment groups (P1 and P2) demonstrated a reduction in blood glucose levels compared to the positive control, with a greater decrease observed in group with the high dose of Vitamin D3, although the difference of glucose level between P1 and P2 was not statistically significant. These findings suggest that vitamin D3 administration plays a beneficial role in lowering blood glucose levels in alloxan-induced diabetic Wistar rats. It may help improve glucose regulation by enhancing insulin sensitivity or protecting pancreatic β-cells from oxidative damage. This paper describes our experimental approach, from the methodology through to the results and discussion, to explore the impact of Vitamin D3 on diabetic Wistar rats.
Uric Acid as a Significant Risk Factor for Hypertension Severity, Unlike Lipid Profiles Basuki, Sri Wahyu; Triastuti, N Juni; Erna Herawati; Sintowati, Retno; Faizah , Ariyani; Anisa Putri, Dede; Amalia, Raisya; Embiysne , Viamell; Amalia, Regal; Kusuma Ningrum, Sukma
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.01.5

Abstract

Hypertension remains a global health problem experienced by the world's population, as evidenced by its high prevalence and mortality rate. For 90-95% of hypertension sufferers, the cause of hypertension was reported as unknown. However, there are several risk factors associated with hypertension, notably genetic factors, age, gender, diabetes mellitus, lifestyle and diet, as well as lipid and uric acid profiles. This study aims to analyze uric acid and propyl lipid levels with hypertension severity. The study employed a quantitative research design. Data were collected through purposive sampling, yielding a total sample of 110 participants. The dataset was subsequently analyzed using logistic regression test. Based on the logistic regression statistical test, the following results were obtained: uric acid levels (p-value <0.05; OR >1; CI did not exceed 1); triglyceride levels (p-value >0.05; OR >1; CI exceeded 1); total cholesterol levels (p-value >0.05; OR <1; CI exceeded 1); and low-density lipoprotein levels (p-value >0.05; OR >1; CI exceeded 1). Thus, it can be concluded that abnormal uric acid levels significantly affect the severity of hypertension. Abnormal triglyceride levels and low-density lipoprotein levels show a tendency to increase the risk of hypertension severity but are not yet statistically significant. There is a tendency for abnormal total cholesterol levels to be less risky for severe hypertension compared to normal total cholesterol levels, but this disparity is not significant. Nevertheless, the probability of all variables with abnormal levels possessed a 12% risk of hypertension severity remains.

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